Nucleosides - RNA / BOC Sciences

N4-Acetyl-5'-O-(dimethoxytrityl)-5-methyl-2'-O-methylcytidine

Description: N4-Acetyl-5'-O-(dimethoxytrityl)-5-methyl-2'-O-methylcytidine, a modified cytidine, has become an integral component of nucleoside analogues in the biomedical industry. This versatile molecule serves as a unit in the development of antiviral drugs designed to impact viral RNA polymerase and reverse transcriptase while also being investigated for its potential as an anticancer agent. Its utility and importance continue to make it a crucial element in modern biology and medicine.

CAT: BRP-00378

CAS: 869355-20-4

MF: C34H37N3O8

MF: 615.68

Purity: ≥95%

Appearance: White to light yellow powder

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Density: 1.27±0.1 g/cm3

InChIKey: AICFKYRNVVDUMK-PBAMLIMUSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1NC(=O)C)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C34H37N3O8/c1-21-19-37(33(40)36-31(21)35-22(2)38)32-30(43-5)29(39)28(45-32)20-44-34(23-9-7-6-8-10-23,24-11-15-26(41-3)16-12-24)25-13-17-27(42-4)18-14-25/h6-19,28-30,32,39H,20H2,1-5H3,(H,35,36,38,40)/t28-,29-,30-,32-/m1/s1

Synonyms: 5'-O-DMT-N4-Ac-2'-O-Methy-5-Methycytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-5-methyl-2'-O-methylcytidine; N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)guanosine, 2',3'-diacetate

Description: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)guanosine, 2',3'-diacetate is a chemically modified guanosine nucleoside. This compound features a 5'-O protection with a bis(4-methoxyphenyl)phenylmethyl (also known as DMT) group, an N-(2-methyl-1-oxopropyl) group at the guanine base, and acetyl groups protecting both the 2' and 3' hydroxyl positions of the ribose sugar. These modifications enhance stability and facilitate selective reactions during oligonucleotide synthesis. This compound is particularly useful in the preparation of modified nucleic acids for research in molecular biology, providing increased control over the synthesis and modification of RNA and DNA molecules.

CAT: BRP-00380

CAS: 210362-16-6

MF: C39H41N5O10

MF: 739.77

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Density: 1.35±0.1 g/cm3

InChIKey: BSJXJCSWIJAQGJ-GONXPTGJSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-4-acetyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate

InChI: InChI=1S/C39H41N5O10/c1-22(2)35(47)42-38-41-34-31(36(48)43-38)40-21-44(34)37-33(53-24(4)46)32(52-23(3)45)30(54-37)20-51-39(25-10-8-7-9-11-25,26-12-16-28(49-5)17-13-26)27-14-18-29(50-6)19-15-27/h7-19,21-22,30,32-33,37H,20H2,1-6H3,(H2,41,42,43,47,48)/t30-,32-,33-,37-/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-, 2',3'-diacetate; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate; 2',3'-di-Ac-5'-DMT-G(iBu)

1-[(2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

Description: 4'-C-Fluoro-2'-C-methyluridine is a modified form of uridine where the oxygen at the 2' position of the ribose sugar is replaced by a methyl group, and a fluorine atom is attached to the carbon at the 4' position of the ribose sugar. This modification enhances the stability and binding affinity of the nucleotide, making it useful in various molecular biology applications, including RNA structure studies, antisense oligonucleotide design, and as a substrate for enzymatic reactions in RNA biochemistry research.

CAT: BRP-00392

CAS: 1613589-04-0

MF: C10H13FN2O6

MF: 276.22

Purity: ≥95%

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Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Density: 1.68±0.1 g/cm3

InChIKey: NVGHRKFZVNJJFZ-MVHNUAHISA-N

CanonicalSMILES: O[C@]1(C)[C@H](O)[C@](CO)(F)O[C@H]1N2C(NC(C=C2)=O)=O

IUPAC Name: 1-[(2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H13FN2O6/c1-9(18)6(16)10(11,4-14)19-7(9)13-3-2-5(15)12-8(13)17/h2-3,6-7,14,16,18H,4H2,1H3,(H,12,15,17)/t6-,7+,9+,10+/m0/s1

Synonyms: 1613589-04-0;1-[(2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione;Adafosbuvir PM;SCHEMBL15817679;Uridine, 4'-C-fluoro-2'-C-methyl-;TS-09379;1-((2R,3R,4S,5S)-5-Fluoro-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;

N-Acetyl-2',3'-Acetyl-Guanosine

Description: N-Acetyl-2',3'-O-acetylguanosine is a modified nucleoside derived from guanosine, a component of RNA. In this modified form, an acetyl group is attached to the 2' and 3' positions of the ribose sugar of guanosine, and an additional acetyl group is attached to the N6 position of the guanine base. This modification alters the chemical properties of guanosine, potentially affecting its interactions with other molecules, its stability, or its role in biological processes. N-Acetyl-2',3'-O-acetylguanosine is often used in biochemical and molecular biology research as a tool to study RNA structure, function, and metabolism. It may also have potential applications in RNA-based therapeutics or diagnostics.

CAT: BRP-00425

CAS: 65360-02-3

MF: C16H19N5O8

MF: 409.35

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Density: 1.72±0.1 g/cm3

InChIKey: KYQBEZWLVKJJHO-SDBHATRESA-N

CanonicalSMILES: CC(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1H-purin-9-yl)-4-acetyloxy-2-(hydroxymethyl)oxolan-3-yl] acetate

InChI: InChI=1S/C16H19N5O8/c1-6(23)18-16-19-13-10(14(26)20-16)17-5-21(13)15-12(28-8(3)25)11(27-7(2)24)9(4-22)29-15/h5,9,11-12,15,22H,4H2,1-3H3,(H2,18,19,20,23,26)/t9-,11-,12-,15-/m1/s1

Synonyms: Guanosine, N-acetyl-, 2',3'-diacetate; (2R,3R,4R,5R)-2-(2-Acetamido-6-oxo-3,6-dihydro-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diyl diacetate

5'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine

Description: 5'-O-tert-Butyldimethylsilyl-N2-isobutyrylguanosine is a chemically modified ribonucleoside used in oligonucleotide synthesis. This compound features a 5'-O-tert-butyldimethylsilyl (TBDMS) protecting group on the ribose sugar, providing stability during chemical synthesis, and an N2-isobutyryl (ibu) protecting group on the guanine base. These modifications facilitate the incorporation of guanosine into RNA sequences while protecting reactive groups, ensuring precise and efficient synthesis of RNA oligonucleotides for various applications in molecular biology and biochemistry.

CAT: BRP-00462

CAS: 89494-39-3

MF: C20H33N5O6Si

MF: 467.59

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.37±0.1 g/cm3

InChIKey: RUKACXRBRJHKDV-XWXWGSFUSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO[Si](C)(C)C(C)(C)C)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[tert-butyl(dimethyl)silyl]oxymethyl]-3,4-dihydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C20H33N5O6Si/c1-10(2)16(28)23-19-22-15-12(17(29)24-19)21-9-25(15)18-14(27)13(26)11(31-18)8-30-32(6,7)20(3,4)5/h9-11,13-14,18,26-27H,8H2,1-7H3,(H2,22,23,24,28,29)/t11-,13-,14-,18-/m1/s1

Synonyms: 5'-O-[(1,1-Dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine; N-(9-((2R,3R,4S,5R)-5-((tert-butyldimethylsilyloxy)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; 5'-TBDMS-ibu-rG

3',5'-TIPS-N-AC-Guanosine

Description: 3',5'-TIPS-N-AC-Guanosine is a chemically modified nucleoside used in nucleic acid synthesis. It contains 3',5'-TIPS protecting groups on the ribose sugar and an N-AC modification on the guanine base. These modifications enable precise control over nucleotide incorporation while protecting reactive sites, facilitating efficient synthesis of modified nucleic acids for applications in molecular biology and biochemistry.

CAT: BRP-00463

CAS: 847979-69-5

MF: C24H41N5O7Si2

MF: 567.78

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.34±0.1 g/cm3

InChIKey: MURIXOGCFLEACT-ZDXOVATRSA-N

CanonicalSMILES: O=C1N=C(NC(=O)C)NC2=C1N=CN2C3OC4CO[Si](O[Si](OC4C3O)(C(C)C)C(C)C)(C(C)C)C(C)C

IUPAC Name: N-(9-((6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)acetamide

InChI: InChI=1S/C24H41N5O7Si2/c1-12(2)37(13(3)4)33-10-17-20(35-38(36-37,14(5)6)15(7)8)19(31)23(34-17)29-11-25-18-21(29)27-24(26-16(9)30)28-22(18)32/h11-15,17,19-20,23,31H,10H2,1-9H3,(H2,26,27,28,30,32)/t17-,19-,20-,23-/m1/s1

Synonyms: N-Acetyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]guanosine

5'-DMTr-2'-O-MOE-rG(iBu)-3'-succinate TEA salt

Description: 5'-DMTr-2'-O-MOE-rG(iBu)-3'-succinate TEA salt, utilized in oligonucleotide synthesis, features a 5'-DMTr protecting group and a 3'-succinate group. The nucleoside unit is guanosine (rG), modified with a 2'-O-methoxyethyl (MOE) group and isobutyryl (iBu) protection on the guanine amino group. The TEA salt formulation improves solubility. It is employed in the synthesis of modified RNA sequences with improved stability and target specificity, suitable for applications such as RNA interference (RNAi) and RNA-based therapeutics.

CAT: BRP-00602

CAS: 2622236-65-9

MF: C42H47N5O12.C6H15N

MF: 915.05

Purity: ≥98%

Appearance: White to yellow powder

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Storage: Store at -20 °C

InChIKey: IWABYMODQWLWLW-OYXYNOIHSA-N

CanonicalSMILES: CCN(CC)CC.CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)CCC(=O)O)OCCOC

IUPAC Name: 4-[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-(2-methoxyethoxy)-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl]oxy-4-oxobutanoic acid;N,N-diethylethanamine

InChI: InChI=1S/C42H47N5O12.C6H15N/c1-25(2)38(51)45-41-44-37-34(39(52)46-41)43-24-47(37)40-36(56-22-21-53-3)35(59-33(50)20-19-32(48)49)31(58-40)23-57-42(26-9-7-6-8-10-26,27-11-15-29(54-4)16-12-27)28-13-17-30(55-5)18-14-28;1-4-7(5-2)6-3/h6-18,24-25,31,35-36,40H,19-23H2,1-5H3,(H,48,49)(H2,44,45,46,51,52);4-6H2,1-3H3/t31-,35-,36-,40-;/m1./s1

Synonyms: Triethylamine 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl)oxy)-4-oxobutanoate; 5'-DMT-2'-O-MOE-G(iBu)-3'-succinate, TEA salt; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-guanosine-3'-O-succinate, triethylamine salt

Related CAS: 2622236-64-8 (free base)

5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU

Description: 5'-POM-(E)-vinyl phosphonate-2'-O-Me-rU is a modified nucleoside where a POM-(E)-vinyl phosphonate group is attached to the 5'-position and a 2'-O-methyl group is attached to the ribose of uridine (rU). This modification can alter the nucleotide's stability and interactions with enzymes involved in nucleic acid synthesis and modification. It is used in biochemical research to study RNA synthesis, RNA-protein interactions, and the development of nucleotide analogs for therapeutic applications.

CAT: BRP-00705

CAS: 2172373-51-0

MF: C23H35N2O12P

MF: 562.51

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.34±0.1 g/cm3

InChIKey: IQVFHCHMSAXIBF-QSEATPFUSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(C=CP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C(O)C2OC

IUPAC Name: ((((E)-2-((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)vinyl)phosphoryl)bis(oxy))bis(methylene) bis(2,2-dimethylpropanoate)

InChI: InChI=1S/C23H35N2O12P/c1-22(2,3)19(28)33-12-35-38(31,36-13-34-20(29)23(4,5)6)11-9-14-16(27)17(32-7)18(37-14)25-10-8-15(26)24-21(25)30/h8-11,14,16-18,27H,12-13H2,1-7H3,(H,24,26,30)/b11-9+/t14-,16-,17-,18-/m1/s1

Synonyms: 1-[(5E)-6-[Bis[(2,2-dimethyl-1-oxopropoxy)methoxy]phosphinyl]-5,6-dideoxy-2-O-methyl-β-D-ribo-hex-5-enofuranosyl]-2,4(1H,3H)-pyrimidinedione; POM-(E)-vinyl phosphonate-2'-O-Me-rU; 5'-POM-vinyl phosphonate, 2'-OMe-U; 5'-VP-2'-OME-U; 5'-(E)-VP-2'-OMe-U

3'-O-DMTr-2'-O-Me-rG(iBu)

Description: 3'-O-DMTr-2'-O-Me-rG(iBu) is a modified ribonucleoside where a dimethoxytrityl (DMTr) group is attached to the 3'-hydroxyl, a methyl group is attached to the 2'-hydroxyl of the ribose, and an isobutyryl (iBu) group protects the exocyclic amine of guanine (rG). This compound is utilized in the synthesis of oligonucleotides, offering enhanced stability and selective reactivity in solid-phase synthesis for RNA research and therapeutic applications.

CAT: BRP-00706

MF: C36H39N5O8

MF: 669.74

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

InChIKey: VNMWCNBFDWYPHY-WIFIACMTSA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

InChI: InChI=1S/C36H39N5O8/c1-21(2)32(43)39-35-38-31-28(33(44)40-35)37-20-41(31)34-30(47-5)29(27(19-42)48-34)49-36(22-9-7-6-8-10-22,23-11-15-25(45-3)16-12-23)24-13-17-26(46-4)18-14-24/h6-18,20-21,27,29-30,34,42H,19H2,1-5H3,(H2,38,39,40,43,44)/t27-,29-,30-,34-/m1/s1

3'-O-DMTr-2'-O-Me-rU

Description: 3'-O-DMTr-2'-O-Me-rU is a modified ribonucleoside with a dimethoxytrityl (DMTr) group at the 3'-hydroxyl and a methyl group at the 2'-hydroxyl of the ribose moiety, based on uridine (rU). It is used in the chemical synthesis of RNA oligonucleotides, providing increased stability and protecting groups that facilitate efficient coupling reactions during oligonucleotide assembly, particularly in research and therapeutic RNA applications.

CAT: BRP-00707

CAS: 801295-70-5

MF: C31H32N2O8

MF: 560.60

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.35±0.1 g/cm3

InChIKey: GAGVWDWBNQZNFA-YXINZVNLSA-N

CanonicalSMILES: O=C1C=CN(C(=O)N1)C2OC(CO)C(OC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C2OC

IUPAC Name: 1-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

InChI: InChI=1S/C31H32N2O8/c1-37-23-13-9-21(10-14-23)31(20-7-5-4-6-8-20,22-11-15-24(38-2)16-12-22)41-27-25(19-34)40-29(28(27)39-3)33-18-17-26(35)32-30(33)36/h4-18,25,27-29,34H,19H2,1-3H3,(H,32,35,36)/t25-,27-,28-,29-/m1/s1

Synonyms: Uridine, 3'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-

5'-O-DMTr-3'-β-OH-5-Me-dU(Boc)

Description: 5'-O-DMTr-3'-β-OH-5-Me-dU(Boc) is a modified deoxyribonucleoside where a dimethoxytrityl (DMTr) group is attached to the 5'-hydroxyl, a β-hydroxyl group is at the 3' position, and a methyl group is at the 5' position of uridine (5-Me-dU). Additionally, a tert-butoxycarbonyl (Boc) group protects the uracil base. This compound is utilized in the synthesis of DNA oligonucleotides, offering enhanced protection and stability. It is particularly useful in nucleic acid research and therapeutic developments, facilitating efficient coupling reactions during solid-phase synthesis.

CAT: BRP-00708

CAS: 2155800-37-4

MF: C36H40N2O9

MF: 644.72

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.263±0.06 g/cm3

Boiling Point: 746.2±70.0 °C at 760 mmHg

InChIKey: YMANYIRKWIQJPA-JFHPUIQFSA-N

CanonicalSMILES: O=C(OC(C)(C)C)N1C(=O)C(=CN(C1=O)C2OC(COC(C=3C=CC=CC3)(C4=CC=C(OC)C=C4)C5=CC=C(OC)C=C5)C(O)C2)C

IUPAC Name: tert-butyl 3-((2R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2,6-dioxo-3,6-dihydropyrimidine-1(2H)-carboxylate

InChI: InChI=1S/C36H40N2O9/c1-23-21-37(33(41)38(32(23)40)34(42)47-35(2,3)4)31-20-29(39)30(46-31)22-45-36(24-10-8-7-9-11-24,25-12-16-27(43-5)17-13-25)26-14-18-28(44-6)19-15-26/h7-19,21,29-31,39H,20,22H2,1-6H3/t29-,30-,31-/m1/s1

Synonyms: 5'-O-DMTr-3'-β-OH-2'-deoxy-5-Me-dU(Boc)

3'-β-F-5-Me-dU

Description: 3'-β-F-5-Me-dU is a modified deoxyribonucleoside with a fluorine atom at the 3' position and a methyl group at the 5' position of uridine (dU). This modification increases the stability of the nucleoside and is used in the synthesis of DNA oligonucleotides for applications in research and potential therapeutic agents due to its resistance to enzymatic degradation.

CAT: BRP-00709

CAS: 135886-29-2

MF: C10H13FN2O4

MF: 244.22

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.44±0.1 g/cm3

InChIKey: UXCAQJAQSWSNPQ-BWZBUEFSSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)F

IUPAC Name: 1-[(2R,4R,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C10H13FN2O4/c1-5-3-13(10(16)12-9(5)15)8-2-6(11)7(4-14)17-8/h3,6-8,14H,2,4H2,1H3,(H,12,15,16)/t6-,7-,8-/m1/s1

Synonyms: 1-(2,3-Dideoxy-3-fluoro-β-D-threo-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; 3'-Deoxy-3'-fluorothymidine; 3'-Fluoro-2',3'-dideoxythymidine; 3'-Fluoro-3'-deoxythymidine; 3'-β-F-2'-5-Me-dU

2'-O-POM-rA(Bz)

Description: 2'-O-POM-rA(Bz) is a modified ribonucleoside where a 2'-O-(pivaloyloxymethyl) (POM) group is attached to the ribose sugar and a benzoyl (Bz) group protects the adenine base. This modification enhances stability and protects the ribonucleoside during the synthesis of RNA oligonucleotides, making it useful for applications in RNA research and therapeutic development.

CAT: BRP-00711

CAS: 2842847-62-3

MF: C23H27N5O7

MF: 485.50

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.47±0.1 g/cm3

InChIKey: HNTKEEIVPSGJCI-VGKBRBPRSA-N

CanonicalSMILES: CC(C)(C)C(=O)OCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)O

IUPAC Name: [(2R,3R,4R,5R)-2-(6-benzamidopurin-9-yl)-4-hydroxy-5-(hydroxymethyl)oxolan-3-yl]oxymethyl 2,2-dimethylpropanoate

InChI: InChI=1S/C23H27N5O7/c1-23(2,3)22(32)34-12-33-17-16(30)14(9-29)35-21(17)28-11-26-15-18(24-10-25-19(15)28)27-20(31)13-7-5-4-6-8-13/h4-8,10-11,14,16-17,21,29-30H,9,12H2,1-3H3,(H,24,25,27,31)/t14-,16-,17-,21-/m1/s1

Synonyms: (((2R,3R,4R,5R)-2-(6-Benzamido-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)methyl pivalate; N6-Bz-2'-O-POM adenosine; 2'-O-Pivaloyloxymethyl-N6-Bz-adenosine

2',3'-di-O-iBu-rG(iBu)

Description: 2',3'-di-O-iBu-rG(iBu) is a modified ribonucleoside with isobutyryl (iBu) groups attached to both the 2' and 3' hydroxyl positions of the ribose sugar, and an additional isobutyryl group protecting the guanine base. These modifications improve the stability of the nucleoside, making it valuable for the synthesis of RNA oligonucleotides used in various biological and therapeutic applications.

CAT: BRP-00712

CAS: 56489-75-9

MF: C22H31N5O8

MF: 493.52

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.49±0.1 g/cm3

InChIKey: JJRMTPVXETZPOA-QEPJRFBGSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)OC(=O)C(C)C)OC(=O)C(C)C

IUPAC Name: [(2R,3R,4R,5R)-2-(hydroxymethyl)-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]-4-(2-methylpropanoyloxy)oxolan-3-yl] 2-methylpropanoate

InChI: InChI=1S/C22H31N5O8/c1-9(2)17(29)25-22-24-16-13(18(30)26-22)23-8-27(16)19-15(35-21(32)11(5)6)14(12(7-28)33-19)34-20(31)10(3)4/h8-12,14-15,19,28H,7H2,1-6H3,(H2,24,25,26,29,30)/t12-,14-,15-,19-/m1/s1

Synonyms: (2R,3R,4R,5R)-2-(Hydroxymethyl)-5-(2-isobutyramido-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl bis(2-methylpropanoate); Guanosine, N-(2-methyl-1-oxopropyl)-, 2',3'-bis(2-methylpropanoate); 5'-HO-tri(iBu)G; N2-Isobutyroyl-2',3'-di-O-isobutyroyl guanosine; 2'-O,3'-O,N2-triisobutyrylguanosine

5'-O-Bz-rA(Bz)

Description: 5'-O-Bz-rA(Bz) is a modified ribonucleoside where benzoyl (Bz) groups protect both the 5'-hydroxyl position and the adenine base. This dual protection enhances the stability of the ribonucleoside during the chemical synthesis of RNA oligonucleotides. It is particularly useful in nucleic acid research and therapeutic development, facilitating efficient coupling reactions and ensuring the integrity of the nucleoside throughout various biochemical processes.

