Nucleosides

DMT-cEt-A(Bz)

Description: DMT-cEt-A(Bz) is a nucleoside analog based on an adenosine scaffold with a constrained ethyl (cEt) modification on the ribose, where the nucleobase is protected with a benzoyl (Bz) group, and the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. DMT-cEt-A(Bz) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02734

CAS: 1197033-18-3

Molecular Formula: C40H37N5O7

Molecular Weight: 699.76

Purity: ≥95%

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Density: 1.36±0.1 g/cm3

InChIKey: CDFUACRUGQPKNI-YUJUXCJOSA-N

CanonicalSMILES: C[C@H]1[C@]2([C@H]([C@@H](O1)[C@@H](O2)N3C=NC4=C(N=CN=C43)NC(=O)C5=CC=CC=C5)O)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC

IUPAC Name: N-[9-[(1R,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]purin-6-yl]benzamide

InChI: InChI=1S/C40H37N5O7/c1-25-39(22-50-40(27-12-8-5-9-13-27,28-14-18-30(48-2)19-15-28)29-16-20-31(49-3)21-17-29)34(46)33(51-25)38(52-39)45-24-43-32-35(41-23-42-36(32)45)44-37(47)26-10-6-4-7-11-26/h4-21,23-25,33-34,38,46H,22H2,1-3H3,(H,41,42,44,47)/t25-,33+,34-,38+,39-/m0/s1

Synonyms: N-(9-((1R,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-9H-purin-6-yl)benzamide; Benzamide, N-[9-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-deoxy-α-L-mannofuranosyl]-9H-purin-6-yl]-; 5'-ODMT cEt N-Bz A; 9-(2,5-Anhydro-4-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-6-deoxy-α-L-mannofuranosyl)-N-benzoyl-9H-purin-6-amine; cEt-N6-benzoyladenosine; DMT-(C-Et)-LNA-A(Bz); 5'-O-DMTr-cEt-BNA-N6-Bz-adenosine; 5'-O-DMT cEt A(Bz)

DMT-cEt-G(iBu)

Description: DMT-cEt-G(iBu) is a nucleoside analog based on a guanosine scaffold with a constrained ethyl (cEt) modification on the ribose, where the nucleobase is protected with an isobutyryl (iBu) group, and the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. DMT-cEt-G(iBu) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02735

CAS: 945628-65-9

Molecular Formula: C37H39N5O8

Molecular Weight: 681.75

Purity: ≥95%

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Density: 1.39±0.1 g/cm3

InChIKey: IBDQCNVRHGCMBR-SOZRNBFUSA-N

CanonicalSMILES: C[C@H]1[C@]2([C@H]([C@@H](O1)[C@@H](O2)N3C=NC4=C3N=C(NC4=O)NC(=O)C(C)C)O)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC

IUPAC Name: N-[9-[(1R,3R,4R,6S,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C37H39N5O8/c1-21(2)32(44)40-35-39-31-28(33(45)41-35)38-20-42(31)34-29-30(43)36(50-34,22(3)49-29)19-48-37(23-9-7-6-8-10-23,24-11-15-26(46-4)16-12-24)25-13-17-27(47-5)18-14-25/h6-18,20-22,29-30,34,43H,19H2,1-5H3,(H2,39,40,41,44,45)/t22-,29+,30-,34+,36-/m0/s1

Synonyms: DMT-(C-Et)-LNA-G(iBu); 5'-O-DMTr-cEt-BNA-N2-iBu-guanosine; 5'-O-DMT cEt G(iBu); N-(9-((1R,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-7-hydroxy-6-methyl-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; DMT-cEt-N2-isobutyroylguanosine; Propanamide, N-[9-[2,5-anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-6-deoxy-α-L-mannofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-; 5'-ODMT cEt N-iBu G

DMT-(CN-LNA)-5MeC(Bz)

Description: DMT-(CN-LNA)-5MeC(Bz) is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, the nucleobase is 5-methylcytidine protected with a benzoyl (Bz) group, and the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group. This modification enhances duplex thermal stability, increases binding affinity to complementary strands, and improves resistance to nuclease degradation. DMT-(CN-LNA)-5MeC(Bz) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02736

Molecular Formula: C40H36N4O8

Molecular Weight: 700.75

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InChIKey: VHAMQKFRTVXTEC-JZFRJSNESA-N

CanonicalSMILES: O[C@@H]([C@H]([C@@H]1N2C(N=C(NC(C3=CC=CC=C3)=O)C(C)=C2)=O)O[C@H]4C#N)[C@]4(O1)COC(C5=CC=CC=C5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7

InChI: InChI=1S/C40H36N4O8/c1-25-23-44(38(47)43-35(25)42-36(46)26-10-6-4-7-11-26)37-33-34(45)39(52-37,32(22-41)51-33)24-50-40(27-12-8-5-9-13-27,28-14-18-30(48-2)19-15-28)29-16-20-31(49-3)21-17-29/h4-21,23,32-34,37,45H,24H2,1-3H3,(H,42,43,46,47)/t32-,33+,34-,37+,39-/m0/s1

