CAS 2131025-83-5 Cimdelirsen sodium

Cimdelirsen sodium

Cimdelirsen sodium is a small interfering RNA (siRNA) therapeutic designed to target and silence specific messenger RNA (mRNA) sequences associated with disease-related proteins. By utilizing the RNA interference (RNAi) mechanism, cimdelirsen sodium binds to its target mRNA, promoting its degradation and preventing the production of harmful proteins. Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

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Catalog

BRP-02091

Synonyms

ISIS 766720 sodium; ISIS-766720 sodium; ISIS766720 sodium; IONIS-GHR-LRx sodium; DNA, d([2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]m5rC-sp-T-sp-T-sp-T-sp-G-sp-G-sp-G-sp-T-sp-G-sp-A-sp-A-sp-[2'-O-(2-methoxyethyl)]m5rU-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2-methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA), 5'-[26-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[6-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]hexyl]amino]-3-oxopropoxy]methyl]-8,12,19-trioxo-16-oxa-7,13,20-triazahexacos-1-yl hydrogen phosphate], sodium salt (1:20); Cimderlirsen sodium; IONIS-GHR-LRx; ISIS 766720, sodiated

CAS

2131025-83-5

Molecular Weight

9128.16

Molecular Formula

C296H415N83Na20O152P20S15

Sequence

RNA, (ccacctttgggtgaauagca), sodium salt (1:20)

Related CAS

2131025-82-4 (free acid)

Cimdelirsen sodium - CAS 2131025-83-5

Cimdelirsen sodium