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Lumasiran - CAS 1834610-13-7

Catalog number: BRP-02067

Lumasiran

Lumasiran is a siRNA product that reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

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Ordering Information
Catalog Number Size Price Stock Quantity
BRP-02067 5 mg $1688 In stock
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Catalog
BRP-02067
Synonyms
ALN-G01; RNA, (Gm-sp-Am-sp-Cm-Um-Um-Um-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Um-Gm-Gm-Am-Am-Am-Um-Am-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-Um-Am-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Am-Gm-Gm-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Am-Am-Gm-Um-Cm-sp-Cm-sp-Am) (1:1)
CAS
1834610-13-7
Molecular Weight
16,340 Da
Molecular Formula
C530H712F10N173O320P43S6
Purity
98% by SEC-HPLC
Solubility
Soluble in Water
Appearance
White to off-white Solid
Storage
Store at -20 °C, stored under nitrogen, away from moisture
Sequence
RNA, (uauauuuccaggaugaaagucca), complex with RNA (gacuuucauccuggaaauaua) (1:1)
Related CAS
1834612-06-4 (sodium)

Chemical Structure:


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