Synonyms: N-(1-((1R,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; 5'-DMTr-CN-LNA-5-Me-rC(Bz); 5'-DMTr-CN-LNA-N4-benzoyl-5-methylcytidine

DMT-(CN-LNA)-A(Bz)

Description: DMT-(CN-LNA)-A(Bz) is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, the nucleobase is adenine protected with a benzoyl (Bz) group, and the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group. This modification increases duplex thermal stability, enhances binding affinity to complementary strands, and improves resistance to nuclease degradation. DMT-(CN-LNA)-A(Bz) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02737

Molecular Formula: C40H34N6O7

Molecular Weight: 710.75

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InChIKey: UMNDJKRRBHLKAK-BVNFGCNBSA-N

CanonicalSMILES: O[C@@H]([C@H]([C@@H]1N2C(N=CN=C3NC(C4=CC=CC=C4)=O)=C3N=C2)O[C@H]5C#N)[C@]5(O1)COC(C6=CC=CC=C6)(C7=CC=C(OC)C=C7)C8=CC=C(OC)C=C8

InChI: InChI=1S/C40H34N6O7/c1-49-29-17-13-27(14-18-29)40(26-11-7-4-8-12-26,28-15-19-30(50-2)20-16-28)51-22-39-31(21-41)52-33(34(39)47)38(53-39)46-24-44-32-35(42-23-43-36(32)46)45-37(48)25-9-5-3-6-10-25/h3-20,23-24,31,33-34,38,47H,22H2,1-2H3,(H,42,43,45,48)/t31-,33+,34-,38+,39-/m0/s1

Synonyms: N-(9-((1R,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-9H-purin-6-yl)benzamide; 5'-DMTr-CN-LNA-N6-Bz-A; 5'-DMTr-CN-LNA-N6-benzoyladenosine

DMT-(CN-LNA)-G(iBu)

Description: DMT-(CN-LNA)-G(iBu) is a nucleoside analog based on a Locked Nucleic Acid (LNA) scaffold, where the ribose ring is conformationally locked by a 2'-O to 4'-C methylene bridge, the nucleobase is guanosine protected with an isobutyryl (iBu) group, and the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group. This modification enhances duplex thermal stability, increases binding affinity to complementary strands, and improves resistance to nuclease degradation. DMT-(CN-LNA)-G(iBu) is commonly used in the synthesis of antisense oligonucleotides, siRNAs, and other therapeutic nucleic acids, providing improved potency, specificity, and in vivo stability.

CAT: BRP-02738

Molecular Formula: C37H36N6O8

Molecular Weight: 692.73

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InChIKey: DTVHUWBCWJTSRY-LTLPDDCTSA-N

CanonicalSMILES: O[C@@H]([C@H]([C@@H]1N2C(N=C(NC(C(C)C)=O)NC3=O)=C3N=C2)O[C@H]4C#N)[C@]4(O1)COC(C5=CC=CC=C5)(C6=CC=C(OC)C=C6)C7=CC=C(OC)C=C7

InChI: InChI=1S/C37H36N6O8/c1-21(2)32(45)41-35-40-31-28(33(46)42-35)39-20-43(31)34-29-30(44)36(51-34,27(18-38)50-29)19-49-37(22-8-6-5-7-9-22,23-10-14-25(47-3)15-11-23)24-12-16-26(48-4)17-13-24/h5-17,20-21,27,29-30,34,44H,19H2,1-4H3,(H2,40,41,42,45,46)/t27-,29+,30-,34+,36-/m0/s1

Synonyms: N-(9-((1R,3R,4R,6S,7S)-1-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-6-cyano-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; 5'-DMTr-CN-LNA-N2-iBu-G; 5'-DMTr-CN-LNA-N2-isobutyroylguanosine

2'-O-POM-rC(Ac)

Description: 2'-O-POM-rC(Ac) is a ribonucleoside analog in which cytidine is protected at the 2'-hydroxyl with a pivaloyloxymethyl (POM) group and at the nucleobase with an acetyl (Ac) group. These protective groups stabilize the nucleoside during solid-phase RNA synthesis, minimizing side reactions and ensuring efficient chain assembly. 2'-O-POM-rC(Ac) is used as a building block in the synthesis of modified oligoribonucleotides for research and therapeutic applications.

CAT: BRP-02739

Molecular Formula: C17H25N3O8

Molecular Weight: 399.40

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InChIKey: XEJDDMFTMGCJLH-FMKGYKFTSA-N

CanonicalSMILES: O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C(N=C(NC(C)=O)C=C2)=O)O[C@@H]1CO

InChI: InChI=1S/C17H25N3O8/c1-9(22)18-11-5-6-20(16(25)19-11)14-13(12(23)10(7-21)28-14)26-8-27-15(24)17(2,3)4/h5-6,10,12-14,21,23H,7-8H2,1-4H3,(H,18,19,22,25)/t10-,12-,13-,14-/m1/s1

Synonyms: (((2R,3R,4R,5R)-2-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)methyl pivalate; N-Acetyl-2'-O-(pivaloyloxymethyl)cytidine; 2'-O-(Pivaloyloxymethyl)-N4-acetylcytidine; N4-Acetyl-2'-O-(pivaloyloxymethyl)cytidine; N4-Ac-2'-O-POM-cytidine; 2'-O-POM-Ac-rC; 2'-O-POM-N4-acetylcytidine

2'-O-POM-rC(Bz)

Description: 2'-O-POM-rC(Bz) is a ribonucleoside analog in which cytidine is protected at the 2'-hydroxyl with a pivaloyloxymethyl (POM) group and at the nucleobase with a benzoyl (Bz) group. These protective groups stabilize the nucleoside during solid-phase RNA synthesis, preventing undesired side reactions and allowing efficient chain elongation. 2'-O-POM-rC(Bz) is widely used as a building block in the preparation of modified oligoribonucleotides for research and therapeutic applications.

CAT: BRP-02740

Molecular Formula: C22H27N3O8

Molecular Weight: 461.47

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InChIKey: WXPPKPPFDILVCF-KLICCBINSA-N

CanonicalSMILES: O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C(N=C(NC(C3=CC=CC=C3)=O)C=C2)=O)O[C@@H]1CO

InChI: InChI=1S/C22H27N3O8/c1-22(2,3)20(29)32-12-31-17-16(27)14(11-26)33-19(17)25-10-9-15(24-21(25)30)23-18(28)13-7-5-4-6-8-13/h4-10,14,16-17,19,26-27H,11-12H2,1-3H3,(H,23,24,28,30)/t14-,16-,17-,19-/m1/s1

Synonyms: (((2R,3R,4R,5R)-2-(4-Benzamido-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)methyl pivalate; N-Benzoyl-2'-O-(pivaloyloxymethyl)cytidine; 2'-O-(Pivaloyloxymethyl)-N4-benzoylcytidine; N4-Benzoyl-2'-O-(pivaloyloxymethyl)cytidine; N4-Bz-2'-O-POM-cytidine; 2'-O-POM-Bz-rC; 2'-O-POM-N4-benzoylcytidine

2'-O-POM-MeC(Bz)

Description: 2'-O-POM-MeC(Bz) is a ribonucleoside analog in which 5-methylcytidine is protected at the 2'-hydroxyl with a pivaloyloxymethyl (POM) group and at the nucleobase with a benzoyl (Bz) group. These protective groups stabilize the nucleoside during solid-phase RNA synthesis, reducing undesired side reactions and enabling efficient chain elongation. 2'-O-POM-MeC(Bz) is used as a building block in the preparation of modified oligoribonucleotides for research and therapeutic applications.

CAT: BRP-02741

Molecular Formula: C23H29N3O8

Molecular Weight: 475.50

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InChIKey: WQVSFUPAGYPXBE-WOCWXWTJSA-N

CanonicalSMILES: O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C(N=C(NC(C3=CC=CC=C3)=O)C(C)=C2)=O)O[C@@H]1CO

InChI: InChI=1S/C23H29N3O8/c1-13-10-26(22(31)25-18(13)24-19(29)14-8-6-5-7-9-14)20-17(16(28)15(11-27)34-20)32-12-33-21(30)23(2,3)4/h5-10,15-17,20,27-28H,11-12H2,1-4H3,(H,24,25,29,31)/t15-,16-,17-,20-/m1/s1

Synonyms: (((2R,3R,4R,5R)-2-(4-Benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)methyl pivalate; N-Benzoyl-5-methyl-2'-O-(pivaloyloxymethyl)cytidine; 2'-O-(Pivaloyloxymethyl)-N4-benzoyl-5-methylcytidine; N4-Benzoyl-2'-O-(pivaloyloxymethyl)-5-methylcytidine; N4-Bz-2'-O-POM-5-methylcytidine; 2'-O-POM-Bz-5-Me-rC; 2'-O-POM-N4-benzoyl-5-methylcytidine

2'-O-POM-rG(iBu)

Description: 2'-O-POM-rG(iBu) is a ribonucleoside analog in which guanosine is protected at the 2'-hydroxyl with a pivaloyloxymethyl (POM) group and at the nucleobase with an isobutyryl (iBu) group. These protective groups provide stability during solid-phase RNA synthesis, preventing side reactions and ensuring efficient chain elongation. 2'-O-POM-rG(iBu) is used as a building block in the synthesis of modified oligoribonucleotides for research and therapeutic applications.

