2'-O-Methyl-C(Bz)-Suc-CPG; 500 Å (RNA)

2'-O-Methyl-C(Bz)-Suc-CPG; 500 Å is a reagent used in the solid-phase synthesis of RNA oligonucleotides for incorporating 2'-O-methylcytidine residues. It features a benzoyl-protected cytosine base and a succinyl linker attached to controlled pore glass (CPG) with a 500 Å pore size. The 2'-O-methyl modification enhances the RNA's stability and resistance to enzymatic degradation, making this reagent ideal for synthesizing stable RNA sequences with precise cytosine incorporation.

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Catalog

BRP-02243

Synonyms

5'-O-(4,4'-Dimethoxytrityl)-N4-benzoyl-2'-O-methylacytosine-3'-Suc-CPG 500 Å; N4-Benzoyl-2'-O-methyl-5'-O-DMT-cytosine-3'-Suc-CPG 500 Å; N4-Benzoyl-2'-O-methyl-5'-O-dimethoxytritylcytosine-3'-Suc-CPG 500 Å

Appearance

White powder

Storage

Store at -20 °C

Symbol

2'-OMe-C-RNA-CPG

Shipping

Room temperature.

Cleavage Conditions

Use concentrated ammonia for 90 min at 25°C or 30 min at 60°C, or 1:1 ammonia:methylamine (AMA) for 25 min at 25°C when using fast deprotecting amidites.

Deprotection Conditions

When using fast deprotection amidites (such as C-Ac; G-DMF), use concentrated ammonia at 60°C for 1 hour or AMA for 30 minutes. When using standard amidites (such as C-Bz; G-iBu), please use concentrated ammonia at 60°C for 5 hours. Compatible with the deprotection chemicals used by 2' Fluoro; 2' modified phosphoramidite and TBDMS protected reagents.

Chemical Structure:

Reference Reading

1. Border-zone and watershed infarctions

Cataldo D'Amore, Maurizio Paciaroni. Front Neurol Neurosci. 2012;30:181-4. doi: 10.1159/000333638.

Border-zone (BZ) and watershed infarcts occur at the junction of two artery territories and are precipitated by a hemodynamic impairment although they cannot be excluded from microembolic etiology. These strokes may often be preceded by specifically precipitating circumstances that induce hypotension and/or hypovolemia (rising from a supine position, exercise, Valsalva's maneuver, administration of antihypertensive drugs, bleeding and anemia). Anterior BZ infarction occurs with a motor deficit of one or both contralateral limbs, associated with aphasia or mood disturbance. Campimetric disturbances are a constant feature of posterior BZ infarct associated with fluent aphasia and hemihypoesthesia. Subcortical and capsule-thalamic BZ infarctions often mimic lacunar syndrome due to small-vessel disease. Cerebellar BZ infarction is associated with non-specific vertigo syndrome or ataxia, while in brainstem BZ infarction patients are comatose with other signs of brainstem being compromised.

2. Transport properties of MoS2/V7(Bz)8 and graphene/V7(Bz)8 vdW junctions tuned by bias and gate voltages

Hong Yu, Danting Li, Yan Shang, Lei Pei, Guiling Zhang, Hong Yan, Long Wang. RSC Adv. 2022 Jun 13;12(27):17422-17433. doi: 10.1039/d2ra02196j.

The MoS2/V7(Bz)8 and graphene/V7(Bz)8 vdW junctions are designed and the transport properties of their four-terminal devices are comparatively investigated based on density functional theory (DFT) and the nonequilibrium Green's function (NEGF) technique. The MoS2 and graphene nanoribbons act as the source-to-drain channel and the spin-polarized one-dimensional (1D) benzene-V multidecker complex nanowire (V7(Bz)8) serves as the gate channel. Gate voltages applied on V7(Bz)8 exert different influences of electron transport on MoS2/V7(Bz)8 and graphene/V7(Bz)8. In MoS2/V7(Bz)8, the interplay of source and gate bias potentials could induce promising properties such as negative differential resistance (NDR) behavior, output/input current switching, and spin-polarized currents. In contrast, the gate bias plays an insignificant effect on the transport along graphene in graphene/V7(Bz)8. This dissimilarity is attributed to the fact that the conductivity follows the sequence of MoS2 < V7(Bz)8 < graphene. These transport characteristics are examined by analyzing the conductivity, the currents, the local density of states (LDOS), and the transmission spectra. These results are valuable in designing multi-terminal nanoelectronic devices.

3. Liquid Marble Photosensor

Andrew Adamatzky, Michail-Antisthenis Tsompanas, Thomas C Draper, Claire Fullarton, Richard Mayne. Chemphyschem. 2020 Jan 3;21(1):90-98. doi: 10.1002/cphc.201900949.

A liquid marble is a liquid droplet coated by a hydrophobic powder. The liquid marble does not wet adjacent surfaces and therefore can be manipulated as a dry soft body. A Belousov-Zhabotinsky (BZ) reaction is an oscillatory chemical reaction exhibiting waves of oxidation. We demonstrate how to make a photo-sensor from BZ medium liquid marbles. We insert electrodes into a liquid marble, prepared from BZ solution and coated with polyethylene powder. The electrodes record a potential difference which oscillates due to oxidation wave-fronts crossing the electrodes. When the BZ marble is illuminated by a light source, the oxidation wave-fronts are hindered and, thus, the electrical potential recorded ceases to oscillate. We characterise several types of responses of BZ marble photosensors to various stimuli, and provide explanations of the recorded activity. BZ liquid marble photosensors may find applications in the fields of liquid electronics, soft robotics and unconventional computing.