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N4-Bz-5'-O-DMTr-2'-O-Me-cytidine-3'-CED-phosphoramidite
N4-Bz-5'-O-DMTr-2'-O-Me-cytidine-3'-CED-phosphoramidite is a modified phosphoramidite designed for use in the synthesis of stable and efficient oligonucleotides. Its protective groups and modifications enhance the stability of the resulting nucleic acids and facilitate their incorporation into nucleic acid chains during solid-phase synthesis. This compound is crucial in the production of antisense oligonucleotides, siRNA, probes, and primers, providing enhanced resistance to enzymatic degradation and improved performance in various applications.
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Catalog
BRP-02177
Synonyms
N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methycytidine-3'-O-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite; 2'-O-Me-C(Bz)-3'-phosphoramidite; 2'-OMe-Bz-C Phosphoramidite; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methylcytidine 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-3'-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-2'-O-methylcytidine; N4-Benzoyl-5'-O-DMT-2'-O-methylcytidine 3'-CE phosphoramidite
CAS
110764-78-8
IUPAC Name
N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
Molecular Weight
863.93
Molecular Formula
C47H54N5O9P
Canonical SMILES
CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OC)N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC
InChI
InChI=1S/C47H54N5O9P/c1-32(2)52(33(3)4)62(59-30-14-28-48)61-42-40(60-45(43(42)57-7)51-29-27-41(50-46(51)54)49-44(53)34-15-10-8-11-16-34)31-58-47(35-17-12-9-13-18-35,36-19-23-38(55-5)24-20-36)37-21-25-39(56-6)26-22-37/h8-13,15-27,29,32-33,40,42-43,45H,14,30-31H2,1-7H3,(H,49,50,53,54)/t40-,42-,43-,45-,62?/m1/s1
InChIKey
JFFSFQRVIPPCBC-VKBHKTMGSA-N
Purity
≥95%
Appearance
White Powder
Storage
Store at -20 °C
Chemical Structure:
