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Thiol-Modifier C6 S-S
Thiol-Modifier C6 S-S incorporates a thiol reactive functional group for conjugation. This disulphide product can also be used to modify the 3'-position by using the phosphoramidite as the first adduct in the oligo sequence.
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Catalog
BRP-02226
Synonyms
1-O-Dimethoxytrityl-hexyl-disulfide, 1'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; Thiol-Modifier C6 S-S CE Phosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 6-[[6-[bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl 2-cyanoethyl ester; N,N-Bis(1-methylethyl)phosphoramidous Acid [[6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl 2-Cyanoethylester; 6-[[6-[Bis(4-methoxyphenyl)phenylmethoxy]hexyl]dithio]hexyl 2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite
CAS
148254-21-1
IUPAC Name
3-[6-[6-[bis(4-methoxyphenyl)-phenylmethoxy]hexyldisulfanyl]hexoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
Molecular Weight
769.05
Molecular Formula
C42H61N2O5S2P
Canonical SMILES
CC(C)N(C(C)C)P(OCCCCCCSSCCCCCCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC)OCCC#N
InChI
InChI=1S/C42H61N2O5PS2/c1-35(2)44(36(3)4)50(49-32-18-29-43)48-31-15-8-10-17-34-52-51-33-16-9-7-14-30-47-42(37-19-12-11-13-20-37,38-21-25-40(45-5)26-22-38)39-23-27-41(46-6)28-24-39/h11-13,19-28,35-36H,7-10,14-18,30-34H2,1-6H3
InChIKey
VEONRKLBSGQZRU-UHFFFAOYSA-N
Boiling Point
757.4±60.0 °C at 760 mmHg
Purity
>95% by HPLC
Appearance
Colorless oily matter
Storage
Store at -20 °C
Chemical Structure:
Reference Reading
1.The p53-like Protein CEP-1 Is Required for Meiotic Fidelity in C. elegans.
Mateo AF1, Kessler Z2, Jolliffe AK1, McGovern O2, Yu B3, Nicolucci A3, Yanowitz JL4, Derry WB5. Curr Biol. 2016 Apr 13. pii: S0960-9822(16)30246-9. doi: 10.1016/j.cub.2016.03.036. [Epub ahead of print]
The passage of genetic information during meiosis requires exceptionally high fidelity to prevent birth defects and infertility. Accurate chromosome segregation during the first meiotic division relies on the formation of crossovers between homologous chromosomes and a series of precisely controlled steps to exchange genetic information. Many studies have hinted at a role for p53 in meiosis, but how it functions in this process is poorly understood. Here, we have identified a cooperative role for the p53-like protein CEP-1 and the meiotic protein HIM-5 in maintaining genome stability in the C. elegans germline. Loss of cep-1 and him-5 results in synthetic lethality that is dependent on the upstream DNA damage checkpoint but independent of the downstream core apoptotic pathway. We show that this synthetic lethality is the result of defective crossover formation due to reduced SPO-11-dependent double-strand breaks. Using cep-1 separation-of-function alleles, we show that cep-1 and him-5 also suppress inappropriate activation of the nonhomologous end joining (NHEJ) pathway.
