Nucleosides

Description: 7-Deaza-2'-O-methylguanosine is a modified nucleoside where the nitrogen at position 7 of the guanine base is replaced by a carbon atom (7-deaza modification) and the 2'-hydroxyl group of the ribose sugar is substituted with a methyl group. These modifications enhance the compound's chemical stability and reduce susceptibility to enzymatic degradation. It is commonly used in RNA-related studies, particularly in therapeutic oligonucleotides and structural investigations, where it improves duplex stability and modulates interactions with proteins or enzymes.

CAT: BRP-02489

CAS: 444018-81-9

Molecular Formula: C12H16N4O5

Molecular Weight: 296.28

Purity: ≥95%

Description: DMT-(C-Et)-LNA-5MeC(Bz) is a modified nucleoside designed for oligonucleotide synthesis. The structure features a cytidine base, with a benzoyl (Bz) group attached to the N-position of the base, and a methyl (Me) group at the C-5 position of the base, which enhances the stability and specificity of the molecule. The 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group for efficient solid-phase coupling during synthesis. This modified nucleoside is used in RNA synthesis to improve the stability, resistance to degradation, and binding affinity of the resulting oligonucleotides, particularly for therapeutic or research applications.

CAT: BRP-02491

CAS: 1197033-15-0

Molecular Formula: C40H39N3O8

Molecular Weight: 689.77

Purity: ≥95%

Description: 5'-O-DMTr-2'-O,4'-C-methylene adenosine is a modified nucleoside designed for use in oligonucleotide synthesis. It features an adenosine base, with a 2'-O modification and a 4'-C-methylene linkage to the ribose sugar, which introduces additional stability by altering the sugar's conformation. The 5'-hydroxyl group is protected with a dimethoxytrityl (DMTr) group, allowing for efficient coupling during solid-phase synthesis. This modification improves the stability of the resulting oligonucleotides, reducing susceptibility to nucleases and enhancing their performance in research and therapeutic applications, such as gene editing or antisense oligonucleotide therapies.

CAT: BRP-02492

Molecular Formula: C32H31N5O6

Molecular Weight: 581.63

Purity: ≥95%

Description: 5'-O-Sulfamoyladenosine, a natural antitumor agent, is a modified adenosine derivative in which the 5'-hydroxyl group of the ribose sugar is replaced with a sulfamoyl (-SO2NH2) group. This modification introduces a sulfonamide functionality, altering the chemical and biological properties of the nucleoside. 5'-O-Sulfamoyladenosine is commonly used as a structural analog in biochemical studies, particularly to investigate enzymatic mechanisms involving adenosine-containing substrates, such as kinases or ligases. Its unique functional group also makes it a potential scaffold in drug design for targeting nucleotide-binding enzymes.

CAT: BRP-02494

CAS: 25030-31-3

Molecular Formula: C10H14N6O6S

Molecular Weight: 346.32

Purity: ≥95%

Appearance: White to off-white solid

Description: 2'-O-Hexadecanyluridine is a modified uridine nucleoside where a hexadecanyl group (a long 16-carbon alkyl chain) is attached to the 2'-hydroxyl group of the ribose sugar. This lipid modification significantly enhances the hydrophobicity of the molecule, making it amphiphilic. Such modifications are often employed in the development of nucleic acid-based therapeutics, including RNA and antisense oligonucleotides, to improve cellular uptake, binding affinity, and stability. The lipid chain can also facilitate interactions with lipid membranes, making this compound useful in drug delivery systems or in studying membrane-nucleoside interactions.

CAT: BRP-02495

CAS: 2382942-69-8

Molecular Formula: C25H44N2O6

Molecular Weight: 468.63

Purity: ≥97%

Appearance: White or off-white solid

Description: 5'-O-DMT-2',3'-Seco-2'-O-Benzoyl-N6-benzoyl Adenosine is a nucleoside analog in which the ribose ring is opened at the 2',3'-positions (seco modification), with the 2'-hydroxyl protected by a benzoyl (Bz) group, the adenine base protected at the N6 position with a benzoyl group, and the 5'-hydroxyl masked with a dimethoxytrityl (DMT) group. These protecting groups ensure stability and controlled reactivity during solid-phase oligonucleotide synthesis. This compound is used as a synthetic intermediate for incorporating modified adenosine residues into oligonucleotides for research and therapeutic applications.

CAT: BRP-02696

CAS: 1120329-51-2

Molecular Formula: C45H41N5O8

Molecular Weight: 779.84

Purity: ≥95%

Appearance: White solid

Description: cEt-adenosine is a chemically modified adenosine nucleoside in which the ribose ring is constrained by a 2',4'-conformationally restricted ethyl bridge (cEt, constrained ethyl), locking the sugar into a specific N-type conformation. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. cEt-adenosine is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, where it contributes to higher potency, improved pharmacokinetics, and overall enhanced stability in vivo.

CAT: BRP-02720

CAS: 1197033-34-3

Molecular Formula: C12H15N5O4

Molecular Weight: 293.28

Purity: 97%

Description: cEt-5-methylcytidine is a chemically modified cytidine nucleoside in which the ribose is constrained by a 2',4'-conformationally restricted ethyl (cEt) bridge, locking the sugar into an N-type conformation, and the cytosine base carries a 5-methyl substitution. This dual modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. It is widely used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, contributing to higher potency, improved pharmacokinetics, and overall enhanced in vivo stability.

CAT: BRP-02721

CAS: 1197033-37-6

Molecular Formula: C12H17N3O5

Molecular Weight: 283.28

Purity: ≥98%

Description: cEt-guanosine is a chemically modified guanosine nucleoside in which the ribose ring is constrained by a 2',4'-conformationally restricted ethyl (cEt) bridge, locking the sugar in an N-type (C3'-endo) conformation. This structural modification increases duplex thermal stability, improves binding affinity to complementary nucleic acid strands, and enhances resistance to nuclease degradation. cEt-guanosine is commonly employed in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, where it contributes to higher potency, improved pharmacokinetics, and increased in vivo stability.

CAT: BRP-02722

CAS: 1197033-35-4

Molecular Formula: C12H15N5O5

Molecular Weight: 309.28

Purity: ≥98%

Description: cEt-5-methyluridine is a chemically modified uridine nucleoside in which the ribose ring is constrained by a 2',4'-conformationally restricted ethyl (cEt) bridge, locking the sugar into an N-type (C3'-endo) conformation, and the uracil base carries a 5-methyl substitution. This dual modification enhances duplex thermal stability, improves binding affinity to complementary strands, and increases resistance to nuclease degradation. It is widely used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing higher potency, improved pharmacokinetics, and enhanced in vivo stability.

CAT: BRP-02723

CAS: 1197032-96-4

Molecular Formula: C12H16N2O6

Molecular Weight: 284.26

Purity: ≥95%

Description: (S)-cEt-rA(Bz) is a chemically modified adenosine nucleoside in which the ribose is constrained by a 2',4'-conformationally restricted ethyl (cEt) bridge, locking the sugar in an N-type conformation, and the adenine base is protected at the N6 position with a benzoyl (Bz) group. This modification enhances duplex thermal stability, increases binding affinity to complementary strands, and improves resistance to nuclease degradation. N4-Benzoyl-cEt-adenosine is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids to provide improved potency, specificity, and in vivo stability.

CAT: BRP-02724

CAS: 1197033-12-7

Molecular Formula: C19H19N5O5

Molecular Weight: 397.39

Purity: ≥98%

Description: (S)-cEt-5-Me-rC(Bz) is a chemically modified ribonucleoside in which 5-methylcytidine carries a constrained ethyl (cEt) modification on the ribose, locking it in an N-type (C3'-endo) conformation, with the base protected by a benzoyl (Bz) group. This modification enhances duplex thermal stability, increases binding affinity to complementary strands, and improves resistance to nuclease degradation. (S)-cEt-5-Me-rC(Bz) is used as a building block in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02725

CAS: 1197033-07-0

Molecular Formula: C19H21N3O6

Molecular Weight: 387.39

Purity: ≥98%

Description: (S)-cEt-rG(iBu) is a chemically modified ribonucleoside in which guanosine carries a constrained ethyl (cEt) modification on the ribose, locking it in an N-type (C3'-endo) conformation, and the guanine base is protected with an isobutyryl (iBu) group. This modification enhances duplex thermal stability, increases binding affinity to complementary strands, and improves resistance to nuclease degradation. (S)-cEt-rG(iBu) is used as a building block in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02726

CAS: 945628-64-8

Molecular Formula: C16H21N5O6

Molecular Weight: 379.37

Purity: ≥98%

Description: CN-LNA-adenosine is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, in which the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, and the nucleobase is adenosine. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. CN-LNA-adenosine is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02727

Molecular Formula: C12H12N6O4

Molecular Weight: 304.27

Description: CN-LNA-5-methylcytidine is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, and the nucleobase is 5-methylcytidine. This modification enhances duplex thermal stability, increases binding affinity to complementary strands, and improves resistance to nuclease degradation. CN-LNA-5-methylcytidine is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing higher potency, specificity, and in vivo stability.

CAT: BRP-02728

Molecular Formula: C12H14N4O5

Molecular Weight: 294.27

Description: CN-LNA-guanosine is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, and the nucleobase is guanosine. This modification enhances duplex thermal stability, increases binding affinity to complementary strands, and improves resistance to nuclease degradation. CN-LNA-guanosine is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing higher potency, specificity, and in vivo stability.

CAT: BRP-02729

Molecular Formula: C12H12N6O5

Molecular Weight: 320.27

Description: CN-LNA-5-methyluridine is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, and the nucleobase is 5-methyluridine. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. CN-LNA-5-methyluridine is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02730

CAS: 2404654-10-8

Molecular Formula: C12H13N3O6

Molecular Weight: 295.25

Description: (CN-LNA)-A(Bz) is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, and the nucleobase is adenine protected with a benzoyl (Bz) group. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. (CN-LNA)-A(Bz) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02731

Molecular Formula: C19H16N6O5

Molecular Weight: 408.37

Description: (CN-LNA)-5MeC(Bz) is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, and the nucleobase is 5-methylcytidine protected with a benzoyl (Bz) group. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. (CN-LNA)-5MeC(Bz) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02732

Molecular Formula: C19H18N4O6

Molecular Weight: 398.38

Description: (CN-LNA)-G(iBu) is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, and the nucleobase is guanosine protected with an isobutyryl (iBu) group. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. (CN-LNA)-G(iBu) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02733

Molecular Formula: C16H18N6O6

Molecular Weight: 390.36