CAT: BRP-02742

Molecular Formula: C20H29N5O8

Molecular Weight: 467.48

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InChIKey: DWCMHMWKHDQFIB-CNEMSGBDSA-N

CanonicalSMILES: O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C=NC3=C2N=C(NC(C(C)C)=O)NC3=O)O[C@@H]1CO

InChI: InChI=1S/C20H29N5O8/c1-9(2)15(28)23-19-22-14-11(16(29)24-19)21-7-25(14)17-13(12(27)10(6-26)33-17)31-8-32-18(30)20(3,4)5/h7,9-10,12-13,17,26-27H,6,8H2,1-5H3,(H2,22,23,24,28,29)/t10-,12-,13-,17-/m1/s1

Synonyms: (((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)methyl pivalate; 2'-OPOM-iBu-G; 2'-O-POM-G(iBu); 2'-O-POM Guanosine (iBu); N2-iBu-2'-O-POM-guanosine; N2-Isobutyroyl-2'-O-(pivaloyloxymethyl)guanosine

2'-O-POM-rG(dmf)

Description: 2'-O-POM-rG(dmf) is a ribonucleoside analog in which guanosine is protected at the 2'-hydroxyl with a pivaloyloxymethyl (POM) group and at the nucleobase with a dimethylformamidine (dmf) group. These protective groups stabilize the nucleoside during solid-phase RNA synthesis, minimizing side reactions and allowing efficient chain assembly. 2'-O-POM-rG(dmf) is used as a building block in the preparation of modified oligoribonucleotides for research and therapeutic applications.

CAT: BRP-02743

Molecular Formula: C19H28N6O7

Molecular Weight: 452.47

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InChIKey: QWYLYEFGQNXHOE-XNIJJKJLSA-N

CanonicalSMILES: O[C@H]1[C@@H](OCOC(C(C)(C)C)=O)[C@H](N2C=NC3=C2N=C(N=CN(C)C)NC3=O)O[C@@H]1CO

InChI: InChI=1S/C19H28N6O7/c1-19(2,3)17(29)31-9-30-13-12(27)10(6-26)32-16(13)25-8-20-11-14(25)22-18(23-15(11)28)21-7-24(4)5/h7-8,10,12-13,16,26-27H,6,9H2,1-5H3,(H,22,23,28)/t10-,12-,13-,16-/m1/s1

Synonyms: (((2R,3R,4R,5R)-2-(2-(((Dimethylamino)methylene)amino)-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)methyl pivalate; 2'-OPOM-DMF-G; 2'-O-POM-G(DMF); 2'-O-POM Guanosine (DMF); N2-DMF-2'-O-POM-guanosine; N2-Dimethylformamide-2'-O-(pivaloyloxymethyl)guanosine

5'-O-DMT-N6-benzoyl-2',3'-seco-β-adenine

Description: 5'-O-DMT-N6-benzoyl-2',3'-seco-β-adenine is a nucleoside analog in which the ribose ring is opened at the 2',3'-positions (seco modification), the 5'-hydroxyl is protected with a dimethoxytrityl (DMT) group, and the adenine base is protected at the N6 position with a benzoyl (Bz) group. This design provides stability and controlled reactivity during solid-phase oligonucleotide synthesis. 5'-O-DMT-N6-benzoyl-2',3'-seco-β-adenine is used as a synthetic intermediate for incorporating modified adenine residues into oligonucleotides for research and therapeutic applications.

CAT: BRP-02744

CAS: 1044505-21-6

Molecular Formula: C38H37N5O7

Molecular Weight: 675.73

Purity: ≥98%

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Density: 1.293±0.14 g/cm3

InChIKey: IKKJMRNTMQLEPN-JHOUSYSJSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@H](CO)O[C@H](CO)N4C=NC5=C(N=CN=C54)NC(=O)C6=CC=CC=C6

IUPAC Name: N-[9-[(1R)-1-[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxypropan-2-yl]oxy-2-hydroxyethyl]purin-6-yl]benzamide

InChI: InChI=1S/C38H37N5O7/c1-47-30-17-13-28(14-18-30)38(27-11-7-4-8-12-27,29-15-19-31(48-2)20-16-29)49-23-32(21-44)50-33(22-45)43-25-41-34-35(39-24-40-36(34)43)42-37(46)26-9-5-3-6-10-26/h3-20,24-25,32-33,44-45H,21-23H2,1-2H3,(H,39,40,42,46)/t32-,33+/m0/s1

Synonyms: Benzamide, N-[9-[(1R)-1-[(1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-(hydroxymethyl)ethoxy]-2-hydroxyethyl]-9H-purin-6-yl]-; 6-N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine; N-(9-((R)-1-(((S)-1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxypropan-2-yl)oxy)-2-hydroxyethyl)-9H-purin-6-yl)benzamide; 5'-O-DMT-2',3'-Seco-N6-benzoyl Adenosine; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',3'-secoadenosine

5'-O-DMT-N4-acetyl-2',3'-seco-β-cytosine

Description: 5'-O-DMT-N4-acetyl-2',3'-seco-β-cytosine is a nucleoside analog in which the ribose ring is opened at the 2',3'-positions (seco modification), the cytosine base is protected at the N4 position with an acetyl (Ac) group, and the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group. These protecting groups provide stability and controlled reactivity during solid-phase oligonucleotide synthesis. This compound serves as a synthetic intermediate for incorporating modified cytosine residues into oligonucleotides for research and therapeutic applications.

CAT: BRP-02745

CAS: 1120329-54-5

Molecular Formula: C32H35N3O8

Molecular Weight: 589.64

Purity: ≥98%

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Density: 1.253±0.14 g/cm3

InChIKey: GCQMRUFKRHLPNR-MFMCTBQISA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)[C@@H](CO)O[C@@H](CO)COC(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)C4=CC=C(C=C4)OC

IUPAC Name: N-[1-[(1R)-1-[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxypropan-2-yl]oxy-2-hydroxyethyl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C32H35N3O8/c1-22(38)33-29-17-18-35(31(39)34-29)30(20-37)43-28(19-36)21-42-32(23-7-5-4-6-8-23,24-9-13-26(40-2)14-10-24)25-11-15-27(41-3)16-12-25/h4-18,28,30,36-37H,19-21H2,1-3H3,(H,33,34,38,39)/t28-,30+/m0/s1

Synonyms: Acetamide, N-[1-[(1R)-1-[(1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-(hydroxymethyl)ethoxy]-2-hydroxyethyl]-1,2-dihydro-2-oxo-4-pyrimidinyl]-; N-(1-((R)-1-(((S)-1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxypropan-2-yl)oxy)-2-hydroxyethyl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide; 5'-O-DMT-2',3'-Seco-N4-Acetyl Cytidine; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2',3'-secocytidine

5'-O-DMT-N2-isobutyryl-2',3'-seco-β-guanine

Description: 5'-O-DMT-N2-isobutyryl-2',3'-seco-β-guanine is a nucleoside analog in which the ribose ring is opened at the 2',3'-positions (seco modification), the guanine base is protected at the N2 position with an isobutyryl (iBu) group, and the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group. These modifications stabilize the compound and allow controlled reactivity during solid-phase oligonucleotide synthesis. It is used as a synthetic intermediate for incorporating modified guanine residues into oligonucleotides for research and therapeutic applications.

CAT: BRP-02746

CAS: 1044505-27-2

Molecular Formula: C35H39N5O8

Molecular Weight: 657.71

Purity: ≥98%

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Density: 1.319±0.14 g/cm3

InChIKey: BAXLCPMSHNZUPB-URLMMPGGSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2[C@@H](CO)O[C@@H](CO)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC

IUPAC Name: N-[9-[(1R)-1-[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxypropan-2-yl]oxy-2-hydroxyethyl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C35H39N5O8/c1-22(2)32(43)38-34-37-31-30(33(44)39-34)36-21-40(31)29(19-42)48-28(18-41)20-47-35(23-8-6-5-7-9-23,24-10-14-26(45-3)15-11-24)25-12-16-27(46-4)17-13-25/h5-17,21-22,28-29,41-42H,18-20H2,1-4H3,(H2,37,38,39,43,44)/t28-,29+/m0/s1

Synonyms: Propanamide, N-[9-[(1R)-1-[(1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-(hydroxymethyl)ethoxy]-2-hydroxyethyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-; N-(9-((R)-1-(((S)-1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxypropan-2-yl)oxy)-2-hydroxyethyl)-6-oxo-6,9-dihydro-3H-purin-2-yl)isobutyramide; 5'-O-DMT-2',3'-Seco-N2-Isobutyryl Guanosine; N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2',3'-secoguanosine

5'-O-DMT-2',3'-seco-β-uracil

Description: 5'-O-DMT-2',3'-seco-β-uracil is a modified nucleoside derivative where the ribose ring is cleaved at the 2',3'-positions (seco modification), the nucleobase is uracil in its β-anomeric form, and the 5'-hydroxyl group is protected with a 4,4'-dimethoxytrityl (DMT) group. This structure serves as a protected synthetic intermediate in nucleic acid chemistry, enabling incorporation of uracil-based residues into oligonucleotides, particularly in studies of RNA structure, stability, and therapeutic oligonucleotide design.

CAT: BRP-02747

CAS: 251943-33-6

Molecular Formula: C30H32N2O8

Molecular Weight: 548.58

Purity: ≥98%

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Density: 1.290±0.06 g/cm3

InChIKey: XSPAPRULJFAPFE-XTEPFMGCSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@H](CO)O[C@H](CO)N4C=CC(=O)NC4=O

IUPAC Name: 1-[(1R)-1-[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxypropan-2-yl]oxy-2-hydroxyethyl]pyrimidine-2,4-dione

InChI: InChI=1S/C30H32N2O8/c1-37-24-12-8-22(9-13-24)30(21-6-4-3-5-7-21,23-10-14-25(38-2)15-11-23)39-20-26(18-33)40-28(19-34)32-17-16-27(35)31-29(32)36/h3-17,26,28,33-34H,18-20H2,1-2H3,(H,31,35,36)/t26-,28+/m0/s1

Synonyms: 2,4(1H,3H)-Pyrimidinedione, 1-[(1R)-1-[(1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-(hydroxymethyl)ethoxy]-2-hydroxyethyl]-; 5'-O-(4,4'-Dimethoxytrityl)-2',3'-secouridine; 1-((R)-1-(((S)-1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxypropan-2-yl)oxy)-2-hydroxyethyl)pyrimidine-2,4(1H,3H)-dione; 5'-O-DMT-2',3'-Seco Uridine

5'-O-DMT-2',3'-Seco-2'-O-Benzoyl-N4-Acetyl Cytidine

Description: 5'-O-DMT-2',3'-Seco-2'-O-Benzoyl-N4-Acetyl Cytidine is a nucleoside analog in which the ribose ring is opened at the 2',3'-positions (seco modification), with the 2'-hydroxyl protected by a benzoyl (Bz) group, the cytosine base protected at the N4 position with an acetyl (Ac) group, and the 5'-hydroxyl masked with a dimethoxytrityl (DMT) group. These modifications ensure stability and controlled reactivity during solid-phase oligonucleotide synthesis. This compound is used as a synthetic intermediate for incorporating modified cytidine residues into oligonucleotides for research and therapeutic applications.

CAT: BRP-02748

CAS: 120329-55-6

Molecular Formula: C39H39N3O9

Molecular Weight: 693.75

Purity: ≥95%

Appearance: White solid

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InChIKey: LWTHPUGLGJJZKY-PUDHBBIYSA-N

CanonicalSMILES: OC[C@H](O[C@H](COC(C1=CC=CC=C1)=O)N2C(N=C(NC(C)=O)C=C2)=O)COC(C3=CC=CC=C3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5

InChI: InChI=1S/C39H39N3O9/c1-27(44)40-35-22-23-42(38(46)41-35)36(26-49-37(45)28-10-6-4-7-11-28)51-34(24-43)25-50-39(29-12-8-5-9-13-29,30-14-18-32(47-2)19-15-30)31-16-20-33(48-3)21-17-31/h4-23,34,36,43H,24-26H2,1-3H3,(H,40,41,44,46)/t34-,36+/m0/s1

Synonyms: 5'-O-DMT-2'-O-benzoyl-N4-acetyl-2',3'-seco-β-cytosine; (R)-2-(4-Acetamido-2-oxopyrimidin-1(2H)-yl)-2-(((S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxypropan-2-yl)oxy)ethyl benzoate; N4-Acetyl-2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',3'-secocytidine

5'-O-DMT-2',3'-Seco-2'-O-Benzoyl-N2-Isobutyryl Guanosine

Description: 5'-O-DMT-2',3'-Seco-2'-O-Benzoyl-N2-Isobutyryl Guanosine is a nucleoside analog in which the ribose ring is opened at the 2',3'-positions (seco modification), with the 2'-hydroxyl protected by a benzoyl (Bz) group, the guanine base protected at the N2 position with an isobutyryl (iBu) group, and the 5'-hydroxyl masked with a dimethoxytrityl (DMT) group. These protecting groups provide stability and controlled reactivity during solid-phase oligonucleotide synthesis. This compound is used as a synthetic intermediate for incorporating modified guanosine residues into oligonucleotides for research and therapeutic applications.

CAT: BRP-02749

CAS: 1120329-60-3

Molecular Formula: C42H43N5O9

Molecular Weight: 761.82

Purity: ≥95%

Appearance: White solid

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Density: 1.294±0.14 g/cm3

InChIKey: GBJOMCGXKQOKOM-OIDHKYIRSA-N

CanonicalSMILES: OC[C@H](O[C@H](COC(C1=CC=CC=C1)=O)N2C(N=C(NC(C(C)C)=O)NC3=O)=C3N=C2)COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6

InChI: InChI=1S/C42H43N5O9/c1-27(2)38(49)45-41-44-37-36(39(50)46-41)43-26-47(37)35(25-54-40(51)28-11-7-5-8-12-28)56-34(23-48)24-55-42(29-13-9-6-10-14-29,30-15-19-32(52-3)20-16-30)31-17-21-33(53-4)22-18-31/h5-22,26-27,34-35,48H,23-25H2,1-4H3,(H2,44,45,46,49,50)/t34-,35+/m0/s1

