Nucleosides - RNA / BOC Sciences

N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine

Description: N4-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine is a valuable compound extensively used in the biomedical industry acting as a key intermediate for the synthesis of nucleotides and nucleosides. This product finds application in the development of antiviral drugs targeting various diseases caused by viral infections.

CAT: BRP-00165

CAS: 81256-87-3

MF: C43H49N3O8Si

MF: 763.95

Purity: ≥98% by HPLC

Appearance: White to Light Yellow Powder to Crystalline Powder

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Storage: Store at -20°C

Density: 1.2±0.1 g/cm3

InChIKey: AOXWVTIMEGOVNF-PKGPUZNISA-N

CanonicalSMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=CC(=NC2=O)NC(=O)C3=CC=CC=C3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C43H49N3O8Si/c1-42(2,3)55(6,7)54-38-37(47)35(53-40(38)46-27-26-36(45-41(46)49)44-39(48)29-14-10-8-11-15-29)28-52-43(30-16-12-9-13-17-30,31-18-22-33(50-4)23-19-31)32-20-24-34(51-5)25-21-32/h8-27,35,37-38,40,47H,28H2,1-7H3,(H,44,45,48,49)/t35-,37-,38-,40-/m1/s1

Synonyms: 5'-DMT-2'-tBDSilyl Cytidine (n-bz); 5'-DMT-2'-TBDMS-Bz-rC; 5'-O-DMT-2'-O-TBDMS-N-Bz-Cytidine; N-(1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N-benzoylcytidine; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[tert-butyl(dimethyl)silyl]cytidine; N4-Benzoyl-2'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)cytidine

5'-O-DMT-N2-DMF-guanosine

Description: 5'-O-DMT-N2-DMF-guanosine, a remarkably powerful nucleoside analog, assumes a crucial role in the realm of biomedicine in combatting select malignancies. Its extraordinary molecular architecture endows it with the ability to impede the proliferation of neoplastic cells via targeted interference with distinct signaling cascades. By virtue of this distinct attribute, this compound holds potential for augmented therapeutic efficacy and mitigated untoward ramifications when used concomitantly with other chemotherapeutic agents.

CAT: BRP-00166

CAS: 126922-60-9

MF: C34H36N6O7

MF: 640.69

Purity: ≥98% by HPLC

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Density: 1.4±0.1 g/cm3

InChIKey: FWBIVABFLXJWQH-NXKHUQPWSA-N

CanonicalSMILES: CN(C)C=NC1=NC(=O)C2C(=N1)N(C=N2)C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)O

IUPAC Name: N'-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-6-oxo-5H-purin-2-yl]-N,N-dimethylmethanimidamide

InChI: InChI=1S/C34H36N6O7/c1-39(2)19-36-33-37-30-27(31(43)38-33)35-20-40(30)32-29(42)28(41)26(47-32)18-46-34(21-8-6-5-7-9-21,22-10-14-24(44-3)15-11-22)23-12-16-25(45-4)17-13-23/h5-17,19-20,26-29,32,41-42H,18H2,1-4H3/b36-19+/t26-,27?,28-,29-,32-/m1/s1

Synonyms: 5'-DMT-DMF-rG; 5'-O-(4,4'-Dimethoxytrityl)-N2-DMF-Guanosine; 5'-O-DMT-N2-DMF-rG; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-N-[(dimethylamino)methylene]guanosine; N'-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-N,N-dimethylformimidamide; 5'-O-DMT-G(DMF)

N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]cytidine

Description: N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]cytidine is a chemical compound used in the synthesis of oligonucleotides. This compound features a cytidine nucleoside that has been modified with a benzoyl (bz) group protecting the amino group at the N4 position and a bis(4-methoxyphenyl)phenylmethyl (commonly known as dimethoxytrityl or DMT) group protecting the 5' hydroxyl position. These protective groups prevent unwanted side reactions during the stepwise assembly of nucleotide chains in automated DNA or RNA synthesis, ensuring efficient and precise production of oligonucleotides. This reagent is essential for various applications in molecular biology, genetic research, and the development of nucleic acid-based therapeutics.

CAT: BRP-00167

CAS: 81246-76-6

MF: C37H35N3O8

MF: 649.69

Purity: ≥95%

Appearance: Yellow Solid

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Storage: Store at -20°C

Density: 1.3±0.1 g/cm3

Melting Point: 132-135°C

InChIKey: KCLOEKUQZJAMFG-NHASGABXSA-N

Solubility: Soluble in Chloroform, Dichloromethane, DMSO, Methanol

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C37H35N3O8/c1-45-28-17-13-26(14-18-28)37(25-11-7-4-8-12-25,27-15-19-29(46-2)20-16-27)47-23-30-32(41)33(42)35(48-30)40-22-21-31(39-36(40)44)38-34(43)24-9-5-3-6-10-24/h3-22,30,32-33,35,41-42H,23H2,1-2H3,(H,38,39,43,44)/t30-,32-,33-,35-/m1/s1

Synonyms: 5'-DMT Cytidine (n-bz); 5'-O-(4,4'-Dimethoxytrityl)-N4-benzoylcytidine; Cytidine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-; N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide; N-Benzoyl-5'-O-(4,4'-dimethoxytrityl)cytidine; N4-Benzoyl-5'-O-DMT-D-cytidine; N-Benzoyl-5'-(di-p-methoxytrityl)cytidine

5'-O-DMT-inosine

Description: 5'-O-DMT-inosine is also known as 5'-O-dimethoxytrityl inosine, beholding immense significance primarily in the realm of nucleotide and nucleoside research. Notably, its profound properties have positioned it as a crucial catalyst in the intricate process of formulating cutting-edge antiviral medications .

CAT: BRP-00168

CAS: 119898-59-8

MF: C31H30N4O7

MF: 570.59

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at -20 °C

Density: 1.4±0.1 g/cm3

Boiling Point: 833.3±75.0°C at 760 mmHg

InChIKey: PQXVLEMIGAJLIN-BQOYKFDPSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=NC6=C5N=CNC6=O)O)O

IUPAC Name: 9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C31H30N4O7/c1-39-22-12-8-20(9-13-22)31(19-6-4-3-5-7-19,21-10-14-23(40-2)15-11-21)41-16-24-26(36)27(37)30(42-24)35-18-34-25-28(35)32-17-33-29(25)38/h3-15,17-18,24,26-27,30,36-37H,16H2,1-2H3,(H,32,33,38)/t24-,26-,27-,30-/m1/s1

Synonyms: 5'-O-DMTr-Inosine; 5'-DMT-rI; 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]inosine; 9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 5'-O-(4,4'-Dimethoxytrityl)inosine

N4-Acetyl-5'-O-DMT-cytidine

Description: N4-Acetyl-5'-O-DMT-cytidine is a prominent biochemical compound with antiviral properties, used for studying an array of viral afflictions. Its potency lies in its remarkable ability to impede the replication of distinct viral strains.

CAT: BRP-00170

CAS: 121058-82-0

MF: C32H33N3O8

MF: 587.63

Purity: 98%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 1.32±0.1 g/cm3 (Predicted)

InChIKey: AFQGZOMSSIQDMD-PYYPWFDZSA-N

CanonicalSMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)O

IUPAC Name: N-[1-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C32H33N3O8/c1-20(36)33-27-17-18-35(31(39)34-27)30-29(38)28(37)26(43-30)19-42-32(21-7-5-4-6-8-21,22-9-13-24(40-2)14-10-22)23-11-15-25(41-3)16-12-23/h4-18,26,28-30,37-38H,19H2,1-3H3,(H,33,34,36,39)/t26-,28-,29-,30-/m1/s1

Synonyms: 5'-DMT Cytidine (n-acetyl); 5'-DMT-Ac-rC; N-Acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]cytidine; 5'-O-(4,4'-Dimethoxytrityl)-N4-acetylcytidine; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)cytidine; N-(1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)acetamide

N6-Benzoyl-5'-O-DMT-adenosine

Description: N6-Benzoyl-5'-O-DMT-adenosine is an indispensable compound, serving multifarious applications in studying ailments such as cancer and neurodegenerative disorder.

CAT: BRP-00171

CAS: 81246-82-4

MF: C38H35N5O7

MF: 673.71

Purity: ≥95%

Appearance: White to Off-white Crystalline Powder

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Storage: Store at 2-8°C

Density: 1.36±0.1 g/cm3

InChIKey: QPHBEJADZCSKCY-GONXPTGJSA-N

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)NC(=O)C7=CC=CC=C7)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3,4-dihydroxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C38H35N5O7/c1-47-28-17-13-26(14-18-28)38(25-11-7-4-8-12-25,27-15-19-29(48-2)20-16-27)49-21-30-32(44)33(45)37(50-30)43-23-41-31-34(39-22-40-35(31)43)42-36(46)24-9-5-3-6-10-24/h3-20,22-23,30,32-33,37,44-45H,21H2,1-2H3,(H,39,40,42,46)/t30-,32-,33-,37-/m1/s1

Synonyms: 5'-DMT Adenosine (n-bz); 5'-O-DMT-N6-Bz Adenosine; N6-Benzoyl-5'-O-DMT-D-adenosine; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl adenosine; 5'-DMT-Bz-rA; 5'-O-DMTr-N6-benzoyladenosine; N-benzoyl-5'-0-[bis(4-methoxyphenyl]phenylmethyl]adenosine; 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N6-benzoyladenosine

2'-Deoxy-5'-O-DMT-uridine

Description: 2'-Deoxy-5'-O-DMT-uridine, an esteemed compound employed in biomedicine, holds immense value. It finds frequent application in pharmaceutical research, specifically in designing antiviral drugs that combat RNA-based viruses.

CAT: BRP-00172

CAS: 23669-79-6

MF: C30H30N2O7

MF: 530.57

Purity: ≥98% by HPLC

Appearance: White to Pale Yellow Crystalline Powder

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Storage: Store at -20°C

Density: 1.294±0.06 g/cm3

Melting Point: 120 °C

InChIKey: BYGKUWPLEGHFKX-ZRRKCSAHSA-N

Solubility: Soluble in Acetonitrile (20 mg/mL)

CanonicalSMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(CC(O4)N5C=CC(=O)NC5=O)O

IUPAC Name: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C30H30N2O7/c1-36-23-12-8-21(9-13-23)30(20-6-4-3-5-7-20,22-10-14-24(37-2)15-11-22)38-19-26-25(33)18-28(39-26)32-17-16-27(34)31-29(32)35/h3-17,25-26,28,33H,18-19H2,1-2H3,(H,31,34,35)/t25-,26+,28+/m0/s1

Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine; 5'-O-DMT-dU; 2'-Deoxy-5'-O-DMT-D-uridine; 5'-O-DMT-2'-deoxyuridine; 5'-O-(Bis(4-methoxyphenyl)benzyl)-2'-deoxyuridine; 1-[(2R,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxyoxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 2'-Deoxy-5'-O-(4,4'-dimethoxytrityl)uridine; 5'-O-[α,α-bis(p-methoxyphenyl)benzyl]-2'-deoxy-Uridine

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-deoxyuridine

Description: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-2'-deoxyuridine is a modified deoxyuridine nucleoside used in oligonucleotide synthesis. It contains a 1,1,3,3-tetraisopropyl-1,3-disiloxane linker connecting the 3' and 5' positions of the sugar moiety, thereby protecting it. This modification helps ensure stability during synthesis. As a result, precise and efficient oligonucleotide assembly can be achieved for various molecular biology and biotechnology applications.

