Nucleosides

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2'-Modified Nucleosides
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5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

Description: 5'-NH2-3'-O-TBDMS-2'-O-4'-C-Locked-Ur includes an amino (NH2) group replaced to the 5' hydroxyl, a tert-butyldimethylsilyl (TBDMS) group attached to the 3' hydroxyl, and a 2'-O modificationa, a 4'-carbon locked uracil (Locked-Ur). It is used in oligonucleotide synthesis to introduce amino functional groups.
CAT: BRP-01012
MF: C16H27N3O5Si
MF: 369.49
Purity: ≥98% by HPLC
Appearance: White, off-white to faint yellow powder
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Storage: Store at 2-8 °C
InChIKey: QJDAOGPSEQMRJU-IATRGZMQSA-N
IUPAC Name: 1-((1S,3R,4R,7S)-1-(aminomethyl)-7-((tert-butyldimethylsilyl)oxy)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione
InChI: InChI=1S/C16H27N3O5Si/c1-15(2,3)25(4,5)24-12-11-13(23-16(12,8-17)9-22-11)19-7-6-10(20)18-14(19)21/h6-7,11-13H,8-9,17H2,1-5H3,(H,18,20,21)/t11-,12+,13-,16+/m1/s1
Synonyms: 5'-amino-3'-O-(t-butyldimethylsilyl)-1-(2'-O,4'-C-methylene-beta-D-ribofuranosyl)-uridineacil; 5'-NH2-3'-O-TBDMS-LNA-Ur

5'-N3-3'-O-TBDMS-2'-O-4'-C-Locked-Ur

Description: 5'-N3-3'-O-TBDMS-2'-O-4'-C-Locked-Ur consists of an N3 replaced to the 5' hydroxyl, a tert-butyldimethylsilyl (TBDMS) group attached to the 3' hydroxyl, and a 2'-O modificationa, a 4'-carbon locked uracil (Locked-Ur). It is used in oligonucleotide synthesis to introduce specific functional groups.
CAT: BRP-01013
MF: C16H25N5O5Si
MF: 395.49
Purity: ≥98% by HPLC
Appearance: White, off-white to faint yellow powder
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Storage: Store at 2-8 °C
InChIKey: YVKIMFHCMXNURY-IATRGZMQSA-N
IUPAC Name: 1-((1S,3R,4R,7S)-1-(azidomethyl)-7-((tert-butyldimethylsilyl)oxy)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione
InChI: InChI=1S/C16H25N5O5Si/c1-15(2,3)27(4,5)26-12-11-13(21-7-6-10(22)19-14(21)23)25-16(12,9-24-11)8-18-20-17/h6-7,11-13H,8-9H2,1-5H3,(H,19,22,23)/t11-,12+,13-,16+/m1/s1
Synonyms: 5'-Azido-3'-O-(t-butyldimethylsilyl)-1-(2'-O,4'-C-methylene-beta-D-ribofuranosyl)-uridineacil; 5'-N3-3'-O-TBDMS-LNA-Ur

5'-O-DMTr-2'-O-Me-A(iBu)

Description: 5'-O-DMTr-2'-O-Me-A(iBu) consists of a dimethoxytrityl (DMTr) protecting group attached to the 5' hydroxyl, along with an isobutyl (iBu) group attached to the 2' position of ribose. It is used in oligonucleotide synthesis to introduce protecting groups and provide specific chemical properties.
CAT: BRP-01015
MF: C36H39N5O7
MF: 653.74
Purity: ≥98% by HPLC
Appearance: White to off-white powder
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Storage: Store at -20 °C
InChIKey: PNFDGHXTXJOSKF-JYYIKNSZSA-N
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)isobutyramide
InChI: InChI=1S/C36H39N5O7/c1-22(2)34(43)40-32-29-33(38-20-37-32)41(21-39-29)35-31(46-5)30(42)28(48-35)19-47-36(23-9-7-6-8-10-23,24-11-15-26(44-3)16-12-24)25-13-17-27(45-4)18-14-25/h6-18,20-22,28,30-31,35,42H,19H2,1-5H3,(H,37,38,40,43)/t28-,30-,31-,35-/m1/s1
Synonyms: N2-isobutyryl-5'-O-4,4'-dimethoxytrityl)-2'-O-methyl-adenosine

7-Me-2'-O-Me-Gr

Description: 7-Me-2'-O-Me-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of a methyl group (Me) attached to the 7th position of guanine and a methyl (Me) group at the 2' position of ribose. This modification is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, allowing for tailored modifications and improved nucleic acid properties.
CAT: BRP-01016
CAS: 1125657-23-9
MF: C12H17N5O5
MF: 311.29
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InChIKey: CJRPFMAFZQADLD-IOSLPCCCSA-N
CanonicalSMILES: CN1C=[N+](C2=C1C(=NC(=N2)N)[O-])C3C(C(C(O3)CO)O)OC
IUPAC Name: 2-amino-9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-7-methylpurin-9-ium-6-olate
InChI: InChI=1S/C12H17N5O5/c1-16-4-17(9-6(16)10(20)15-12(13)14-9)11-8(21-2)7(19)5(3-18)22-11/h4-5,7-8,11,18-19H,3H2,1-2H3,(H2-,13,14,15,20)/t5-,7-,8-,11-/m1/s1
Synonyms: 7-Me-2'-O-Me-guanosine; (9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium-2-yl)amide; 2-Amino-9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-7-methyl-9H-purin-7-ium-6-olate; Guanosine, 7-methyl-2'-O-methyl-, inner salt
Related CAS: 1093268-98-4 (7-Methyl-2'-O-methylguanosine)

3'-O-propargyl-2-amino-Ar

Description: 3'-O-propargyl-2-amino-Ar is a modified nucleoside used in oligonucleotide synthesis. It consists of a propargyl group attached to the 3' position of ribose and a 2-amino group attached to the adenine base. This modification is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, enabling conjugation or further modifications for various applications.
CAT: BRP-01017
CAS: 1451256-05-5
MF: C13H16N6O4
MF: 320.31
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Density: 1.76±0.1 g/cm3
Boiling Point: 757.8±70.0 °C at 760 mmHg
InChIKey: BVSATFBMHIPHQP-WOUKDFQISA-N
CanonicalSMILES: C#CCOC1C(OC(C1O)N2C=NC3=C(N=C(N=C32)N)N)CO
IUPAC Name: (2R,3R,4S,5R)-2-(2,6-diaminopurin-9-yl)-5-(hydroxymethyl)-4-prop-2-ynoxyoxolan-3-ol
InChI: InChI=1S/C13H16N6O4/c1-2-3-22-9-6(4-20)23-12(8(9)21)19-5-16-7-10(14)17-13(15)18-11(7)19/h1,5-6,8-9,12,20-21H,3-4H2,(H4,14,15,17,18)/t6-,8-,9-,12-/m1/s1
Synonyms: 3'-O-propargyl-2-amino-adenosine; 2-Amino-3'-O-2-propyn-1-yladenosine

7-Me-3'-O-Me-Gr

Description: 7-Me-3'-O-Me-Gr is a modified nucleoside used in oligonucleotide synthesis. It consists of a methyl group (Me) attached to the 7th position of guanine and a methyl (Me) group at the 3' position of ribose. This modification is employed in oligonucleotide synthesis to introduce specific functionalities or properties into the oligonucleotide sequence, allowing for tailored modifications and improved nucleic acid properties.
CAT: BRP-01018
MF: C12H17N5O5
MF: 311.29
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InChIKey: BQGWLQOGQUOEIW-IOSLPCCCSA-N
IUPAC Name: 2-amino-9-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)-7-methyl-9H-purin-7-ium-6-olate
InChI: InChI=1S/C12H17N5O5/c1-16-4-17(9-6(16)10(20)15-12(13)14-9)11-7(19)8(21-2)5(3-18)22-11/h4-5,7-8,11,18-19H,3H2,1-2H3,(H2-,13,14,15,20)/t5-,7-,8-,11-/m1/s1
Synonyms: 7-methyl-3'-O-methyl-guanosine

