Dim-Dmoc phosphoramidites enable synthesis under mild deprotection conditions (pH 4-8), preserving sensitive functional groups that would degrade under conventional synthesis methods.
Alkyl halides, benzyl halides, maleimides, epoxides, aziridines, vinyl arenes, esters, thioesters, and allyl halides can be successfully incorporated without degradation.
It provides stable protection for reactive groups, enabling production of DNA/RNA analogs with noncanonical nucleosides that are incompatible with traditional phosphoramidite methods.
These analogs are valuable for studying protein-nucleic acid interactions, investigating natural nucleic acid function, and developing specialized RNA constructs for experimental applications.
Yes, this versatile technology supports synthesis of both sensitive DNA and RNA analogs, accommodating a wide range of research and molecular biology applications.
We provide Dim-Dmoc phosphoramidites and Dmoc supports for tailored synthesis, enabling creation of sequences containing specific sensitive groups or noncanonical nucleosides for advanced studies.
