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2'-Modified Nucleotides
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2'-Fluoro-2'-deoxyuridine-5'-triphosphate trisodium salt
Description: 2'-Fluoro-2'-deoxyuridine-5'-triphosphate trisodium salt, a nucleotide analog in biochemistry and molecular biology, stands out due to its versatility as a substrate for DNA Polymerases in DNA synthesis studies. Moreover, it shows promise as an anti-cancer agent in treating breast cancer and pancreatic cancer by hindering DNA replication. With this in mind, its relevance and significance linger in the scientific community and beyond.
CAT: BRP-02009
MF: C9H11FN2Na3O14P3
MF: 552.08
Purity: ≥97% by HPLC
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Storage: Store at -20°C
InChIKey: SYJHCABZXNADML-LLWADOMFSA-K
CanonicalSMILES: [Na].[Na].[Na].O=C1C=CN(C(=O)N1)C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2F
IUPAC Name: trisodium;((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChI: InChI=1S/C9H14FN2O14P3.3Na/c10-6-7(14)4(24-8(6)12-2-1-5(13)11-9(12)15)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;/h1-2,4,6-8,14H,3H2,(H,19,20)(H,21,22)(H,11,13,15)(H2,16,17,18);;;/q;3*+1/p-3/t4-,6-,7-,8-;;;/m1.../s1
Synonyms: 2'-Deoxy-2'-fluorouridine-5'-triphosphate sodium salt; 2'-Deoxy-2'-fluorouridine 5'-(tetrahydrogen triphosphate) trisodium salt; 2'-Fluoro-dUTP trisodium salt; 2'-F-2'-dUTP.Na3
Related CAS: 66840-02-6 (free acid)
2'-Fluoro-2'-deoxycytidine-5'-triphosphate trisodium salt
Description: 2'-Fluoro-2'-deoxycytidine-5'-triphosphate trisodium salt is an essential molecule in the realm of molecular biology. With its ability to serve as a substrate for DNA polymerase and incorporating into DNA during PCR amplification, it plays a crucial role in gene expression. The fluorine nullifies the destabilizing effects on the PCR products, thereby improving its specificity, making it a preferred choice for mutation analysis and diagnostic testing. Furthermore, its potentiality as an antiviral agent adds to its importance as a contender for the treatment of chronic hepatitis B.
CAT: BRP-02010
MF: C9H12FN3Na3O13P3
MF: 551.09
Purity: ≥97% by HPLC
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InChIKey: YKEIUAOIVAXJRI-XVFCMESISA-K
CanonicalSMILES: [Na].[Na].[Na].O=C1N=C(N)C=CN1C2OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2F
IUPAC Name: trisodium;((2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChI: InChI=1S/C9H15FN3O13P3/c10-6-7(14)4(24-8(6)13-2-1-5(11)12-9(13)15)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,14H,3H2,(H,19,20)(H,21,22)(H2,11,12,15)(H2,16,17,18)/p-3/t4-,6-,7-,8-/m1/s1
Synonyms: 2'-F-2'-dCTP.Na3; 2'-Fluoro-dCTP trisodium salt; 2'-Deoxy-2'-fluorocytidine 5'-(tetrahydrogen triphosphate) trisodium salt; 2'-Fluoro CTP trisodium salt; 2'-Fluoro-2'-deoxy-CTP trisodium salt; 2'-Fluoro-2'-deoxycytidine triphosphate trisodium salt
Related CAS: 66840-03-7 (free acid)
2'-Fluoro-2'-deoxyadenosine-5'-triphosphate trisodium salt
Description: 2'-Fluoro-2'-deoxyadenosine-5'-triphosphate trisodium salt is a highly valuable compound in biomedicine, notably in the exploration, recognition, and mending of DNA. It is a versatile tool, integral in DNA synthesis and labeling, suitable for PCR, sequencing, and hybridization applications. Its potential in treating chronic lymphocytic leukemia is noteworthy in its antileukemic qualities; it has been reported to activate apoptosis in leukemia cells, thus emphasizing its capacity in potentially developing therapeutic regimens for this ailment.