2,3'-Anhydro-5-Me-Ur

Description: 2,3'-Anhydro-5-Me-Ur is a modified nucleoside used in oligonucleotide synthesis. It is a derivative of uridine where the hydroxyl groups at the 2' and 3' positions of ribose are eliminated, and a methyl (Me) group is attached to the 5th position of the uracil base. This modification is employed in oligonucleotide synthesis to introduce specific structural features or properties into the oligonucleotide sequence, allowing for various applications in research and biotechnology.
CAT: BRP-01019
MF: C10H14N2O5
MF: 242.23
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InChIKey: OPNAHQQKNKLRRL-IWLPKDRNSA-N
IUPAC Name: (2R,3R,5R,11R)-11-hydroxy-3-(hydroxymethyl)-8-methyl-2,3,10,10a-tetrahydro-5H,9H-2,5-methanopyrimido[2,1-b][1,5,3]dioxazepin-9-one
InChI: InChI=1S/C10H14N2O5/c1-4-2-12-9-6(14)7(5(3-13)16-9)17-10(12)11-8(4)15/h2,5-7,9-10,13-14H,3H2,1H3,(H,11,15)/t5-,6-,7+,9-,10?/m1/s1
Synonyms: 2,3'-Anhydro-5-Me-uridine

2',4-Anhydro-pU

Description: 2',4-Anhydro-pU is a modified nucleoside used in oligonucleotide synthesis. It is a derivative of pseudouridine where the hydroxyl groups at the 2' and 4' positions of ribose are eliminated. This modification is employed in oligonucleotide synthesis to introduce specific structural features or properties into the oligonucleotide sequence, which may influence RNA structure, stability, or interactions with other molecules.
CAT: BRP-01020
MF: C9H12N2O5
MF: 228.20
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InChIKey: RVTBSCYISWGRMI-KEWYIRBNSA-N
CanonicalSMILES: O=C1NC=C2C(OC3C(O)C(OC23)CO)N1
IUPAC Name: (4bS,6R,7R,7aR)-7-hydroxy-6-(hydroxymethyl)-3,4b,6,7,7a,8a-hexahydrofuro[2',3':4,5]furo[2,3-d]pyrimidin-2(1H)-one
InChI: InChI=1S/C9H12N2O5/c12-2-4-5(13)7-6(15-4)3-1-10-9(14)11-8(3)16-7/h1,4-8,12-13H,2H2,(H2,10,11,14)/t4-,5-,6+,7-,8?/m1/s1
Synonyms: 2',4-Anhydro-pseudouridine; Furo[2',3':4,5]furo[2,3-d]pyrimidin-2(1H)-one, 3,4b,6,7,7a,8a-hexahydro-7-hydroxy-6-(hydroxymethyl)-, (4bS,6R,7R,7aR)-

2-Iodo-9-β-D-ribofuranosyl-9H-purine

Description: 2-Iodo-9-β-D-ribofuranosyl-9H-purine is a modified nucleoside used in oligonucleotide synthesis. It consists of an iodine atom (I) attached to the 2-position of 9-β-D-ribofuranosyl-9H-purine. This modification is employed in oligonucleotide synthesis for various applications, including labeling, cross-linking studies, or structural probing experiments.
CAT: BRP-01021
CAS: 125425-46-9
MF: C10H11IN4O4
MF: 378.12
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Density: 2.53±0.1 g/cm3
Melting Point: 163-165 °C
Boiling Point: 695.9±65.0 °C at 760 mmHg
InChIKey: JNWLMGAOAHHDJY-JXOAFFINSA-N
CanonicalSMILES: IC=1N=CC=2N=CN(C2N1)C3OC(CO)C(O)C3O
IUPAC Name: (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(2-iodo-9H-purin-9-yl)tetrahydrofuran-3,4-diol
InChI: InChI=1S/C10H11IN4O4/c11-10-12-1-4-8(14-10)15(3-13-4)9-7(18)6(17)5(2-16)19-9/h1,3,5-7,9,16-18H,2H2/t5-,6-,7-,9-/m1/s1
Synonyms: 2-Iodo-purine-ribose; 2-I-purine-ribose; 9H-Purine, 2-iodo-9-β-D-ribofuranosyl-

1-Methylpseudoisocytidine

Description: 1-Methylpseudoisocytidine is a modified nucleoside used in oligonucleotide synthesis. It is a derivative of pseudoisocytidine where a methyl group (Me) is attached to the nitrogen atom. This modification is employed in oligonucleotide synthesis to introduce specific structural features or properties into the oligonucleotide sequence, allowing for various applications in RNA research and therapeutics.
CAT: BRP-01022
CAS: 80229-06-7
MF: C10H15N3O5
MF: 257.25
Purity: ≥98% by HPLC
Appearance: White, off-white to light yellow powder
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Storage: Store at -20 °C
Density: 1.79±0.1 g/cm3
Boiling Point: 540.4±60.0 °C at 760 mmHg
InChIKey: MIXBUOXRHTZHKR-XUTVFYLZSA-N
CanonicalSMILES: CN1C=C(C(=O)N=C1N)C2C(C(C(O2)CO)O)O
IUPAC Name: 2-amino-5-[(2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1-methylpyrimidin-4-one
InChI: InChI=1S/C10H15N3O5/c1-13-2-4(9(17)12-10(13)11)8-7(16)6(15)5(3-14)18-8/h2,5-8,14-16H,3H2,1H3,(H2,11,12,17)/t5-,6-,7-,8+/m1/s1
Synonyms: N1-methyl-Pseudoisocytidine; 2-Amino-5-((2S,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1-methylpyrimidin-4(1H)-one; N1-Me-Pseudo-iso-Cytidine; 2-Amino-1-methyl-5-β-D-ribofuranosyl-4(1H)-pyrimidinone; 1-Methyl-pseudoisocytidine

2'-O-(2-Fluoroethyl)-5-methyluridine

Description: 2'-O-(2-Fluoroethyl)-5-methyluridine is a modified nucleoside used in oligonucleotide synthesis. It is a nucleoside where a 2-fluoroethyl group is attached to the 2' position of ribose and a methyl group (Me) is attached to the 5th position of uracil. This modified nucleoside is employed in oligonucleotide synthesis to introduce specific structural features or properties into the oligonucleotide sequence, which can affect RNA structure, stability, or interactions with other molecules.
CAT: BRP-01023
CAS: 860640-48-8
MF: C12H17FN2O6
MF: 304.27
Purity: ≥98% by HPLC
Appearance: White powder
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Storage: Store at 2-8 °C, Keep in a dark and dry place
Density: 1.47±0.1 g/cm3
InChIKey: GLPXIFDTRGSUFI-TURQNECASA-N
CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)OCCF
IUPAC Name: 1-[(2R,3R,4R,5R)-3-(2-fluoroethoxy)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
InChI: InChI=1S/C12H17FN2O6/c1-6-4-15(12(19)14-10(6)18)11-9(20-3-2-13)8(17)7(5-16)21-11/h4,7-9,11,16-17H,2-3,5H2,1H3,(H,14,18,19)/t7-,8-,9-,11-/m1/s1
Synonyms: 5-methyl-2'-O-(2-fluoroethyl)-uridine; 5-Me-2'-O-(2-fluoroethyl)-Ur; 1-((2R,3R,4R,5R)-3-(2-fluoroethoxy)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

5-Aminoallyl uridine

Description: 5-Aminoallyl uridine is a modified nucleoside used in oligonucleotide synthesis. It is a nucleoside where an aminoallyl group is attached to the 5th position of uridine. This modification is commonly employed in oligonucleotide synthesis for various applications such as labeling, conjugation, or attachment of fluorophores, biotin, or other molecules for downstream applications like microarray analysis, RNA labeling, or affinity purification.
CAT: BRP-01024
CAS: 97695-16-4
MF: C12H17N3O6
MF: 299.28
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Density: 1.632±0.06 g/cm3
InChIKey: FERHGDYGOMEXLT-TURQNECASA-N
CanonicalSMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)CO)O)O)C=CCN
IUPAC Name: 5-(3-aminoprop-1-enyl)-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
InChI: InChI=1S/C12H17N3O6/c13-3-1-2-6-4-15(12(20)14-10(6)19)11-9(18)8(17)7(5-16)21-11/h1-2,4,7-9,11,16-18H,3,5,13H2,(H,14,19,20)/t7-,8-,9-,11-/m1/s1
Synonyms: 5-amineallyl-uridine; 5-(3-Amino-1-propen-1-yl)-Uridine; 5-amineallyl-Ur; 5-(3-Amino-1-propen-1-yl)uridine; Uridine, 5-(3-amino-1-propenyl)-; 5-(3-aminoallyl)uridine

2',3',5'-O-TBDMS-A(Bz)

Description: 2',3',5'-O-TBDMS-A(Bz) consists of an adenosine (A) nucleotide modified with a highly protected 2',3',5'-tri-tert-butyldimethylsilyl (TBDMS) group at the ribose, along with a benzoyl (Bz) group attached. This structure is employed in oligonucleotide synthesis to introduce adenosine residues with robust protection, ensuring stability and compatibility throughout synthesis and subsequent reactions.
CAT: BRP-01197
CAS: 86529-09-1
MF: C35H59N5O5Si3
MF: 714.14
Purity: ≥98% by HPLC
Appearance: White, off-white to faint yellow powder
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Storage: Store at 2-8 °C
Density: 1.09±0.1 g/cm3
InChIKey: WPSOJPUXGQJMCS-CRDHKZEPSA-N
CanonicalSMILES: CC(C)(C)[Si](C)(C)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)O[Si](C)(C)C(C)(C)C)O[Si](C)(C)C(C)(C)C
IUPAC Name: N-[9-[(2R,3R,4R,5R)-3,4-bis[[tert-butyl(dimethyl)silyl]oxy]-5-[[tert-butyl(dimethyl)silyl]oxymethyl]oxolan-2-yl]purin-6-yl]benzamide
InChI: InChI=1S/C35H59N5O5Si3/c1-33(2,3)46(10,11)42-21-25-27(44-47(12,13)34(4,5)6)28(45-48(14,15)35(7,8)9)32(43-25)40-23-38-26-29(36-22-37-30(26)40)39-31(41)24-19-17-16-18-20-24/h16-20,22-23,25,27-28,32H,21H2,1-15H3,(H,36,37,39,41)/t25-,27-,28-,32-/m1/s1
Synonyms: N6-benzoyl-2',3',5'-tri-O-(tert-Butyldimethylsilyl)-A(Bz); N-Benzoyl-2',3',5'-tris-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine

3',5'-TIPDS-2'-OMe-2,6-diamino-purine-ribose

Description: 3',5'-TIPDS-2'-OMe-2,6-diamino-purine-ribose involves a ribose sugar modified with 3',5'-di-tert-isopropylsilyl (TIPDS) groups and a 2'-O-methyl group, linked to a 2,6-diamino-purine base. This compound is utilized in oligonucleotide synthesis for specific modifications at the ribose and nucleobase levels, enhancing stability and functionality in various biochemical and therapeutic applications.
CAT: BRP-01198
CAS: 128219-75-0
MF: C23H42N6O5Si2
MF: 538.80
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Density: 1.31±0.1 g/cm3
Boiling Point: 615.7±65.0 °C at 760 mmHg
InChIKey: MMHILCBTBJRYCQ-WGQQHEPDSA-N
CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=NC4=C(N=C(N=C43)N)N)OC)O[Si](O1)(C(C)C)C(C)C)C(C)C
IUPAC Name: 9-[(6aR,8R,9R,9aR)-9-methoxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]purine-2,6-diamine
InChI: InChI=1S/C23H42N6O5Si2/c1-12(2)35(13(3)4)31-10-16-18(33-36(34-35,14(5)6)15(7)8)19(30-9)22(32-16)29-11-26-17-20(24)27-23(25)28-21(17)29/h11-16,18-19,22H,10H2,1-9H3,(H4,24,25,27,28)/t16-,18-,19-,22-/m1/s1
Synonyms: 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-2'-O-methyl-2,6-diamino-purine-ribose; Adenosine, 2-amino-2'-O-methyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-; 9-((6aR,8R,9R,9aR)-2,2,4,4-tetraisopropyl-9-methoxytetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purine-2,6-diamine

3',5'-TIPDS-pU

Description: 3',5'-TIPDS-pU features a ribose sugar protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups, linked to a pseudouridine (pU) nucleoside. This structure is used in oligonucleotide synthesis to introduce pseudouridine modifications, which can influence RNA structure, function, and stability in biological systems.
CAT: BRP-01199
CAS: 80545-49-9
MF: C21H38N2O7Si2
MF: 486.71
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Density: 1.16±0.1 g/cm3
InChIKey: UDNONSPJEFNIKP-YDZRNGNQSA-N
CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)C3=CNC(=O)NC3=O)O)O[Si](O1)(C(C)C)C(C)C)C(C)C
IUPAC Name: 5-[(6aR,8S,9S,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-1H-pyrimidine-2,4-dione
InChI: InChI=1S/C21H38N2O7Si2/c1-11(2)31(12(3)4)27-10-16-19(29-32(30-31,13(5)6)14(7)8)17(24)18(28-16)15-9-22-21(26)23-20(15)25/h9,11-14,16-19,24H,10H2,1-8H3,(H2,22,23,25,26)/t16-,17+,18+,19-/m1/s1
Synonyms: 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-pseudouridine; 5-((6aR,8S,9S,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)pyrimidine-2,4(1H,3H)-dione; 5-[3,5-O-[1,1,3,3-Tetrakis(1-methylethyl)-1,3-disiloxanediyl]-β-D-ribofuranosyl]-2,4(1H,3H)-pyrimidinedione

N2-Bz-3',5'-TIPDS-iso-Cr

Description: N2-Bz-3',5'-TIPDS-iso-Cr is a modified cytidine nucleotide where the nitrogen at position 2 (N2) of the cytosine base is protected with a benzoyl (Bz) group. The ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification enhances the stability and specificity of the nucleotide during oligonucleotide synthesis, crucial for applications in nucleic acid research and biotechnology.
CAT: BRP-01200
CAS: 2940876-61-7
MF: C28H43N3O7Si2
MF: 589.83
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Density: 1.23±0.1 g/cm3
InChIKey: XMTLUQOKYPYIFK-LYPBTDJXSA-N
CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)N(C=C1)C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C
IUPAC Name: N-(1-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-4-oxo-1,4-dihydropyrimidin-2-yl)benzamide
InChI: InChI=1S/C28H43N3O7Si2/c1-17(2)39(18(3)4)35-16-22-25(37-40(38-39,19(5)6)20(7)8)24(33)27(36-22)31-15-14-23(32)29-28(31)30-26(34)21-12-10-9-11-13-21/h9-15,17-20,22,24-25,27,33H,16H2,1-8H3,(H,29,30,32,34)/t22-,24-,25-,27-/m1/s1
Synonyms: N2-benzoyl-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-iso-cytidine

N6-iBu-3',5'-TIPDS-Ar

Description: N6-iBu-3',5'-TIPDS-Ar features an adenosine nucleotide where the nitrogen at position 6 (N6) of the adenine base is protected with an isobutyryl (iBu) group. Similarly, the ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification is used in oligonucleotide synthesis to introduce modified adenosine residues, ensuring stability and enhancing functionality in nucleic acid applications.
CAT: BRP-01201
CAS: 163774-15-0
MF: C26H45N5O6Si2
MF: 579.84
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Density: 1.27±0.1 g/cm3
InChIKey: ZYESLHXCOCSGRD-RKCWLVDCSA-N
CanonicalSMILES: CC(C)C(=O)NC1=C2C(=NC=N1)N(C=N2)C3C(C4C(O3)CO[Si](O[Si](O4)(C(C)C)C(C)C)(C(C)C)C(C)C)O
IUPAC Name: N-[9-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]purin-6-yl]-2-methylpropanamide
InChI: InChI=1S/C26H45N5O6Si2/c1-14(2)25(33)30-23-20-24(28-12-27-23)31(13-29-20)26-21(32)22-19(35-26)11-34-38(15(3)4,16(5)6)37-39(36-22,17(7)8)18(9)10/h12-19,21-22,26,32H,11H2,1-10H3,(H,27,28,30,33)/t19-,21-,22-,26-/m1/s1
Synonyms: N6-isobutyryl-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-adenosine; N-(9-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-9H-purin-6-yl)isobutyramide; N-(2-Methyl-1-oxopropyl)-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine

N2-dmf-3',5'-TIPDS-Gr

Description: N2-dmf-3',5'-TIPDS-Gr comprises a guanosine nucleotide where the nitrogen at position 2 (N2) of the guanine base is protected with a dimethylformamide (dmf) group. The ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification is applied in oligonucleotide synthesis to incorporate modified guanosine residues, ensuring stability and compatibility in various nucleic acid studies.
CAT: BRP-01202
CAS: 120853-22-7
MF: C25H44N6O6Si2
MF: 580.83
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Density: 1.28±0.1 g/cm3
InChIKey: SQVNAKSYJCMYQC-UMCMBGNQSA-N
CanonicalSMILES: O=C1N=C(N=CN(C)C)NC2=C1N=CN2C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C
IUPAC Name: N'-(9-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide
InChI: InChI=1S/C25H44N6O6Si2/c1-14(2)38(15(3)4)34-11-18-21(36-39(37-38,16(5)6)17(7)8)20(32)24(35-18)31-13-26-19-22(31)28-25(29-23(19)33)27-12-30(9)10/h12-18,20-21,24,32H,11H2,1-10H3,(H,28,29,33)/t18-,20-,21-,24-/m1/s1
Synonyms: N2-dimethylformamidine-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-guanosine; N-[(Dimethylamino)methylene]-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]guanosine

N4-Bz-3',5'-TIPDS-5-Me-Cr

Description: N4-Bz-3',5'-TIPDS-5-Me-Cr is a modified cytidine nucleotide where the nitrogen at position 4 (N4) of the cytosine base is protected with a benzoyl (Bz) group. Similar to the other compounds, the ribose sugar at positions 3' and 5' is protected with 3',5'-di-tert-isopropylsilyl (TIPDS) groups. This modification is utilized in oligonucleotide synthesis to introduce modified cytidine residues, enhancing stability and specificity for applications in molecular biology, diagnostics, and therapeutics.
CAT: BRP-01203
CAS: 2940859-44-7
MF: C29H45N3O7Si2
MF: 603.85
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Density: 1.22±0.1 g/cm3
InChIKey: NSDMZZWBUMTBDG-PAHOUZJPSA-N
CanonicalSMILES: O=C1N=C(NC(=O)C=2C=CC=CC2)C(=CN1C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C)C
IUPAC Name: N-(1-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide
InChI: InChI=1S/C29H45N3O7Si2/c1-17(2)40(18(3)4)36-16-23-25(38-41(39-40,19(5)6)20(7)8)24(33)28(37-23)32-15-21(9)26(31-29(32)35)30-27(34)22-13-11-10-12-14-22/h10-15,17-20,23-25,28,33H,16H2,1-9H3,(H,30,31,34,35)/t23-,24-,25-,28-/m1/s1
Synonyms: N4-benzoyl-3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-5-methyl-cytidine

5'-O-DMT-2'-O-TBDMS-N6-Acetyl-Adenosine

Description: 5'-O-DMT-2'-O-TBDMS-N6-Acetyl-Adenosine is a modified nucleoside where adenosine is altered with an acetyl group attached to the N6 position. It features protective groups (DMT and TBDMS) on the 5'- and 2'- hydroxyl groups respectively, which enhance stability and solubility in biochemical assays. This modification is useful in RNA synthesis and modification studies, allowing researchers to investigate how specific chemical alterations affect nucleic acid function and interactions with proteins.
CAT: BRP-01221
CAS: 1115247-32-9
MF: C39H47N5O7Si
MF: 725.92
Purity: ≥97% by HPLC
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Density: 1.23±0.1 g/cm3
InChIKey: VDNBCIWKZZGQST-SPBWOXKUSA-N
CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6)C(O)C3O[Si](C)(C)C(C)(C)C)C
IUPAC Name: N-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)acetamide
InChI: InChI=1S/C39H47N5O7Si/c1-25(45)43-35-32-36(41-23-40-35)44(24-42-32)37-34(51-52(7,8)38(2,3)4)33(46)31(50-37)22-49-39(26-12-10-9-11-13-26,27-14-18-29(47-5)19-15-27)28-16-20-30(48-6)21-17-28/h9-21,23-24,31,33-34,37,46H,22H2,1-8H3,(H,40,41,43,45)/t31-,33-,34-,37-/m1/s1
Synonyms: N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine; N6-Acetyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-adenosine
* Only for research. Not suitable for any diagnostic or therapeutic use.

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