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Cyclic N6-threonylcarbamoyladenosine
Cyclic N6-threonylcarbamoyladenosine (ct6A) is a highly modified nucleoside found in tRNA that plays a critical role in maintaining the accuracy and efficiency of protein synthesis. Its complex structure, involving a cyclic threonine-derived moiety attached to adenosine, contributes to the stability and proper functioning of tRNA. This modification is essential for precise codon recognition and preventing translation errors, highlighting its importance in the overall process of gene expression and cellular function. Research into ct6A and other tRNA modifications provides valuable insights into the mechanisms of translation and has potential applications in genetic, molecular biology, and synthetic biology fields.
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Catalog
BRP-02148
Synonyms
N-[(4S)-4,5-Dihydro-4-[(1R)-1-hydroxyethyl]-5-oxo-2-oxazolyl]adenosine; N6-cyclicthreonyladenosine; cyclic t(6)A; ct(6)A; Cyclic N(6)-threonylcarbamoyladenosine; Cyclic threonylcarbamoyladenosine; cyclic N(6)-(L-threonylcarbamoyl)adenosine; N-{(4S)-4-[(1R)-1-hydroxyethyl]-5-oxo-1,3-oxazolidin-2-ylidene}adenosine; cyclic t6A
CAS
1415901-62-0
IUPAC Name
(4S)-2-[[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]purin-6-yl]amino]-4-[(1R)-1-hydroxyethyl]-4H-1,3-oxazol-5-one
Molecular Weight
394.34
Molecular Formula
C15H18N6O7
Canonical SMILES
CC(C1C(=O)OC(=N1)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O)O
InChI
InChI=1S/C15H18N6O7/c1-5(23)7-14(26)28-15(19-7)20-11-8-12(17-3-16-11)21(4-18-8)13-10(25)9(24)6(2-22)27-13/h3-7,9-10,13,22-25H,2H2,1H3,(H,16,17,19,20)/t5-,6-,7+,9-,10-,13-/m1/s1
InChIKey
NIMLOKNRDJCYPO-DWVDDHQFSA-N
Boiling Point
728.5±70.0 °C at 760 mmHg
Density
2.04±0.1 g/cm3
Symbol
ct6A
Chemical Structure:
