Nucleosides

Description: 5'-DMTr-2'-O-MOE-rG(dmf)-3'-succinate, TEA salt is a modified guanosine derivative utilized in RNA synthesis. It features a 5'-O-(4,4'-dimethoxytrityl) (DMTr) group to protect the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group for enhanced stability and resistance to nuclease degradation, and an N2-dimethylformamidine (dmf) group protecting the exocyclic amine of guanine. The 3'-O-succinate moiety facilitates attachment to solid-phase supports, and the triethylamine (TEA) salt form improves solubility and handling. This compound is essential in the synthesis of RNA oligonucleotides for applications such as siRNA, antisense RNA, and mRNA therapeutics, ensuring precise and efficient assembly of stable, functional RNA sequences.

CAT: BRP-02443

Molecular Formula: C41H46N6O11.C6H15N

Molecular Weight: 900.04

Purity: ≥98%

Description: LNA-5-Me-U Succinate, triethylamine salt is a chemically modified uridine derivative used in the synthesis of locked nucleic acid (LNA) oligonucleotides. Its structure features a 5'-O-(4,4'-dimethoxytrityl) (DMT) group to protect the 5'-hydroxyl, a locked nucleic acid (LNA) conformation via a methylene bridge connecting the 2'-oxygen and 4'-carbon of the ribose ring for enhanced structural rigidity, and a 5-methyl substitution on the uracil base to improve thermal stability and base-pairing specificity. The 3'-O-succinate moiety allows for attachment to solid-phase supports, while the triethylamine (TEA) salt form enhances solubility. This compound is essential for synthesizing LNA-modified oligonucleotides, which exhibit increased binding affinity to complementary DNA or RNA strands, enhanced nuclease resistance, and superior thermal stability. These properties make it valuable for antisense therapies, siRNA, microRNA research, and other applications requiring high-affinity, stable oligonucleotide interactions. It ensures precise and efficient assembly of highly stable nucleic acid analogs.

CAT: BRP-02444

CAS: 2376615-26-6

Molecular Formula: C36H36N2O11.C6H15N

Molecular Weight: 773.87

Purity: ≥98%

Description: 5'-O-DMT-2'-O-MOE-N6-Me-A(Bz)-3'-O-succinate, TEA salt is a modified adenosine derivative used in RNA synthesis. It features a 5'-O-(4,4'-dimethoxytrityl) (DMT) group for protecting the 5'-hydroxyl, a 2'-O-methoxyethyl (MOE) group for enhanced stability and nuclease resistance, and an N6-methyl group on the adenine base for improved structural and functional properties. The N6-benzoyl (Bz) group protects the exocyclic amine of adenine, and the 3'-O-succinate moiety facilitates attachment to solid-phase supports, while the triethylamine (TEA) salt improves solubility.
This compound is critical for the synthesis of RNA oligonucleotides with enhanced pharmacokinetics, commonly used in therapeutic applications such as siRNA, antisense oligonucleotides, and mRNA therapeutics. It ensures high fidelity, stability, and efficiency in assembling RNA sequences with modified structural properties tailored for biological applications.

CAT: BRP-02445

Molecular Formula: C46H47N5O11.C6H15N

Molecular Weight: 947.10

Purity: ≥98%

Description: N6-Methyl-3'-O-methyladenosine is a modified adenosine nucleoside in which the nitrogen at the N6 position of the adenine base is methylated, and the 3'-hydroxyl group of the ribose sugar is methylated. The methylation at the N6 position is a common modification seen in RNA, often associated with regulating gene expression, stability, and translation. The 3'-O-methylation protects the nucleoside from enzymatic degradation and can influence the structure and function of RNA molecules, including their interactions with proteins and other nucleic acids. This compound is typically used in the study of RNA modifications, post-transcriptional regulation, and the design of modified oligonucleotides for therapeutic purposes.

CAT: BRP-02452

CAS: 60037-52-7

Molecular Formula: C12H17N5O4

Molecular Weight: 295.29

Purity: ≥98%

Appearance: White or off-white solid

Description: N4-L-Lactyl cytidine is a modified cytidine nucleoside where the N4 position of the cytosine base is esterified with an L-lactyl group. The lactyl group, derived from L-lactic acid, introduces a carboxylate ester functionality, which can alter the solubility, stability, and reactivity of the nucleoside. This modification may influence the molecule's ability to interact with enzymes, such as nucleases or polymerases, and could be used to study the effects of ester groups in nucleic acid metabolism, structure, and function. Additionally, N4-L-lactylation might be explored in drug design, particularly in the development of nucleoside analogs with altered pharmacokinetic properties.

CAT: BRP-02453

Molecular Formula: C12H17N3O7

Molecular Weight: 315.28

Purity: ≥97%

Appearance: White or off-white solid

Description: N6-L-Lactyl adenosine is a modified adenosine nucleoside in which the N6 position of the adenine base is esterified with an L-lactyl group, which is derived from L-lactic acid. This modification introduces a lactyl group, a carboxylate ester, to the nucleoside, which can alter its solubility, stability, and reactivity. The N6-lactylation could affect the molecule's interactions with enzymes, proteins, or nucleic acids, potentially influencing its role in RNA processing, gene regulation, or metabolic pathways. This modified nucleoside could be useful in the design of nucleoside analogs for therapeutic applications, including enhancing bioavailability or targeting specific cellular processes in research and drug development.

CAT: BRP-02454

Molecular Formula: C12H17N3O7

Molecular Weight: 339.31

Purity: ≥98%

Appearance: White or off-white solid

Description: N2-L-Lactyl guanosine is a modified guanosine nucleoside where the N2 position of the guanine base is esterified with an L-lactyl group, derived from L-lactic acid. This modification introduces a carboxylate ester functionality, which can influence the physicochemical properties of the nucleoside, such as its solubility, stability, and interactions with enzymes or other biomolecules. The L-lactyl group may also affect the nucleoside's role in nucleic acid metabolism, gene expression, or its ability to form specific interactions within RNA or DNA structures. This compound could be used in studies involving nucleoside analogs, enzymatic processes, or the development of therapeutics with enhanced properties, such as improved bioavailability or targeted delivery.

CAT: BRP-02455

Molecular Formula: C13H17N5O7

Molecular Weight: 355.31

Purity: ≥98%

Appearance: White or off-white solid

Description: 2'-O-(2-Aminoethyl)-5'-O-DMTr-5-methyluridine is a modified uridine nucleoside where the 2' position of the sugar is functionalized with a 2-aminoethyl group, the 5' position is protected with a dimethoxytrityl group, and the uracil base is methylated at the 5' position. This modified nucleoside could be useful in oligonucleotide synthesis, particularly in the creation of functionalized oligonucleotides for molecular biology applications, such as drug delivery, chemical biology, or synthetic biology. The 2-aminoethyl group might allow for further functionalization, and the methylation could influence base pairing or stability.

CAT: BRP-02459

CAS: 242147-79-1

Molecular Formula: C33H37N3O8

Molecular Weight: 603.66

Purity: ≥95%

Appearance: White powder

Description: N6-Acetyl-7-iodo-2'-O-methyl-7-deazaadenosine is a modified nucleoside that is used in the synthesis of nucleic acid analogs. The presence of the iodine atom and the acetyl group, along with the 2'-methoxy and 7-deaza modifications, alters the chemical properties of the nucleoside, making it suitable for specific applications in molecular biology and medicine.

CAT: BRP-02462

Molecular Formula: C14H17IN4O5

Molecular Weight: 448.22

Purity: ≥95%

Description: 2'-O-Methyl-7-deazaadenosine is a modified nucleoside that is characterized by the absence of a nitrogen atom at the 7-position of the purine base and the presence of a methyl group at the 2'-position. This compound is a type of 7-deazaadenosine derivative, which is often used in the synthesis of nucleic acid analogs and for research purposes.

CAT: BRP-02463

CAS: 68345-70-0

Molecular Formula: C12H16N4O4

Molecular Weight: 280.28

Purity: ≥95%

Description: 5'-O-Acetyluridine is a modified nucleoside derivative that is known to play a role in RNA modifications. 5'-O-Acetyluridine is a modified form of uridine with an acetyl group attached to the 5' hydroxyl group. This modification is often used to protect the 5' position during nucleic acid synthesis or other biochemical reactions, allowing for more controlled and efficient synthesis of RNA or other nucleic acid analogs. The acetyl group can be removed later under appropriate conditions if needed, making it a reversible protective group.

CAT: BRP-02477

CAS: 6773-44-0

Molecular Formula: C11H14N2O7

Molecular Weight: 286.24

Purity: ≥95%

Description: CNT2 inhibitor-1 is a modified nucleoside where an amino group is attached at the 8-position of the adenine base. This amino group is linked to a 1,1'-biphenyl group (a biphenyl structure with a methyl group at the 4-position of one phenyl ring). This modification could alter the physical properties of the nucleoside, such as hydrophobicity or steric effects, potentially influencing its interaction with other nucleic acids or proteins. Such modifications are often used in research to investigate the effects of structural changes on nucleoside interactions, stability, and binding affinity in oligonucleotide-based applications.

CAT: BRP-02478

CAS: 880155-70-4

Molecular Formula: C23H24N6O4

Molecular Weight: 448.47

Purity: ≥95%

Appearance: Beige to light yellow solid

Description: 8-Benzylaminoinosine is a modified nucleoside in which a benzylamine group is attached to the 8-position of the inosine base. Inosine itself is a purine nucleoside consisting of hypoxanthine attached to a ribose sugar, and the benzylamine modification introduces a bulky, hydrophobic group that can alter the compound's interactions with enzymes, receptors, or nucleic acids. This modification may be used to investigate the effects of altered steric or electronic properties on inosine's biological activities, particularly in research related to purine metabolism, nucleoside transport, or signaling pathways. It could also be explored in the development of potential therapeutic agents targeting purine-related pathways.

CAT: BRP-02479

CAS: 87515-42-2

Molecular Formula: C17H19N5O5

Molecular Weight: 373.36

Purity: ≥95%

Description: N2-Isobutyroyl-3',5'-O-TIPS-arabino-guanosine is a modified nucleoside where several key modifications are introduced to the guanosine structure. The N2-isobutyroyl group is attached to the N2 position of the guanine base, providing steric protection and potentially influencing interactions with enzymes or other biomolecules. The 3',5'-O-TIPS modification refers to the introduction of a triisopropylsilyl (TIPS) group at both the 3' and 5' positions of the ribose sugar, which enhances the stability of the nucleoside by protecting the hydroxyl groups from unwanted reactions during synthesis. The arabino configuration of the sugar indicates that it is an isomer of ribose, which can influence the nucleoside's binding affinity and stability. This modified guanosine is likely used in research or applications requiring enhanced stability or specific interactions in DNA or RNA-based systems, such as oligonucleotide synthesis, gene editing, or the development of prodrugs.

CAT: BRP-02481

CAS: 160684-47-9

Molecular Formula: C26H45N5O7Si2

Molecular Weight: 595.84

Purity: ≥95%

Description: Homoadenosine is a modified nucleoside where the adenosine base is attached to a ribose sugar at the 5'-position, similar to the natural structure of adenosine, but with a modification at the 6-position of the adenine base. This modification typically involves replacing the amino group with a different substituent, such as a hydrogen atom or an alkyl group, in order to modify its biological properties. The 5'-homoadenosine structure can be used in various biochemical and pharmacological applications, including studies on nucleoside analogs, RNA interference, and in the development of potential therapeutic agents. It can also play a role in exploring the effects of modified nucleosides on nucleic acid interactions and stability.

CAT: BRP-02482

CAS: 22415-88-9

Molecular Formula: C11H15N5O4

Molecular Weight: 281.27

Purity: ≥95%

Description: Homouridine is a modified nucleoside where the uridine base is altered at the 5-position. Typically, the modification involves replacing the 5-hydroxymethyl group with a different group, such as a hydrogen atom or an alkyl group, which affects the molecule's properties and behavior. This structural modification can impact the nucleoside's ability to interact with RNA or DNA, and may be used in research exploring nucleotide analogs, the development of modified oligonucleotides, or as part of investigations into RNA metabolism and stability. Homouridine can be used to examine the effects of small structural changes on the function of nucleosides within biological systems or as potential candidates in antiviral or therapeutic applications.

CAT: BRP-02483

CAS: 30685-57-5

Molecular Formula: C10H14N2O6

Molecular Weight: 258.23

Purity: ≥95%

Description: N6-Benzoyl-5'-O-DMTr-2'-O-[(2-methylamino)-2-oxoethyl]adenosine is a modified nucleoside used in RNA synthesis. This modified nucleoside is primarily used in the synthesis of custom RNA oligonucleotides, such as those for RNA-based therapeutics, gene silencing, or other RNA-related applications. The modifications help ensure stability, specificity, and functional activity in biological systems.

CAT: BRP-02484

CAS: 1025783-21-4

Molecular Formula: C41H40N6O8

Molecular Weight: 744.81

Purity: ≥98%

Appearance: White or off-white solid

Description: N2-iso-Butyryl-5'-O-DMTr-2'-O-[(2-methylamino)-2-oxoethyl]guanosine is a modified guanosine nucleoside used in RNA synthesis. The N2-iso-butyryl group protects the amine at the N2 position of the guanine base, ensuring controlled reactivity during oligonucleotide synthesis. The 5'-O-DMTr protects the 5'-hydroxyl group, enabling selective activation and chain elongation. The 2'-O-[(2-methylamino)-2-oxoethyl] modification at the ribose enhances the RNA's stability by improving its resistance to nucleases and modifying its interaction with RNA-binding proteins. This nucleoside is particularly useful for designing RNA molecules with increased stability and functionality for therapeutic and research applications. The structural modifications offer enhanced protection, making it suitable for precision RNA synthesis.

CAT: BRP-02485

CAS: 1025783-23-6

Molecular Formula: C38H42N6O9

Molecular Weight: 726.78

Purity: ≥98%

Appearance: White or off-white solid

Description: N4-Benzoyl-5'-O-DMTr-2'-O-[(2-methylamino)-2-oxoethyl]-5-methylcytidine is a modified nucleoside designed for RNA synthesis. This nucleoside is used in RNA oligonucleotide synthesis, particularly for creating RNA molecules with enhanced stability, resistance to degradation, and improved functionality in therapeutic or molecular biology applications.

CAT: BRP-02486

CAS: 1025783-19-0

Molecular Formula: C41H42N4O9

Molecular Weight: 734.80

Purity: ≥98%

Appearance: White or off-white solid

Description: 7-Deaza-2'-O-(2-methoxyethyl)guanosine is a nucleoside analog featuring a 7-deaza modification, where the nitrogen at position 7 of the guanine base is replaced by a carbon, and a 2-methoxyethyl group is attached to the 2'-hydroxyl position of the ribose sugar. These structural changes enhance the chemical and enzymatic stability of the molecule, reduce immune recognition, and improve binding affinity to complementary strands. It is widely used in the synthesis of modified RNA or antisense oligonucleotides for therapeutic applications, such as increasing duplex stability and optimizing pharmacokinetic properties in gene regulation studies.

CAT: BRP-02488

Molecular Formula: C14H20N4O6

Molecular Weight: 340.34

Purity: ≥95%