CAT: BRP-00173

CAS: 98495-56-8

MF: C21H38N2O6Si2

MF: 470.72

Purity: ≥97%

Appearance: White to off-white powder

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Density: 1.12±0.1 g/cm3

InChIKey: PEDMJTBGYAMVDO-NLWGTHIKSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(CC(O2)N3C=CC(=O)NC3=O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: 1-[(6aR,8R,9aS)-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C21H38N2O6Si2/c1-13(2)30(14(3)4)26-12-18-17(28-31(29-30,15(5)6)16(7)8)11-20(27-18)23-10-9-19(24)22-21(23)25/h9-10,13-18,20H,11-12H2,1-8H3,(H,22,24,25)/t17-,18+,20+/m0/s1

Synonyms: 2'-Deoxy-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)uridine; 2'-Deoxy-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]uridine; 5',3'-O-(1,1,3,3-Tetraisopropyldisiloxane-1,3-diyl)-2'-deoxyuridine; 2'-Deoxy-3',5'-TIPDS-Ur; 3',5'-TIPS-2'-dU

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-5-methyluridine

Description: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)-5-methyluridine, a remarkably powerful biomedicine, is harnessed in the treatment of an array of afflictions. Unearthed on diverse biomedical platforms, this compound unfurls unparalleled therapeutic potential in vanquishing cancer, combating viral infections, and mitigating genetic disorders. Its profound mechanism revolves around meticulously targeting and steering distinct cellular pathways, paving the way for gene expression modulation, viral replication inhibition, and impeding tumor proliferation.

CAT: BRP-00174

CAS: 130983-87-8

MF: C22H40N2O7Si2

MF: 500.73

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.16±0.1 g/cm3

InChIKey: FXSUFWJWZYCZNU-ANTGDGSKSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C(C3C(O2)CO[Si](O[Si](O3)(C(C)C)C(C)C)(C(C)C)C(C)C)O

IUPAC Name: 1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C22H40N2O7Si2/c1-12(2)32(13(3)4)28-11-17-19(30-33(31-32,14(5)6)15(7)8)18(25)21(29-17)24-10-16(9)20(26)23-22(24)27/h10,12-15,17-19,21,25H,11H2,1-9H3,(H,23,26,27)/t17-,18-,19-,21-/m1/s1

Synonyms: 3',5'-TIPS-5-Me Uridine; 3',5'-TIPS-5-methyluridine; 5-Methyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]uridine; 3',5'-O-(Tetraisopropyldisiloxanediyl)-5-methyluridine; 3',5'-TIPDS-5-Me-Ur; 3',5'-O-(Tetraisopropyldisiloxane-1,3-diyl)-5-methyl-uridine

N4-Acetyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine

Description: N4-Acetyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine, a remarkable biomedical entity, exhibits profound efficacy in addressing specific ailments and pathologies. In the realm of biomedicine, this compound has garnered immense attention owing to its auspicious implications in the synthesis of antiviral agents and nucleoside analogs targeting diverse viral afflictions.

CAT: BRP-00175

CAS: 85335-73-5

MF: C23H41N3O7Si2

MF: 527.76

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.24±0.1 g/cm3

InChIKey: DQGHXFWTOQROJQ-ZHHKINOHSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=CC(=NC3=O)NC(=O)C)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: N-[1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C23H41N3O7Si2/c1-13(2)34(14(3)4)30-12-18-21(32-35(33-34,15(5)6)16(7)8)20(28)22(31-18)26-11-10-19(24-17(9)27)25-23(26)29/h10-11,13-16,18,20-22,28H,12H2,1-9H3,(H,24,25,27,29)/t18-,20-,21-,22-/m1/s1

Synonyms: 3',5'-O-TIPPS-N4-acetylcytidine; N4-Acetyl-3',5'-O-TIPPS-cytidine; N-Acetyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]cytidine; N4-Acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine; 3',5'-TIPS-N-Ac-Cytidine

3',5'-TIPS-N-Ac-Adenosine

Description: 3',5'-TIPS-N-Ac-Adenosine, a crucial nucleoside employed in biomedicine, exhibits remarkable anti-inflammatory prowess. Its immunosuppressive effects enable the management of allergic ailments such as asthma and allergic rhinitis.

CAT: BRP-00176

CAS: 828247-65-0

MF: C24H41N5O6Si2

MF: 551.78

Purity: ≥95%

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Density: 1.29±0.1 g/cm3 (Predicted)

InChIKey: ZULOPXIJTCCZDJ-UMCMBGNQSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=NC4=C(N=CN=C43)NC(=O)C)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: N-[9-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]purin-6-yl]acetamide

InChI: InChI=1S/C24H41N5O6Si2/c1-13(2)36(14(3)4)32-10-18-21(34-37(35-36,15(5)6)16(7)8)20(31)24(33-18)29-12-27-19-22(28-17(9)30)25-11-26-23(19)29/h11-16,18,20-21,24,31H,10H2,1-9H3,(H,25,26,28,30)/t18-,20-,21-,24-/m1/s1

Synonyms: N-Acetyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine; 3',5'-TIPS-N-Acetyl-adenosine; N-Acetyl-3'-O,5'-O-[oxybis(diisopropylsilanediyl)]adenosine; N6-Acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)-adenosine; N-{9-[(6aR,8R,9R,9aS)-9-Hydroxy-2,2,4,4-tetraisopropyltetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-9H-purin-6-yl}acetamide

3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine

Description: 3',5'-O-(1,1,3,3-Tetraisopropyl-1,3-disiloxanediyl)uridine, a bioactive agent synthesized for biomedical applications, demonstrates exceptional efficacy in combating specific viral infections namely, hepatitis C and respiratory syncytial virus (RSV). By exerting potent antiviral effects, this compound significantly impedes viral replication, culminating in the effective prevention and management of these viral infections.

CAT: BRP-00177

CAS: 69304-38-7

MF: C21H38N2O7Si2

MF: 486.71

Purity: ≥98% by HPLC

Appearance: White to off-white crystalline powder

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Storage: Store at RT

Density: 1.17±0.1 g/cm3

Melting Point: 75-76 °C

InChIKey: KKLQDUCRZCCKHG-VBSBHUPXSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=CC(=O)NC3=O)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: 1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C21H38N2O7Si2/c1-12(2)31(13(3)4)27-11-16-19(29-32(30-31,14(5)6)15(7)8)18(25)20(28-16)23-10-9-17(24)22-21(23)26/h9-10,12-16,18-20,25H,11H2,1-8H3,(H,22,24,26)/t16-,18-,19-,20-/m1/s1

Synonyms: 3',5'-TIPS-Uridine; 3',5'-TIPPS-uridine; 3',5'-O-[1,1,3,3-Tetrakis(1-methylethyl)-1,3-disiloxanediyl]uridine; 3',5'-O-(1,1,3,3-Tetraisopropyldisiloxan-1,3-diyl)uridine; 3',5'-O-(Tetraisopropyldisiloxanediyl)uridine; 3',5'-TIPDS-Ur

N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)guanosine

Description: N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)guanosine is a compound, exhibiting great application for studying distinctive maladies. Its usage encompasses the development of pharmaceutical drugs that precisely modulate guanosine metabolism.

CAT: BRP-00178

CAS: 87865-78-9

MF: C26H45N5O7Si2

MF: 595.84

Purity: ≥95%

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InChIKey: RYRMXMSXLHPLAT-GUQHISFFSA-N

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C4C(O3)CO[Si](O[Si](O4)(C(C)C)C(C)C)(C(C)C)C(C)C)O

IUPAC Name: N-[9-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C26H45N5O7Si2/c1-13(2)23(33)29-26-28-22-19(24(34)30-26)27-12-31(22)25-20(32)21-18(36-25)11-35-39(14(3)4,15(5)6)38-40(37-21,16(7)8)17(9)10/h12-18,20-21,25,32H,11H2,1-10H3,(H2,28,29,30,33,34)/t18-,20-,21-,25-/m1/s1

Synonyms: N2-Isobutyryl-3',5'-O-TIPPS-guanosine; 3',5'-O-TIPPS-N2-isobutyrylguanosine; N2-Isobutyryl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-D-guanosine; 9-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]-N2-isobutyrylguanine; N2-isobutyryl-9-[3,5-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl]guanine; 3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-N2-isobutyroylguanosine; 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-N2-isobutyrylguanosine; N2-iBu-3',5'-TIPDS-Gr; N2-iBu-3',5'-O-TIPDS-guanosine

N4-Benzoyl-3 ,5 -O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine

Description: N4-Benzoyl-3,5-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine, a formidable biomedical agent, stands as a beacon of hope in the realm of viral infection treatment. Acutely attuned to cytidine-sensitive viruses, this compound, hailing from the prestigious nucleoside analog drug family, adroitly disrupts the replication mechanism ensnaring the targeted foes.

CAT: BRP-00179

CAS: 69304-43-4

MF: C28H43N3O7Si2

MF: 589.83

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

Density: 1.23±0.1 g/cm3(Predicted)

Melting Point: 101 °C

InChIKey: NFIAUHQTSCWVMS-LYPBTDJXSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=CC(=NC3=O)NC(=O)C4=CC=CC=C4)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: N-[1-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]-2-oxopyrimidin-4-yl]benzamide

InChI: InChI=1S/C28H43N3O7Si2/c1-17(2)39(18(3)4)35-16-22-25(37-40(38-39,19(5)6)20(7)8)24(32)27(36-22)31-15-14-23(30-28(31)34)29-26(33)21-12-10-9-11-13-21/h9-15,17-20,22,24-25,27,32H,16H2,1-8H3,(H,29,30,33,34)/t22-,24-,25-,27-/m1/s1

Synonyms: N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-Cytidine; 3',5'-TIPS-N-Bz-Cytidine; N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine; 3',5'-TIPS-N4-Benzoyl-cytidine

N6-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine

CAT: BRP-00180

CAS: 79154-57-7

MF: C29H43N5O6Si2

MF: 613.87

Purity: ≥98%

Appearance: White or almost white crystalline powder

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Storage: Store at RT

InChIKey: MYWCSMGAHXNSPA-UQCYUJMQSA-N

CanonicalSMILES: CC(C)[Si]1(OCC2C(C(C(O2)N3C=NC4=C(N=CN=C43)NC(=O)C5=CC=CC=C5)O)O[Si](O1)(C(C)C)C(C)C)C(C)C

IUPAC Name: N-[9-[(6aR,8R,9R,9aS)-9-hydroxy-2,2,4,4-tetra(propan-2-yl)-6a,8,9,9a-tetrahydro-6H-furo[3,2-f][1,3,5,2,4]trioxadisilocin-8-yl]purin-6-yl]benzamide

InChI: InChI=1S/C29H43N5O6Si2/c1-17(2)41(18(3)4)37-14-22-25(39-42(40-41,19(5)6)20(7)8)24(35)29(38-22)34-16-32-23-26(30-15-31-27(23)34)33-28(36)21-12-10-9-11-13-21/h9-13,15-20,22,24-25,29,35H,14H2,1-8H3,(H,30,31,33,36)/t22-,24-,25-,29-/m1/s1

Synonyms: 3',5'-TIPS-N-Bz-Adenosine; N6-Benzoyl-3',5'-O-TIPPS-adenosine; 3',5'-O-TIPPS-N6-benzoyladenosine; N6-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)-D-adenosine

2',3',6'-TAc-Ino

Description: 2',3',6'-TAc-Ino, also known as Inosine Triacetate, is a nucleoside analogue utilized in the study of RNA structure and function. It's also used in antiviral drug development targeting diseases like hepatitis C and the flu.

CAT: BRP-00181

CAS: 3181-38-2

MF: C16H18N4O8

MF: 394.34

Purity: ≥97% by HPLC

Appearance: Crystal Powder

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Storage: Store at 2-8°C

Density: 1.62±0.1 g/cm3

Melting Point: 234-236°C

Boiling Point: 620.7±65.0 °C at 760 mmHg

InChIKey: SFEQTFDQPJQUJM-XNIJJKJLSA-N

Solubility: Soluble in Methanol (Sparingly), Water (Sparingly)

CanonicalSMILES: CC(=O)OCC1C(C(C(O1)N2C=NC3=C2N=CNC3=O)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl acetate

InChI: InChI=1S/C16H18N4O8/c1-7(21)25-4-10-12(26-8(2)22)13(27-9(3)23)16(28-10)20-6-19-11-14(20)17-5-18-15(11)24/h5-6,10,12-13,16H,4H2,1-3H3,(H,17,18,24)/t10-,12-,13-,16-/m1/s1

Synonyms: 2',3',5'-Tri-O-Acetyl-Inosine; NSC 66386; (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-oxo-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diyl diacetate; O2',O3',O5'-tri-acetylinosine; Inosine 2',3',5'-triacetate

2',3',5'-Tri-O-acetyl-cytidine hydrochloride

Description: 2',3',5'-Tri-O-acetyl-cytidine hydrochloride, a chemical compound extensively used in biomedical research, is a modification of cytidine acetylated at its 2', 3', and 5' positions. This enhancement elevates the compound's stability and solubility that leads to easier experimental usage. Studies have investigated the efficacy of 2',3',5'-Tri-O-acetyl-cytidine hydrochloride as an effective antiviral therapy for viral infections like HIV and an antitumor drug.

CAT: BRP-00182

CAS: 63639-21-4

MF: C15H19N3O8.HCl

MF: 405.79

Purity: ≥97% by HPLC

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Melting Point: 34-38 °C

InChIKey: DMDAYVSFFBNVOE-VNQMUNOFSA-N

CanonicalSMILES: CC(=O)OCC1C(C(C(O1)N2C=CC(=NC2=O)N)OC(=O)C)OC(=O)C.Cl

IUPAC Name: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl acetate;hydrochloride

InChI: InChI=1S/C15H19N3O8.ClH/c1-7(19)23-6-10-12(24-8(2)20)13(25-9(3)21)14(26-10)18-5-4-11(16)17-15(18)22;/h4-5,10,12-14H,6H2,1-3H3,(H2,16,17,22);1H/t10-,12-,13-,14-;/m1./s1

Synonyms: 2',3',5'-Tri-O-acetylcytidine HCl; (2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate hydrochloride

Related CAS: 56787-28-1 (free base)

2',3',5'-Tri-O-acetyladenosine

Description: 2',3',5'-Tri-O-acetyladenosine is a chemical compound used in biomedicine as a precursor for synthesizing adenosine-containing drugs for the treatment of cardiovascular and neurological diseases, as well as cancer. It is also used as a tool compound for studying adenosine-based signaling pathways in cells.

CAT: BRP-00183

CAS: 7387-57-7

MF: C16H19N5O7

MF: 393.35

Purity: ≥95%

Appearance: White Solid

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Storage: Store at -20°C

Density: 1.62±0.1 g/cm3 (Predicted)

Melting Point: 168-170°C

Boiling Point: 594.1±60.0°C (Predicted)

InChIKey: GCVZNVTXNUTBFB-XNIJJKJLSA-N

Solubility: Soluble in Chloroform (Sparingly), DMSO (Slightly), Methanol (Sparingly)

CanonicalSMILES: CC(=O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methyl acetate

InChI: InChI=1S/C16H19N5O7/c1-7(22)25-4-10-12(26-8(2)23)13(27-9(3)24)16(28-10)21-6-20-11-14(17)18-5-19-15(11)21/h5-6,10,12-13,16H,4H2,1-3H3,(H2,17,18,19)/t10-,12-,13-,16-/m1/s1

Synonyms: (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-amino-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate; Adenosine 2',3',5'-Triacetate; Tri-O-acetyladenosine; NSC 76766; 2',3',5'-Tri-O-acetyl-D-adenosine; 2',3',5'-Tri-O-acetyl-β-D-ribofuranosyl adenine

PN401

Description: PN-401 is a synthetic uridine pro-drug that is converted to uridine in vivo. Uridine, a pyrimidine nucleotide, has been used in a variety of diseases including depressive disorders and inherited myopathies.

CAT: BRP-00184

CAS: 4105-38-8

MF: C15H18N2O9

MF: 370.314

Purity: 98%

Appearance: Off-white Powder

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Storage: Store at -20°C

Density: 1.43±0.1 g/cm3(Predicted)

Melting Point: 127.0-131.0 °C

InChIKey: AUFUWRKPQLGTGF-FMKGYKFTSA-N

Solubility: Soluble in Methol

CanonicalSMILES: CC(=O)OCC1C(C(C(O1)N2C=CC(=O)NC2=O)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methyl acetate

InChI: InChI=1S/C15H18N2O9/c1-7(18)23-6-10-12(24-8(2)19)13(25-9(3)20)14(26-10)17-5-4-11(21)16-15(17)22/h4-5,10,12-14H,6H2,1-3H3,(H,16,21,22)/t10-,12-,13-,14-/m1/s1

Synonyms: Uridine Triacetate; Triacetyluridine; 2',3',5'-Tri-O-Acetyluridine; Vistonuridine; 2',3',5'-Triacetyluridine; Uridine 2',3',5'-Triacetate; PN 401; RG 2133; Tri-O-acetyl uridine; PN-401; RG 2133; RG2133; RG-2133; Tri-O-acetyluridine

2',3',5'-Tri-O-acetyl Guanosine

Description: 2',3',5'-Tri-O-acetyl guanosine is a chemical compound commonly used in organic synthesis and nucleic acid chemistry. It features acetyl groups attached to the 2', 3', and 5' positions of the guanosine molecule. This modification serves to protect the reactive hydroxyl groups of guanosine, allowing for precise control over chemical reactions involving the nucleoside. It is often employed as a building block in the synthesis of modified nucleosides, nucleotides, and oligonucleotides for various research and biotechnological applications, including RNA interference, gene expression modulation, and pharmaceutical development.

CAT: BRP-00185

CAS: 6979-94-8

MF: C16H19N5O8

MF: 409.35

Purity: ≥98%

Appearance: White powder

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Storage: Store at 2-8 °C

Density: 1.7±0.1 g/cm³

Melting Point: 226-231 °C

Boiling Point: 655.8 °C at 760 mmHg

InChIKey: ULXDFYDZZFYGIY-SDBHATRESA-N

Solubility: Soluble in DMSO (Slightly)

CanonicalSMILES: CC(=O)OCC1C(C(C(O1)N2C=NC3=C2N=C(NC3=O)N)OC(=O)C)OC(=O)C

IUPAC Name: [(2R,3R,4R,5R)-3,4-diacetyloxy-5-(2-amino-6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl acetate

InChI: InChI=1S/C16H19N5O8/c1-6(22)26-4-9-11(27-7(2)23)12(28-8(3)24)15(29-9)21-5-18-10-13(21)19-16(17)20-14(10)25/h5,9,11-12,15H,4H2,1-3H3,(H3,17,19,20,25)/t9-,11-,12-,15-/m1/s1

Synonyms: 2',3',5'-Triacetylguanosine; Guanosine 2',3',5'-triacetate; Guanosine Triacetate; NSC 66387; Triacetylguanosine