Nucleosides - RNA / BOC Sciences

3',5'-O-DTBS-2'-O-TBDMS-rA

Description: 3',5'-O-DTBS-2'-O-TBDMS-rA is a chemically modified adenosine nucleoside used in oligonucleotide synthesis. It is characterized by protective groups, including di-tert-butylsilyl (DTBS) groups at both the 3' and 5' hydroxyl positions, and a tert-butyldimethylsilyl (TBDMS) group at the 2' hydroxyl position of the ribose sugar. These modifications help protect the nucleoside during synthesis, ensuring stability and precision in the creation of oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-01491

CAS: 212375-93-4

MF: C24H43N5O4Si2

MF: 521.80

Purity: ≥97%

Appearance: White to off-white powder

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Density: 1.19±0.1 g/cm3

Melting Point: 191-193.4 °C

Boiling Point: 578.2±60.0 °C at 760 mmHg

InChIKey: NKVFXNVWNYNCJM-QTQZEZTPSA-N

CanonicalSMILES: CC(C)(C)[Si]1(OCC2C(O1)C(C(O2)N3C=NC4=C(N=CN=C43)N)O[Si](C)(C)C(C)(C)C)C(C)(C)C

IUPAC Name: 9-[(4aR,6R,7R,7aR)-2,2-ditert-butyl-7-[tert-butyl(dimethyl)silyl]oxy-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl]purin-6-amine

InChI: InChI=1S/C24H43N5O4Si2/c1-22(2,3)34(10,11)32-18-17-15(12-30-35(33-17,23(4,5)6)24(7,8)9)31-21(18)29-14-28-16-19(25)26-13-27-20(16)29/h13-15,17-18,21H,12H2,1-11H3,(H2,25,26,27)/t15-,17-,18-,21-/m1/s1

Synonyms: Adenosine, 3',5'-O-[bis(1,1-dimethylethyl)silylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 3',5'-O-Bis(t-butylsilyl)-2'-O-(t-butyldimethylsilyl)adenosine

3',5'-O-DTBS-2'-O-TBDMS-rC

Description: 3',5'-O-DTBS-2'-O-TBDMS-rC is a chemically modified cytidine nucleoside used in oligonucleotide synthesis. It features protective groups including di-tert-butylsilyl (DTBS) groups at both the 3' and 5' hydroxyl positions, and a tert-butyldimethylsilyl (TBDMS) group at the 2' hydroxyl position of the ribose sugar. These modifications ensure stability and protection during synthesis, facilitating the creation of high-quality, customized oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-01492

CAS: 438582-96-8

MF: C23H43N3O5Si2

MF: 497.78

Purity: ≥97%

Appearance: White to off-white powder

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Density: 1.13±0.1 g/cm3

Boiling Point: 519.6±60.0 °C at 760 mmHg

InChIKey: IAERLBNQNFRAMO-NXWXRZEISA-N

CanonicalSMILES: CC(C)(C)[Si]1(OCC2C(O1)C(C(O2)N3C=CC(=NC3=O)N)O[Si](C)(C)C(C)(C)C)C(C)(C)C

IUPAC Name: 1-[(4aR,6R,7R,7aR)-2,2-ditert-butyl-7-[tert-butyl(dimethyl)silyl]oxy-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl]-4-aminopyrimidin-2-one

InChI: InChI=1S/C23H43N3O5Si2/c1-21(2,3)32(10,11)30-18-17-15(29-19(18)26-13-12-16(24)25-20(26)27)14-28-33(31-17,22(4,5)6)23(7,8)9/h12-13,15,17-19H,14H2,1-11H3,(H2,24,25,27)/t15-,17-,18-,19-/m1/s1

Synonyms: Cytidine, 3',5'-O-[bis(1,1-dimethylethyl)silylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 3',5'-O-[Bis(1,1-dimethylethyl)silylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]cytidine

3',5'-O-DTBS-2'-O-TBDMS-rU

Description: 3',5'-O-DTBS-2'-O-TBDMS-rU is a chemically modified uridine nucleoside used in oligonucleotide synthesis. It is characterized by protective groups, including di-tert-butylsilyl (DTBS) groups at both the 3' and 5' hydroxyl positions, and a tert-butyldimethylsilyl (TBDMS) group at the 2' hydroxyl position of the ribose sugar. These modifications protect the nucleoside during synthesis, ensuring stability and precision in the creation of oligonucleotides for various applications in molecular biology and biotechnology.

CAT: BRP-01493

CAS: 212375-92-3

MF: C23H42N2O6Si2

MF: 498.76

Purity: ≥97%

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Density: 1.11±0.1 g/cm3

InChIKey: HWUBERHQHCSGOU-NXWXRZEISA-N

CanonicalSMILES: CC(C)(C)[Si]1(OCC2C(O1)C(C(O2)N3C=CC(=O)NC3=O)O[Si](C)(C)C(C)(C)C)C(C)(C)C

IUPAC Name: 1-[(4aR,6R,7R,7aR)-2,2-ditert-butyl-7-[tert-butyl(dimethyl)silyl]oxy-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxasilin-6-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C23H42N2O6Si2/c1-21(2,3)32(10,11)30-18-17-15(29-19(18)25-13-12-16(26)24-20(25)27)14-28-33(31-17,22(4,5)6)23(7,8)9/h12-13,15,17-19H,14H2,1-11H3,(H,24,26,27)/t15-,17-,18-,19-/m1/s1

Synonyms: Uridine, 3',5'-O-[bis(1,1-dimethylethyl)silylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-; 3',5'-O-[Bis(1,1-dimethylethyl)silylene]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]uridine

5-Ethynyluridine

Description: 5-Ethynyluridine is a modified uridine nucleoside featuring an ethynyl group (-C≡CH) attached to the fifth carbon atom of the uracil base. This modification provides unique properties such as enhanced base stacking interactions and increased stability of nucleic acid structures. It is commonly used in RNA labeling and detection applications, including RNA synthesis, site-specific modification, and click chemistry-mediated conjugation reactions for studying RNA dynamics and function in biological systems.

CAT: BRP-01494

CAS: 69075-42-9

MF: C11H12N2O6

MF: 268.22

Purity: ≥98%

Appearance: White to off-white powder

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Density: 1.67±0.1 g/cm3

Melting Point: 188-190 °C

InChIKey: QCWBIPKYTBFWHH-FDDDBJFASA-N

CanonicalSMILES: C#CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-ethynylpyrimidine-2,4-dione

InChI: InChI=1S/C11H12N2O6/c1-2-5-3-13(11(18)12-9(5)17)10-8(16)7(15)6(4-14)19-10/h1,3,6-8,10,14-16H,4H2,(H,12,17,18)/t6-,7-,8-,10-/m1/s1

Synonyms: 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4-(1H,3H)-dione; 5-Ethynyl uridine; 5-EU

N6-p-Sulfophenyladenosine sodium salt

Description: N6-p-Sulfophenyladenosine sodium salt is a modified adenosine derivative used extensively in biochemical and pharmacological research. Its unique modification at the N6 position allows for the detailed study of adenosine receptor interactions, signal transduction pathways, and the development of potential therapeutic agents targeting adenosine-related pathways. The addition of the sulfophenyl group can significantly influence its binding properties and biological activities, making it a valuable tool in various research applications.

CAT: BRP-01501

CAS: 1349749-05-8

MF: C16H16N5NaO7S

MF: 445.38

Purity: ≥95%

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InChIKey: JYEFPEJJPNYEHO-KHXPSBENSA-M

CanonicalSMILES: C1=CC(=CC=C1NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O)S(=O)(=O)[O-].[Na+]

IUPAC Name: sodium;4-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]benzenesulfonate

InChI: InChI=1S/C16H17N5O7S.Na/c22-5-10-12(23)13(24)16(28-10)21-7-19-11-14(17-6-18-15(11)21)20-8-1-3-9(4-2-8)29(25,26)27;/h1-4,6-7,10,12-13,16,22-24H,5H2,(H,17,18,20)(H,25,26,27);/q;+1/p-1/t10-,12-,13-,16-;/m1./s1

Synonyms: Benzenesulfonic acid, 4-[(9-β-D-ribofuranosyl-9H-purin-6-yl)amino]-, sodium salt(1:1); N6-(p-Sulfophenyl)adenosine sodium salt; 4-[(9-β-D-Ribofuranosyl-9H-purin-6-yl)amino]benzenesulfonic acid sodium salt; N-(p-Sulfophenyl)adenosine sodium salt

Related CAS: 143668-15-9 (free acid)

6-Chlorouridine

Description: 6-Chlorouridine is a valuable modified nucleoside used in biochemical, pharmacological, and chemical biology research. Its chlorination at the 6-position allows scientists to study the effects of halogenation on nucleotide function, RNA structure, and potential therapeutic applications. This compound provides insights into the role of modified nucleosides in various biological processes and aids in the development of novel therapeutic agents and research tools.

CAT: BRP-01502

CAS: 255723-79-6

MF: C9H11ClN2O6

MF: 278.65

Purity: ≥95%

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Density: 1.80±0.1 g/cm3

InChIKey: CYMWXTBIGHJEJG-YXZULKJRSA-N

CanonicalSMILES: C1=C(N(C(=O)NC1=O)C2C(C(C(O2)CO)O)O)Cl

IUPAC Name: 6-chloro-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H11ClN2O6/c10-4-1-5(14)11-9(17)12(4)8-7(16)6(15)3(2-13)18-8/h1,3,6-8,13,15-16H,2H2,(H,11,14,17)/t3-,6-,7-,8-/m1/s1

Synonyms: 6-chloro-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

Adenosine, monohydrochloride

Description: Adenosine monohydrochloride is a hydrochloride salt form of adenosine, a nucleoside composed of adenine and ribose. Adenosine plays a crucial role in biochemical processes such as energy transfer (e.g., ATP) and signal transduction as a neurotransmitter. In its monohydrochloride form, adenosine is more soluble in water, making it useful for various biochemical and pharmaceutical applications. This compound is employed in research focused on cellular metabolism, enzyme functions, and nucleic acid interactions. Additionally, adenosine monohydrochloride is used in studies investigating the effects of adenosine on cardiovascular and neurological functions.

CAT: BRP-01521

CAS: 19065-22-6

MF: C10H13N5O4.HCl

MF: 303.70

Purity: ≥98% by HPLC

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InChIKey: YFJCRJZTDYDCRZ-MCDZGGTQSA-N

CanonicalSMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)CO)O)O)N.Cl

IUPAC Name: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol;hydrochloride

InChI: InChI=1S/C10H13N5O4.ClH/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10;/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13);1H/t4-,6-,7-,10-;/m1./s1

Synonyms: Adenosine hydrochloride; Adenosine hydrochloride (1:1); (2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol hydrochloride; 9-β-D-Ribofuranosyl-9H-purin-6-amine monohydrochloride; 9-β-D-Ribofuranosyladenine monohydrochloride; D-Adenosine monohydrochloride; Adenine riboside monohydrochloride; β-D-Adenosine monohydrochloride; β-Adenosine monohydrochloride

Related CAS: 58-61-7 (free base) ; 58056-57-8 (x-hydrochloride )

Uridine, monohydrate

Description: Uridine hydrate is a hydrated form of uridine, a nucleoside consisting of uracil attached to a ribose sugar. Uridine is a key component of RNA and plays a significant role in cellular processes, including the synthesis of nucleic acids, glycoproteins, and cell membranes. Uridine hydrate is often used in biochemical and medical research to study RNA synthesis, metabolism, and the effects of nucleosides on cellular functions. It is also investigated for its potential therapeutic benefits in neurological disorders, liver function improvement, and cognitive enhancement. The hydrated form of uridine ensures better solubility and stability for various experimental and clinical applications.

CAT: BRP-01522

CAS: 128475-15-0

MF: C9H12N2O6.H2O

MF: 262.22

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InChIKey: IDZICQNRCHBMKN-IAIGYFSYSA-N

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O.O

IUPAC Name: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione;hydrate

InChI: InChI=1S/C9H12N2O6.H2O/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16;/h1-2,4,6-8,12,14-15H,3H2,(H,10,13,16);1H2/t4-,6-,7-,8-;/m1./s1

Synonyms: Uridine, hydrate (1:1); Uridine hydrate; 1-β-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione hydrate; 1-β-D-Ribofuranosyluracil hydrate; β-Uridine hydrate

Related CAS: 58-96-8 (anhydrous) ; 921930-23-6 (dihydrate)

Guanosine, dihydrate

Description: Guanosine dihydrate is a hydrated form of guanosine, a nucleoside composed of the nitrogenous base guanine attached to a ribose sugar molecule, with two water molecules associated. Guanosine is an essential building block of RNA and plays critical roles in cellular metabolism and signaling. In research and biochemical applications, guanosine dihydrate is used to study RNA synthesis, structure, and function. It is also valuable in exploring nucleotide interactions, enzyme activity related to nucleic acids, and cellular energy transfer processes. The dihydrate form ensures better solubility and stability in aqueous solutions, facilitating its use in various experimental and therapeutic contexts.

CAT: BRP-01523

CAS: 6010-14-6

MF: C10H13N5O5.2H2O

MF: 319.27

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InChIKey: HNZAKYGFPANILR-LGVAUZIVSA-N

CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)O)N=C(NC2=O)N.O.O

IUPAC Name: 2-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one;dihydrate

InChI: InChI=1S/C10H13N5O5.2H2O/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9;;/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19);2*1H2/t3-,5-,6-,9-;;/m1../s1

Synonyms: Guanosine, hydrate (1:2); Guanosine dihydrate; 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one dihydrate; 2-Amino-1,9-dihydro-9-β-D-ribofuranosyl-6H-purin-6-one dihydrate; Guanine ribonucleoside dihydrate; Vernine dihydrate

Related CAS: 118-00-3 (anhydrous) ; 1143525-19-2 (monohydrate)

Cytidine, monohydrochloride

Description: Cytidine monohydrochloride is the hydrochloride salt form of cytidine, a nucleoside consisting of cytosine attached to a ribose sugar. Cytidine is a crucial component of RNA, playing a vital role in cellular processes such as protein synthesis and cell signaling. In its monohydrochloride form, cytidine is more soluble in water, which enhances its applicability in biochemical and pharmaceutical research. This compound is used to study RNA synthesis, metabolism, and the regulatory mechanisms of nucleic acids. Additionally, cytidine monohydrochloride is investigated for its potential therapeutic benefits, including neuroprotection, cognitive enhancement, and treatment of certain genetic disorders. The increased solubility and stability of the monohydrochloride form make it suitable for various experimental and clinical applications.

CAT: BRP-01524

CAS: 7244-51-1

MF: C9H13N3O5.HCl

MF: 279.68

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Melting Point: 205-206.5 °C

InChIKey: KCURWTAZOZXKSJ-IAIGYFSYSA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl

IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride

InChI: InChI=1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8;/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16);1H/t4-,6-,7-,8-;/m1./s1

Synonyms: Cytidine, hydrochloride (1:1); Cytosine, 1-β-D-ribofuranosyl-, monohydrochloride; Cytidine hydrochloride; 1-(β-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine hydrochloride; 1-β-D-Ribofuranosylcytosine hydrochloride; 4-Amino-1-β-D-ribofuranosyl-2(1H)-pyrimidinone hydrochloride; Cytosine riboside hydrochloride; β-D-Cytidine hydrochloride

Related CAS: 65-46-3 (free base)

3',5'-di-O-Benzoyl-2,2'-anhydro-L-uridine

Description: 3',5'-di-O-Benzoyl-2,2'-anhydro-L-uridine is a modified nucleoside derivative where uridine is chemically altered by the addition of benzoyl groups at the 3' and 5' positions and the formation of an anhydro bridge between the 2' positions of two ribose moieties. This modification impacts the nucleoside's structural and chemical properties, often used to study nucleoside behavior and interactions in biological systems. In research, this compound is utilized to investigate RNA synthesis, structure, and function, providing insights into nucleic acid chemistry and the effects of specific modifications on RNA activity. It is also valuable in developing nucleotide analogs for therapeutic and diagnostic purposes, exploring how such modifications can influence nucleic acid stability, binding affinity, and enzymatic processing. The benzoyl protection and anhydro linkage help enhance the molecule's stability and facilitate its use in various biochemical applications.

CAT: BRP-01525

CAS: 31615-96-0

MF: C23H18N2O7

MF: 434.40

Purity: ≥95% by HPLC

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Density: 1.48±0.1 g/cm3

Boiling Point: 589.0±60.0 °C at 760 mmHg

InChIKey: WLLCZAIADALVGH-FFGOWVMKSA-N

CanonicalSMILES: C1=CC=C(C=C1)C(=O)OCC2C(C3C(O2)N4C=CC(=O)N=C4O3)OC(=O)C5=CC=CC=C5

IUPAC Name: [(2S,4S,5S,6R)-5-benzoyloxy-10-oxo-3,7-dioxa-1,9-diazatricyclo[6.4.0.02,6]dodeca-8,11-dien-4-yl]methyl benzoate

InChI: InChI=1S/C23H18N2O7/c26-17-11-12-25-20-19(32-23(25)24-17)18(31-22(28)15-9-5-2-6-10-15)16(30-20)13-29-21(27)14-7-3-1-4-8-14/h1-12,16,18-20H,13H2/t16-,18-,19+,20-/m0/s1

Synonyms: 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 3-(benzoyloxy)-2-[(benzoyloxy)methyl]-2,3,3a,9a-tetrahydro-, (2S,3S,3aR,9aS)-; (2S,3S,3aR,9aS)-3-(Benzoyloxy)-2-[(benzoyloxy)methyl]-2,3,3a,9a-tetrahydro-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one; 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, dibenzoate (ester), stereoisomer; 6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 3-(benzoyloxy)-2-[(benzoyloxy)methyl]-2,3,3a,9a-tetrahydro-, [2S-(2α,3β,3aβ,9aβ)]-; 3',5'-Di-O-benzoyl-O2,2'-anhydro-L-uridine

4'-C-Azido-2'-deoxy-2'-fluorocytidine

Description: 4'-C-Azido-2'-deoxy-2'-fluorocytidine is a modified nucleoside analog that has been studied for its potential antiviral properties. It belongs to a class of compounds that are designed to interfere with viral replication by targeting viral enzymes or RNA synthesis. The azido group (-N3) and fluorine substitution (-F) are modifications aimed at enhancing its activity or specificity against certain viruses.

CAT: BRP-01531

CAS: 1145869-35-7

MF: C9H11FN6O4

MF: 286.22

Purity: ≥95%

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InChIKey: KTOLOIKYVCHRJW-JVZYCSMKSA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)N=[N+]=[N-])O)F

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C9H11FN6O4/c10-5-6(18)9(3-17,14-15-12)20-7(5)16-2-1-4(11)13-8(16)19/h1-2,5-7,17-18H,3H2,(H2,11,13,19)/t5-,6+,7-,9-/m1/s1

Synonyms: Cytidine, 4'-C-azido-2'-deoxy-2'-fluoro-; 4'-C-azido-2'-deoxy-2'-fluoro-cytidine; 4-amino-1-((2R,3R,4R,5R)-5-azido-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

2'-Fluoro-N2-dimethylformamidine-2'-deoxyguanosine

Description: 2'-Fluoro-N2-dimethylformamidine-2'-deoxyguanosine is a nucleoside analog that is modified to potentially inhibit viral replication. This compound typically incorporates a dimethylformamidine group (-N(CH3)2) at the N2 position of the guanine base and a fluorine substitution at the 2' position of the deoxyribose sugar. These modifications are often designed to enhance binding affinity or specificity for viral polymerases or reverse transcriptases, thereby interfering with viral nucleic acid synthesis.

CAT: BRP-01532

MF: C13H17FN6O4

MF: 340.32

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C

InChIKey: KBFMHYOHKLKPFN-GRIPGOBMSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)F

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C13H17FN6O4/c1-19(2)4-16-13-17-10-8(11(23)18-13)15-5-20(10)12-7(14)9(22)6(3-21)24-12/h4-7,9,12,21-22H,3H2,1-2H3,(H,17,18,23)/t6-,7-,9-,12-/m1/s1

Synonyms: dmf-2'-F-dG; N2-Dimethylformamidine-2'-Fluoro-2'-Deoxyguanosine; N'-(9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; N2-dmf-2'-F-dG; 2'-F-dG(DMF)

3'-O-TBDMS-2'-F-dC(Ac)

Description: 3'-O-TBDMS-2'-F-dC(Ac) is a modified nucleoside where an acetyl group is attached to the N4 position of the cytidine base, and the ribose sugar is protected with a t-butyl-dimethylsilyl group at the 3' hydroxyl. Additionally, fluorine is substituted at the 2' position of the ribose. These modifications are commonly utilized in scientific research and pharmaceutical development to alter the nucleoside's stability, specificity, or biological activity for various applications.

CAT: BRP-01533

MF: C17H28FN3O5Si

MF: 401.51

Purity: ≥98% by HPLC

Appearance: White to light yellow powder

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Storage: Store at 2-8 °C

InChIKey: VGWVGGIROFIQHX-NMFUWQPSSA-N

IUPAC Name: N-(1-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

InChI: InChI=1S/C17H28FN3O5Si/c1-10(23)19-12-7-8-21(16(24)20-12)15-13(18)14(11(9-22)25-15)26-27(5,6)17(2,3)4/h7-8,11,13-15,22H,9H2,1-6H3,(H,19,20,23,24)/t11-,13-,14-,15-/m1/s1

Synonyms: N4-Acetyl-3'-O-(t-butyl-dimethylsilyl)-2'-fluoro-2'-deoxycytidine; N4-Ac-2'-F-3'-O-TBDMS-dC

3'-O-TBDMS-2'-F-dA(Bz)

Description: 3'-O-TBDMS-2'-F-dA(Bz) is a chemically modified nucleoside used in nucleic acid research and synthesis. This modification is employed to study nucleotide interactions, stability, and potential therapeutic applications by altering the chemical and biological properties of the nucleoside.

CAT: BRP-01534

CAS: 1244763-25-4

MF: C23H30FN5O4Si

MF: 487.61

Purity: ≥98% by HPLC

Appearance: White to light yellow powder

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Storage: Store at 2-8 °C

Density: 1.32±0.1 g/cm3

InChIKey: VTZHRUXQJMHXQW-RPLGYBLPSA-N

CanonicalSMILES: O=C(NC1=NC=NC2=C1N=CN2C3OC(CO)C(O[Si](C)(C)C(C)(C)C)C3F)C=4C=CC=CC4

IUPAC Name: N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

InChI: InChI=1S/C23H30FN5O4Si/c1-23(2,3)34(4,5)33-18-15(11-30)32-22(16(18)24)29-13-27-17-19(25-12-26-20(17)29)28-21(31)14-9-7-6-8-10-14/h6-10,12-13,15-16,18,22,30H,11H2,1-5H3,(H,25,26,28,31)/t15-,16-,18-,22-/m1/s1

Synonyms: Adenosine, N-benzoyl-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-; N-Benzoyl-2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoroadenosine; N6-benzoyl-3'-O-(t-butyl-dimethylsilyl)-2'-fluorine-2'-deoxyadenosine; N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide

3'-O-TBDMS-2'-F-dG(iBu)

Description: 3'-O-TBDMS-2'-F-dG(iBu) is a chemically modified nucleoside used in biochemical and pharmaceutical research. This compound is designed to alter the properties of guanosine for specific applications, such as enhancing stability, modifying base-pairing interactions, or studying enzymatic reactions involving guanine derivatives.

CAT: BRP-01535

CAS: 2382967-92-0

MF: C20H32FN5O5Si

MF: 469.59

Purity: ≥98% by HPLC

Appearance: White to off-white powder

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Storage: Store at 2-8 °C

Density: 1.36±0.1 g/cm3

InChIKey: ACBLMVCONMEAIO-LZDVPDMXSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O[Si](C)(C)C(C)(C)C)F

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-[tert-butyl(dimethyl)silyl]oxy-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C20H32FN5O5Si/c1-10(2)16(28)24-19-23-15-13(17(29)25-19)22-9-26(15)18-12(21)14(11(8-27)30-18)31-32(6,7)20(3,4)5/h9-12,14,18,27H,8H2,1-7H3,(H2,23,24,25,28,29)/t11-,12-,14-,18-/m1/s1

Synonyms: 2'-F-3'-TBS-iBu-dG; N2-isobutyryl-3'-O-(t-butyl-dimethylsilyl)-2'-fluorine-2'-deoxyguanosine; Guanosine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-N-(2-methyl-1-oxopropyl)-; N-(9-((2R,3R,4R,5R)-4-((tert-butyldimethylsilyl)oxy)-3-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide

5'-O-DMT-N4-Acetyl-2'-fluoro-5-methyl-2'-deoxycytidine

Description: 5'-O-DMT-N4-acetyl-2'-Fluoro-5-methyl-2'-deoxycytidine is a chemically modified nucleoside used in the synthesis of oligonucleotides to enhance their stability, specificity, and resistance to enzymatic degradation, making it valuable for developing therapeutic agents, such as antisense oligonucleotides and siRNAs, and for studying nucleic acid interactions and enzymatic processes in research.

CAT: BRP-01541

MF: C33H34FN3O7

MF: 603.65

Purity: >98%

Appearance: White to light yellow powder

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InChIKey: STUFCHVUNHNWMI-BUVRPPHQSA-N

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C33H34FN3O7/c1-20-18-37(32(40)36-30(20)35-21(2)38)31-28(34)29(39)27(44-31)19-43-33(22-8-6-5-7-9-22,23-10-14-25(41-3)15-11-23)24-12-16-26(42-4)17-13-24/h5-18,27-29,31,39H,19H2,1-4H3,(H,35,36,38,40)/t27-,28-,29-,31-/m1/s1

Synonyms: N-(1-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-5-methyl-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide; 5'-O-DMT-N4-Acetyl-2'-Fluoro-5-methyl-2'-deoxycytidine; N4-Acetyl-5'-O-DMT-2'-fluoro-5-methyl-2'-deoxycytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-5-methylcytidine; 5'-O-DMT-2'-F-5-Me-dC(Ac); N4-Acetyl-2'-deoxy-5'-O-DMT-2'-fluoro-5-methylcytidine

N4-Acetyl-5-Iodo-2'-fluoro-2'-deoxycytidine

Description: N4-Acetyl-5-Iodo-2'-fluoro-2'-deoxycytidine is a chemically modified nucleoside used in oligonucleotide synthesis to enhance stability and resistance to enzymatic degradation due to its 2'-fluoro modification. The 5-iodo group allows for labeling and detection in various assays, while the N4-acetyl group protects the nucleobase during synthesis. This modified nucleoside is valuable for developing stable and specific therapeutic oligonucleotides, such as antisense oligonucleotides and siRNAs, and is also useful in research to study nucleic acid interactions and enzymatic processes.

CAT: BRP-01547

CAS: 2940869-29-2

MF: C11H13FIN3O5

MF: 413.14

Purity: ≥95%

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Density: 2.19±0.1 g/cm3

InChIKey: KDMMJHWZVCPNLN-FDDDBJFASA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1I)C2C(C(C(O2)CO)O)F

IUPAC Name: N-[1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodo-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C11H13FIN3O5/c1-4(18)14-9-5(13)2-16(11(20)15-9)10-7(12)8(19)6(3-17)21-10/h2,6-8,10,17,19H,3H2,1H3,(H,14,15,18,20)/t6-,7-,8-,10-/m1/s1

Synonyms: N4-Ac-5-I-2'-F-dC; N4-Ac-5-iodo-2'-fluoro-2'-dC

5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-2'-fluoro-2'-deoxyguanosine

Description: 5'-O-(4,4'-Dimethoxytrityl)-N2-dimethylformamidine-2'-fluoro-2'-deoxyguanosine is a chemically modified nucleoside used in oligonucleotide synthesis. This nucleoside features a 5'-O-(4,4'-Dimethoxytrityl) protecting group on the 5' hydroxyl, a N2-dimethylformamidine group at the guanosine base, and a 2'-fluoro modification on the deoxyribose sugar. It is employed to enhance stability and specificity in oligonucleotide design, particularly useful for developing therapeutic oligonucleotides like antisense oligonucleotides and siRNAs, and for conducting research on nucleic acid interactions and structure-function relationships.

CAT: BRP-01548

CAS: 2377586-41-7

MF: C34H35FN6O6

MF: 642.68

Purity: ≥98% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.35±0.1 g/cm3

Boiling Point: 839.5±75.0 °C at 760 mmHg

InChIKey: YYXHJLCVHPOJDK-UUEOAETPSA-N

CanonicalSMILES: CN(C)C=NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)F

IUPAC Name: N'-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C34H35FN6O6/c1-40(2)19-37-33-38-30-28(31(43)39-33)36-20-41(30)32-27(35)29(42)26(47-32)18-46-34(21-8-6-5-7-9-21,22-10-14-24(44-3)15-11-22)23-12-16-25(45-4)17-13-23/h5-17,19-20,26-27,29,32,42H,18H2,1-4H3,(H,38,39,43)/t26-,27-,29-,32-/m1/s1

Synonyms: N2-dmf-DMT-2'-F-dG; 5'-O-DMT-N2-dimethylformamide-2'-fluoro-2'-deoxyguanosine; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-2'-fluoro-N-[(dimethylamino)methylene]guanosine; N'-(9-((2R,3R,4R,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-fluoro-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide

N1-Methylene pivalate-N2-dibutylformamidine-2'-fluoro-guanosine

Description: N1-Methylene pivalate-N2-dibutylformamidine-2'-fluoro-guanosine is a modified guanosine nucleoside designed with protective groups at the N1 and N2 positions, alongside a 2'-fluoro modification on the ribose, enhancing stability and resistance to enzymatic degradation. This compound is pivotal in synthesizing modified oligonucleotides for biomedical research, improving nucleic acid performance in applications like gene therapy and molecular diagnostics.

CAT: BRP-01563

MF: C25H39FN6O6

MF: 538.62

Purity: ≥95% by HPLC

Appearance: White powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

InChIKey: OSNSETGWWMLVPD-VALFRTSSSA-N

IUPAC Name: (2-(((dibutylamino)methylene)amino)-9-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-1-yl)methyl pivalate

InChI: InChI=1S/C25H39FN6O6/c1-6-8-10-30(11-9-7-2)13-28-24-29-20-18(21(35)32(24)15-37-23(36)25(3,4)5)27-14-31(20)22-17(26)19(34)16(12-33)38-22/h13-14,16-17,19,22,33-34H,6-12,15H2,1-5H3/t16-,17-,19-,22-/m1/s1

Synonyms: N1-methylene pivalate-N2-dibutylformamidine-2'-F-Gr