GL67 - CAS 179075-30-0 Catalog number: Model.CurrentData.Catalog

Genzyme Lipid 67 is a cholesterol derivatized with spermine to create a cationic lipid. GL67 has been proven to efficiently mediate gene transfer into mammalian cells and was a key formulation component that successfully completed clinical studies for the delivery of pDNA via inhalation.

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Synonyms
N4-Cholesteryl-Spermine HCl Salt
CAS
179075-30-0
IUPAC Name
[(3S)-10,13-dimethyl-17-(6-methylheptan-2-yl)-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-(3-aminopropyl)-N-[4-(3-aminopropylamino)butyl]carbamate
Molecular Weight
614.99
Molecular Formula
C38H70N4O2
Canonical SMILES
CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)N(CCCCNCCCN)CCCN)C)C
InChI
InChI=1S/C38H70N4O2/c1-28(2)11-8-12-29(3)33-15-16-34-32-14-13-30-27-31(17-19-37(30,4)35(32)18-20-38(33,34)5)44-36(43)42(26-10-22-40)25-7-6-23-41-24-9-21-39/h13,28-29,31-35,41H,6-12,14-27,39-40H2,1-5H3/t29?,31-,32?,33?,34?,35?,37?,38?/m0/s1
InChIKey
KBBLYWGVXTZWCU-JPEXWTJSSA-N
Boiling Point
690.9±55.0°C at 760 mmHg
Density
1.03±0.1 g/cm3
Storage
Store at -20°C
Description
Genzyme Lipid 67 is a cholesterol derivatized with spermine to create a cationic lipid. GL67 has been proven to efficiently mediate gene transfer into mammalian cells and was a key formulation component that successfully completed clinical studies for the delivery of pDNA via inhalation.

Chemical Structure:

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