Teprasiran is a small interfering RNA (siRNA) therapeutic that harnesses the mechanism of RNA interference (RNAi) to target and silence specific messenger RNA (mRNA) sequences responsible for the production of disease-related proteins. By binding to these mRNA molecules, teprasiran induces their degradation and prevents the synthesis of pathogenic proteins, thus interrupting the disease process at a molecular level.
Reference Reading
1. Bile duct injury outcomes following cholecystectomy: a cross sectional study
Sepehr Eslami, Lotfallah Abedini, Milad Kabiri Samani, Nazanin Vahedi Nouri, Mehdi Rabiee Am J Clin Exp Immunol . 2020 Jun 15;9(3):53-57.
Background:Considering the importance of the repairing time in patients with biliary duct injury, the aim of this study was to evaluate the outcomes of patents with bile duct injury following cholecystectomy.Methods:In this cross sectional study that was conducted on 64 patients with bile duct injury following cholecystectomy was referred to Shafa hospital in Tehran-Iran during 2010-2019 due to repair of biliary duct. Then patients were divided into two groups based on early and late referring time after bile duct injury, the postoperative outcomes were evaluated in two groups.Results:The alanine transaminase (ALT) and the aspartate aminotransferase (AST) in the late group were significantly higher than the early group. There were significant differences between the two groups based on the results of endoscopic retrograde cholangiopancreatography (ERCP) and magnetic resonance cholangiopancreatography (MRCP) (P < 0.05). The frequency of bile duct dilatation, cholangitis and itching in late group were significantly higher than early group, also the frequency of uncomplicated outcome in the early group were significantly more than late group (P < 0.05).Conclusion:The postoperative complication of biliary duct injury reduced, if patients diagnosed and referred at the same early stages (early referral).
2. Risk Factors Associated with Recurrent Pregnancy Loss and Outcome of Pre-Implantation Genetic Screening of Affected Couples
Azadeh Ghaheri, Babak Babaabasi, Fariba Ramezanali, Alireza Biglari, Mehdi Totonchi, Nayeralsadat Fatemi, Maryam Varkiani Int J Fertil Steril . 2021 Oct;15(4):269-274. doi: 10.22074/IJFS.2021.137626.1027.
Background:Recurrent pregnancy loss (RPL) is a multifactorial disorder which affects up to 5% of couples around the world. Several factors are considered to be involved in RPL; but, the etiology remains unexplained in 35-60% of cases. The aim of this study was to assess the frequency of risk factors associated with RPL in a group of our clinic clients, and their pre-implantation genetic screening (PGS) outcome.Materials and methods:We designed a retrospective descriptive study among, 602 Iranian couples referred to the Royan Reproductive Clinic (Tehran-Iran) from 2006 to 2018. Their karyotyping test and PGS outcomes were analyzed. PGS had been applied by array comparative genomic hybridization (array-CGH) on embryos from these patients. Also, karyotyping test had been performed using standard cytogenetic techniques.Results:G-banding analysis revealed a frequency of 15.61% chromosomal abnormalities in RPL couples. Also, the reciprocal translocations were more frequent (33/1204 cases) compared to the other structural abnormalities. Pregnancy rate per embryo transferred were 50% with array-CGH approach.Conclusion:Our findings could confirm a positive correlation between chromosomal abnormalities and RPL rate. Applying PGS for the RPL couples, leads to improvement of pregnancy success rate.
3. Inflammatory Markers in the Serum and Bronchoalveolar Lavage in Children with Non-Cystic Fibrosis Bronchiectasis
Esmaeil Mortaz, Maryam Hasanzad, Amir Rezaei, Hosseinali Ghaffaripour, Habib Emami, Ali Akbar Velayati, Alireza Mahdaviani Tanaffos . 2021 Apr;20(4):306-311.
Background:It is known that inflammatory responses occur in the airways of patients with non-cystic fibrosis bronchiectasis during respiratory exacerbations but the role of these cytokines is not clear in this condition. Herein we evaluated the levels of interleukin-1β (IL-1β), IL-8 and tumor necrosis factor α (TNF-α) in the serum and bronchoalveolar lavage among children with non-cystic fibrosis bronchiectasis.Materials and methods:This cross-sectional study was performed on all children with non-cystic fibrosis bronchiectasis who were admitted with respiratory exacerbation in the pediatric pulmonology ward of Masih Daneshvari Hospital, Tehran-Iran. All patients underwent fiberoptic bronchoscopy and spirometry before and after the bronchoscopy. IL-1β, IL-8, and TNF-α levels were measured in the serum and bronchoalveolar lavage.Results:Patients included 10 (59%) female and 7 (41%) male subjects with mean age of 13.8 years (range, 5-18). Mean values for forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) were below the normal range before and after bronchoscopy. Mean value for FVC (from 55% to 63%, P= 0.01) and FEV1 (from 60% to 64%, P= 0.26) increased after bronchoscopy compared to before that. IL-1β and IL-8 levels were increased and TNF-α level was decreased in the serum and bronchoalveolar lavage but no significant correlation was found between spirometry and these cytokines levels.Conclusion:Changes in inflammatory cytokines levels in serum and bronchoalveolar lavage during respiratory exacerbation in patients with noncystic fibrosis bronchiectasis have no significant correlation with spirometry and cannot be used in clinical practice.