Synonyms: Propanamide, N-[9-[(1R)-2-(benzoyloxy)-1-[(1S)-2-[bis(4-methoxyphenyl)phenylmethoxy]-1-(hydroxymethyl)ethoxy]ethyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-2-methyl-; (R)-2-(((S)-1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxypropan-2-yl)oxy)-2-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl benzoate; 5'-O-DMT-2'-O-benzoyl-N2-isobutyryl-2',3'-seco-β-guanine; N2-Isobutyryl-2'-O-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',3'-secoguanosine

5'-O-DMT-2',3'-Seco-2'-O-Benzoyl Uridine

Description: 5'-O-DMT-2',3'-Seco-2'-O-Benzoyl Uridine is a nucleoside analog in which the ribose ring is opened at the 2',3'-positions (seco modification), the 2'-hydroxyl is protected with a benzoyl (Bz) group, and the 5'-hydroxyl is masked with a dimethoxytrityl (DMT) group. These protecting groups provide stability and controlled reactivity during solid-phase oligonucleotide synthesis. This compound is used as a synthetic intermediate for incorporating modified uridine residues into oligonucleotides for research and therapeutic applications.

CAT: BRP-02750

CAS: 251943-34-7

Molecular Formula: C37H36N2O9

Molecular Weight: 652.70

Purity: ≥95%

Appearance: White solid

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InChIKey: INQCHBJFCVVVIU-UZNNEEJFSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OC[C@H](CO)O[C@H](COC(=O)C4=CC=CC=C4)N5C=CC(=O)NC5=O

IUPAC Name: [(2R)-2-[(2S)-1-[bis(4-methoxyphenyl)-phenylmethoxy]-3-hydroxypropan-2-yl]oxy-2-(2,4-dioxopyrimidin-1-yl)ethyl] benzoate

InChI: InChI=1S/C37H36N2O9/c1-44-30-17-13-28(14-18-30)37(27-11-7-4-8-12-27,29-15-19-31(45-2)20-16-29)47-24-32(23-40)48-34(39-22-21-33(41)38-36(39)43)25-46-35(42)26-9-5-3-6-10-26/h3-22,32,34,40H,23-25H2,1-2H3,(H,38,41,43)/t32-,34+/m0/s1

Synonyms: 2'-O-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2',3'-secouridine; (R)-2-(((S)-1-(Bis(4-methoxyphenyl)(phenyl)methoxy)-3-hydroxypropan-2-yl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)ethyl benzoate; 5'-O-DMT-2',3'-Seco-2'-O-U(bz); 5'-O-DMT-2'-O-benzoyl-2',3'-seco-β-uracil

5'-O-DMT-N2-dimethylformamide-2'-O-(2-methoxyethyl)guanosine

Description: 5'-O-DMT-N2-dimethylformamide-2'-O-(2-methoxyethyl)guanosine is a chemically modified guanosine nucleoside in which the 5'-hydroxyl is protected by a 4,4'-dimethoxytrityl (DMT) group, the guanine base carries an N2-dimethylformamide (dmf) protecting group, and the ribose sugar is substituted at the 2'-hydroxyl with a 2-methoxyethyl (MOE) group. This type of derivative is used as a key phosphoramidite building block in solid-phase oligonucleotide synthesis, where the MOE modification enhances nuclease resistance and binding affinity, while the base and hydroxyl protections ensure selective reactivity during automated synthesis cycles.

CAT: BRP-02751

Molecular Formula: C37H42N6O8

Molecular Weight: 698.78

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InChIKey: JLHXJBGTLAFCQZ-QSYCCZFCSA-N

CanonicalSMILES: O[C@H]1[C@@H](OCCOC)[C@H](N2C=NC3=C2N=C(N=CN(C)C)NC3=O)O[C@@H]1COC(C4=CC=CC=C4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6

IUPAC Name: N'-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

InChI: InChI=1S/C37H42N6O8/c1-42(2)22-39-36-40-33-30(34(45)41-36)38-23-43(33)35-32(49-20-19-46-3)31(44)29(51-35)21-50-37(24-9-7-6-8-10-24,25-11-15-27(47-4)16-12-25)26-13-17-28(48-5)18-14-26/h6-18,22-23,29,31-32,35,44H,19-21H2,1-5H3,(H,40,41,45)/t29-,31-,32-,35-/m1/s1

Synonyms: N2-DMF-5'-O-DMTr-2'-O-MOE-rG; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine; 5'-O-DMT-N2-dimethylformamide-2'-O-methoxyethylguanosine; N2-Dimethylformamide-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2-methoxyethyl)guanosine; 2'-O-MOE-5'-O-DMT-G(DMF); 5'-O-DMT-2'-O-MOE-N2-DMF-rG

5'-O-(4,4'-Dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-N-benzoyl-5-methylcytidine

Description: 5'-O-(4,4'-Dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-N-benzoyl-5-methylcytidine is a protected nucleoside derivative of 5-methylcytidine, in which the 5'-hydroxyl is masked with a 4,4'-dimethoxytrityl (DMT) group, the 2'-hydroxyl is protected by a bulky tert-butyldimethylsilyl (TBDMS) group, and the exocyclic N4-amino group of the base is protected with a benzoyl substituent. This compound serves as an intermediate or protected building block in chemical RNA synthesis, where the 5-methylcytidine modification enhances duplex stability and epigenetic relevance, while the protecting groups control site-selective reactivity during stepwise solid-phase assembly of oligonucleotides.

CAT: BRP-02752

CAS: 160107-13-1

Molecular Formula: C44H51N3O8Si

Molecular Weight: 777.98

Purity: ≥95%

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Density: 1.18±0.1 g/cm3

InChIKey: UANWHNFQIRMOOG-VBQUSUMGSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C2=CC=CC=C2)[C@H]3[C@@H]([C@@H]([C@H](O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C44H51N3O8Si/c1-29-27-47(42(50)46-39(29)45-40(49)30-15-11-9-12-16-30)41-38(55-56(7,8)43(2,3)4)37(48)36(54-41)28-53-44(31-17-13-10-14-18-31,32-19-23-34(51-5)24-20-32)33-21-25-35(52-6)26-22-33/h9-27,36-38,41,48H,28H2,1-8H3,(H,45,46,49,50)/t36-,37-,38-,41-/m1/s1

Synonyms: Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-; N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-5-methylcytidine; 5'-DMT-2'-tBDSilyl-5-methylcytidine (n-bz); 5'-DMT-2'-TBDMS-Bz-5-Me-rC; N4-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[tert-butyl(dimethyl)silyl]-5-methylcytidine; N4-Benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-5-methylcytidine

5'-O-(4,4'-Dimethoxitrityl)-2'-O-TBDMS-5-methyluridine

Description: 5'-O-(4,4'-Dimethoxitrityl)-2'-O-TBDMS-5-methyluridine is a protected nucleoside derivative of 5-methyluridine, in which the 5'-hydroxyl group is masked with a 4,4'-dimethoxytrityl (DMT) group and the 2'-hydroxyl group is protected by a tert-butyldimethylsilyl (TBDMS) group. It is used as a key intermediate in chemical RNA synthesis, where the 5-methyluridine modification contributes to enhanced base-pairing stability and biological relevance, while the protecting groups ensure selective reactivity during solid-phase oligonucleotide assembly.

CAT: BRP-02753

CAS: 145784-40-3

Molecular Formula: C37H46N2O8Si

Molecular Weight: 674.86

Purity: 95%

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Density: 1.23±0.1 g/cm3

InChIKey: JPCJMZCIINYVKA-UKNNOAMWSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)O[Si](C)(C)C(C)(C)C

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C37H46N2O8Si/c1-24-22-39(35(42)38-33(24)41)34-32(47-48(7,8)36(2,3)4)31(40)30(46-34)23-45-37(25-12-10-9-11-13-25,26-14-18-28(43-5)19-15-26)27-16-20-29(44-6)21-17-27/h9-22,30-32,34,40H,23H2,1-8H3,(H,38,41,42)/t30-,31-,32-,34-/m1/s1

Synonyms: Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-5-methyl-; 2'-O-tert-Butyldimethylsilyl-5'-O-DMT-thymine; 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; 5'-DMT-2'-tBDSilyl thymine; 5'-O-DMT-2'-O-TBDMS-5-methyluridine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-t-butyldimethylsilyl-5-methyluridine; 2'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-5-methyluridine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-[(1,1-dimethylethyl)-dimethylsilyl]-5-methyluridine

DMT-cEt-A(Bz)

DMT-cEt-G(iBu)

DMT-(CN-LNA)-5MeC(Bz)

DMT-(CN-LNA)-A(Bz)

DMT-(CN-LNA)-G(iBu)

2'-O-POM-rC(Ac)

2'-O-POM-rC(Bz)

2'-O-POM-MeC(Bz)

2'-O-POM-rG(iBu)

2'-O-POM-rG(dmf)

5'-O-DMT-N6-benzoyl-2',3'-seco-β-adenine

5'-O-DMT-N4-acetyl-2',3'-seco-β-cytosine

5'-O-DMT-N2-isobutyryl-2',3'-seco-β-guanine

5'-O-DMT-2',3'-seco-β-uracil

5'-O-DMT-2',3'-Seco-2'-O-Benzoyl-N4-Acetyl Cytidine

5'-O-DMT-2',3'-Seco-2'-O-Benzoyl-N2-Isobutyryl Guanosine

5'-O-DMT-2',3'-Seco-2'-O-Benzoyl Uridine

5'-O-DMT-N2-dimethylformamide-2'-O-(2-methoxyethyl)guanosine

5'-O-(4,4'-Dimethoxitrityl)-2'-O-(tert-butyldimethylsilyl)-N-benzoyl-5-methylcytidine

5'-O-(4,4'-Dimethoxitrityl)-2'-O-TBDMS-5-methyluridine

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