Nucleosides - RNA / BOC Sciences

5'-DMT-2'-tBDSilyl Adenosine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Adenosine (n-PAC) is a chemical reagent used in oligonucleotide synthesis. It features an adenosine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for 5' hydroxyl protection and a 2'-tBDSilyl (tert-butyldimethylsilyl) group for 2' hydroxyl protection. Additionally, the N6 position of adenosine is protected by a PAC (phenoxyacetyl) group. These protective modifications prevent side reactions during the sequential assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise oligonucleotide production. This reagent is crucial for various applications in molecular biology, genetic research, and therapeutic development.

CAT: BRP-01306

CAS: 121058-83-1

MF: C45H51N5O8Si

MF: 818.00

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Density: 1.23±0.1 g/cm3

InChIKey: QGHUBPNLGMARKQ-DQZBACKDSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C45H51N5O8Si/c1-44(2,3)59(6,7)58-40-39(52)36(57-43(40)50-29-48-38-41(46-28-47-42(38)50)49-37(51)27-55-35-16-12-9-13-17-35)26-56-45(30-14-10-8-11-15-30,31-18-22-33(53-4)23-19-31)32-20-24-34(54-5)25-21-32/h8-25,28-29,36,39-40,43,52H,26-27H2,1-7H3,(H,46,47,49,51)/t36-,39-,40-,43-/m1/s1

Synonyms: N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)-2-phenoxyacetamide; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)adenosine; N6-Pac-5'-O-DMT-2'-O-TBDMS-rA; 5'-O-(dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N6-phenoxyacetyladenosine

5'-DMT-2'-tBDSilyl Cytidine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Cytidine (n-PAC) is a specialized reagent used in the synthesis of oligonucleotides. It consists of a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for protecting the 5' hydroxyl position and a 2'-tBDSilyl (tert-butyldimethylsilyl) group for protecting the 2' hydroxyl position. Additionally, the amino group at the N4 position of cytidine is protected by a PAC (phenoxyacetyl) group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and accurate oligonucleotide production. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01307

CAS: 259144-71-3

MF: C44H51N3O9Si

MF: 793.98

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Density: 1.19±0.1 g/cm3

InChIKey: AEVPUWXDGCKYTH-OGEJDOPKSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2O[Si](C)(C)C(C)(C)C)NC(=O)COC=6C=CC=CC6

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-phenoxyacetamide

InChI: InChI=1S/C44H51N3O9Si/c1-43(2,3)57(6,7)56-40-39(49)36(55-41(40)47-27-26-37(46-42(47)50)45-38(48)29-53-35-16-12-9-13-17-35)28-54-44(30-14-10-8-11-15-30,31-18-22-33(51-4)23-19-31)32-20-24-34(52-5)25-21-32/h8-27,36,39-41,49H,28-29H2,1-7H3,(H,45,46,48,50)/t36-,39-,40-,41-/m1/s1

Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)cytidine; Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(phenoxyacetyl)-; 5'-O-DMT-2'-O-TBDMS-rC(Pac)

5'-DMT-2'-tBDSilyl Guanosine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Guanosine (n-PAC) is a specialized reagent used in the synthesis of oligonucleotides. It features a guanosine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and a 2'-tBDSilyl (tert-butyldimethylsilyl) group to protect the 2' hydroxyl position. Additionally, the amino group at the N2 position of guanosine is protected by a PAC (phenoxyacetyl) group. These protective modifications prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and accurate oligonucleotide production. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01308

CAS: 121058-84-2

MF: C45H51N5O9Si

MF: 834.01

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Density: 1.26±0.1 g/cm3

InChIKey: XPYPOARJDHWYJZ-AEGBRLROSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C2N=C(NC3=O)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-phenoxyacetamide

