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3'-DMT-T-Suc-CPG; 1000 Å
3'-DMT-T-Suc-CPG; 1000 Å is a reagent used in the solid-phase synthesis of oligonucleotides for incorporating thymine residues. It features a 3'-DMT protective group on the thymine base and a succinyl linker that connects the nucleoside to controlled pore glass (CPG) with a pore size of 1000 Å. This setup is ideal for synthesizing longer DNA sequences with precise thymine incorporation and facilitates efficient deprotection and release of the oligonucleotide from the solid support.
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Catalog
BRP-02250
Synonyms
3'-O-(4,4'-Dimethoxytrityl)-2'-deoxythymine-5'-Suc-CPG 1000 Å; 2'-deoxy-3'-O-DMT-thymine-5'-Suc-CPG 1000 Å; 2'-deoxy-3'-O-dimethoxytritylthymine-5'-Suc-CPG 1000 Å
Appearance
White powder
Storage
Store at 2-8 °C
Shipping
Room temperature.
Cleavage Conditions
Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.
Deprotection Conditions
When using fast deprotecting amidites (e.g., C-Ac; G-DMF; G-PAC), please use concentrated ammonia for 1h or AMA for 30 min at 60°C. When using standard amidites (e.g., C-Bz; G-iBu), please use concentrated ammonia for 5h at 60°C.
Chemical Structure:
