Name: Cemdisiran
Brand: BOC Sciences
Rating: 5 (1 reviews)

Cemdisiran

Cemdisiran is an N-acetylgalactosamine (GalNAc) conjugated siRNA for the treatment of complement-mediated diseases by suppressing liver production of complement 5 (C5) protein.

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Catalog

BRP-02069

Synonyms

ALN-CC5; RNA, (Am-sp-Am-sp-(2'-deoxy-2'-fluoro)G-Cm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Um-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)A-Am-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-Am-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-Am-Um-Am-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)G-Cm-Um-Um-sp-Um-sp-Um-dT-dT) (1:1); siRNA ALN-CC5; Small interfering RNA ALN CC5; Small interfering RNA Cemdisiran

CAS

1639264-46-2

Molecular Weight

16782.53

Molecular Formula

C542H711F17N169O330P45S6

Solubility

Soluble in Water

Appearance

White to off-white solid

Storage

Store at 2-8 °C, sealed storage, away from moisture

Sequence

RNA, (uauuauaaaaauaucuugcuuuutt), complex with RNA (aagcaagauauuuuuauaaua) (1:1)

Chemical Structure:

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Cemdisiran - CAS 1639264-46-2

Cemdisiran