CAS 1834610-13-7 Lumasiran - RNA / BOC Sciences

Lumasiran

Lumasiran is a siRNA product that reduces hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes glycolate oxidase and thereby inhibits the synthesis of oxalate, which is the toxic metabolite that is directly associated with the clinical manifestations of Primary hyperoxaluria type 1 (PH1).

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Ordering Information

Catalog Number	Size	Price	Stock	Quantity
BRP-02067	5 mg	$1688	In stock

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Catalog

BRP-02067

Synonyms

ALN-G01; RNA, (Gm-sp-Am-sp-Cm-Um-Um-Um-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Um-Gm-Gm-Am-Am-Am-Um-Am-Um-Am), 3'-[[(2S,4R)-1-[29-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-14,14-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-1,12,19,25-tetraoxo-16-oxa-13,20,24-triazanonacos-1-yl]-4-hydroxy-2-pyrrolidinyl]methyl hydrogen phosphate], complex with RNA (Um-sp-(2'-deoxy-2'-fluoro)A-sp-Um-Am-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-Am-Gm-Gm-Am-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)A-Am-Am-Gm-Um-Cm-sp-Cm-sp-Am) (1:1)

CAS

1834610-13-7

Molecular Weight

16,340 Da

Molecular Formula

C530H712F10N173O320P43S6

Purity

98% by SEC-HPLC

Solubility

Soluble in Water

Appearance

White to off-white Solid

Storage

Store at -20 °C, stored under nitrogen, away from moisture

Sequence

RNA, (uauauuuccaggaugaaagucca), complex with RNA (gacuuucauccuggaaauaua) (1:1)

Related CAS

1834612-06-4 (sodium)

Lumasiran - CAS 1834610-13-7

Lumasiran