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2,6-Diamino(N2,N6-diPac)-DMT-2'-O-TBDMS-purine riboside-CE-Phosphoramidite
2,6-Diamino(N2,N6-diPac)-DMT-2'-O-TBDMS-purine riboside-CE-phosphoramidite is a modified phosphoramidite reagent used for the synthesis of oligonucleotides. It features multiple protective groups: a dimethoxytrityl (DMT) group at the 5'-hydroxyl position, a tert-butyldimethylsilyl (TBDMS) group at the 2'-hydroxyl position, and cyanoethyl (CE) group on the phosphoramidite at the 3' position. These modifications ensure the stability and integrity of the purine riboside during the synthesis process, facilitating the creation of high-quality, stable oligonucleotides for research and therapeutic applications.
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Catalog
BRP-02200
Synonyms
(2R,3R,4R,5R)-5-(2,6-bis(2-phenoxyacetamido)-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Diaminopurine (di-PAC) CED phosphoramidite; 2,6-Diamino(N2,N6-diPhenoxyacetyl)-5'-O-(4,4'-Dimethoxytrityl)-2'-O-tert-butyldimethylsilyl-purine riboside-3'-cyanoethyl Phosphoramidite; DMT-2'-O-TBDMS-N2-Pac-A(N6-Pac) 3'-CE-Phosphoramidite
CAS
2101776-87-6
IUPAC Name
N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]-2-[(2-phenoxyacetyl)amino]purin-6-yl]-2-phenoxyacetamide
Molecular Weight
1167.37
Molecular Formula
C62H75N8O11PSi
Canonical SMILES
CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=C(N=C32)NC(=O)COC4=CC=CC=C4)NC(=O)COC5=CC=CC=C5)COC(C6=CC=CC=C6)(C7=CC=C(C=C7)OC)C8=CC=C(C=C8)OC
InChI
InChI=1S/C62H75N8O11PSi/c1-42(2)70(43(3)4)82(78-37-21-36-63)80-55-51(38-77-62(44-22-15-12-16-23-44,45-28-32-47(73-8)33-29-45)46-30-34-48(74-9)35-31-46)79-59(56(55)81-83(10,11)61(5,6)7)69-41-64-54-57(65-52(71)39-75-49-24-17-13-18-25-49)67-60(68-58(54)69)66-53(72)40-76-50-26-19-14-20-27-50/h12-20,22-35,41-43,51,55-56,59H,21,37-40H2,1-11H3,(H2,65,66,67,68,71,72)/t51-,55-,56-,59-,82?/m1/s1
InChIKey
LFCZZILBKNBHDI-IGXISVFNSA-N
Chemical Structure:
