Long RNA oligos are longer oligonucleotides than short RNA oligonucleotides, typically in the range of 50 - 200 nucleotides. As a well-known company in the field of biological sciences, BOC Sciences has accumulated rich expertise in providing high-quality services and products to the scientific community, and specializes in providing comprehensive solutions for long RNA oligonucleotide synthesis and related services.
BOC Sciences offers custom long RNA oligos synthesis services to meet individual project requirements. Our solid-phase synthesis service can prepare RNA oligonucleotides up to 300 nt in length. Our expert team utilizes advanced methodologies to ensure high-quality synthesis of long RNA oligos. We use high-quality reagents to ensure the accuracy and purity of our synthesized oligonucleotides. In addition, our enzymatic synthesis service can be used to prepare RNA oligonucleotides with modified nucleotides, which can be used in various applications.
Ligation of synthetic RNA fragments is a basic method of preparing long RNA. The desired modifications can be doped into oligonucleotides of the appropriate length by chemical synthesis, and then the individual fragments can be ligated to form full-length RNA.
Chemical ligation is a method of preparing large fragments of nucleic acids, ranging from the initial use of compounds such as cyanogen bromide, water-soluble carbodiimide, or 3-phosphate sulfate to click chemistry synthesis. It can be achieved by cycloaddition reactions between azides and alkyne-functionalized dissociates.
Chemical modifications are key to improve RNA pairing affinity, metabolic stability and cellular uptake, and are absolutely essential for the discovery and development of highly active RNA therapeutic candidates. Therefore, many chemical modifications have been developed to be introduced into RNA oligonucleotides to improve their thermal stability, serum stability, cellular activity or pharmacokinetic properties. RNA can also be used as a control for gene expression analyses, structural analyses as well as RNA-based diagnostic tests.
BOC Sciences is committed to being at the forefront of technological advancement. By utilizing state-of-the-art synthesis platforms and precision equipment, the company ensures the production of long RNA oligonucleotides of exceptional quality and consistency.
Strict quality control measures are implemented at every stage of the synthesis process to guarantee the accuracy, purity and integrity of long RNA oligos. Various analytical techniques including mass spectrometry and capillary electrophoresis are employed to ensure the highest quality standards are met.
BOC Sciences understands the unique requirements of each research project. Researchers can customize long RNA oligos by specifying desired length, sequence, modification, and purification options. This customization increases experimental flexibility and ensures that oligonucleotides are tailored to meet the specific needs of each project.
Our team of experts works closely with each client to understand their specific requirements and provide a custom solution to meet their needs.
BOC Sciences combines the knowledge of different business units to help you succeed in drug discovery and biomedical research. Contact us for more about your needs. The expertise of our scientists, engineers and support team are at your disposal.
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