InChI: InChI=1S/C45H51N5O9Si/c1-44(2,3)60(6,7)59-39-38(52)35(58-42(39)50-28-46-37-40(50)48-43(49-41(37)53)47-36(51)27-56-34-16-12-9-13-17-34)26-57-45(29-14-10-8-11-15-29,30-18-22-32(54-4)23-19-30)31-20-24-33(55-5)25-21-31/h8-25,28,35,38-39,42,52H,26-27H2,1-7H3,(H2,47,48,49,51,53)/t35-,38-,39-,42-/m1/s1

Synonyms: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-phenoxyacetamide; N-Pac-5'-O-DMT-2'-O-TBDMS-rG; 5'-O-DMT-2'-O-TBDMS-rG(Pac); 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)guanosine; 5'-O-(dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N2-phenoxyacetylguanosine

5'-DMT-2'-tBDSilyl Adenosine (n,n-dibz)

Description: 5'-DMT-2'-tBDSilyl Adenosine (n,n-dibz) is a specialized reagent used in the chemical synthesis of oligonucleotides. This compound consists of an adenosine nucleoside that is modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and a 2'-tBDSilyl (tert-butyldimethylsilyl) group to protect the 2' hydroxyl position. Additionally, the amino groups at the N6 position of adenosine are protected by dibenzoyl (n,n-dibz) groups. These protective groups are essential for preventing unwanted side reactions during the sequential assembly of nucleotide chains in automated DNA or RNA synthesis, thereby ensuring efficient and precise oligonucleotide production. This reagent is crucial for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01309

CAS: 200284-75-9

MF: C51H53N5O8Si

MF: 892.08

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Density: 1.22±0.1 g/cm3

Boiling Point: 939.1±75.0 °C at 760 mmHg

InChIKey: VHDQKLHGBANZKX-QGBKNRJASA-N

CanonicalSMILES: O=C(C=1C=CC=CC1)N(C(=O)C=2C=CC=CC2)C=3N=CN=C4C3N=CN4C5OC(COC(C=6C=CC=CC6)(C7=CC=C(OC)C=C7)C8=CC=C(OC)C=C8)C(O)C5O[Si](C)(C)C(C)(C)C

IUPAC Name: N-benzoyl-N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C51H53N5O8Si/c1-50(2,3)65(6,7)64-44-43(57)41(31-62-51(36-21-15-10-16-22-36,37-23-27-39(60-4)28-24-37)38-25-29-40(61-5)30-26-38)63-49(44)55-33-54-42-45(55)52-32-53-46(42)56(47(58)34-17-11-8-12-18-34)48(59)35-19-13-9-14-20-35/h8-30,32-33,41,43-44,49,57H,31H2,1-7H3/t41-,43-,44-,49-/m1/s1

Synonyms: Adenosine, N,N-dibenzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 2'-O-t-Butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-N6-dibenzoyladenosine

5'-DMT-5-Propynyl-2'-(O-Methyl) Cytidine (n-bz)

Description: 5'-DMT-5-Propynyl-2'-(O-Methyl) Cytidine (n-bz) is a specialized reagent used in oligonucleotide synthesis. It features a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for protecting the 5' hydroxyl position, a 5-propynyl group on the cytosine ring, and a 2'-(O-Methyl) group for protecting the 2' hydroxyl position. Additionally, the N4 amino group is protected by a benzoyl (n-bz) group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is crucial for applications in molecular biology, genetic research, and nucleic acid-based therapeutics development.

CAT: BRP-01310

MF: C41H39N3O8

MF: 701.76

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InChIKey: CJDAMOMLUIMTME-LZURGKRNSA-N

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-2-oxo-5-(prop-1-yn-1-yl)-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C41H39N3O8/c1-5-12-28-25-44(40(47)43-37(28)42-38(46)27-13-8-6-9-14-27)39-36(50-4)35(45)34(52-39)26-51-41(29-15-10-7-11-16-29,30-17-21-32(48-2)22-18-30)31-19-23-33(49-3)24-20-31/h6-11,13-25,34-36,39,45H,26H2,1-4H3,(H,42,43,46,47)/t34-,35-,36-,39-/m1/s1

Synonyms: 5'-DMT-5-Propynyl-2'-O-Me-C(Bz)

5'-DMT-2,6-diamino purine riboside (n6,n6-dmf) (n2-ibu)

Description: 5'-DMT-2,6-Diamino Purine Riboside (N6,N6-DMF) (N2-ibu) is a specialized reagent used in oligonucleotide synthesis. It consists of a purine riboside nucleoside modified with a 5'-DMT (dimethoxytrityl) group for protecting the 5' hydroxyl position, dimethylformamidine (DMF) groups protecting the N6 amino groups, and an isobutyryl (ibu) group protecting the N2 position. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01311

MF: C38H43N7O7

MF: 709.79

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InChIKey: VPXSLKLNUOULQH-BEGXHNNXSA-N

IUPAC Name: N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-6-(((dimethylamino)methylene)amino)-9H-purin-2-yl)isobutyramide

InChI: InChI=1S/C38H43N7O7/c1-23(2)35(48)43-37-41-33(40-21-44(3)4)30-34(42-37)45(22-39-30)36-32(47)31(46)29(52-36)20-51-38(24-10-8-7-9-11-24,25-12-16-27(49-5)17-13-25)26-14-18-28(50-6)19-15-26/h7-19,21-23,29,31-32,36,46-47H,20H2,1-6H3,(H,41,42,43,48)/t29-,31-,32-,36-/m1/s1

Synonyms: 2-Amino-5'-O-(dimethoxytrityl)-N6-(dimethylaminomethylidene)-N2-isobutyryl-adenosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-[(dimethylamino)methylene]-2-[(2-methyl-1-oxopropyl)amino]adenosine; 5'-DMT-N2-amino-ibu rA(N6-DMF)

5'-DMT-8-Bromo Adenosine (n,n-dibuf)

Description: 5'-DMT-8-Bromo Adenosine (N,N-dibuf) is a specialized reagent used in the synthesis of oligonucleotides. It consists of an adenosine nucleoside modified with an 8-bromo group on the adenine base, a 5'-DMT (dimethoxytrityl) group protecting the 5' hydroxyl position, and N,N-dibutyryl groups protecting the amino groups at the N6 position. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is crucial for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01312

CAS: 197712-18-8

MF: C40H47BrN6O6

MF: 787.74

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Density: 1.36±0.1 g/cm3

Boiling Point: 881.6±75.0 °C at 760 mmHg

InChIKey: IRILBDUSCUMPSP-NFXQKKKASA-N

CanonicalSMILES: BrC1=NC=2C(=NC=NC2N1C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3O)N=CN(CCCC)CCCC

IUPAC Name: N'-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-8-bromo-9H-purin-6-yl)-N,N-dibutylformimidamide

InChI: InChI=1S/C40H47BrN6O6/c1-5-7-22-46(23-8-6-2)26-44-36-33-37(43-25-42-36)47(39(41)45-33)38-35(49)34(48)32(53-38)24-52-40(27-12-10-9-11-13-27,28-14-18-30(50-3)19-15-28)29-16-20-31(51-4)21-17-29/h9-21,25-26,32,34-35,38,48-49H,5-8,22-24H2,1-4H3/t32-,34-,35-,38-/m1/s1

Synonyms: Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-8-bromo-N-[(dibutylamino)methylene]-

5'-DMT-5-Propynyl Cytidine (n-bz)

Description: 5'-DMT-5-Propynyl Cytidine (n-bz) is a specialized reagent used in oligonucleotide synthesis. It consists of a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position, a 5-propynyl group on the cytosine ring, and a benzoyl (n-bz) group protecting the N4 amino group. These protective groups are essential for preventing unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is critical for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01313

MF: C40H37N3O8

MF: 687.74

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InChIKey: IBWXYBVVQWPUCS-UYHDOTGISA-N

IUPAC Name: N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-5-(prop-1-yn-1-yl)-1,2-dihydropyrimidin-4-yl)benzamide

