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2'-O-Methyl-rG(N-Ac) phosphoramidite
2'-O-Methyl-rG(N-Ac) phosphoramidite is an anticancer agent with antiviral and antiparasitic activities. 2'-O-Methyl-rG(N-Ac) phosphoramidite is a modified guanosine phosphoramidite used in oligonucleotide synthesis. It features a 2'-O-methyl group, which enhances the stability of the oligonucleotide by increasing resistance to nucleases and improving binding affinity. The N-Ac (N-acetyl) group protects the amino group of the guanine base during synthesis. This reagent is particularly useful for synthesizing RNA molecules with increased stability and improved hybridization properties, making it valuable for applications in molecular biology, diagnostics, and therapeutic development.
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Catalog
BRP-02166
Synonyms
Ac-2'-OMe-rG Phosphoramidite; N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylguanosine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite; 5'-O-DMT-2'-O-Me-rG(Ac)-3'-CE phosphoramidite; 5'-O-DMT-2'-O-Me-rG(N-Ac)-3'-CED; 5'-DMT-2'-OMe-rG(N-Ac) Phosphoramidite; Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]
CAS
909033-40-5
IUPAC Name
N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide
Molecular Weight
841.89
Molecular Formula
C43H52N7O9P
Canonical SMILES
CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=NC3=C2N=C(NC3=O)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
InChI
InChI=1S/C43H52N7O9P/c1-27(2)50(28(3)4)60(57-24-12-23-44)59-37-35(58-41(38(37)55-8)49-26-45-36-39(49)47-42(46-29(5)51)48-40(36)52)25-56-43(30-13-10-9-11-14-30,31-15-19-33(53-6)20-16-31)32-17-21-34(54-7)22-18-32/h9-11,13-22,26-28,35,37-38,41H,12,24-25H2,1-8H3,(H2,46,47,48,51,52)/t35-,37-,38-,41-,60?/m1/s1
InChIKey
FBABQKPBRXEHBT-USUFPPIWSA-N
Purity
≥98%
Storage
Store at -20 °C
Chemical Structure:
