Nucleosides - RNA / BOC Sciences

DMT-2'-O-Me-Ur-3'-succinate, TEA salt

Description: DMT-2'-O-Me-Ur-3'-succinate, TEA salt is a uridine (U) nucleoside derivative featuring a methyl group (Me) at the 2'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is utilized in biochemical studies to investigate RNA biology and nucleoside chemistry. Its structure allows researchers to explore how modifications at the 2'-position of uridine affect RNA structure, stability, and interactions with proteins, providing insights into cellular processes and potential therapeutic targets.

CAT: BRP-01224

MF: C35H36N2O11 (free acid)

MF: 660.67 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-methoxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-uridine-3'-O-succinate, triethylamine salt

Related CAS: 114745-30-1 (free base) ; 1792211-00-7 (TEA salt (1:1))

N2-iBu-DMT-2'-O-Me-Gr-3'-succinate, TEA salt

Description: N2-iBu-DMT-2'-O-Me-Gr-3'-succinate, TEA salt is a nucleoside analog that comprises guanosine (G) with an isobutyl (iBu) group at the N2 position and a methyl group (Me) at the 2'-position, along with a succinate group stabilized by TEA salt. It is employed in biochemical and molecular biology research to study nucleoside modifications and their impact on RNA function. This compound is valuable for exploring guanosine derivatives' roles in RNA metabolism, structure, and enzymatic reactions involved in nucleic acid synthesis and modification.

CAT: BRP-01225

MF: C40H43N5O11 (free acid)

MF: 769.80 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxy-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylguanosine-3'-O-succinate, triethylamine salt; Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)-, 3'-(hydrogen butanedioate), triethylamine salt; DMT-2'-O-Me-G(iBu)-3'-succinate, TEA salt

Related CAS: 114745-31-2 (free base)

N6-Bz-DMT-2'-O-Me-Ar-3'-succinate, TEA salt

Description: N6-Bz-DMT-2'-O-Me-Ar-3'-succinate, TEA salt is an adenosine (A) derivative that features a benzoyl (Bz) group at the N6 position and a methyl group (Me) at the 2'-position, with succinate and TEA salt for solubility. It is utilized in biochemical and molecular biology studies to investigate modified nucleosides' effects on RNA structure and function. Researchers use this compound to explore how specific chemical modifications at critical positions of adenosine affect RNA-protein interactions, enzymatic processes, and cellular signaling pathways.

CAT: BRP-01226

MF: C43H41N5O8 (free acid)

MF: 787.81 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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IUPAC Name: 4-[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyl-adenosine-3'-O-succinate, triethylamine salt; DMT-2'-O-Me-A(Bz)-3'-succinate, TEA salt

Related CAS: 2940857-85-0 (free base)

5'-O-DMTr-2'-O-MOE-5-Me-C(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-MOE-5-Me-C(Bz)-3'-O-succinate, TEA salt is a modified nucleoside that contains a cytosine (C) base substituted with a 5-Me-C(Bz) group and a 2'-position methoxyethyl (MOE) modification, with succinate and TEA salt to improve solubility. It is used in synthetic biology and RNA research to investigate nucleoside structure-function relationships and their roles in biological processes. This compound allows researchers to study how specific chemical modifications impact RNA stability, secondary structure formation, and interactions with proteins, advancing our understanding of nucleic acid biochemistry and potential therapeutic applications.

CAT: BRP-01227

MF: C45H47N3O12 (free acid)

MF: 821.88 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-benzamido-5-methyl-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N4-benzoyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-O-succinate, triethylamine salt; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-5-methyl-, 3'-(hydrogen butanedioate), triethylamine salt

Related CAS: 1536204-26-8 (free base) ; 1536204-27-9 (TEA salt (1:1))

5'-DMT-2'-O-MOE-C(Ac)-3'-succinate, TEA salt

Description: 5'-DMT-2'-O-MOE-C(Ac)-3'-succinate, TEA salt is a nucleoside derivative that features a cytosine (C) base modified with an acetyl (Ac) group at the 2'-position and a succinate group at the 3'-position. The TEA (triethylamine) salt formulation ensures improved solubility and stability in aqueous solutions. This compound is used in biochemical research to study RNA structure and function, particularly in exploring how modifications at specific nucleoside positions affect RNA-protein interactions and enzymatic processes.