CAT: BRP-02011
MF: C10H12FN5Na3O12P3
MF: 575.12
Purity: ≥97% by HPLC
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InChIKey: UDMNUAJYCWIRCI-PUOVIKMVSA-K
CanonicalSMILES: [Na].[Na].[Na].O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC1OC(N2C=NC=3C(=NC=NC32)N)C(F)C1O
IUPAC Name: trisodium ((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChI: InChI=1S/C10H15FN5O12P3.3Na/c11-5-7(17)4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(5)16-3-15-6-8(12)13-2-14-9(6)16;;;/h2-5,7,10,17H,1H2,(H,21,22)(H,23,24)(H2,12,13,14)(H2,18,19,20);;;/q;3*+1/p-3/t4-,5-,7-,10-;;;/m1.../s1
Synonyms: 2'-F-2'-dATP.Na3; 2'-F-dATP trisodium salt; 2'-Deoxy-2'-fluoroadenosine-5'-triphosphate trisodium salt; 2'-Deoxy-2'-fluoroadenosine 5'-(tetrahydrogen triphosphate) sodium salt (1:3); 2'-Fluoro ATP trisodium salt; 2'-Fluoro-2'-deoxy-ATP trisodium salt; 2'-Fluoro-2'-deoxyadenosine-5'-triphosphate trisodium salt; trisodium ((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
Related CAS: 73449-07-7 (free acid)
2'-Fluoro-2'-deoxyguanosine-5'-triphosphate trisodium salt
Description: 2'-Fluoro-2'-deoxyguanosine-5'-triphosphate trisodium salt, a potent nucleotide analogue, displays antiviral activity by inhibiting viral DNA polymerase. Employed in the treatment of Hepatitis B and Herpes, it is noted for its ability to enhance the pharmacological features of nucleotide-based antiviral medications through its structural modifications. The utilization of this molecule is paramount in the development of novel antiviral therapies.
CAT: BRP-02012
MF: C10H12FN5Na3O13P3
MF: 591.12
Purity: ≥97% by HPLC
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InChIKey: VBHFAAUXQSKIAJ-MPTIMWNFSA-K
CanonicalSMILES: [Na].[Na].[Na].C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F)N=C(NC2=O)N
IUPAC Name: trisodium;((2R,3R,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl hydrogen triphosphate
InChI: InChI=1S/C10H15FN5O13P3.3Na/c11-4-6(17)3(1-26-31(22,23)29-32(24,25)28-30(19,20)21)27-9(4)16-2-13-5-7(16)14-10(12)15-8(5)18;;;/h2-4,6,9,17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,12,14,15,18);;;/q;3*+1/p-3/t3-,4-,6-,9-;;;/m1.../s1
Synonyms: 2'-F-2'-dGTP.Na3; 2'-F-dGTP trisodium salt; 2'-Deoxy-2'-fluoroguanosine-5'-triphosphate trisodium salt; 2'-Deoxy-2'-fluoroguanosine 5'-(tetrahydrogen triphosphate) trisodium salt; 2'-Fluoro GTP trisodium salt; 2'-Fluoro-2'-deoxy-GTP trisodium salt; 2'-Fluoro-2'-deoxyguanosine triphosphate trisodium salt; 2'-Fluoro-dGTP trisodium salt
Related CAS: 202186-97-8 (free acid)
Sofosbuvir Impurity 31
Description: PSI-7409, the active 5'-triphosphate metabolite of PSI-7851, is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase.
CAT: BRP-02016
CAS: 1015073-42-3
MF: C10H16FN2O14P3
MF: 500.16
Purity: >95%
Appearance: White to off-white solid
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Storage: Store at -20 °C
Density: 1.97±0.1 g/cm3
InChIKey: IPHULAIUXUVCHH-VPCXQMTMSA-N
Solubility: Soluble in DMSO
CanonicalSMILES: CC1(C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F
IUPAC Name: [[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
InChI: InChI=1S/C10H16FN2O14P3/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19)/t5-,7-,8-,10-/m1/s1
Synonyms: PSI-7409; PSI 7409; PSI7409; Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-2'-methyl-, (2'R)-; (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine 5'-(tetrahydrogen triphosphate); GS 461203; Sofosbuvir triphosphate; Sofosbuvir-TP; Sofosbuvir-triphosphate; 2'-F-2'-C-Me-dUTP; 2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate
Related CAS: 1621884-22-7 (tetrasodium salt) ; 2144794-62-5 (TEA salt (1:4))
2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate sodium salt
Description: PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively.
CAT: BRP-02017
CAS: 1621884-22-7
MF: C10H12FN2Na4O14P3
MF: 588.09
Purity: ≥95% by HPLC
Appearance: White to off-white solid
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Storage: Store at -20 °C
InChIKey: MEVRFPOAFPAGDY-DLULJLDFSA-J
Solubility: Soluble in DMSO
CanonicalSMILES: CC1(C(C(OC1N2C=CC(=O)NC2=O)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)F.[Na+].[Na+].[Na+].[Na+]
IUPAC Name: tetrasodium;[[[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
InChI: InChI=1S/C10H16FN2O14P3.4Na/c1-10(11)7(15)5(25-8(10)13-3-2-6(14)12-9(13)16)4-24-29(20,21)27-30(22,23)26-28(17,18)19;;;;/h2-3,5,7-8,15H,4H2,1H3,(H,20,21)(H,22,23)(H,12,14,16)(H2,17,18,19);;;;/q;4*+1/p-4/t5-,7-,8-,10-;;;;/m1..../s1
Synonyms: 2'-F-2'-C-Me-dUTP.4Na; (2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine 5'-(tetrahydrogen triphosphate) sodium salt; GS 461203 sodium salt; PSI 7409 sodium salt; Sofosbuvir triphosphate sodium salt; Sofosbuvir-TP sodium salt; PSI-7409 tetrasodium; Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-2'-methyl-, sodium salt (1:4), (2'R)-
Related CAS: 1015073-42-3 (free acid)
2'-Deoxy-2'-fluoroguanosine-5'-monophosphate
Description: 2'-Deoxy-2'-fluoroguanosine-5'-monophosphate is a vital compound used in the biomedical industry. It exhibits therapeutic potential in the treatment of certain viral infections and cancer. This product could be employed as an antiviral agent, targeting viral replication pathways, or as an anticancer agent for inhibiting tumor growth.
CAT: BRP-02018
CAS: 170784-58-4
MF: C10H13FN5O7P
MF: 365.21
Purity: ≥95% by HPLC
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Storage: Store at -20 °C
Density: 2.39±0.1 g/cm3
Boiling Point: 844.6±75.0 °C at 760 mmHg
InChIKey: ZTDPJNQLNRZPCT-DXTOWSMRSA-N
CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)O)O)F)N=C(NC2=O)N
IUPAC Name: [(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl dihydrogen phosphate
InChI: InChI=1S/C10H13FN5O7P/c11-4-6(17)3(1-22-24(19,20)21)23-9(4)16-2-13-5-7(16)14-10(12)15-8(5)18/h2-4,6,9,17H,1H2,(H2,19,20,21)(H3,12,14,15,18)/t3-,4-,6-,9-/m1/s1
Synonyms: 2'-Deoxy-2'-fluoro-5'-guanylic acid; 2'-Fluoro-2'-deoxyguanosine-5'-monophosphate; 9-(2-Deoxy-2-fluoro-β-D-ribofuranosyl)guanine-5'-monophosphate; 2'-deoxy-2'-fluoroguanosine 5'-(dihydrogen phosphate)
Related CAS: 170784-59-5 (diammonium salt) ; 956473-19-1 (TEA salt)
PSI 7411 Ammonium Salt
Description: PSI 7411 is used in biological studies as nucleotide analog polymerase inhibitor for hepatitis C virus QS-9851.
CAT: BRP-02021
MF: C10H14FN2O8P.xNH3
MF: 340.20 (free acid)
Purity: ≥95% by HPLC
Appearance: White Solid
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Storage: Store at 2-8 °C, protect from light
Melting Point: 160-173°C
Solubility: Soluble in DMSO (Slightly), Methanol (Slightly)
IUPAC Name: azane;[(2R,3R,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methyl dihydrogen phosphate
Synonyms: 2'-F-2'-Me(up)-UMP.NH4; 2'-Fluoro-2'-methyl(up)-uridine-5'-monophosphate, ammonium salt; (2'R)-2'-Deoxy-2'-fluoro-2'-methyl-5'-uridylic Acid Ammonium Salt; Sofosbuvir Impurity 34 ammonium salt
Related CAS: 1015073-43-4 (free acid)
2'-Deoxy-2'-fluoro-5-methylcytidine 5'-triphosphate
Description: 2'-Deoxy-2'-fluoro-5-methylcytidine 5'-triphosphate is an indispensable chemical compound, emerging as a pivotal analog to the innate cytidine triphosphate (CTP), thus contributing to the synthesis of tinkered nucleic acids. Highly instrumental, this modified derivative exhibiting remarkable prospects in the realm of antiviral drug development, chiefly focusing on RNA viruses, including the formidable influenza virus. Given its unique attributes, this exceptional compound serving as an invaluable implement fostering an in-depth comprehension and effective counteraction against divergent infectious maladies provoked by RNA viruses.
CAT: BRP-02039
CAS: 847647-94-3
MF: C10H17FN3O13P3
MF: 499.17
Purity: ≥98%
Appearance: Colorless transparent liquid
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Storage: Store at -20 °C, Always avoid freeze-thaw cycles
Density: 2.33±0.1 g/cm3
Boiling Point: 803.7±75.0 °C at 760 mmHg
InChIKey: ZGJOFWKMPGJMDN-JXOAFFINSA-N
CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)F
IUPAC Name: [[(2R,3R,4R,5R)-5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
InChI: InChI=1S/C10H17FN3O13P3/c1-4-2-14(10(16)13-8(4)12)9-6(11)7(15)5(25-9)3-24-29(20,21)27-30(22,23)26-28(17,18)19/h2,5-7,9,15H,3H2,1H3,(H,20,21)(H,22,23)(H2,12,13,16)(H2,17,18,19)/t5-,6-,7-,9-/m1/s1
Synonyms: ((2R,3R,4R,5R)-5-(4-Amino-5-methyl-2-oxopyrimidin-1(2H)-yl)-4-fluoro-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate; Cytidine 5'-(tetrahydrogen triphosphate), 2'-deoxy-2'-fluoro-5-methyl-; 2'-Fluoro-2'-deoxy-5-methylcytidine 5'-triphosphate
Related CAS: 2088981-72-8 (TEA salt (1:4))
