Nucleosides - RNA / BOC Sciences

N4-Ac-2'-O-Me-5-Me-Cr

Description: N4-Ac-2'-O-Me-5-Me-Cr comprises an acetyl group (Ac) attached to the N4 position of cytosine, a methyl (Me) group at the 2' position of ribose, and a methyl group (Me) at the 5th position of cytosine. It is used in oligonucleotide synthesis and can alter the properties of the resulting oligonucleotide.

CAT: BRP-00994

CAS: 741725-58-6

MF: C13H19N3O6

MF: 313.31

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Density: 1.53±0.1 g/cm3

InChIKey: DGSGYQXEJYKLEH-DNRKLUKYSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)CO)O)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C13H19N3O6/c1-6-4-16(13(20)15-11(6)14-7(2)18)12-10(21-3)9(19)8(5-17)22-12/h4,8-10,12,17,19H,5H2,1-3H3,(H,14,15,18,20)/t8-,9-,10-,12-/m1/s1

Synonyms: N4-acetyl-2'-O-methyl-5-methyl-cytidine; N4-Acetyl-5-methyl-2'-O-methyl-cytidine; Cytidine, N-acetyl-5-methyl-2'-O-methyl-

N4-dmf-2'-O-Me-5-Me-Cr

Description: N4-dmf-2'-O-Me-5-Me-Cr contains a dibutylformamidine (dmf) group attached to the N4 position of cytosine, a methyl (Me) group at the 2' position of ribose, and a methyl group (Me) at the 5th position of cytosine. It is utilized in oligonucleotide synthesis and can introduce specific functionalities to the oligonucleotide.

CAT: BRP-00995

MF: C14H22N4O5

MF: 326.35

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InChIKey: DICOFXKPAKWPIN-PRULPYPASA-N

CanonicalSMILES: O=C1N=C(N=CN(C)C)C(=CN1C2OC(CO)C(O)C2OC)C

IUPAC Name: N'-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide

InChI: InChI=1S/C14H22N4O5/c1-8-5-18(14(21)16-12(8)15-7-17(2)3)13-11(22-4)10(20)9(6-19)23-13/h5,7,9-11,13,19-20H,6H2,1-4H3/t9-,10-,11-,13-/m1/s1

Synonyms: N4-dimethylformamidine-2'-O-methyl-5-methyl-cytidine

Related CAS: 2920179-30-0 (Z-isomer)

N3-BOM-3'-O-Bz-2'-O-Me-U

Description: N3-BOM-3'-O-Bz-2'-O-Me-U is a modified nucleoside used in oligonucleotide synthesis. This modification consists of a benzyl oxy methyl (BOM) group attached to the N3 position of uracil, a benzoyl (Bz) group at the 3' position of ribose, and a methyl (Me) group at the 2' position of ribose. It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence.

CAT: BRP-00996

CAS: 2197181-75-0

MF: C25H26N2O8

MF: 482.49

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.39±0.1 g/cm3

Boiling Point: 632.2±65.0 °C at 760 mmHg

InChIKey: DJMBMKCDFWFZOO-JMJGKCIBSA-N

CanonicalSMILES: COC1C(C(OC1N2C=CC(=O)N(C2=O)COCC3=CC=CC=C3)CO)OC(=O)C4=CC=CC=C4

IUPAC Name: [(2R,3R,4R,5R)-5-[2,4-dioxo-3-(phenylmethoxymethyl)pyrimidin-1-yl]-2-(hydroxymethyl)-4-methoxyoxolan-3-yl] benzoate

InChI: InChI=1S/C25H26N2O8/c1-32-22-21(35-24(30)18-10-6-3-7-11-18)19(14-28)34-23(22)26-13-12-20(29)27(25(26)31)16-33-15-17-8-4-2-5-9-17/h2-13,19,21-23,28H,14-16H2,1H3/t19-,21-,22-,23-/m1/s1

Synonyms: N3-Benzyloxymethyl-3'-O-Benzoyl-2'-O-Methyl-uridine

N6-Bz-DMT-2'-O-4'-C-Locked-Ar

Description: N6-Bz-DMT-2'-O-4'-C-Locked-Ar is a modified nucleoside used in oligonucleotide synthesis. This modification consists of a benzoyl (Bz) group attached to the N6 position of adenine, a dimethoxytrityl (DMT) protecting group, a 2'-O modification, and a 4'-carbon locked adenine (Locked-Ar). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-00997

CAS: 206055-74-5

MF: C39H35N5O7

MF: 685.72

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.38±0.1 g/cm3

InChIKey: QKRIAIFSTHOZRG-WBZZMTOKSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC45COC(C4O)C(O5)N6C=NC7=C(N=CN=C76)NC(=O)C8=CC=CC=C8

IUPAC Name: N-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]purin-6-yl]benzamide

InChI: InChI=1S/C39H35N5O7/c1-47-29-17-13-27(14-18-29)39(26-11-7-4-8-12-26,28-15-19-30(48-2)20-16-28)50-22-38-21-49-32(33(38)45)37(51-38)44-24-42-31-34(40-23-41-35(31)44)43-36(46)25-9-5-3-6-10-25/h3-20,23-24,32-33,37,45H,21-22H2,1-2H3,(H,40,41,43,46)/t32-,33+,37-,38-/m1/s1

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-adenosine; N-(9-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-9H-purin-6-yl)benzamide; N-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-α-L-lyxofuranosyl]-9H-purin-6-yl]benzamide; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-O,4'-C-methyleneadenosine; 5'-DMTr-LNA-N6-Bz-A

N4-Ac-DMT-2'-O-4'-C-Locked-Cr

Description: N4-Ac-DMT-2'-O-4'-C-Locked-Cr is a modified nucleoside used in oligonucleotide synthesis. This modification consists of an acetyl (Ac) group attached to the N4 position of cytosine, a dimethoxytrityl (DMT) protecting group, a 2'-O modification, and a 4'-carbon locked cytosine (Locked-Cr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-00998

CAS: 1092705-83-3

MF: C33H33N3O8

MF: 599.64

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Density: 1.34±0.1 g/cm3

InChIKey: MQRGVNKBORBIIG-FHRWSLRQSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC3(COC2C3O)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)NC(=O)C

IUPAC Name: N-(1-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C33H33N3O8/c1-21(37)34-27-17-18-36(31(39)35-27)30-28-29(38)32(44-30,19-42-28)20-43-33(22-7-5-4-6-8-22,23-9-13-25(40-2)14-10-23)24-11-15-26(41-3)16-12-24/h4-18,28-30,38H,19-20H2,1-3H3,(H,34,35,37,39)/t28-,29+,30-,32-/m1/s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O,4'-C-methylenecytidine

N2-dmf-DMT-2'-O-4'-C-Locked-Gr

Description: N2-dmf-DMT-2'-O-4'-C-Locked-Gr is a modified nucleoside used in oligonucleotide synthesis. This modification consists of a dibutylformamidine (dmf) group attached to the N2 position of guanine, a dimethoxytrityl (DMT) protecting group, a 2'-O modification, and a 4'-carbon locked guanine (Locked-Gr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-00999

CAS: 709641-78-1

MF: C35H36N6O7

MF: 652.70

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, in tightly closed container, protected from light and humidity

Density: 1.38±0.1 g/cm3

Boiling Point: 858.1±75.0 °C at 760 mmHg

InChIKey: GHGCTOJSLHYKAF-GGVMLGSCSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CO4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N'-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C35H36N6O7/c1-40(2)20-37-33-38-30-27(31(43)39-33)36-21-41(30)32-28-29(42)34(48-32,18-46-28)19-47-35(22-8-6-5-7-9-22,23-10-14-25(44-3)15-11-23)24-12-16-26(45-4)17-13-24/h5-17,20-21,28-29,32,42H,18-19H2,1-4H3,(H,38,39,43)/t28-,29+,32-,34-/m1/s1

Synonyms: N2-dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-guanosine; N'-(9-((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; N'-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-α-L-lyxofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide; 5'-DMT-2'-O-4'-C-Locked-G(dmf)

N2-iBu-O6-CE-DMT-2'-OMe-Gr

Description: N2-iBu-O6-CE-DMT-2'-OMe-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of an isobutyl (iBu) group attached to the N2 position of guanine, a cyanoethyl (CE) group attached to the O6 position of guanine, a dimethoxytrityl (DMT) protecting group, a methyl (Me) group at the 2' position of ribose, and a modified guanine (Gr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-01000

CAS: 2227139-81-1

MF: C39H42N6O8

MF: 722.79

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.31±0.1 g/cm3

InChIKey: UBLMNMAUYACHGY-GONXPTGJSA-N

CanonicalSMILES: N#CCCOC1=NC(=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3OC)NC(=O)C(C)C

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-6-(2-cyanoethoxy)-9H-purin-2-yl)isobutyramide

InChI: InChI=1S/C39H42N6O8/c1-24(2)35(47)43-38-42-34-31(36(44-38)51-21-9-20-40)41-23-45(34)37-33(50-5)32(46)30(53-37)22-52-39(25-10-7-6-8-11-25,26-12-16-28(48-3)17-13-26)27-14-18-29(49-4)19-15-27/h6-8,10-19,23-24,30,32-33,37,46H,9,21-22H2,1-5H3,(H,42,43,44,47)/t30-,32-,33-,37-/m1/s1

Synonyms: N2-isobutyryl-O6-cyanoethyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine

DMT-2'-O-Me-5-Me-Cr

Description: DMT-2'-O-Me-5-Me-Cr is a modified nucleoside used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMT) protecting group, a methyl (Me) group at the 2' position of ribose, and methyl groups (Me) at the 5th position of cytosine. It is utilized in oligonucleotide synthesis to confer specific properties or functionalities to the resulting oligonucleotide, which can be crucial for various applications in molecular biology, diagnostics, and therapeutics.

CAT: BRP-01001

CAS: 2940862-09-7

MF: C32H35N3O7

MF: 573.64

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Density: 1.28±0.1 g/cm3

Boiling Point: 734.1±70.0 °C at 760 mmHg

InChIKey: QTKGHPBFWOEEHR-NODMTMHWSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-methylpyrimidin-2-one

InChI: InChI=1S/C32H35N3O7/c1-20-18-35(31(37)34-29(20)33)30-28(40-4)27(36)26(42-30)19-41-32(21-8-6-5-7-9-21,22-10-14-24(38-2)15-11-22)23-12-16-25(39-3)17-13-23/h5-18,26-28,30,36H,19H2,1-4H3,(H2,33,34,37)/t26-,27-,28-,30-/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-cytidine; 5-Methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-cytidine

N2-Ac-DMT-2'-OMe-Gr

Description: N2-Ac-DMT-2'-OMe-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of an acetyl (Ac) group attached to the N2 position of guanine, a dimethoxytrityl (DMT) protecting group, a methyl (Me) group at the 2' position of ribose, and a modified guanine (Gr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-01002

CAS: 909033-39-2

MF: C34H35N5O8

MF: 641.67

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Density: 1.38±0.1 g/cm3

InChIKey: IJLYUZAEWUUOCY-DWCTZGTLSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3OC

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

InChI: InChI=1S/C34H35N5O8/c1-20(40)36-33-37-30-27(31(42)38-33)35-19-39(30)32-29(45-4)28(41)26(47-32)18-46-34(21-8-6-5-7-9-21,22-10-14-24(43-2)15-11-22)23-12-16-25(44-3)17-13-23/h5-17,19,26,28-29,32,41H,18H2,1-4H3,(H2,36,37,38,40,42)/t26-,28-,29-,32-/m1/s1

Synonyms: N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-guanosine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methylguanosine

N4-dmf-DMT-2'-O-Me-5-Me-Cr

Description: N4-dmf-DMT-2'-O-Me-5-Me-Cr is a modified nucleoside used in oligonucleotide synthesis. It consists of a dibutylformamidine (dmf) group attached to the N4 position of cytosine, a dimethoxytrityl (DMT) protecting group, a methyl (Me) group at the 2' position of ribose, and methyl groups (Me) at the 5th position of cytosine. It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enhancing stability or enabling interactions with complementary sequences.

CAT: BRP-01003

MF: C35H40N4O7

MF: 628.71

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InChIKey: BEDTXIPBGSIHIU-WTGZKXAYSA-N

CanonicalSMILES: O=C1N=C(N=CN(C)C)C(=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2OC)C

IUPAC Name: N'-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)-N,N-dimethylformimidamide

InChI: InChI=1S/C35H40N4O7/c1-23-20-39(34(41)37-32(23)36-22-38(2)3)33-31(44-6)30(40)29(46-33)21-45-35(24-10-8-7-9-11-24,25-12-16-27(42-4)17-13-25)26-14-18-28(43-5)19-15-26/h7-20,22,29-31,33,40H,21H2,1-6H3/t29-,30-,31-,33-/m1/s1

Synonyms: N4-dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-5-methyl-cytidine

Related CAS: 2940857-82-7 (Z-isomer)

N4-Ac-DMT-2'-O-propargyl-Cr

Description: N4-Ac-DMT-2'-O-propargyl-Cr is a modified nucleoside used in oligonucleotide synthesis. It consists of an acetyl (Ac) group attached to the N4 position of cytosine, a dimethoxytrityl (DMT) protecting group, and a propargyl group attached to the 2' position of ribose, along with a modified cytosine (Cr). It is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, which can be useful for various applications in molecular biology and biotechnology.

CAT: BRP-01004

CAS: 1498305-50-2

MF: C35H35N3O8

MF: 625.67

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Density: 1.25±0.1 g/cm3

InChIKey: WTXRMORXMCBUCK-WXQJYUTRSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2OCC#C)NC(=O)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C35H35N3O8/c1-5-21-44-32-31(40)29(46-33(32)38-20-19-30(36-23(2)39)37-34(38)41)22-45-35(24-9-7-6-8-10-24,25-11-15-27(42-3)16-12-25)26-13-17-28(43-4)18-14-26/h1,6-20,29,31-33,40H,21-22H2,2-4H3,(H,36,37,39,41)/t29-,31-,32-,33-/m1/s1

Synonyms: N4-Ac-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-cytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-2-propyn-1-ylcytidine

N2-Ac-DMT-2'-O-propargyl-Gr

Description: N2-Ac-DMT-2'-O-propargyl-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of an acetyl (Ac) group attached to the N2 position of guanine, a dimethoxytrityl (DMT) protecting group, and a propargyl group attached to the 2' position of ribose, along with a modified guanine (Gr). The modification is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enabling various applications in molecular biology and biotechnology.

CAT: BRP-01005

MF: C36H35N5O8

MF: 665.70

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InChIKey: CEGYIJROMOEVDV-UTBAFCPYSA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

InChI: InChI=1S/C36H35N5O8/c1-5-19-47-31-30(43)28(49-34(31)41-21-37-29-32(41)39-35(38-22(2)42)40-33(29)44)20-48-36(23-9-7-6-8-10-23,24-11-15-26(45-3)16-12-24)25-13-17-27(46-4)18-14-25/h1,6-18,21,28,30-31,34,43H,19-20H2,2-4H3,(H2,38,39,40,42,44)/t28-,30-,31-,34-/m1/s1

Synonyms: N2-Ac-5'-O-(4,4'-dimethoxytrityl)-2'-O-propargyl-guanosine

3',5'-O-diDMT-2'-O-propargyl-Ur

Description: 3',5'-O-diDMT-2'-O-propargyl-Ur is a modified nucleoside used in oligonucleotide synthesis. It consists of two dimethoxytrityl (DMT) protecting groups attached to the 3' and 5' hydroxyl groups of uracil, and a propargyl group attached to the 2' position of ribose. The modification is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enabling various applications in molecular biology and biotechnology.

CAT: BRP-01006

MF: C54H50N2O10

MF: 887.00

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InChIKey: FHAVBSPASFBLTH-BUBCVBHASA-N

IUPAC Name: 1-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

InChI: InChI=1S/C54H50N2O10/c1-6-35-63-50-49(66-54(38-15-11-8-12-16-38,41-21-29-45(61-4)30-22-41)42-23-31-46(62-5)32-24-42)47(65-51(50)56-34-33-48(57)55-52(56)58)36-64-53(37-13-9-7-10-14-37,39-17-25-43(59-2)26-18-39)40-19-27-44(60-3)28-20-40/h1,7-34,47,49-51H,35-36H2,2-5H3,(H,55,57,58)/t47-,49-,50-,51-/m1/s1

Synonyms: 3',5'-O-di(4,4'-dimethoxytrityl)-2'-O-propargyl-uridine

5'-O-DMTr-2'-O-TBDMS-G(Ac)

Description: 5'-O-DMTr-2'-O-TBDMS-G(Ac) is a modified nucleoside used in oligonucleotide synthesis. It consists of a dimethoxytrityl (DMTr) protecting group at the 5' hydroxyl, a tert-butyldimethylsilyl (TBDMS) group at the 2' position of ribose, and an acetyl (Ac) group attached to guanine. This modification is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enabling various applications in molecular biology and biotechnology.

CAT: BRP-01007

CAS: 1256468-15-1

MF: C39H47N5O8Si

MF: 741.92

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C

Density: 1.26±0.1 g/cm3

InChIKey: WMJSMYRPSADDEA-QGGAYTEESA-N

CanonicalSMILES: O=C1N=C(NC(=O)C)NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3O[Si](C)(C)C(C)(C)C

IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

InChI: InChI=1S/C39H47N5O8Si/c1-24(45)41-37-42-34-31(35(47)43-37)40-23-44(34)36-33(52-53(7,8)38(2,3)4)32(46)30(51-36)22-50-39(25-12-10-9-11-13-25,26-14-18-28(48-5)19-15-26)27-16-20-29(49-6)21-17-27/h9-21,23,30,32-33,36,46H,22H2,1-8H3,(H2,41,42,43,45,47)/t30-,32-,33-,36-/m1/s1

Synonyms: N2-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]guanosine; 5'-O-DMT-2'-O-TBDMS-N2-Acetyl-Guanosine

5-Acrylic-5'-DMT-dU

Description: 5-Acrylic-5'-DMT-dU features an acrylic group attached to the 5 position of deoxyuridine, along with a dimethoxytrityl (DMT) protecting group. It is used in oligonucleotide synthesis to introduce specific functionalities, such as for covalent modification or interaction with other biomolecules.

CAT: BRP-01008

CAS: 923023-62-5

MF: C33H32N2O9

MF: 600.62

Purity: ≥98% by HPLC

Appearance: White, off-white to yellow powder

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Storage: Store at 2-8 °C

Density: 1.369±0.06 g/cm3

InChIKey: GRDHCWWOTJFHSF-CTJHEALJSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(CC(O4)N5C=C(C(=O)NC5=O)C=CC(=O)O)O

IUPAC Name: (E)-3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enoic acid

InChI: InChI=1S/C33H32N2O9/c1-41-25-13-9-23(10-14-25)33(22-6-4-3-5-7-22,24-11-15-26(42-2)16-12-24)43-20-28-27(36)18-29(44-28)35-19-21(8-17-30(37)38)31(39)34-32(35)40/h3-17,19,27-29,36H,18,20H2,1-2H3,(H,37,38)(H,34,39,40)/b17-8+/t27-,28+,29+/m0/s1

Synonyms: 5-Acrylic-5'-O-(4,4'-dimethoxytrityl)-uridine; (E)-3-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid; (2E)-3-[1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]-2-propenoic acid; (E)-5-(2-Carboxyvinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine

5-Acrylic-5'-DMT-dU TEA salt

Description: 5-Acrylic-5'-DMT-dU TEA salt is the triethylammonium (TEA) salt form of 5-Acrylic-5'-DMT-dU, typically used to provide better solubility or handling during synthesis.