CAT: BRP-01228

MF: C45H58N4O12

MF: 846.97

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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InChIKey: GISCEWMZFVCQKL-WKHDLHBGSA-N

CanonicalSMILES: CCN(CC)CC.CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)OC(=O)CCC(=O)O)OCCOC

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C39H43N3O12.C6H15N/c1-25(43)40-32-20-21-42(38(47)41-32)37-36(51-23-22-48-2)35(54-34(46)19-18-33(44)45)31(53-37)24-52-39(26-8-6-5-7-9-26,27-10-14-29(49-3)15-11-27)28-12-16-30(50-4)17-13-28;1-4-7(5-2)6-3/h5-17,20-21,31,35-37H,18-19,22-24H2,1-4H3,(H,44,45)(H,40,41,43,47);4-6H2,1-3H3/t31-,35-,36-,37-;/m1./s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-cytidine-3'-O-succinate, triethylamine salt; Triethylamine 4-(((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoate

5'-O-DMT-2'-O-MOE-U-3'-succinate, TEA salt

Description: 5'-O-DMT-2'-O-MOE-U-3'-succinate, TEA salt is a nucleoside analog that contains a uridine (U) base with a methoxyethyl (MOE) modification at the 2'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is utilized in nucleic acid synthesis and modification studies to investigate the impact of chemical modifications on RNA stability and structure. Researchers use this compound to explore how modifications at the 2'-position of uridine influence RNA function and interactions with proteins.

CAT: BRP-01229

MF: C37H40N2O12 (free acid)

MF: 704.73 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-(2-methoxyethoxy)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-uridine 3'-O-succinate, triethylamine salt

5'-O-DMT-2'-O-MOE-A(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMT-2'-O-MOE-A(Bz)-3'-O-succinate, TEA salt is an adenosine (A) derivative that features a benzoyl (Bz) group at the 2'-position and a methoxyethyl (MOE) modification at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is employed in biochemical research to investigate modified nucleosides' effects on RNA structure, stability, and function. This compound is valuable for studying adenosine derivatives' roles in RNA metabolism, enzymatic processes, and interactions with RNA-binding proteins.

CAT: BRP-01230

MF: C45H45N5O11 (free acid)

MF: 831.88 (free acid)

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-[(2R,3R,4R,5R)-5-(6-benzamidopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine 3'-O-succinate, triethylamine salt

Related CAS: 444814-78-2 (free base)

5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-C(Bz)-3'-O-succinate, TEA salt is a nucleoside derivative that contains a cytosine (C) base modified with a benzoyl (Bz) group at the 2'-position and a TMBTM group at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is used in nucleic acid synthesis and modification research to explore the impact of chemical modifications on RNA structure and function. This compound allows researchers to study how specific modifications at critical positions of cytosine influence RNA-protein interactions and enzymatic activities.

CAT: BRP-01231

MF: C52H53N3O14S (free acid)

MF: 976.06 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-benzamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N4-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-cytidine-3'-O-succinate, triethylamine salt

5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-G(iBu)-3'-O-succinate, TEA salt is a guanosine (G) nucleoside analog that is modified with an isobutyl (iBu) group at the 2'-position and a TMBTM group at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is utilized in biochemical and molecular biology research to investigate modified nucleosides' effects on RNA structure and function. Researchers use this compound to explore how modifications at the 2'-position of guanosine impact RNA stability, enzymatic reactions, and interactions with RNA-binding proteins.

CAT: BRP-01232

MF: C50H55N5O14S (free acid)

MF: 982.07 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-guanosine-3'-O-succinate, triethylamine salt

5'-O-DMTr-2'-O-TMBTM-U-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-U-3'-O-succinate, TEA salt is a uridine (U) nucleoside derivative that features a TMBTM modification at the 2'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is used in nucleic acid research to study RNA modifications and their impact on RNA biology. This compound allows researchers to investigate how modifications at the 2'-position of uridine affect RNA structure, stability, and interactions with proteins, providing insights into cellular processes and potential therapeutic applications.

CAT: BRP-01233

MF: C45H48N2O14S (free acid)

MF: 872.94 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at 2-8 °C

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-uridine-3'-O-succinate, triethylamine salt

5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-2'-O-TMBTM-A(Bz)-3'-O-succinate, TEA salt is an adenosine (A) derivative that contains a benzoyl (Bz) group at the 2'-position and a TMBTM modification at the 2'-position, with a succinate group at the 3'-position and stabilized with TEA salt. It is employed in biochemical and molecular biology research to study nucleoside modifications and their impact on RNA function. This compound allows researchers to explore how modifications at the 2'-position of adenosine influence RNA metabolism, structure, and interactions with proteins involved in RNA processing and regulation.

CAT: BRP-01234

MF: C53H53N5O13S (free acid)

MF: 1000.09 (free acid)

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((2,4,6-trimethoxybenzyl)thio)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N6-benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(2,4,6-trimethoxybenzylthiomethyl)-adenosine-3'-O-succinate, triethylamine salt

5'-O-DMTr-2'-O-TOM-U succinate

Description: 5'-O-DMTr-2'-O-TOM-U succinate is a nucleoside derivative that features a uridine (U) base with a TOM (2'-O-TOM) modification at the 2'-position and a succinate group at the 3'-position. It is used in nucleic acid synthesis and modification studies to investigate the role of modified nucleosides in RNA structure and function. The succinate modification aids in enhancing solubility and stability in biochemical assays, making it suitable for studying RNA-protein interactions and enzymatic activities involved in RNA metabolism.

CAT: BRP-01235

MF: C44H56N2O12Si

MF: 833.02

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: TWSPHFOHWURPEH-GLONBZIJSA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C44H56N2O12Si/c1-28(2)59(29(3)4,30(5)6)56-27-54-41-40(58-39(50)23-22-38(48)49)36(57-42(41)46-25-24-37(47)45-43(46)51)26-55-44(31-12-10-9-11-13-31,32-14-18-34(52-7)19-15-32)33-16-20-35(53-8)21-17-33/h9-21,24-25,28-30,36,40-42H,22-23,26-27H2,1-8H3,(H,48,49)(H,45,47,51)/t36-,40-,41-,42-/m1/s1

Synonyms: 5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-uridine-succinate; 5'-O-DMTr-2'-O-TOM-U-3'-O-succinate

5'-O-DMTr-2'-O-TOM-C(Ac) succinate

Description: 5'-O-DMTr-2'-O-TOM-C(Ac) succinate is a cytosine (C) nucleoside analog that contains an acetyl (Ac) group at the 2'-position and a TOM (2'-O-TOM) modification at the 2'-position, with a succinate group at the 3'-position. It is utilized in biochemical research to explore modified nucleosides' effects on RNA stability and function. This compound allows researchers to investigate how modifications at the 2'-position of cytosine influence RNA structure, enzymatic processes, and interactions with proteins, advancing our understanding of nucleic acid biochemistry and potential therapeutic applications.

CAT: BRP-01236

MF: C46H59N3O12Si

MF: 874.07

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: AQUZVAWRHRMGSV-LAYMWRTISA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C46H59N3O12Si/c1-29(2)62(30(3)4,31(5)6)59-28-57-43-42(61-41(53)24-23-40(51)52)38(60-44(43)49-26-25-39(47-32(7)50)48-45(49)54)27-58-46(33-13-11-10-12-14-33,34-15-19-36(55-8)20-16-34)35-17-21-37(56-9)22-18-35/h10-22,25-26,29-31,38,42-44H,23-24,27-28H2,1-9H3,(H,51,52)(H,47,48,50,54)/t38-,42-,43-,44-/m1/s1

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-cytidine-succinate; 5'-O-DMTr-2'-O-TOM-C(Ac)-3'-O-succinate

5'-O-DMTr-2'-O-TOM-A(Ac) succinate

Description: 5'-O-DMTr-2'-O-TOM-A(Ac) succinate is an adenosine (A) nucleoside derivative featuring an acetyl (Ac) group at the 2'-position and a TOM (2'-O-TOM) modification at the 2'-position, with a succinate group at the 3'-position. This derivative is used in nucleic acid research to study RNA modifications and their impact on RNA structure and function. It allows researchers to explore how modifications at specific positions of adenosine affect RNA stability, enzymatic processes, and interactions with RNA-binding proteins.

CAT: BRP-01237

MF: C47H59N5O11Si

MF: 898.10

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: BWTSLHAPYYEBNJ-LSWBLBMOSA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(6-acetamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C47H59N5O11Si/c1-29(2)64(30(3)4,31(5)6)61-28-59-43-42(63-40(56)24-23-39(54)55)38(62-46(43)52-27-50-41-44(51-32(7)53)48-26-49-45(41)52)25-60-47(33-13-11-10-12-14-33,34-15-19-36(57-8)20-16-34)35-17-21-37(58-9)22-18-35/h10-22,26-27,29-31,38,42-43,46H,23-25,28H2,1-9H3,(H,54,55)(H,48,49,51,53)/t38-,42-,43-,46-/m1/s1

Synonyms: N6-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-adenosine-succinate; 5'-O-DMTr-2'-O-TOM-A(Ac)-3'-O-succinate

5'-O-DMTr-2'-O-TOM-G(Ac) succinate

Description: 5'-O-DMTr-2'-O-TOM-G(Ac) succinate is a guanosine (G) nucleoside analog that contains an acetyl (Ac) group at the 2'-position and a TOM (2'-O-TOM) modification at the 2'-position, with a succinate group at the 3'-position. It is employed in biochemical and molecular biology research to investigate modified nucleosides' effects on RNA structure and function. Researchers use this compound to explore how modifications at the 2'-position of guanosine influence RNA stability, enzymatic reactions, and interactions with RNA-binding proteins.

CAT: BRP-01238

MF: C47H59N5O12Si

MF: 914.10

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at -20 °C

InChIKey: RJLDLOKSNHEKQI-LRZYOCIQSA-N

IUPAC Name: 4-(((2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

InChI: InChI=1S/C47H59N5O12Si/c1-28(2)65(29(3)4,30(5)6)62-27-60-42-41(64-39(56)24-23-38(54)55)37(63-45(42)52-26-48-40-43(52)50-46(49-31(7)53)51-44(40)57)25-61-47(32-13-11-10-12-14-32,33-15-19-35(58-8)20-16-33)34-17-21-36(59-9)22-18-34/h10-22,26,28-30,37,41-42,45H,23-25,27H2,1-9H3,(H,54,55)(H2,49,50,51,53,57)/t37-,41-,42-,45-/m1/s1

Synonyms: N2-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-triisopropylsilyloxymethyl-guanosine-succinate; 5'-O-DMTr-2'-O-TOM-G(Ac)-3'-O-succinate

Abasic Succinate

Description: Abasic Succinate is a nucleoside analog where the nucleobase is absent (abasic), with a succinate group attached. Abasic nucleosides are used in nucleic acid research as controls or reference compounds to study the role of specific bases in DNA or RNA structure, function, and interactions with enzymes or proteins.

CAT: BRP-01239

CAS: 1428324-58-6

MF: C30H32O8

MF: 520.58

Purity: ≥98% by HPLC

Appearance: White to yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

InChIKey: PURLJYSNZCUYOW-RRPNLBNLSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(CCO4)OC(=O)CCC(=O)O

IUPAC Name: 4-[(2R,3S)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]oxolan-3-yl]oxy-4-oxobutanoic acid

InChI: InChI=1S/C30H32O8/c1-34-24-12-8-22(9-13-24)30(21-6-4-3-5-7-21,23-10-14-25(35-2)15-11-23)37-20-27-26(18-19-36-27)38-29(33)17-16-28(31)32/h3-15,26-27H,16-20H2,1-2H3,(H,31,32)/t26-,27+/m0/s1

Synonyms: 4-(((2R,3S)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid

5'-O-DMTr-C(Ac)-3'-O-succinate, TEA salt

Description: 5'-O-DMTr-C(Ac)-3'-O-succinate, TEA salt is a nucleoside derivative that features a cytosine (C) base modified with an acetyl (Ac) group at the 3'-position and a succinate group at the 3'-position, stabilized with TEA salt. It is employed in biochemical and molecular biology research to study nucleoside modifications and their effects on RNA function. This compound allows researchers to investigate how modifications at the 3'-position of cytosine influence RNA metabolism, structure, and interactions with proteins involved in RNA processing and regulation.

CAT: BRP-01240

MF: C36H37N3O11 (free acid)

MF: 687.70 (free acid)

Purity: ≥95% by HPLC

Appearance: White, off-white to light yellow powder

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Storage: Store at -20 °C, in tightly closed containers, protected from humidity

IUPAC Name: 4-(((2R,3S,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine

Synonyms: N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-cytidine 3'-O-succinate, triethylamine salt

2'-O-Allylcytidine

Description: 2'-O-Allylcytidine is a modified nucleoside where the ribose sugar has an allyl group attached at the 2' position. This modification is used in the synthesis of RNA with altered properties, aiding in the study of RNA structure, function, and interactions. It is valuable in research applications, including the development of novel therapeutic RNA molecules and the investigation of RNA-based mechanisms.

CAT: BRP-01257

CAS: 133766-25-3

MF: C12H17N3O5

MF: 283.28

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Density: 1.53±0.1 g/cm3

Boiling Point: 526.0±60.0 °C at 760 mmHg

InChIKey: SGODVCJEFNCZPV-QCNRFFRDSA-N

CanonicalSMILES: C=CCOC1C(C(OC1N2C=CC(=NC2=O)N)CO)O

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-enoxyoxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C12H17N3O5/c1-2-5-19-10-9(17)7(6-16)20-11(10)15-4-3-8(13)14-12(15)18/h2-4,7,9-11,16-17H,1,5-6H2,(H2,13,14,18)/t7-,9-,10-,11-/m1/s1

Synonyms: 2'-(O-allyl) Cytidine; 2'-O-2-Propen-1-ylcytidine; Cytidine, 2'-O-2-propenyl-; 2'-Allylcytidine

5'-DMT-2'-tBDSilyl Adenosine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Adenosine (n-PAC) is a chemical reagent used in oligonucleotide synthesis. It features an adenosine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for 5' hydroxyl protection and a 2'-tBDSilyl (tert-butyldimethylsilyl) group for 2' hydroxyl protection. Additionally, the N6 position of adenosine is protected by a PAC (phenoxyacetyl) group. These protective modifications prevent side reactions during the sequential assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise oligonucleotide production. This reagent is crucial for various applications in molecular biology, genetic research, and therapeutic development.

CAT: BRP-01306

CAS: 121058-83-1

MF: C45H51N5O8Si

MF: 818.00

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Density: 1.23±0.1 g/cm3

InChIKey: QGHUBPNLGMARKQ-DQZBACKDSA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)COC4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]purin-6-yl]-2-phenoxyacetamide

InChI: InChI=1S/C45H51N5O8Si/c1-44(2,3)59(6,7)58-40-39(52)36(57-43(40)50-29-48-38-41(46-28-47-42(38)50)49-37(51)27-55-35-16-12-9-13-17-35)26-56-45(30-14-10-8-11-15-30,31-18-22-33(53-4)23-19-31)32-20-24-34(54-5)25-21-32/h8-25,28-29,36,39-40,43,52H,26-27H2,1-7H3,(H,46,47,49,51)/t36-,39-,40-,43-/m1/s1

Synonyms: N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)-2-phenoxyacetamide; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)adenosine; N6-Pac-5'-O-DMT-2'-O-TBDMS-rA; 5'-O-(dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N6-phenoxyacetyladenosine

5'-DMT-2'-tBDSilyl Cytidine (n-PAC)

Description: 5'-DMT-2'-tBDSilyl Cytidine (n-PAC) is a specialized reagent used in the synthesis of oligonucleotides. It consists of a cytidine nucleoside modified with a 5'-DMT (dimethoxytrityl) group for protecting the 5' hydroxyl position and a 2'-tBDSilyl (tert-butyldimethylsilyl) group for protecting the 2' hydroxyl position. Additionally, the amino group at the N4 position of cytidine is protected by a PAC (phenoxyacetyl) group. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and accurate oligonucleotide production. This reagent is essential for applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-01307

CAS: 259144-71-3

MF: C44H51N3O9Si

MF: 793.98

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Density: 1.19±0.1 g/cm3

InChIKey: AEVPUWXDGCKYTH-OGEJDOPKSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2O[Si](C)(C)C(C)(C)C)NC(=O)COC=6C=CC=CC6

IUPAC Name: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)-2-phenoxyacetamide

InChI: InChI=1S/C44H51N3O9Si/c1-43(2,3)57(6,7)56-40-39(49)36(55-41(40)47-27-26-37(46-42(47)50)45-38(48)29-53-35-16-12-9-13-17-35)28-54-44(30-14-10-8-11-15-30,31-18-22-33(51-4)23-19-31)32-20-24-34(52-5)25-21-32/h8-27,36,39-41,49H,28-29H2,1-7H3,(H,45,46,48,50)/t36-,39-,40-,41-/m1/s1

Synonyms: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-phenoxyacetyl)cytidine; Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(phenoxyacetyl)-; 5'-O-DMT-2'-O-TBDMS-rC(Pac)