CAT: BRP-00714

CAS: 33485-36-8

MF: C24H21N5O6

MF: 475.46

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.54±0.1 g/cm3

InChIKey: XJHSVCLICOFQEW-DYVMYPEFSA-N

CanonicalSMILES: C1=CC=C(C=C1)C(=O)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)COC(=O)C5=CC=CC=C5)O)O

IUPAC Name: [(2R,3S,4R,5R)-5-(6-benzamidopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl benzoate

InChI: InChI=1S/C24H21N5O6/c30-18-16(11-34-24(33)15-9-5-2-6-10-15)35-23(19(18)31)29-13-27-17-20(25-12-26-21(17)29)28-22(32)14-7-3-1-4-8-14/h1-10,12-13,16,18-19,23,30-31H,11H2,(H,25,26,28,32)/t16-,18-,19-,23-/m1/s1

Synonyms: Adenosine, N-benzoyl-, 5'-benzoate; Benzamide, N-(9-β-D-ribofuranosyl-9H-purin-6-yl)-, monobenzoate (ester); O5',N6-Dibenzoyladenosine; ((2R,3S,4R,5R)-5-(6-benzamido-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl benzoate

2'-O-propargyl-rC(Ac)

Description: 2'-O-propargyl-rC(Ac) is a modified ribonucleoside where a propargyl group is attached to the 2'-hydroxyl position of cytidine, and the cytosine base is protected by an acetyl (Ac) group. This modification enhances the stability and reactivity of the ribonucleoside, making it useful in the synthesis of RNA oligonucleotides, particularly for click chemistry applications and nucleic acid research.

CAT: BRP-00715

CAS: 1498305-49-9

MF: C14H17N3O6

MF: 323.31

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.45±0.1 g/cm3

InChIKey: RZSMJQNVJQVIFP-OJAKKHQRSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(CO)C(O)C2OCC#C)NC(=O)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C14H17N3O6/c1-3-6-22-12-11(20)9(7-18)23-13(12)17-5-4-10(15-8(2)19)16-14(17)21/h1,4-5,9,11-13,18,20H,6-7H2,2H3,(H,15,16,19,21)/t9-,11-,12-,13-/m1/s1

Synonyms: N-Acetyl-2'-O-2-propyn-1-ylcytidine; N4-Acetyl-2'-O-propargylcytidine; N4-Ac-2'-O-propargyl-Cr; N4-Ac-2'-O-propargyl-cytidine

2'-O-propargyl-rC(Bz)

Description: 2'-O-propargyl-rC(Bz) is a modified ribonucleoside with a propargyl group attached to the 2'-hydroxyl position of cytidine, and the cytosine base is protected by a benzoyl (Bz) group. These modifications improve the nucleoside's stability and facilitate its incorporation into RNA oligonucleotides. It is especially valuable in biochemical research and therapeutic development, enabling advanced applications such as click chemistry and targeted nucleic acid modifications.

CAT: BRP-00716

CAS: 210096-41-6

MF: C19H19N3O6

MF: 385.38

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.40±0.1 g/cm3

InChIKey: AZAKCGNNQUSBGN-GFOCRRMGSA-N

CanonicalSMILES: C#CCOC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)CO)O

IUPAC Name: N-[1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-prop-2-ynoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C19H19N3O6/c1-2-10-27-16-15(24)13(11-23)28-18(16)22-9-8-14(21-19(22)26)20-17(25)12-6-4-3-5-7-12/h1,3-9,13,15-16,18,23-24H,10-11H2,(H,20,21,25,26)/t13-,15-,16-,18-/m1/s1

Synonyms: Cytidine, N-benzoyl-2'-O-2-propynyl-; N-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(prop-2-yn-1-yloxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; N-Benzoyl-2'-O-2-propyn-1-ylcytidine; N4-Benzoyl-2'-O-propargylcytidine

2'-O-MOE-rC(Ac)

Description: 2'-O-MOE-rC(Ac) is a modified ribonucleoside where a 2'-O-methoxyethyl (MOE) group is attached to the ribose sugar, and the cytosine base is protected by an acetyl (Ac) group. This modification enhances the stability and binding affinity of the ribonucleoside, making it particularly useful in the synthesis of RNA oligonucleotides. It is valuable in various biochemical applications, including antisense therapy and RNA interference, where increased stability and efficient hybridization are crucial.