CAT: BRP-01009

MF: C33H32N2O9.C6H15N

MF: 701.82

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

InChIKey: SKPFWOYCDYVDPX-IZFLFKNXSA-N

CanonicalSMILES: CCN(CC)CC.COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(CC(O4)N5C=C(C(=O)NC5=O)C=CC(=O)O)O

IUPAC Name: (E)-3-[1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-2,4-dioxopyrimidin-5-yl]prop-2-enoic acid;N,N-diethylethanamine

InChI: InChI=1S/C33H32N2O9.C6H15N/c1-41-25-13-9-23(10-14-25)33(22-6-4-3-5-7-22,24-11-15-26(42-2)16-12-24)43-20-28-27(36)18-29(44-28)35-19-21(8-17-30(37)38)31(39)34-32(35)40;1-4-7(5-2)6-3/h3-17,19,27-29,36H,18,20H2,1-2H3,(H,37,38)(H,34,39,40);4-6H2,1-3H3/b17-8+;/t27-,28+,29+;/m0./s1

Synonyms: (E)-5-(2-Carboxyvinyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyuridine, triethylamine salt; 5-Acrylic-5'-O-(4,4'-dimethoxytrityl)-uridine,triethylamine salt; (E)-3-(1-((2R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylic acid triethylamine salt; (2E)-3-[1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-β-D-erythro-pentofuranosyl]-1,2,3,4-tetrahydro-2,4-dioxo-5-pyrimidinyl]-2-propenoic acid triethylamine salt

Related CAS: 923023-62-5 (free base)

3',5'-di-O-TBDMS-2'-O-4'-C-Locked-Gr

Description: 3',5'-di-O-TBDMS-2'-O-4'-C-Locked-Gr consists of two tert-butyldimethylsilyl (TBDMS) protecting groups attached to the 3' and 5' hydroxyl groups, along with a 2'-O modificationa, 4'-carbon locked guanine (Locked-Gr). It is used in oligonucleotide synthesis to enhance sequence stability and specific biological activities.

CAT: BRP-01010

CAS: 2940861-48-1

MF: C23H41N5O5Si2

MF: 523.77

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at RT. Keep container tightly closed. Protect from light.

Density: 1.24±0.1 g/cm3

Boiling Point: 616.6±65.0 °C at 760 mmHg

InChIKey: LDLRSVCCRZMOLN-QIEVIBBNSA-N

CanonicalSMILES: O=C1N=C(N)NC2=C1N=CN2C3OC4(COC3C4O[Si](C)(C)C(C)(C)C)CO[Si](C)(C)C(C)(C)C

IUPAC Name: 2-amino-9-((1R,3R,4R,7S)-7-((tert-butyldimethylsilyl)oxy)-1-(((tert-butyldimethylsilyl)oxy)methyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-1,9-dihydro-6H-purin-6-one

InChI: InChI=1S/C23H41N5O5Si2/c1-21(2,3)34(7,8)31-12-23-11-30-15(16(23)33-35(9,10)22(4,5)6)19(32-23)28-13-25-14-17(28)26-20(24)27-18(14)29/h13,15-16,19H,11-12H2,1-10H3,(H3,24,26,27,29)/t15-,16+,19-,23-/m1/s1

Synonyms: 3',5'-di-O-(t-butyl-dimethylsilyl)-2'-O-4'-C-Locked-guanosine

5'-O-Ts-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

Description: 5'-O-Ts-3'-O-TBDMS-2'-O-4'-C-Locked-Ur features a p-toluenesulfonyl (Ts) group attached to the 5' hydroxyl, a tert-butyldimethylsilyl (TBDMS) group attached to the 3' hydroxyl, and a 2'-O modificationa, a 4'-carbon locked uracil (Locked-Ur). It is used in oligonucleotide synthesis to introduce specific protecting groups or functional moieties.

CAT: BRP-01011

CAS: 2387667-44-7

MF: C23H32N2O8SSi

MF: 524.66

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C

Density: 1.33±0.1 g/cm3

InChIKey: YXMSGMAYACMFID-VLVHOKLOSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC3(COC2C3O[Si](C)(C)C(C)(C)C)COS(=O)(=O)C4=CC=C(C=C4)C

IUPAC Name: ((1R,3R,4R,7S)-7-((tert-butyldimethylsilyl)oxy)-3-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-1-yl)methyl 4-methylbenzenesulfonate

InChI: InChI=1S/C23H32N2O8SSi/c1-15-7-9-16(10-8-15)34(28,29)31-14-23-13-30-18(19(23)33-35(5,6)22(2,3)4)20(32-23)25-12-11-17(26)24-21(25)27/h7-12,18-20H,13-14H2,1-6H3,(H,24,26,27)/t18-,19+,20-,23-/m1/s1

Synonyms: 5'-O-Tosyl-3'-O-(t-butyldimethylsilyl)-1-(2'-O,4'-C-methylene-beta-D-ribofuranosyl)-uridineacil; 5'-O-Ts-3'-O-TBDMS-LNA-Ur

5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

Description: 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur includes an amino (NH2) group replaced to the 5' hydroxyl, a tert-butyldimethylsilyl (TBDMS) group attached to the 3' hydroxyl, and a 2'-O modificationa, a 4'-carbon locked uracil (Locked-Ur). It is used in oligonucleotide synthesis to introduce amino functional groups.

CAT: BRP-01012

MF: C16H27N3O5Si

MF: 369.49

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C

InChIKey: QJDAOGPSEQMRJU-IATRGZMQSA-N

IUPAC Name: 1-((1S,3R,4R,7S)-1-(aminomethyl)-7-((tert-butyldimethylsilyl)oxy)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione

InChI: InChI=1S/C16H27N3O5Si/c1-15(2,3)25(4,5)24-12-11-13(23-16(12,8-17)9-22-11)19-7-6-10(20)18-14(19)21/h6-7,11-13H,8-9,17H2,1-5H3,(H,18,20,21)/t11-,12+,13-,16+/m1/s1

Synonyms: 5'-amino-3'-O-(t-butyldimethylsilyl)-1-(2'-O,4'-C-methylene-beta-D-ribofuranosyl)-uridineacil; 5'-NH2-3'-O-TBDMS-LNA-Ur

5'-N3-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

Description: 5'-N3-3'-O-TBDMS-2'-O-4'-C-Locked-Ur consists of an N3 replaced to the 5' hydroxyl, a tert-butyldimethylsilyl (TBDMS) group attached to the 3' hydroxyl, and a 2'-O modificationa, a 4'-carbon locked uracil (Locked-Ur). It is used in oligonucleotide synthesis to introduce specific functional groups.

CAT: BRP-01013

MF: C16H25N5O5Si

MF: 395.49

Purity: ≥98% by HPLC

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C

InChIKey: YVKIMFHCMXNURY-IATRGZMQSA-N

IUPAC Name: 1-((1S,3R,4R,7S)-1-(azidomethyl)-7-((tert-butyldimethylsilyl)oxy)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione

InChI: InChI=1S/C16H25N5O5Si/c1-15(2,3)27(4,5)26-12-11-13(21-7-6-10(22)19-14(21)23)25-16(12,9-24-11)8-18-20-17/h6-7,11-13H,8-9H2,1-5H3,(H,19,22,23)/t11-,12+,13-,16+/m1/s1

Synonyms: 5'-Azido-3'-O-(t-butyldimethylsilyl)-1-(2'-O,4'-C-methylene-beta-D-ribofuranosyl)-uridineacil; 5'-N3-3'-O-TBDMS-LNA-Ur