Inquiry Basket
2'-Modified Nucleosides
(303/303) 3'-Modified Nucleosides
(173/173) 5'-Modified Nucleosides
(252/252) Anhydro-Nucleosides
(13/13) Arabinonucleosides
(34/34) Base Protected Nucleosides
(234/234) Halogen Nucleosides
(134/134) L-Nucleosides
(18/18) Other Nucleosides
(77/77) Other Protected Nucleosides
(23/23) Ribonucleosides
(11/11)
(303/303) 3'-Modified Nucleosides
(173/173) 5'-Modified Nucleosides
(252/252) Anhydro-Nucleosides
(13/13) Arabinonucleosides
(34/34) Base Protected Nucleosides
(234/234) Halogen Nucleosides
(134/134) L-Nucleosides
(18/18) Other Nucleosides
(77/77) Other Protected Nucleosides
(23/23) Ribonucleosides
(11/11)
Backbone
Modification
Base Type
Filtered by
Clear All
LNA-5-Me-U Succinate, triethylamine salt
Description: LNA-5-Me-U Succinate, triethylamine salt is a chemically modified uridine derivative used in the synthesis of locked nucleic acid (LNA) oligonucleotides. Its structure features a 5'-O-(4,4'-dimethoxytrityl) (DMT) group to protect the 5'-hydroxyl, a locked nucleic acid (LNA) conformation via a methylene bridge connecting the 2'-oxygen and 4'-carbon of the ribose ring for enhanced structural rigidity, and a 5-methyl substitution on the uracil base to improve thermal stability and base-pairing specificity. The 3'-O-succinate moiety allows for attachment to solid-phase supports, while the triethylamine (TEA) salt form enhances solubility. This compound is essential for synthesizing LNA-modified oligonucleotides, which exhibit increased binding affinity to complementary DNA or RNA strands, enhanced nuclease resistance, and superior thermal stability. These properties make it valuable for antisense therapies, siRNA, microRNA research, and other applications requiring high-affinity, stable oligonucleotide interactions. It ensures precise and efficient assembly of highly stable nucleic acid analogs.
CAT: BRP-02444
CAS: 2376615-26-6
Molecular Formula: C36H36N2O11.C6H15N
Molecular Weight: 773.87
Purity: ≥98%
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: SXOGFRYRIQRBQA-VCXUDXGESA-N
CanonicalSMILES: O=C(O)CCC(=O)OC1C2OCC1(OC2N3C=C(C(=O)NC3=O)C)COC(C=4C=CC=CC4)(C5=CC=C(OC)C=C5)C6=CC=C(OC)C=C6.N(CC)(CC)CC
IUPAC Name: 4-(((1R,3R,4R,7S)-1-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2,5-dioxabicyclo[2.2.1]heptan-7-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine
InChI: InChI=1S/C36H36N2O11.C6H15N/c1-22-19-38(34(43)37-32(22)42)33-30-31(48-29(41)18-17-28(39)40)35(49-33,20-46-30)21-47-36(23-7-5-4-6-8-23,24-9-13-26(44-2)14-10-24)25-11-15-27(45-3)16-12-25;1-4-7(5-2)6-3/h4-16,19,30-31,33H,17-18,20-21H2,1-3H3,(H,39,40)(H,37,42,43);4-6H2,1-3H3/t30-,31+,33-,35-;/m1./s1
Synonyms: 5'-O-DMT-LNA-5-Me-U Succinate, triethylamine salt; 5'-O-DMTr-LNA-5-Me-U-3'-O-succinate, triethylamine salt
Related CAS: 2376615-25-5 (free base)
-3'-o-succinate,-tea-salt.gif)
5'-O-DMT-2'-O-MOE-N6-Me-A(Bz)-3'-O-succinate, TEA salt
Description: 5'-O-DMT-2'-O-MOE-N6-Me-A(Bz)-3'-O-succinate, TEA salt is a modified adenosine derivative used in RNA synthesis. It features a 5'-O-(4,4'-dimethoxytrityl) (DMT) group for protecting the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group for enhanced stability and nuclease resistance, and an N6-methyl group on the adenine base for improved structural and functional properties. The N6-benzoyl (Bz) group protects the exocyclic amine of adenine, and the 3'-O-succinate moiety facilitates attachment to solid-phase supports, while the triethylamine (TEA) salt improves solubility.
This compound is critical for the synthesis of RNA oligonucleotides with enhanced pharmacokinetics, commonly used in therapeutic applications such as siRNA, antisense oligonucleotides, and mRNA therapeutics. It ensures high fidelity, stability, and efficiency in assembling RNA sequences with modified structural properties tailored for biological applications.
This compound is critical for the synthesis of RNA oligonucleotides with enhanced pharmacokinetics, commonly used in therapeutic applications such as siRNA, antisense oligonucleotides, and mRNA therapeutics. It ensures high fidelity, stability, and efficiency in assembling RNA sequences with modified structural properties tailored for biological applications.
CAT: BRP-02445
Molecular Formula: C46H47N5O11.C6H15N
Molecular Weight: 947.10
Purity: ≥98%
| Size | Price | Stock | Quantity |
|---|---|---|---|
| -- | -- | -- |
Storage: Store at -20 °C
InChIKey: SUDQMBSVVWZQNA-QOQGRXNQSA-N
CanonicalSMILES: COC(C=C1)=CC=C1C(C2=CC=C(OC)C=C2)(C3=CC=CC=C3)OC[C@@H](O4)[C@H]([C@H]([C@@H]4N5C(N=CN=C6N(C)C(C7=CC=CC=C7)=O)=C6N=C5)OCCOC)OC(CCC(O)=O)=O.CCN(CC)CC
IUPAC Name: 4-(((2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)-5-(6-(N-methylbenzamido)-9H-purin-9-yl)tetrahydrofuran-3-yl)oxy)-4-oxobutanoic acid;N,N-diethylethanamine
InChI: InChI=1S/C46H47N5O11.C6H15N/c1-50(44(55)30-11-7-5-8-12-30)42-39-43(48-28-47-42)51(29-49-39)45-41(59-26-25-56-2)40(62-38(54)24-23-37(52)53)36(61-45)27-60-46(31-13-9-6-10-14-31,32-15-19-34(57-3)20-16-32)33-17-21-35(58-4)22-18-33;1-4-7(5-2)6-3/h5-22,28-29,36,40-41,45H,23-27H2,1-4H3,(H,52,53);4-6H2,1-3H3/t36-,40-,41-,45-;/m1./s1
Synonyms: 2'-O-MOE-N6-Me-A(Bz)-3'-succinate, TEA salt; N6-Benzoyl-N6-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methoxyethyl-adenosine 3'-O-succinate, triethylamine salt; Adenosine, N-benzoyl-N6-methyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-(2-methoxyethyl)-, 3'-(hydrogen butanedioate), triethylamine salt; N6-Bz-N6-Me-5'-O-DMTr-2'-O-MOE-rA-3'-O-succinate, triethylamine salt
