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Lumasiran sodium - CAS 1834612-06-4

Catalog number: BRP-02073

Lumasiran sodium

Lumasiran sodium is a siRNA product that reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

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Catalog
BRP-02073
Synonyms
ALN-G01 sodium; Oxlumo; RNA, (Gm-sp-Am-sp-Cm-Um-Um-Um-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Um-Gm-Gm-Am-Am-Am-Um-Am-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate] sodium salt, complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-Um-Am-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Am-Gm-Gm-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Am-Am-Gm-Um-Cm-sp-Cm-sp-Am) sodium salt (1:21:1:22)
CAS
1834612-06-4
Molecular Weight
17,286 Da
Molecular Formula
C530H669F10N173O320P43S6Na43
Appearance
White to off-white solid
Storage
Store at -20 °C, stored under nitrogen, away from moisture
Sequence
RNA, (uauauuuccaggaugaaagucca) sodium salt, complex with RNA (gacuuucauccuggaaauaua), sodium salt (1:21:1:22)
Related CAS
1834610-13-7 (free acid)

Chemical Structure:


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