mRNA Products

Description: EZ Cap Mouse IL-7 mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and detection of the mouse Interleukin-7 (IL-7) cytokine. This mRNA features a Cap 1 structure, which is more efficient for translation in mammalian systems compared to Cap 0. Additionally, it is modified with N1-methylpseudouridine (m1Ψ), which increases transcription efficiency and suppresses RNA-mediated innate immune activation. The inclusion of a poly(A) tail further enhances the stability and lifetime of the mRNA both in vitro and in vivo, while also improving translation initiation efficiency. The mRNA expresses the IL-7 cytokine with an HA tag, which facilitates the detection and purification of the expressed protein. This feature is particularly useful for downstream applications such as protein analysis and functional studies. The HA tag is a well-known epitope derived from the influenza hemagglutinin protein and is commonly used for protein detection and purification. Overall, EZ Cap Mouse IL-7 mRNA (m1Ψ, HA tag) is a powerful tool for studying the role of IL-7 in immune responses and for developing therapeutic strategies related to immunodeficiency, autoimmune diseases, and cancer.

CAT: BRP-02622

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse IFN-γ mRNA (5mCTP, ψUTP) is a highly optimized, chemically modified mRNA designed for enhanced expression and stability. This product incorporates 5-methylcytidine triphosphate (5mCTP) and pseudouridine triphosphate (ψUTP) modifications, which significantly improve transcription efficiency, reduce immunogenicity, and enhance mRNA stability both in vitro and in vivo. The Cap 1 structure further boosts translation efficiency in mammalian systems. Mouse IFN-γ, a critical cytokine involved in immune responses, is encoded by this mRNA, making it an essential tool for studying immune activation, developing therapeutic strategies for viral infections and cancer, and conducting in vivo research.

CAT: BRP-02623

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse IFN-α mRNA (m1ψ) is a highly optimized mRNA product encoding mouse IFN-α, a critical cytokine that plays a key role in the early stages of viral infection by activating the JAK-STAT signaling pathway and inducing the expression of antiviral genes. This product features a Cap 1 structure and is modified with N1-methylpseudouridine (m1ψ) and a poly(A) tail, which enhance translation efficiency, mRNA stability, and reduce immunogenicity. It is particularly useful for studying viral infections, immune modulation, and developing therapeutic strategies for viral diseases, certain cancers, and autoimmune conditions.

CAT: BRP-02624

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Human IL-21 mRNA (m1Ψ, HA tag) is a highly optimized mRNA product designed for enhanced expression and stability. This mRNA encodes human IL-21, a pleiotropic cytokine that plays a crucial role in modulating immune responses. IL-21 has significant effects on various immune cells, including enhancing the cytotoxic activity of natural killer (NK) cells and CD8+ cytotoxic T lymphocytes (CTLs), promoting B cell proliferation and IgG production, and modulating T cell differentiation. It is particularly known for its ability to sustain CTL functions and induce a memory phenotype in CTLs, making it a promising candidate for cancer immunotherapy. Additionally, IL-21 has been shown to inhibit dendritic cell functions and induce regulatory B cells, highlighting its dual role in immune regulation. This mRNA is modified with N1-methylpseudouridine (m1Ψ) and features an HA tag for easy detection and purification, making it a valuable tool for studying IL-21's mechanisms and developing therapeutic strategies for cancer and infectious diseases.

CAT: BRP-02625

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse IL-23 mRNA (m1Ψ, HA tag) is a highly optimized mRNA product designed for enhanced expression and stability. This mRNA encodes mouse IL-23, a cytokine that plays a crucial role in immune regulation and inflammation. IL-23 is known for its ability to promote the survival and proliferation of T cells, enhance the production of pro-inflammatory cytokines, and contribute to the development of Th17 cells, which are important in immune responses against pathogens and in autoimmune diseases. The mRNA is modified with N1-methylpseudouridine (m1Ψ), which enhances translation efficiency and reduces innate immune activation. Additionally, the inclusion of an HA tag facilitates detection and purification of the expressed protein. This product is ideal for studying the mechanisms of IL-23 in immune responses and developing therapeutic strategies for inflammatory and autoimmune conditions.

CAT: BRP-02626

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse IL-23α mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and stability. This mRNA encodes the IL-23α subunit, a critical component of the IL-23 cytokine, which belongs to the IL-12 cytokine family. IL-23 is composed of two subunits, p19 (IL-23α) and p40, and it plays a crucial role in regulating immune responses, particularly in promoting the differentiation and maintenance of Th17 cells. These cells are essential for antimicrobial defense and are implicated in autoimmune diseases. This product features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail, which enhance transcription efficiency, suppress RNA-mediated innate immune activation, and increase mRNA stability in vitro and in vivo. The inclusion of an HA tag facilitates the detection and purification of the expressed protein. Abnormal expression of IL-23 has been linked to various inflammatory diseases, such as psoriasis, Crohn's disease, and multiple sclerosis, making IL-23 and its subunit IL-23α potential targets for therapeutic interventions.

CAT: BRP-02627

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Human IL-29 mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and stability, encoding human IL-29, a cytokine belonging to the type III interferon family. IL-29 plays a crucial role in modulating immune responses, with significant antiviral, anti-proliferative, and immunoregulatory properties. It activates the JAK-STAT signaling pathway through STAT1 and STAT2, and can either promote or inhibit tumor effects depending on the cell type. IL-29 also enhances the production of pro-inflammatory cytokines such as IL-6 and IL-8, and regulates the function of various immune cells, including monocytes, macrophages, and dendritic cells. Additionally, it has been implicated in the pathogenesis of inflammatory autoimmune diseases like rheumatoid arthritis, psoriasis, and systemic lupus erythematosus. This mRNA is modified with N1-methylpseudouridine (m1Ψ) to enhance translation efficiency and reduce immunogenicity, and includes an HA tag for easy detection and purification. It is a valuable tool for studying IL-29's mechanisms in immune regulation and its potential therapeutic applications in autoimmune and inflammatory conditions.

CAT: BRP-02628

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse IL-36γ mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and stability. This mRNA encodes mouse IL-36γ, a cytokine that plays a crucial role in immune regulation and inflammation. IL-36γ acts as an upstream amplifier of inflammatory responses in macrophages and fibroblasts, significantly increasing the expression of pro-inflammatory cytokines such as IL-1α, IL-1β, and CXCL1. It also promotes the survival of alveolar macrophages during early stages of infection, which is critical for limiting viral replication and reducing pathology. This mRNA product features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) to enhance translation efficiency and reduce immunogenicity. The inclusion of an HA tag facilitates the detection and purification of the expressed protein. EZ Cap Mouse IL-36γ mRNA (m1Ψ, HA tag) is a valuable tool for studying the mechanisms of IL-36γ in immune regulation, inflammation, and antiviral responses, as well as for developing therapeutic strategies targeting IL-36γ in infectious diseases and autoimmune conditions.

CAT: BRP-02629

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse RLI mRNA (m1Ψ) is a specialized mRNA product encoding the RLI fusion protein, which combines interleukin-15 (IL-15) and the sushi domain of its receptor IL-15Rα. RLI is an innovative immunotherapeutic agent that enhances the proliferation of natural killer cells (NK cells) and T cells, thereby boosting the immune system's anti-tumor and antiviral responses. The mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail to enhance transcription efficiency, suppress innate immune activation, and increase stability. It is ideal for cancer immunotherapy, antiviral research, and studying immune regulation mechanisms.

CAT: BRP-02630

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse CD86 mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and detection of the mouse CD86 protein. CD86, also known as B7-2, is an important immunomodulatory molecule belonging to the B7 family of transmembrane proteins. It is primarily expressed on the surface of antigen-presenting cells such as dendritic cells, macrophages, and B cells. CD86 plays a crucial role in the immune system by regulating T cell activation and immune responses through its interaction with CD28 and CTLA-4 receptors on T cells. This product features a Cap 1 structure, which is more efficient for translation in mammalian systems compared to Cap 0. It is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail to enhance transcription efficiency, suppress RNA-mediated innate immune activation, and increase mRNA stability in vitro and in vivo. The inclusion of an HA tag facilitates the detection and purification of the expressed protein. This product is ideal for studying immune regulation, developing cancer immunotherapies, and conducting in vivo imaging studies.

CAT: BRP-02632

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse CD137 mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and detection of the mouse CD137 protein. CD137, also known as 4-1BB, is an important immunomodulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. It is primarily expressed on activated T cells, natural killer cells (NK cells), and dendritic cells. Activation of CD137 enhances T cell proliferation and survival, promotes the secretion of cytokines such as IFN-γ and IL-2, and plays a crucial role in enhancing immune responses. This makes CD137 an important target for cancer immunotherapy, where its activation can boost anti-tumor immune responses. This mRNA product features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail. These modifications enhance transcription efficiency, suppress RNA-mediated innate immune activation, and increase mRNA stability in vitro and in vivo. The inclusion of an HA tag facilitates the detection and purification of the expressed protein. This product is ideal for studying immune regulation, developing cancer immunotherapies, and conducting in vivo imaging studies.

CAT: BRP-02633

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse CD252 (OX40L) mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and detection of the mouse CD252 (OX40L) protein. CD252, also known as OX40 ligand, is a key immunomodulatory molecule that promotes T cell activation, proliferation, and survival by interacting with its receptor OX40 on T cells. This mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail to enhance transcription efficiency, suppress innate immune activation, and increase stability. The HA tag facilitates detection and purification of the expressed protein. This product is ideal for studying immune regulation, developing cancer immunotherapies, and conducting in vivo imaging studies.

CAT: BRP-02634

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse CD80 mRNA (m1Ψ, HA tag) is a specialized mRNA product designed for enhanced expression and detection of the mouse CD80 protein, an important immunomodulatory molecule and a member of the B7 family. This mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail to enhance transcription efficiency, suppress RNA-mediated innate immune activation, and increase stability in vitro and in vivo. The inclusion of an HA tag facilitates the detection and purification of the expressed protein. CD80 regulates T cell activation and immune responses by binding to CD28 and CTLA-4 receptors on T cells, promoting activation and proliferation when bound to CD28, and inhibiting responses when bound to CTLA-4. This product is ideal for studying immune regulation, developing immunotherapies, and conducting in vivo imaging studies.

CAT: BRP-02635

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse IL-10 mRNA (m1Ψ) is a specialized mRNA product designed for enhanced expression and stability, encoding mouse IL-10, a key anti-inflammatory cytokine. This mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail to enhance transcription efficiency, suppress RNA-mediated innate immune activation, and increase stability in vitro and in vivo. IL-10 helps maintain immune balance by inhibiting pro-inflammatory cytokines and promoting B cell proliferation. This product is ideal for studying inflammatory and autoimmune diseases, transplant rejection, and developing immunomodulatory therapies.

CAT: BRP-02636

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap Mouse GM-CSF mRNA (m1Ψ) is a specialized mRNA product designed to express mouse granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine that plays a key role in the growth and differentiation of immune cells, particularly granulocytes and macrophages. This product features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ), which enhances translation efficiency, reduces innate immune activation, and increases mRNA stability. GM-CSF mRNA has been used in various studies to investigate its effects on immune modulation and neuroprotection. Additionally, GM-CSF mRNA has been explored in preclinical models of Parkinson's disease, where it demonstrated immunomodulatory and neuroprotective efficacy, particularly when formulated as an extended half-life fusion protein. EZ Cap Mouse GM-CSF mRNA (m1Ψ) is a valuable tool for studying the biological functions of GM-CSF and developing therapeutic strategies targeting immune and neurodegenerative disorders.

CAT: BRP-02638

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap BFP mRNA (m1Ψ) is a specialized mRNA product encoding Blue Fluorescent Protein (BFP), designed for enhanced expression and stability. This mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) and a poly(A) tail to improve transcription efficiency, suppress RNA-mediated immune activation, and increase stability. BFP exhibits an excitation maximum at 380 nm and an emission maximum at 440 nm, making it ideal for live-cell imaging, protein localization studies, and multi-color fluorescence assays. This product is particularly useful for real-time monitoring of cellular processes and simultaneous detection of multiple biomolecules.

CAT: BRP-02639

Concentration: 1.0 mg/mL

Description: EZ Cap EYFP mRNA (m1Ψ) is a specialized mRNA product encoding Enhanced Yellow Fluorescent Protein (EYFP), a brighter and more photostable variant of GFP. This mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) to enhance transcription efficiency, suppress RNA-mediated immune activation, and increase stability. EYFP exhibits an excitation maximum at 514 nm and an emission maximum at 527 nm, making it ideal for live-cell imaging, fluorescence resonance energy transfer (FRET), and multi-color fluorescence applications. This product is particularly useful for studying protein localization, dynamics, and interactions in real-time.

CAT: BRP-02640

Concentration: 1.0 mg/mL

Description: EZ Cap Cre mRNA (5-moUTP) is a specialized mRNA product designed to express Cre recombinase, a tyrosine recombinase that catalyzes homologous recombination between two loxP sites in DNA. This mRNA features a Cap 1 structure and is modified with 5-methoxy-UTP (5-moUTP) to enhance transcription efficiency and suppress RNA-mediated innate immune activation. The addition of a poly(A) tail further increases mRNA stability and translation efficiency in vitro and in vivo. It is ideal for applications involving genetic recombination and gene editing, particularly when used in combination with lipid nanoparticles (LNPs) for efficient delivery.

CAT: BRP-02641

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap mOrange mRNA (m1Ψ) is a specialized mRNA product encoding the orange fluorescent protein mOrange, designed for enhanced expression and stability. This mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) to enhance transcription efficiency and suppress RNA-mediated innate immune activation. The addition of a poly(A) tail further increases mRNA stability and translation efficiency. mOrange's bright orange fluorescence (excitation max at 548 nm, emission max at 562 nm) makes it ideal for live-cell imaging, protein localization studies, and multi-color fluorescence assays, where it can be used in combination with other fluorescent proteins for simultaneous detection of multiple biomolecules.

CAT: BRP-02644

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL

Description: EZ Cap tdTomato mRNA (m1Ψ) is a specialized mRNA product encoding the tdTomato fluorescent protein, which is a bright and photostable red fluorescent protein derived from a tandem dimer of DsRed. This mRNA features a Cap 1 structure and is modified with N1-methylpseudouridine (m1Ψ) to enhance transcription efficiency and suppress RNA-mediated innate immune activation. The m1Ψ modification is known to stabilize mRNA transcripts and increase protein synthesis by limiting the cellular innate immune response. This product is ideal for live-cell imaging, protein localization studies, and multi-color fluorescence assays, where its bright red fluorescence (excitation max at 554 nm, emission max at 581 nm) can be used in combination with other fluorescent proteins for simultaneous detection of multiple biomolecules.

CAT: BRP-02645

Purity: ≥95% (Agarose Gel Electrophoresis)

Appearance: Colorless liquid

Concentration: 1.0 mg/mL