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dG-CPG; 1000 Å is a reagent used in the solid-phase synthesis of oligonucleotides for incorporating N2-isobutyryl-deoxyguanosine (dG) residues. It includes a 5'-O-DMT (dimethoxytrityl) protective group, which protects the 5' end of the guanine base during synthesis. The N2-isobutyryl group protects the guanine's exocyclic amino group, and the 3'-suc (succinyl) linker connects the nucleoside to controlled pore glass (CPG) with a 2000 Å pore size. This configuration supports efficient synthesis and loading of long DNA sequences while ensuring precise incorporation and protection of guanine residues.
Chemical Structure: