Universal Support-CPG (DMT-Ribose-Linker); 1000 Å

Coronavirus disease 2019 laid bare the gaps in our health systems. Isolation and discoordination of both individuals and systems, inequities at local and global scales, and false choices between our prosperity and our health, all exacerbated the crisis. To build a better "normal" and not just a new one, health care should employ the approach of targeted universalism, which demonstrates that we can often get to universally held societal objectives by using targeted strategies that help provide an advantage to those that have been systematically disadvantaged. The goal is universal, but achieving it requires multiple strategies that target the needs of various groups to help them share in the universal goal. This approach is perhaps most easily understood, and most urgently needed, in the context of improving health equity. Using targeted strategies to permanently remake our health systems will honor the lives of those we lost far too early.

This article will review quantum particle creation in expanding universes. The emphasis will be on the basic physical principles and on selected applications to cosmological models. The needed formalism of quantum field theory in curved spacetime will be summarized, and applied to the example of scalar particle creation in a spatially flat Universe. Estimates for the creation rate will be given and applied to inflationary cosmology models. Analog models which illustrate the same physical principles and may be experimentally realizable are also discussed.

Meaning has been established pervasively as a central concept throughout disciplines that were involved in cognitive revolution. Its metaphoric usage comes to be, first and foremost, through the interpreter's constraint: representational relationships and contents are considered to be in the "eye" or mind of the observer and shared properties among observers themselves are knowable through interlinguistic phenomena, such as translation. Despite the instability of meaning in relation to its underdetermination by reference, it can be a tertium comparationis or "third comparator" for extended human cognition if gauged through invariants that exist in transfer processes such as translation, as all languages and cultures are rooted in pan-human experience and, thus, share and express species-specific ontology. Meaning, seen as a cognitive competence, does not stop outside of the body but extends, depends, and partners with other agents and the environment. A novel approach for exploring the transfer properties of some constituent items of the original natural semantic metalanguage in English, that is, semantic primitives, is presented: FrameNet's semantic frames, evoked by the primes SEE and FEEL, were extracted from EuroParl, a parallel corpus that allows for the automatic word alignment of items with their synonyms. Large Ontology Multilingual Extraction was used. Afterward, following the Semantic Mirrors Method, a procedure that consists back-translating into source language, a translatological examination of translated and original versions of items was performed. A fully automated pipeline was designed and tested, with the purpose of exploring associated frame shifts and, thus, beginning a research agenda on their alleged universality as linguistic features of translation, which will be complemented with and contrasted against further massive feedback through a citizen science approach, as well as cognitive and neurophysiological examinations. Additionally, an embodied account of frame semantics is proposed.