InChI: InChI=1S/C40H37N3O8/c1-4-11-27-24-43(39(47)42-36(27)41-37(46)26-12-7-5-8-13-26)38-35(45)34(44)33(51-38)25-50-40(28-14-9-6-10-15-28,29-16-20-31(48-2)21-17-29)30-18-22-32(49-3)23-19-30/h5-10,12-24,33-35,38,44-45H,25H2,1-3H3,(H,41,42,46,47)/t33-,34-,35-,38-/m1/s1

Synonyms: 5'-DMT-5-Propynyl-C(Bz)

5'-DMT Adenosine (N6-Fmoc)

Description: 5'-DMT Adenosine (N6-Fmoc) is a specialized reagent used in the synthesis of oligonucleotides. It consists of an adenosine nucleoside that has been modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and an N6-Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the N6 amino group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01314

MF: C46H41N5O8

MF: 791.85

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InChIKey: IXEUDLDKQXKANT-FOQJVDBMSA-N

IUPAC Name: (9H-fluoren-9-yl)methyl (9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

InChI: InChI=1S/C46H41N5O8/c1-55-31-20-16-29(17-21-31)46(28-10-4-3-5-11-28,30-18-22-32(56-2)23-19-30)58-25-38-40(52)41(53)44(59-38)51-27-49-39-42(47-26-48-43(39)51)50-45(54)57-24-37-35-14-8-6-12-33(35)34-13-7-9-15-36(34)37/h3-23,26-27,37-38,40-41,44,52-53H,24-25H2,1-2H3,(H,47,48,50,54)/t38-,40-,41-,44-/m1/s1

Synonyms: N6-Fmoc-5'-O-DMT-Adenosine

5'-DMT Cytidine (N4-Fmoc)

Description: 5'-DMT Cytidine (N4-Fmoc) is a specialized reagent used in the synthesis of oligonucleotides. It features a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and an N4-Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the N4 amino group. These protective groups are crucial for preventing unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01315

MF: C45H41N3O9

MF: 767.82

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InChIKey: NHPZYWACOHOCQC-QIRDGMKKSA-N

IUPAC Name: (9H-fluoren-9-yl)methyl (1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate

InChI: InChI=1S/C45H41N3O9/c1-53-31-20-16-29(17-21-31)45(28-10-4-3-5-11-28,30-18-22-32(54-2)23-19-30)56-27-38-40(49)41(50)42(57-38)48-25-24-39(46-43(48)51)47-44(52)55-26-37-35-14-8-6-12-33(35)34-13-7-9-15-36(34)37/h3-25,37-38,40-42,49-50H,26-27H2,1-2H3,(H,46,47,51,52)/t38-,40+,41+,42-/m1/s1

Synonyms: N4-Fmoc-5'-O-DMT-cytidine

5'-DMT Cytidine (n-ibu)

Description: 5'-DMT Cytidine (N-ibu) is a specialized reagent used in the synthesis of oligonucleotides. It consists of a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and an isobutyryl (ibu) group protecting the N4 amino group. These protective groups are essential for preventing unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is crucial for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01316

CAS: 141946-76-1

MF: C34H37N3O8

MF: 615.67

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Density: 1.30±0.1 g/cm3

InChIKey: BSWZUOHBMILLLQ-SSKIFPDDSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2O)NC(=O)C(C)C

IUPAC Name: N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)isobutyramide

InChI: InChI=1S/C34H37N3O8/c1-21(2)31(40)35-28-18-19-37(33(41)36-28)32-30(39)29(38)27(45-32)20-44-34(22-8-6-5-7-9-22,23-10-14-25(42-3)15-11-23)24-12-16-26(43-4)17-13-24/h5-19,21,27,29-30,32,38-39H,20H2,1-4H3,(H,35,36,40,41)/t27-,29-,30-,32-/m1/s1

Synonyms: N4-iBu-5'-O-DMT-cytidine; Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-

5'-DMT Guanosine (N2-Fmoc)

Description: 5'-DMT Guanosine (N2-Fmoc) is a specialized reagent used in the synthesis of oligonucleotides. It consists of a guanosine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and an N2-Fmoc (9-fluorenylmethyloxycarbonyl) group protecting the N2 amino group. These protective groups are crucial for preventing unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01317

MF: C46H41N5O9

MF: 807.85

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InChIKey: IFXLKLGOPCQLTM-KEJRJOSKSA-N

IUPAC Name: (9H-fluoren-9-yl)methyl (9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)carbamate

InChI: InChI=1S/C46H41N5O9/c1-56-30-20-16-28(17-21-30)46(27-10-4-3-5-11-27,29-18-22-31(57-2)23-19-29)59-25-37-39(52)40(53)43(60-37)51-26-47-38-41(51)48-44(49-42(38)54)50-45(55)58-24-36-34-14-8-6-12-32(34)33-13-7-9-15-35(33)36/h3-23,26,36-37,39-40,43,52-53H,24-25H2,1-2H3,(H2,48,49,50,54,55)/t37-,39-,40-,43-/m1/s1

Synonyms: 5'-O-DMT-Fmoc-rG

5'-DMT Cytidine (n-PAC)

Description: 5'-DMT Cytidine (N-PAC) is a specialized reagent used in the synthesis of oligonucleotides. This compound features a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and a PAC (phenoxyacetyl) group protecting the N4 amino group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is crucial for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01318

MF: C38H37N3O9

MF: 679.72

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InChIKey: WUUDYVZMSNJZAC-MBWVZDRISA-N

IUPAC Name: N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-phenoxyacetamide

InChI: InChI=1S/C38H37N3O9/c1-46-28-17-13-26(14-18-28)38(25-9-5-3-6-10-25,27-15-19-29(47-2)20-16-27)49-23-31-34(43)35(44)36(50-31)41-22-21-32(40-37(41)45)39-33(42)24-48-30-11-7-4-8-12-30/h3-22,31,34-36,43-44H,23-24H2,1-2H3,(H,39,40,42,45)/t31-,34-,35-,36-/m1/s1

Synonyms: N4-Pac-5'-O-DMT-cytidine

5'-DMT Guanosine (n-PAC)

Description: 5'-DMT Guanosine (N-PAC) is a specialized reagent used in the synthesis of oligonucleotides. This compound features a guanosine nucleoside modified with a 5'-DMT (dimethoxytrityl) group to protect the 5' hydroxyl position and a PAC (phenoxyacetyl) group protecting the N2 amino group. These protective groups are essential for preventing unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is crucial for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01319

CAS: 121058-81-9

MF: C39H37N5O9

MF: 719.74

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Density: 1.40±0.1 g/cm3

InChIKey: CGSGHXPPKFOVHX-KKKGQUFWSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)NC(=O)COC7=CC=CC=C7)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-phenoxyacetamide

InChI: InChI=1S/C39H37N5O9/c1-49-27-17-13-25(14-18-27)39(24-9-5-3-6-10-24,26-15-19-28(50-2)20-16-26)52-21-30-33(46)34(47)37(53-30)44-23-40-32-35(44)42-38(43-36(32)48)41-31(45)22-51-29-11-7-4-8-12-29/h3-20,23,30,33-34,37,46-47H,21-22H2,1-2H3,(H2,41,42,43,45,48)/t30-,33-,34-,37-/m1/s1

Synonyms: N2-Phenoxyacetyl-5'-O-(4,4'-dimethoxytrityl)guanosine; 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N2-phenoxyacetyl-guanosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-phenoxyacetyl)guanosine; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(phenoxyacetyl)-; 5'-O-DMT-Pac-rG

5-(1-Propynyl)cytidine

Description: 5-(1-Propynyl)cytidine is a modified nucleoside where a propynyl group (-C≡CH) is attached to the 5-position of the cytidine base. This modification alters the chemical structure of the nucleoside, potentially affecting its base-pairing properties and interactions with other molecules. 5-(1-Propynyl)cytidine is used in various biochemical and medicinal chemistry applications, including RNA modification studies, development of nucleic acid-based therapeutics, and as a tool

CAT: BRP-01400

CAS: 188254-40-2

MF: C12H15N3O5

MF: 281.26

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Density: 1.59±0.1 g/cm3

Boiling Point: 550.8±60.0 °C at 760 mmHg

InChIKey: XXSIICQLPUAUDF-TURQNECASA-N

CanonicalSMILES: CC#CC1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O

IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-prop-1-ynylpyrimidin-2-one

InChI: InChI=1S/C12H15N3O5/c1-2-3-6-4-15(12(19)14-10(6)13)11-9(18)8(17)7(5-16)20-11/h4,7-9,11,16-18H,5H2,1H3,(H2,13,14,19)/t7-,8-,9-,11-/m1/s1

Synonyms: 5-Propynyl-ribo Cytidine; Cytidine, 5-(1-propyn-1-yl)-; 5-(1-Propyn-1-yl)cytidine; Cytidine, 5-(1-propynyl)-; 5-(1-Propynyl)-cytidine

5-(1-Propynyl)uridine

Description: 5-(1-Propynyl)uridine is a modified nucleoside where a propynyl group (-C≡CH) is attached to the 5-position of the uridine base. This modification can influence the base-pairing properties and interactions of the nucleoside, making it useful for various biochemical and medicinal applications, including RNA modification studies and the development of nucleic acid-based therapeutics.

CAT: BRP-01401

CAS: 188254-39-9

MF: C12H14N2O6

MF: 282.25

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Density: 1.61±0.1 g/cm3

InChIKey: QLOCVMVCRJOTTM-TURQNECASA-N

CanonicalSMILES: CC#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-prop-1-ynylpyrimidine-2,4-dione

InChI: InChI=1S/C12H14N2O6/c1-2-3-6-4-14(12(19)13-10(6)18)11-9(17)8(16)7(5-15)20-11/h4,7-9,11,15-17H,5H2,1H3,(H,13,18,19)/t7-,8-,9-,11-/m1/s1

Synonyms: 5-Propynyl-ribo Uridine; 5-(1-Propyn-1-yl)uridine; Uridine, 5-(1-propynyl)-; 5-Propynyl-uridine; 5-Propynyluridine; 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-(prop-1-yn-1-yl)pyrimidine-2,4(1H,3H)-dione

ribo Isoguanosine (n,n-diisobutylformamidine)

Description: ribo Isoguanosine (n,n-diisobutylformamidine) is a modified form of guanosine used in nucleic acid chemistry and molecular biology research. It features a ribose sugar backbone and a modified guanine base with N,N-diisobutylformamidine. This modification alters the properties of the nucleoside, potentially affecting base pairing and stability in nucleic acid structures. Ribose Isoguanosine finds applications in various areas, including RNA modification studies, nucleic acid labeling, and as a probe in molecular biology assays.

CAT: BRP-01461

MF: C19H30N6O5

MF: 422.48

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InChIKey: YPOHJXMARJLOJQ-SCFUHWHPSA-N

IUPAC Name: N,N-dibutyl-N'-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-3,9-dihydro-2H-purin-6-yl)formimidamide

InChI: InChI=1S/C19H30N6O5/c1-3-5-7-24(8-6-4-2)10-21-16-13-17(23-19(29)22-16)25(11-20-13)18-15(28)14(27)12(9-26)30-18/h10-12,14-15,18,26-28H,3-9H2,1-2H3,(H,22,23,29)/t12-,14-,15-,18-/m1/s1

Synonyms: Ribose Isoguanosine (N,N-diisobutylformamidine)

N-Isobutyrylcytidine

Description: N-Isobutyrylcytidine is a modified form of cytidine used in nucleic acid research and synthesis. It features a cytidine base with an isobutyryl group attached to the amine group of the nucleobase. This modification alters the properties of cytidine and can affect its base pairing and stability in nucleic acid structures. N-Isobutyrylcytidine finds applications in various molecular biology techniques, such as oligonucleotide synthesis, RNA modification studies, and nucleic acid labeling.

CAT: BRP-01462

CAS: 60107-05-3

MF: C13H19N3O6

MF: 313.31

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Density: 1.59±0.1 g/cm3

InChIKey: QNCJITIARBTMOQ-UGKPPGOTSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)CO)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-methylpropanamide

InChI: InChI=1S/C13H19N3O6/c1-6(2)11(20)14-8-3-4-16(13(21)15-8)12-10(19)9(18)7(5-17)22-12/h3-4,6-7,9-10,12,17-19H,5H2,1-2H3,(H,14,15,20,21)/t7-,9-,10-,12-/m1/s1

Synonyms: ribo Cytidine (n-ibu); N-(2-Methyl-1-oxopropyl)cytidine; N-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)isobutyramide; N4-Isobutyrylcytidine

N-Phenoxyacetylcytidine

Description: N-Phenoxyacetylcytidine is a modified form of cytidine used in nucleic acid research and synthesis. It contains a cytidine base with a phenoxyacetyl group attached to the amine group of the nucleobase. This modification alters the properties of cytidine and can influence its base pairing and stability in nucleic acid structures. N-Phenoxyacetylcytidine finds applications in various molecular biology techniques, including oligonucleotide synthesis, RNA modification studies, and nucleic acid labeling.

CAT: BRP-01463

CAS: 124345-56-8

MF: C17H19N3O7

MF: 377.35

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Density: 1.57±0.1 g/cm3

Melting Point: 180-182 °C

InChIKey: SWPJUNUVFHWYME-RAEVTNRLSA-N

CanonicalSMILES: C1=CC=C(C=C1)OCC(=O)NC2=NC(=O)N(C=C2)C3C(C(C(O3)CO)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]-2-phenoxyacetamide

InChI: InChI=1S/C17H19N3O7/c21-8-11-14(23)15(24)16(27-11)20-7-6-12(19-17(20)25)18-13(22)9-26-10-4-2-1-3-5-10/h1-7,11,14-16,21,23-24H,8-9H2,(H,18,19,22,25)/t11-,14-,15-,16-/m1/s1

Synonyms: ribo Cytidine (n-PAC); N4-Phenoxyacetylcytidine; Cytidine, N-(phenoxyacetyl)-; N-(2-Phenoxyacetyl)cytidine; N-(Phenoxyacetyl)cytidine

3',5'-O-DTBS-2'-O-TBDMS-N4-Ac-rC

Description: 3',5'-O-DTBS-2'-O-TBDMS-N4-Ac-rC is a modified cytidine nucleoside used in oligonucleotide synthesis. It is characterized by protective groups such as di-tert-butylsilyl (DTBS) at the 3' and 5' hydroxyl positions, a tert-butyldimethylsilyl (TBDMS) group at the 2' hydroxyl position, and an acetyl group at the N4 position of the cytidine base. These modifications enhance stability and protection during the synthesis process, facilitating the precise and efficient assembly of oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-01488

CAS: 401812-96-2

MF: C25H45N3O6Si2

MF: 539.81

Purity: ≥97%

Appearance: White to off-white powder

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Density: 1.13±0.1 g/cm3

InChIKey: DYKRNVAKLAJPHD-CWJKEVGVSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C3C(O2)CO[Si](O3)(C(C)(C)C)C(C)(C)C)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[1-[(4aR,6R,7R,7aR)-2,2-ditert-butyl-7-[tert-butyl(dimethyl)silyl]oxy-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C25H45N3O6Si2/c1-16(29)26-18-13-14-28(22(30)27-18)21-20(33-35(11,12)23(2,3)4)19-17(32-21)15-31-36(34-19,24(5,6)7)25(8,9)10/h13-14,17,19-21H,15H2,1-12H3,(H,26,27,29,30)/t17-,19-,20-,21-/m1/s1

Synonyms: Cytidine, N-acetyl-3',5'-O-[bis(1,1-dimethylethyl)silylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 3',5'-O-DTBS-2'-O-TBDMS-N4-Acetyl-Cytidine; N-Acetyl-3',5'-O-[bis(1,1-dimethylethyl)silylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]cytidine