Nucleosides

Description: 3-(3-Amino-3-carboxypropyl)-5,6-dihydrouridine is a modified nucleoside that combines the structural features of dihydrouridine and an amino-carboxypropyl side chain. This modification introduces flexibility and additional functional groups into the RNA, impacting its stability and interactions. It is valuable in RNA structure studies, synthetic biology, and the development of RNA-based therapeutics.

CAT: BRP-02143

CAS: 1353039-95-8

Molecular Formula: C13H21N3O8

Molecular Weight: 347.32

Description: It is a metabolite of Uridine, a nucleoside, which is widely distributed in nature. Uridine is one of the four basic components of RNA.

CAT: BRP-02144

Molecular Formula: C13H19N3O8

Molecular Weight: 345.31

Purity: ≥95%

Description: 5-(Carboxyhydroxymethyl)-2'-O-methyluridine methyl ester is a modified nucleoside with enhanced stability and unique functional properties. It is valuable in the fields of RNA therapeutics, biochemical research, and synthetic biology due to its ability to resist enzymatic degradation and engage in specific biochemical interactions. This nucleoside helps in advancing the understanding of RNA modifications and the development of novel RNA-based treatments.

CAT: BRP-02145

CAS: 2450329-71-0

Molecular Formula: C13H18N2O9

Molecular Weight: 346.29

Description: 5-Methoxycarbonylmethyl-2-thio-2'-O-methyluridine is a modified nucleoside with enhanced stability and unique functional properties due to its 2'-O-methyl, 2-thio, and 5-methoxycarbonylmethyl modifications. It is valuable in RNA therapeutics, biochemical research, and synthetic biology, helping to advance the understanding of RNA modifications and the development of novel RNA-based treatments.

CAT: BRP-02146

Molecular Formula: C13H18N2O7S

Molecular Weight: 346.36

Description: 7-Aminocarboxypropylwyosine is a highly modified nucleoside found in tRNA, playing a crucial role in maintaining the accuracy and efficiency of protein synthesis. Its complex structure and specific modifications contribute to the stability and function of tRNA, highlighting its importance in translation and broader cellular processes. This nucleoside is valuable for research in biochemistry, molecular biology, and synthetic biology, offering insights into RNA modifications and their potential applications.

CAT: BRP-02147

CAS: 898543-14-1

Molecular Formula: C18H24N6O7

Molecular Weight: 436.42

Description: Cyclic N6-threonylcarbamoyladenosine (ct6A) is a highly modified nucleoside found in tRNA that plays a critical role in maintaining the accuracy and efficiency of protein synthesis. Its complex structure, involving a cyclic threonine-derived moiety attached to adenosine, contributes to the stability and proper functioning of tRNA. This modification is essential for precise codon recognition and preventing translation errors, highlighting its importance in the overall process of gene expression and cellular function. Research into ct6A and other tRNA modifications provides valuable insights into the mechanisms of translation and has potential applications in genetic, molecular biology, and synthetic biology fields.

CAT: BRP-02148

CAS: 1415901-62-0

Molecular Formula: C15H18N6O7

Molecular Weight: 394.34

Description: Xylitol-[d7] is deuterium labelled Xylitol, which is a lower-calorie alternative to table sugar. Studies have shown that xylitol chewing gum can benefit acute otitis media. Xylitol is categorized by the U.S. FDA as a food additive.

CAT: BRP-02150

Molecular Formula: C5H5D7O5

Molecular Weight: 159.19

Purity: 98%; 99.1% atom D

Appearance: White Solid

Description: N2-iBu-5'-O-DMTr-2'-O-TBS-rG-3'-O-succinate is a modified nucleoside used in the synthesis of oligonucleotides with specific functional groups designed for various biochemical applications. This product is typically employed in the synthesis of oligonucleotides for applications such as gene therapy, antisense oligonucleotide therapy, or other areas requiring modified nucleotides with specific functional capabilities, including enhanced stability or selective reactivity. The modifications such as isobutylation, silylation, and succination allow for customized properties in the synthesized oligonucleotide, providing versatility in various therapeutic and research applications.

CAT: BRP-02430

CAS: 131289-17-3

Molecular Formula: C45H55N5O11Si

Molecular Weight: 870.03

Purity: ≥98%

Description: N6-Bz-5'-O-DMTr-2'-O-TBS-rA-3'-O-succinate is a ribonucleoside derivative used as a building block in the synthesis of modified RNA oligonucleotides. This compound is typically employed in the solid-phase synthesis of RNA or other nucleic acid analogs. The benzoyl protection at the base and the succinate modification allow for controlled reactivity and integration into oligonucleotide chains, enabling the preparation of RNA sequences for research or therapeutic applications, including mRNA therapeutics, siRNA, or antisense oligonucleotides.

CAT: BRP-02431

CAS: 131316-88-6

Molecular Formula: C48H53N5O10Si

Molecular Weight: 888.05

Purity: ≥98%

Description: N4-Ac-5'-O-DMTr-2'-O-TBS-rC-3'-O-succinate is a modified ribonucleoside widely used in the chemical synthesis of RNA. Its structure includes an N4-acetyl (N4-Ac) group protecting the exocyclic amine of cytidine, a 5'-O-(4,4'-dimethoxytrityl) (DMTr) group protecting the 5'-hydroxyl, a 2'-O-tert-butyldimethylsilyl (TBS) group protecting the 2'-hydroxyl, and a 3'-O-succinate moiety designed for attachment to solid supports or further chemical coupling. These protective groups are crucial for ensuring regioselective and efficient nucleotide coupling during oligonucleotide synthesis while preventing undesired side reactions. The 5'-DMTr group allows monitoring of coupling efficiency through colorimetric methods, while the 2'-TBS group is essential for synthesizing RNA with 2'-hydroxyl groups intact. The 3'-succinate functionality facilitates attachment to solid-phase resins, enabling automated oligonucleotide synthesis. This reagent is commonly used in the production of synthetic RNA for research, therapeutics, and RNA-based technologies such as siRNA, mRNA vaccines, and ribozymes.

CAT: BRP-02432

CAS: 2940874-25-7

Molecular Formula: C42H51N3O11Si

Molecular Weight: 801.95

Purity: ≥98%

Description: 5'-O-DMTr-2'-O-TBS-rU-3'-O-succinate is a modified uridine ribonucleoside used extensively in RNA synthesis. Its structure comprises a 5'-O-(4,4'-dimethoxytrityl) (DMTr) group for protecting the 5'-hydroxyl, a 2'-O-tert-butyldimethylsilyl (TBS) group for protecting the 2'-hydroxyl, and a 3'-O-succinate moiety that facilitates attachment to solid supports or further chemical reactions. The DMTr group enables easy monitoring of the coupling efficiency via a colorimetric assay, while the TBS group ensures the selective protection of the 2'-hydroxyl during synthetic steps. The 3'-O-succinate allows the modified nucleotide to be linked to solid-phase resins, enabling automated RNA synthesis. This compound is crucial for constructing RNA molecules with precise modifications, making it valuable in the development of RNA-based therapeutics, mRNA vaccines, and research applications, such as the synthesis of siRNA, antisense RNA, and ribozymes. It is especially important for synthesizing RNA oligonucleotides with controlled regioselectivity and sequence fidelity.

CAT: BRP-02433

CAS: 119702-12-4

Molecular Formula: C40H48N2O11Si

Molecular Weight: 760.90

Purity: ≥98%

Description: N2-DMF-5'-O-DMTr-2'-O-TBS-rG-3'-O-succinate, TEA salt is a protected guanosine derivative used in RNA synthesis. It features an N2-dimethylformamidine (DMF) group to protect the exocyclic amine of guanine, a 5'-O-(4,4'-dimethoxytrityl) (DMTr) group to protect the 5'-hydroxyl, and a 2'-O-tert-butyldimethylsilyl (TBS) group to protect the 2'-hydroxyl. The 3'-O-succinate moiety facilitates attachment to solid supports, and the triethylamine (TEA) salt form improves solubility and usability. This compound is essential for synthesizing RNA oligonucleotides used in applications such as mRNA therapeutics, siRNA, antisense RNA, and ribozymes, ensuring high fidelity and accurate assembly of RNA sequences.

CAT: BRP-02434

Molecular Formula: C44H54N6O10Si.C6H15N

Molecular Weight: 956.23

Purity: ≥98%

Description: 2'-OMe-C(Ac) 3'-succinate, TEA salt is a protected cytidine derivative used in RNA synthesis. It features a 2'-O-methyl (2'-OMe) group to enhance stability and protect the 2'-hydroxyl, an N4-acetyl (Ac) group to protect the exocyclic amine of cytosine, and a 3'-O-succinate moiety for attachment to solid-phase supports. The triethylamine (TEA) salt form improves solubility and handling. This compound is crucial for synthesizing RNA oligonucleotides with enhanced stability and resistance to nuclease degradation, commonly used in applications such as siRNA, antisense oligonucleotides, and other RNA-based therapeutics, ensuring precise and efficient sequence assembly.

CAT: BRP-02435

Molecular Formula: C37H39N3O11.C6H15N

Molecular Weight: 802.92

Purity: ≥98%

Description: DMT-2'-O-Me-Ur-3'-succinate, TEA salt is a modified uridine derivative used in RNA synthesis. It features a 2'-O-methyl (2'-OMe) group to enhance stability and protect the 2'-hydroxyl, and a 3'-O-succinate moiety for attachment to solid-phase supports. The triethylamine (TEA) salt form improves solubility and handling during synthesis. This compound is essential for constructing RNA oligonucleotides with increased stability and resistance to enzymatic degradation, making it valuable for siRNA, antisense oligonucleotides, mRNA therapeutics, and other RNA-based applications, ensuring efficient and precise synthesis of RNA sequences.

CAT: BRP-02436

CAS: 1792211-00-7

Molecular Formula: C35H36N2O11.C6H15N

Molecular Weight: 761.86

Purity: ≥98%

Description: DMT-2'-O-Me-Ur-3'-succinate is a modified uridine derivative used in RNA synthesis. It features a 2'-O-methyl (2'-OMe) group to enhance stability and protect the 2'-hydroxyl, and a 3'-O-succinate moiety for attachment to solid-phase supports. This compound is essential for constructing RNA oligonucleotides with increased stability and resistance to enzymatic degradation, making it valuable for siRNA, antisense oligonucleotides, mRNA therapeutics, and other RNA-based applications, ensuring efficient and precise synthesis of RNA sequences.

CAT: BRP-02437

CAS: 114745-30-1

Molecular Formula: C35H36N2O11

Molecular Weight: 660.67

Purity: ≥98%

Description: 5'-O-DMT-2'-O-MOE-A(Bz)-3'-O-succinate is a modified adenosine derivative used in RNA synthesis. It contains a 5'-O-(4,4'-dimethoxytrityl) (DMT) group to protect the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group for enhanced stability and nuclease resistance, and an N6-benzoyl (Bz) group to protect the exocyclic amine of adenine. The 3'-O-succinate moiety facilitates attachment to solid-phase supports for oligonucleotide synthesis. This compound is crucial for producing RNA oligonucleotides with improved pharmacokinetic properties, commonly used in antisense oligonucleotides, siRNA, and other RNA therapeutics, enabling precise and high-fidelity RNA synthesis.

CAT: BRP-02438

CAS: 444814-78-2

Molecular Formula: C45H45N5O11

Molecular Weight: 831.87

Purity: ≥98%

Description: 5'-DMTr-2'-O-MOE-rG(iBu)-3'-succinate is a modified guanosine nucleoside used in RNA synthesis. It includes a 5'-O-(4,4'-dimethoxytrityl) (DMTr) group for protecting the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group for enhancing stability and nuclease resistance, and an N2-isobutyryl (iBu) group protecting the exocyclic amine of guanine. The 3'-O-succinate moiety enables attachment to solid-phase supports, facilitating automated RNA synthesis. This compound is widely used in producing chemically modified RNA oligonucleotides, particularly for therapeutic applications such as siRNA and antisense oligonucleotides, ensuring high stability, precision, and fidelity in sequence assembly.

CAT: BRP-02439

CAS: 2622236-64-8

Molecular Formula: C42H47N5O12

Molecular Weight: 813.85

Purity: ≥98%

Description: 5'-O-DMTr-2'-O-MOE-5-Me-C(Bz)-3'-O-succinate is a chemically modified cytidine derivative used in RNA synthesis. It features a 5'-O-(4,4'-dimethoxytrityl) (DMTr) group for protecting the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group to enhance stability and nuclease resistance, and a 5-methyl substitution on cytosine for increased base-pairing specificity. The N4-benzoyl (Bz) group protects the exocyclic amine, and the 3'-O-succinate moiety facilitates attachment to solid-phase supports. This compound is essential for synthesizing chemically stabilized RNA oligonucleotides, commonly used in siRNA, antisense oligonucleotides, and other therapeutic RNA applications, ensuring efficient and high-fidelity synthesis of modified RNA sequences.

CAT: BRP-02440

CAS: 1536204-26-8

Molecular Formula: C45H47N3O12

Molecular Weight: 821.87

Purity: ≥98%

Description: 5'-O-DMT-2'-O-MOE-5-Me-U-3'-succinate, TEA salt is a modified uridine derivative used in RNA synthesis. It includes a 5'-O-(4,4'-dimethoxytrityl) (DMT) group for protecting the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group for enhanced stability and nuclease resistance, and a 5-methyl group on uracil to improve base-pairing properties. The 3'-O-succinate moiety allows attachment to solid-phase supports. This compound is crucial for synthesizing modified RNA oligonucleotides, particularly for applications in siRNA, antisense oligonucleotides, and mRNA therapeutics, enabling high-fidelity and stable RNA sequence assembly.

CAT: BRP-02441

CAS: 730979-83-6

Molecular Formula: C38H42N2O12

Molecular Weight: 718.75

Purity: ≥98%

Description: 5'-O-DMT-2'-O-MOE-5-Me-U-3'-succinate, TEA salt is a modified uridine derivative used in RNA synthesis. It includes a 5'-O-(4,4'-dimethoxytrityl) (DMT) group for protecting the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group for enhanced stability and nuclease resistance, and a 5-methyl group on uracil to improve base-pairing properties. The 3'-O-succinate moiety allows attachment to solid-phase supports, while the triethylamine (TEA) salt form improves solubility and ease of handling. This compound is crucial for synthesizing modified RNA oligonucleotides, particularly for applications in siRNA, antisense oligonucleotides, and mRNA therapeutics, enabling high-fidelity and stable RNA sequence assembly.

CAT: BRP-02442

CAS: 730979-84-7

Molecular Formula: C38H42N2O12.C6H15N

Molecular Weight: 819.94

Purity: ≥98%