Cap Analogs - RNA / BOC Sciences

m7Gpppm6AmpG ammonium salt

Description: m7Gpppm6AmpG ammonium salt is a trinucleotide mRNA 5' cap analogs. m7Gpppm6AmpG ammonium can be used for RNA synthesis in vitro.

CAT: BRP-00331

MF: C33H45N15O24P4 (free acid)

MF: 1159.69 (free acid)

Purity: ≥98%

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Synonyms: CAP GAG(m6A) m7G(5')ppp(5')(2'OMe,m6A)pG Ammonium; GAG(m6A) ammonium salt; m7Gppp(2'OMe,m6A)pG ammonium salt; m7G(5')ppp(5')(2'OMe,m6A)pG ammonium salt

Related CAS: 71340-22-2 (free acid)

Im(m7GDP)

Description: Im(m7GDP), or 7-methylguanosine diphosphate imidazole, is a modified nucleotide commonly used in biochemistry and molecular biology research. It features a 7-methylguanosine moiety, which mimics the 5' cap structure of eukaryotic mRNA, and is conjugated with diphosphate and imidazole groups. This compound is particularly useful for studying mRNA capping, translation initiation, and mRNA stability, as well as for synthesizing capped RNA molecules for various experimental applications, including in vitro transcription and RNA-protein interaction studies.

CAT: BRP-00379

CAS: 531553-69-2

MF: C14H19N7O10P2

MF: 507.29

Purity: ≥95%

Appearance: White to off-white powder

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InChIKey: FSLUCUBHOZVVQK-QYVSTXNMSA-N

CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(N4C=CN=C4)O)O)O

IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [hydroxy(imidazol-1-yl)phosphoryl] phosphate

InChI: InChI=1S/C14H19N7O10P2/c1-19-6-21(11-8(19)12(24)18-14(15)17-11)13-10(23)9(22)7(30-13)4-29-33(27,28)31-32(25,26)20-3-2-16-5-20/h2-3,5-7,9-10,13,22-23H,4H2,1H3,(H4-,15,17,18,24,25,26,27,28)/t7-,9-,10-,13-/m1/s1

Synonyms: 5'-Guanylic acid, 7-methyl-, inner salt, anhydride with P-1H-imidazol-1-ylphosphonic acid (1:1); 5'-Guanylic acid, 7-methyl-, inner salt, monoanhydride with 1H-imidazol-1-ylphosphonic acid; m7Gpp; 7-methyl-guanosine diphosphate, IM; 7-methylguanosine diphosphate imidazole

5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)guanosine, 2',3'-diacetate

Description: 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)guanosine, 2',3'-diacetate is a chemically modified guanosine nucleoside. This compound features a 5'-O protection with a bis(4-methoxyphenyl)phenylmethyl (also known as DMT) group, an N-(2-methyl-1-oxopropyl) group at the guanine base, and acetyl groups protecting both the 2' and 3' hydroxyl positions of the ribose sugar. These modifications enhance stability and facilitate selective reactions during oligonucleotide synthesis. This compound is particularly useful in the preparation of modified nucleic acids for research in molecular biology, providing increased control over the synthesis and modification of RNA and DNA molecules.

CAT: BRP-00380

CAS: 210362-16-6

MF: C39H41N5O10

MF: 739.77

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Density: 1.35±0.1 g/cm3

InChIKey: BSJXJCSWIJAQGJ-GONXPTGJSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-4-acetyloxy-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-[2-(2-methylpropanoylamino)-6-oxo-1H-purin-9-yl]oxolan-3-yl] acetate

InChI: InChI=1S/C39H41N5O10/c1-22(2)35(47)42-38-41-34-31(36(48)43-38)40-21-44(34)37-33(53-24(4)46)32(52-23(3)45)30(54-37)20-51-39(25-10-8-7-9-11-25,26-12-16-28(49-5)17-13-26)27-14-18-29(50-6)19-15-27/h7-19,21-22,30,32-33,37H,20H2,1-6H3,(H2,41,42,43,47,48)/t30-,32-,33-,37-/m1/s1

Synonyms: Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-(2-methyl-1-oxopropyl)-, 2',3'-diacetate; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2-isobutyramido-6-oxo-3,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate; 2',3'-di-Ac-5'-DMT-G(iBu)

M7-GpppA sodium salt

Description: M7-GpppA sodium salt is a synthetic cap structure used in the study of mRNA. This cap analog mimics the natural 5' cap found on eukaryotic mRNA, playing a crucial role in mRNA stability, processing, and translation. It is widely used in research involving mRNA synthesis, capping efficiency studies, and the development of mRNA-based therapeutics and vaccines.

CAT: BRP-00395

MF: C21H29N10O17P3 (free acid)

MF: 786.43 (free acid)

Purity: ≥97% by HPLC

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Synonyms: 7-Methylguanosine 5'-(tetrahydrogen triphosphate) inner salt, P''→5'-ester with adenosine sodium salt; Adenosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt, sodium salt; N7-Methyl-guanosine-5'-triphosphate-5'-adenosine sodium salt; m7GpppA sodium salt; 7-methylguanosine-5'-triphosphate-5'-adenosine sodium salt

Related CAS: 62828-63-1 (free acid)

GpppG sodium salt

Description: GpppG sodium salt is a dinucleotide cap analog used in RNA research. It mimics the natural 5' cap structure of eukaryotic mRNA, playing a significant role in mRNA stability, translation initiation, and processing. GpppG is commonly utilized in the study of mRNA synthesis, capping mechanisms, and the development of mRNA-based therapeutics and vaccines.

CAT: BRP-00396

MF: C20H27N10O18P3 (free acid)

MF: 788.41 (free acid)

Purity: ≥97% by HPLC

Appearance: Clear colorless Liquid

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Synonyms: G(5')ppp(5')G Cap Analog sodium salt; Diguanosine triphosphate sodium salt; Diguanosine-5'-triphosphate sodium salt; P1-(Guanosyl) P3-(5'-(guanosyl))triphosphate sodium salt; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine sodium salt; Guanosine triphosphate, 5'→5'-ester with guanosine sodium salt; Diguanosine 5',5'''-triphosphate sodium salt; Gp3G sodium salt; P1,P3-Diguanosine 5'-triphosphate sodium salt; guanosine-5'-triphosphate-5'-guanosine sodium salt

Related CAS: 6674-45-9 (free acid) ; 102783-44-8 (triammonium salt) ; 1314754-91-0 (trisodium salt)

GpppA sodium salt

Description: GpppA sodium salt is a dinucleotide cap analog used in RNA research. It mimics the natural 5' cap structure of eukaryotic mRNA, which is essential for mRNA stability, processing, and efficient translation initiation. GpppA is utilized in studies of mRNA synthesis and capping mechanisms, as well as in the development of mRNA-based therapeutics and vaccines.

CAT: BRP-00397

MF: C20H27N10O17P3 (free acid)

MF: 772.41 (free acid)

Purity: ≥97% by HPLC

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Synonyms: Guanosine 5'-triphosphate-5'-adenosine sodium salt; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with adenosine sodium salt; Guanosine triphosphate, 5'→5'-ester with adenosine sodium salt; Gp3A sodium salt; Gp3A (dinucleotide) sodium salt; P1-Adenosine-5' P3-guanosine-5' triphosphate sodium salt

Related CAS: 1613387-42-0 (trisodium salt) ; 10527-47-6 (free acid)

m7G(5')ppp(5')(2'-OMeA)pG sodium salt

Description: m7G(5')ppp(5')(2'-OMeA)pG sodium salt is a synthetic cap structure used in RNA research. This cap analog features a 7-methylguanosine at the 5' end, a triphosphate bridge, a 2'-O-methyladenosine, and a phosphoguanosine linkage. It mimics the natural mRNA cap structure, enhancing mRNA stability, processing, and translation efficiency. This compound is valuable for studying mRNA function, cap-dependent translation, and for developing mRNA-based therapeutics and vaccines.

CAT: BRP-00398

MF: C32H43N15O24P4 (free acid)

MF: 1145.66 (free acid)

Purity: ≥97% by HPLC

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Synonyms: m7GpppAmpG sodium salt; Adenosine 5'-(tetrahydrogen triphosphate), guanylyl-(5'→3')-2'-O-methyl-, P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt, sodium salt; m7GpppA2'OmepG sodium salt; GAG sodium salt; m7G(5')ppp(5')(2'OMeA)pG sodium salt; N7-methylguanosine-5'-triphospho-5'-(2'-O-methyladenosine)-3'-phosphoguanosine sodium salt

Related CAS: 62858-30-4 (free acid) ; 2941382-07-4 (trisodium salt) ; 2710263-09-3 (triammonium salt)

(3'-OMe-m7G)(5')ppp(5')(2'-OMeA)pG sodium salt

Description: (3'-OMe-m7G)(5')ppp(5')(2'-OMeA)pG sodium salt is a synthetic RNA cap analog. This cap structure includes a 3'-O-methyl modification on the N7-methylguanosine and a 2'-O-methyl modification on adenosine, linked by a triphosphate bridge to guanosine. It mimics natural mRNA cap structures, enhancing RNA stability, processing, and translation efficiency. This compound is valuable in the study of mRNA function, cap-dependent translation mechanisms, and the development of mRNA-based therapeutics and vaccines.

CAT: BRP-00399

MF: C33H45N15O24P4 (free acid)

MF: 1159.71 (free acid)

Purity: ≥97% by HPLC

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Synonyms: m7(3'OMeG)(5')ppp(5')(2'OMeA)pG sodium salt; 3'Ome-m7GpppAmpG sodium salt; Guanosine, 7-methyl-3'-O-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt, sodium salt; 3'-O-methyl-N7-methylguanosine-5'-triphospho-5'-(2'-O-methyladenosine)-3'-phosphoguanosine sodium salt

Related CAS: 2089461-55-0 (free acid) ; 2863631-10-9 (trisodium salt)

GpppG ammonium salt

Description: GpppG ammonium salt is a dinucleotide cap analog used in RNA research. It mimics the natural 5' cap structure of eukaryotic mRNA, playing a significant role in mRNA stability, translation initiation, and processing. GpppG is commonly utilized in the study of mRNA synthesis, capping mechanisms, and the development of mRNA-based therapeutics and vaccines.

CAT: BRP-00414

MF: C20H27N10O18P3 (free acid)

MF: 788.41 (free acid)

Purity: ≥95% by HPLC

Appearance: Clear colorless Liquid

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Synonyms: G(5')ppp(5')G Cap Analog ammonium salt; Diguanosine triphosphate ammonium salt; Diguanosine-5'-triphosphate ammonium salt; P1-(Guanosyl) P3-(5'-(guanosyl))triphosphate ammonium salt; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine ammonium salt; Guanosine triphosphate, 5'→5'-ester with guanosine ammonium salt; Diguanosine 5',5'''-triphosphate ammonium salt; Gp3G ammonium salt; P1,P3-Diguanosine 5'-triphosphate ammonium salt; GpppG Ammonium

Related CAS: 6674-45-9 (free acid) ; 102783-44-8 (triammonium salt) ; 1314754-91-0 (trisodium salt)

M7-GpppG ammonium salt

Description: m7GpppG ammonium salt is a synthetic dinucleotide cap analog. It mimics the natural 5' cap structure of eukaryotic mRNA, featuring a 7-methylguanosine linked via a triphosphate bridge to guanosine. This cap structure is crucial for mRNA stability, processing, and efficient translation initiation. m7GpppG ammonium salt is widely used in research to study mRNA capping, translation mechanisms, and in the development of mRNA-based therapeutics and vaccines.

CAT: BRP-00415

CAS: 1577228-60-4

MF: C21H29N10O18P3 (free acid)

MF: 802.43 (free acid)

Purity: ≥95% by HPLC

Appearance: Clear colorless Liquid

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Synonyms: m7G(5')ppp(5')G ammonium salt; P1-(5'-7-methyl-guanosyl) P3-(5'-(guanosyl))triphosphate, ammonium salt; M7-GpppG ammonium salt; Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt, ammonium salt; m7Gp3G ammonium salt; m7GpppG ammonium salt; M7-GpppG Ammonium; mCAP; mCAP ammonium salt; 7-methylguanosine-5'-triphospho-5'-guanosine ammonium salt

Related CAS: 75252-12-9 (diammonium salt) ; 1644684-21-8 (triammonium salt) ; 130944-80-8 (disodium salt) ; 62828-64-2 (free acid)

M7-GDP-IMZ

Description: m7-GDP-IMZ is a chemically modified nucleotide. It features a 7-methylguanosine linked to a diphosphate group and an imidazole moiety. This compound is often used in biochemical research to study interactions with enzymes and other proteins involved in nucleotide metabolism, RNA synthesis, and processing. The imidazole group can provide unique reactivity, making m7-GDP-IMZ a valuable tool in the investigation of biochemical pathways and the development of nucleotide-based therapies.

CAT: BRP-00416

CAS: 1201817-76-6

MF: C14H17N7Na2O10P2

MF: 551.25

Purity: ≥80% by HPLC

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InChIKey: DLFOIRRSTNECTJ-BJSVFJQSSA-L

CanonicalSMILES: CN1C=[N+](C2=C1C(=NC(=N2)N)[O-])C3C(C(C(O3)COP(=O)([O-])OP(=O)(N4C=CN=C4)[O-])O)O.[Na+].[Na+]

InChI: InChI=1S/C14H19N7O10P2.2Na/c1-19-6-21(11-8(19)12(24)18-14(15)17-11)13-10(23)9(22)7(30-13)4-29-33(27,28)31-32(25,26)20-3-2-16-5-20;;/h2-3,5-7,9-10,13,22-23H,4H2,1H3,(H4-,15,17,18,24,25,26,27,28);;/q;2*+1/p-2/t7-,9-,10-,13-;;/m1../s1

Synonyms: 5'-Guanylic acid, 7-methyl-, inner salt, anhydride with P-1H-imidazol-1-ylphosphonic acid, sodium salt (1:1:2); 2-Amino-9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(((hydroxy((hydroxy(1H-imidazol-1-yl)phosphoryl)oxy)phosphoryl)oxy)methyl)tetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-3H-purin-7-ium disodium salt; M7-GDP-IMZ disodium salt; 7-methylguanosine-5'-diphosphate imidazole

Related CAS: 531553-69-2 (free acid) ; 240137-51-3 (monosodium salt)

3'-OMe-GDP disodium salt

Description: 3'-OMe-GDP disodium salt is a modified nucleotide where the ribose sugar of guanosine has a methyl group at the 3' position. This modification can enhance the stability and alter the binding properties of RNA molecules. 3'-OMe-GDP is used in biochemical and molecular biology research to study RNA synthesis, function, and interactions, as well as in the development of nucleotide-based therapeutics and diagnostic tools.

CAT: BRP-00417

MF: C11H15N5Na2O11P2

MF: 501.19

Purity: ≥97% by HPLC

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InChIKey: FJVMHSWIOYKOKT-IDIVVRGQSA-L

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)O.Na.Na

IUPAC Name: disodium;((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)methyl hydrogen diphosphate

InChI: InChI=1S/C11H17N5O11P2.2Na/c1-24-7-4(2-25-29(22,23)27-28(19,20)21)26-10(6(7)17)16-3-13-5-8(16)14-11(12)15-9(5)18;;/h3-4,6-7,10,17H,2H2,1H3,(H,22,23)(H2,19,20,21)(H3,12,14,15,18);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

Synonyms: 3'-OMe-GDP; 3'-O-Methylguanosine 5'-(tetrahydrogen diphosphate) disodium salt; 3'-O-methyl-GDP disodium salt; 3'-O-Methylguanosine 5'-diphosphate disodium salt; 3'-O-Methylguanosine diphosphate disodium salt

Related CAS: 78771-34-3 (free acid)

3'-OMe-M7-GDP-IMZ

Description: 3'-OMe-m7-GDP-IMZ is a chemically modified nucleotide. It features a 3'-O-methyl modification on the ribose sugar, a 7-methylguanosine base, and a diphosphate linkage to an imidazole group. This compound is used in biochemical and molecular biology research to study mRNA capping, stability, and interactions with enzymes and proteins involved in nucleotide metabolism. The modifications can enhance stability and provide unique reactivity, making it a valuable tool in the development of nucleotide-based therapies and research into RNA function and processing.

CAT: BRP-00418

MF: C15H19N7Na2O10P2

MF: 565.28

Purity: ≥80% by HPLC

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InChIKey: UYMNWTSOELIWLF-IDTAVKCVSA-L

CanonicalSMILES: O=C1N=C(N)NC2=C1[N+](=CN2C3OC(COP(=O)([O-])OP(=O)(O)N4C=NC=C4)C(OC)C3O)C.Na.Na

InChI: InChI=1S/C15H21N7O10P2/c1-20-7-22(12-9(20)13(24)19-15(16)18-12)14-10(23)11(29-2)8(31-14)5-30-34(27,28)32-33(25,26)21-4-3-17-6-21/h3-4,6-8,10-11,14,23H,5H2,1-2H3,(H4-,16,18,19,24,25,26,27,28)/p-2/t8-,10-,11-,14-/m1/s1

Synonyms: M7-GDP-IMZ(3'OMe); 3'-O-Methyl-7-methylguanosine-5'-diphosphate imidazole

Related CAS: 2089461-53-8 (free acid)

(2'-OMe-5'-MP-A)pG TEA salt

Description: (2'-OMe-5'-MP-A)pG TEA salt is a modified dinucleotide used in RNA research. It features a 2'-O-methyl modification on the adenosine nucleotide, linked via a phosphate group to guanosine. The triethylammonium (TEA) salt form enhances solubility and stability. This compound is used to study RNA structure, function, and interactions, and is valuable in the development of RNA-based therapeutics and molecular biology applications.

CAT: BRP-00419

MF: C21H28N10O14P2 (free acid)

MF: 706.46 (free acid)

Purity: ≥97% by HPLC

Appearance: White, off-white to faint yellow powder

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IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-methoxy-2-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate;N,N-diethylethanamine

Synonyms: (2'-OMe-5'-MP-A)pG triethylamine salt; 2'-O-Methyl-5'-O-phosphonoadenylyl-(3'→5')-guanosine triethylamine salt; (2'-OMe-5'-MP-A)pG; pA(2'-OMe)mpG TEA salt; 2'-O-Methyladenosine-5'-monophosphate-guanosine triethylammonium salt

Related CAS: 62828-60-8 (free acid) ; 2638447-50-2 (triethylamine salt (1:3)) ; 2894815-57-5 (triethylamine salt (1:2)) ; 2645354-91-0 (ammonium salt)

(2'-OMe-5'-MP-A)pU TEA salt

Description: (2'-OMe-5'-MP-A)pU TEA salt is a modified dinucleotide used in RNA research. It features a 2'-O-methyl modification on the adenosine nucleotide, linked via a phosphate group to uridine. The triethylammonium (TEA) salt form enhances solubility and stability. This compound is utilized to study RNA structure, function, and interactions, and is valuable in the development of RNA-based therapeutics and in molecular biology applications.

CAT: BRP-00420

MF: C20H27N7O15P2 (free acid)

MF: 667.42 (free acid)

Purity: ≥97% by HPLC

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IUPAC Name: [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-methoxy-2-(phosphonooxymethyl)oxolan-3-yl] [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl hydrogen phosphate;N,N-diethylethanamine

Synonyms: (2'-OMe-5'-MP-A)pU triethylamine salt; ((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-4-methoxytetrahydrofuran-2-yl)methyl dihydrogen phosphate triethylamine salt; (2'-OMe-5'-MP-A)pU; pA(2'-OMe)mpU TEA salt; 2'-O-Methyladenosine-5'-monophosphate-uridine triethylammonium salt

Related CAS: 2956650-76-1 (free acid) ; 2956650-77-2 (triethylamine salt (1:2))

(2'-OMe-5'-MP-G)pG TEA salt

Description: (2'-OMe-5'-MP-G)pG TEA salt is a modified dinucleotide used in RNA research. It features a 2'-O-methyl modification on the guanosine nucleotide, linked via a phosphate group to another guanosine. The triethylammonium (TEA) salt form enhances solubility and stability. This compound is utilized to study RNA structure, function, and interactions, and is valuable in the development of RNA-based therapeutics and in various molecular biology applications.

CAT: BRP-00421

MF: C21H28N10O15P2 (free acid)

MF: 722.46 (free acid)

Purity: ≥97% by HPLC

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IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-methoxy-2-(phosphonooxymethyl)oxolan-3-yl] hydrogen phosphate;N,N-diethylethanamine

Synonyms: (2'-OMe-5'-MP-G)pG triethylamine salt; ((2R,3R,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-(((((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-4-methoxytetrahydrofuran-2-yl)methyl dihydrogen phosphate triethylamine salt; (2'-OMe-5'-MP-G)pG; 2'-O-Methylguanosine-5'-monophosphate-guanosine triethylammonium salt

Related CAS: 2638447-65-9 (free acid) ; 2638447-66-0 (triethylamine salt (1:3))

LZCapAG(3'Acm)

Description: LZCapAG(3'Acm), a Cap1 analogue, can be used as an mRNA co-transcription capping reagent. Under the action of T7 polymerase, LZCapAG(3'Acm), NTPs and template DNA are co-transcribed to produce mRNA with 5 'end Cap1 structure. Capped mRNA can be directly translated and expressed in cells and in vivo. It is widely used in in vitro transcription, gene editing, vaccine development, tumor CAR-T therapy, protein replacement therapy and regenerative medicine.

CAT: BRP-00434

MF: C35H48N16O24P4 (free acid)

MF: 1200.75 (free acid)

Purity: ≥95% by HPLC

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Storage: Store at -20 °C

Synonyms: m7(3'Acm)Gppp(2'OMe)ApG; 9-((2R,3R,4S,5S)-4-(acetamidomethyl)-5-((((((((((2R,3R,4R,5R)-3-(((((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3-hydroxytetrahydrofuran-2-yl)-2-amino-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium ammonium salt; LZCapAG(3'Acm) ammonium salt

LZCapAU(3'Acm)

Description: LZCapAU(3'Acm), a Cap1 analogue, can be used as an mRNA co-transcription capping reagent. Under the action of T7 polymerase, LZCapAU(3'Acm), NTPs and template DNA are co-transcribed to produce mRNA with 5 'end Cap1 structure. Capped mRNA can be directly translated and expressed in cells and in vivo. It is widely used in in vitro transcription, gene editing, vaccine development, tumor CAR-T therapy, protein replacement therapy and regenerative medicine.

CAT: BRP-00435

MF: C34H47N13O25P4 (free acid)

MF: 1161.71 (free acid)

Purity: ≥95% by HPLC

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Storage: Store at -20 °C

Synonyms: m7(3'Acm)Gppp(2'OMe)ApU; LZCapAU(3'Acm) ammonium salt; (2R,3R,4R,5R)-2-((((((((((2S,3S,4R,5R)-3-(acetamidomethyl)-5-(2-amino-7-methyl-6-oxo-1,6-dihydro-9H-purin-7-ium-9-yl)-4-hydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl (((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl) phosphate ammonium salt

LZCapAG(3'Ma-Biotin)

Description: LZCapAG(3'Ma-Biotin), a Cap1 analog with a Biotin label, can be used as an mRNA cotranscription capping agent. Under the action of T7 polymerase, LZCapAG(3'Ma-Biotin), NTPs and template DNA were co-transcribed to produce mRNA with 5 'Cap 1 structure, and the capped mRNA could be directly translated and expressed in cells and in vivo, with excellent expression efficiency. LZCapAG(3'Ma-Biotin) capped mRNA, with a Biotin label, can bind to streptomycin magnetic beads to explore a variety of biological functions.

CAT: BRP-00436

MF: C43H60N18O25P4S (free acid)

MF: 1385.01 (free acid)

Purity: ≥90% by HPLC

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Storage: Store at -20 °C

Synonyms: m7(3'Ma-Biotin)Gppp(2'OMe)ApG; LZCapAG(3'Ma-Biotin) ammonium salt; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3R,4R,5R)-2-((((((((((2S,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1,6-dihydro-9H-purin-7-ium-9-yl)-4-hydroxy-3-((5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)methyl)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) phosphate ammonium salt

LZCapAG(3'Ma-FAM)

Description: LZCapAG(3'Ma-FAM), a Cap1 analog with an FAM fluorescent label, can be used as an mRNA cotranscription capping agent. Under the action of T7 polymerase, LZCapAG(3'Ma-FAM), NTPs and template DNA were co-transcribed to produce mRNA with 5 'Cap 1 structure, and the capped mRNA could be directly translated and expressed in cells and in vivo, with excellent expression efficiency. LZCapAG(3'Ma-FAM) capped mRNA, with FAM label, can be detected by flow cytometry and fluorescence microscopy, and the distribution of mRNA and LNP can be traced and located.

CAT: BRP-00437

MF: C54H56N16O29P4 (free acid)

MF: 1517.02 (free acid)

Purity: ≥90% by HPLC

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Storage: Store at -20 °C

Synonyms: m7(3'Ma-FAM)Gppp(2'OMe)ApG; LZCapAG(3'Ma-FAM) ammonium salt; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3R,4R,5R)-2-((((((((((2S,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1,6-dihydro-9H-purin-7-ium-9-yl)-3-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamido)methyl)-4-hydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) phosphate ammonium salt