Custom miRNA Inhibitor Synthesis

miRNA inhibitors are small, single-stranded RNAs that block endogenous mature miRNAs. BOC Sciences provides miRNA inhibitor synthesis services to accelerate miRNA research progress.

Introduction to miRNA Inhibitor

• What is miRNA Inhibitor

miRNA inhibitors are chemically modified to target miRNA in cells specifically. They are single-stranded RNA complementary to mature miRNA and are designed with methoxy modifications, which can specifically target and knock out a single miRNA molecule. Due to their easy access, simple operation, and short experimental cycle, miRNA inhibitors are expected to be new clinical research and cancer treatment strategy.

• Types of miRNA Inhibitors

1. AntagomiR with a single perfect miRNA target
2. A single perfect miRNA target stabilized by a terminal hairpin structure
3. A tough Decoy with two elevated miRNA targets
4. A shRNA targeting mature miRNA
5. A miRNA sponge with eight contiguous miRNA perfect targets
6. A sponge with eight contiguous bulging miRNA targets
7. A miRNA mask that binds and protects miRNA targets on mRNA

Fig. 1 Schematic representations of seven miRNA inhibitors (Bak RO, 2013)

• How miRNA Inhibitor Works

miRNA inhibitor is a drug that can inhibit the expression of miRNAs. Its mechanism of action is to inhibit miRNA expression by binding to miRNA, thus preventing the binding of miRNA to mRNA. Compared with traditional drugs, miRNA inhibitor has many advantages, such as strong targeting, long-lasting effect, and not easy to drug resistance.

• Applications of miRNA Inhibitor

1. Inhibits microRNA activity in vivo to study loss-of-function effects
2. Screens for miRNA that regulates gene expression and cell development
3. Studies of miRNA roles in biological processes, e.g., cell development, proliferation, differentiation and apoptosis
4. Discovers and validates endogenous miRNA targets

Our miRNA Inhibitor Synthesis Service Content

BOC Sciences' miRNA inhibitor synthesis service uses state-of-the-art synthesis technology and high-purity chemical raw materials to ensure the efficiency and stability of the synthesized product. Our miRNA inhibitor synthesis service is ideal for your research on miRNA regulatory mechanisms.

• Introduction to miRNA Inhibitor Service

1. Design and synthesis of miRNA inhibitors
   Design and synthesis of inhibitors with efficient targeting of miRNAs based on miRNA sequence information provided by customers.
2. Optimize the structure and performance of miRNA inhibitors
   Improve the stability, affinity and biological activity of miRNA inhibitors through chemical modification and structural optimization.
3. Validate the effectiveness of miRNA inhibitors
   Validate the effectiveness and safety of miRNA inhibitors through cellular and animal experiments.
4. Provide customized miRNA inhibitor service
   Provide customized miRNA inhibitor synthesis service according to customers' special needs.
5. Provide large-scale miRNA inhibitor production service
   Provide large-scale miRNA inhibitor production service according to customer's demand.
6. Provide miRNA inhibitor quality control and analysis services
   Through a variety of analytical techniques, we provide quality control and analysis of miRNA inhibitors to ensure product quality and stability.

• miRNA Inhibitor Ordering Information

Why Choose BOC Sciences' miRNA Inhibitor

• Experienced. BOC Sciences has many years of experience in miRNA inhibitor synthesis and is able to provide high quality synthesis services.
• High flexibility. BOC Sciences' miRNA inhibitor synthesis service is very flexible and can be customized to meet the needs of our customers.
• High purity. BOC Sciences' miRNA inhibitor synthesis service can provide high purity products to ensure the reliability of your experimental results.
• Fast delivery: BOC Sciences' miRNA inhibitor synthesis service allows for fast delivery and shortens your research cycle.
• Reasonable price. miRNA inhibitor synthesis services from BOC Sciences are affordable and able to meet the needs of our customers and provide high quality services.

Frequently Asked Questions (FAQ)

What are miRNA inhibitors and how do they work?

miRNA inhibitors are single-stranded RNA molecules that specifically target and block the activity of endogenous microRNAs (miRNAs). By binding to miRNA, they prevent miRNAs from interacting with their target mRNA, thereby inhibiting gene expression regulation.

What are the types of miRNA inhibitors offered by BOC Sciences?

BOC Sciences provides various types of miRNA inhibitors, including AntagomiR (for perfect miRNA targets), tough Decoy (with multiple miRNA targets), shRNA (targeting mature miRNA), miRNA sponges (with several contiguous miRNA targets), and miRNA masks (to protect targets on mRNA). These inhibitors are designed to effectively block miRNA activity.

What are the applications of miRNA inhibitors in research?

miRNA inhibitors are used to study the loss-of-function effects of miRNAs, screen for miRNAs that regulate gene expression, and explore their roles in biological processes like cell development, proliferation, differentiation, and apoptosis. They are also valuable for discovering and validating endogenous miRNA targets.

How does BOC Sciences ensure the quality of miRNA inhibitors?

At BOC Sciences, miRNA inhibitors undergo strict quality control during synthesis. We utilize advanced synthesis technology and high-purity chemicals to ensure the stability and efficiency of the product. In addition, we employ analytical techniques such as HPLC and mass spectrometry to verify product quality.

What chemical modifications can be applied to miRNA inhibitors?

BOC Sciences provides a range of chemical modifications to enhance the stability, affinity, and biological activity of miRNA inhibitors. These modifications help improve the inhibitor's performance in different experimental conditions and increase its effectiveness in targeting specific miRNAs.