CAT: BRP-00717

CAS: 2049081-09-4

MF: C14H21N3O7

MF: 343.34

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.50±0.1 g/cm3

InChIKey: QULXYCXNYGAKCY-OJAKKHQRSA-N

CanonicalSMILES: O=C1N=C(C=CN1C2OC(CO)C(O)C2OCCOC)NC(=O)C

IUPAC Name: N-(1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C14H21N3O7/c1-8(19)15-10-3-4-17(14(21)16-10)13-12(23-6-5-22-2)11(20)9(7-18)24-13/h3-4,9,11-13,18,20H,5-7H2,1-2H3,(H,15,16,19,21)/t9-,11-,12-,13-/m1/s1

Synonyms: N4-Acetyl-2'-O-(2-methoxyethyl)cytidine

3',5'-O-DMTr-2'-O-Me-rA(Bz)

Description: 3',5'-O-DMTr-2'-O-Me-rA(Bz) is a modified ribonucleoside where dimethoxytrityl (DMTr) groups protect both the 3'- and 5'-hydroxyl positions, a methyl group is attached to the 2'-hydroxyl position, and the adenine base is protected by a benzoyl (Bz) group. This configuration enhances the stability and reactivity of the ribonucleoside, making it suitable for the chemical synthesis of RNA oligonucleotides, particularly in automated solid-phase synthesis.

CAT: BRP-00718

MF: C60H55N5O9

MF: 990.13

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

InChIKey: FKPKMEDKVSDOPK-AJCPUZLQSA-N

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-(bis(4-methoxyphenyl)(phenyl)methoxy)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C60H55N5O9/c1-67-47-29-21-43(22-30-47)59(41-17-11-7-12-18-41,44-23-31-48(68-2)32-24-44)72-37-51-53(54(71-5)58(73-51)65-39-63-52-55(61-38-62-56(52)65)64-57(66)40-15-9-6-10-16-40)74-60(42-19-13-8-14-20-42,45-25-33-49(69-3)34-26-45)46-27-35-50(70-4)36-28-46/h6-36,38-39,51,53-54,58H,37H2,1-5H3,(H,61,62,64,66)/t51-,53-,54-,58-/m1/s1

5'-O-DMTr-2'-O-Me-rA

Description: 5'-O-DMTr-2'-O-Me-rA is a modified ribonucleoside where the 5'-hydroxyl position is protected by a dimethoxytrityl (DMTr) group and a methyl group is attached to the 2'-hydroxyl position. This combination improves the stability and efficiency of the ribonucleoside during RNA synthesis, facilitating its use in the production of modified RNA molecules for research and therapeutic applications.

CAT: BRP-00719

CAS: 103285-23-0

MF: C32H33N5O6

MF: 583.65

Purity: ≥98% by HPLC

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Storage: Store at 2-8 °C

Density: 1.35±0.1 g/cm3

Boiling Point: 796.5±70.0 °C at 760 mmHg

InChIKey: GXRYFFDAEWYIBQ-QWOIFIOOSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)N)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

IUPAC Name: (2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-methoxyoxolan-3-ol

InChI: InChI=1S/C32H33N5O6/c1-39-23-13-9-21(10-14-23)32(20-7-5-4-6-8-20,22-11-15-24(40-2)16-12-22)42-17-25-27(38)28(41-3)31(43-25)37-19-36-26-29(33)34-18-35-30(26)37/h4-16,18-19,25,27-28,31,38H,17H2,1-3H3,(H2,33,34,35)/t25-,27-,28-,31-/m1/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-O-methyl-adenosine; Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-; 5-O-(4,4'-dimethoxytrityl)-1-adenin-9-yl-1-deoxy-2-O-methyl-beta-D-ribo-pentofuranose; 5'-ODMT-2'-OMe Adenosine; 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyladenosine