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U-TOM-CE Phosphoramidite
U-TOM-CE phosphoramidite is a phosphoramidite used in oligonucleotide synthesis. It features the TOM (triisopropylsilyloxymethyl) protecting group at the 2'-hydroxyl position and a cyanoethyl (CE) protecting group on the phosphoramidite at the 3' position. The TOM group provides protection during synthesis and can be removed under mild conditions, making this reagent useful for synthesizing RNA oligonucleotides. This phosphoramidite reagent enhances the stability and efficiency of oligonucleotide synthesis, which is crucial for applications in molecular biology, diagnostics, and therapeutic development.
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Catalog
BRP-02203
Synonyms
5'-Dimethoxytrityl-Uridine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; 2'-O-[(Triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)uridine; (2R,3R,4R,5R)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]; 2'-O-TOM-U-3'-CE Phosphoramidite
CAS
220230-62-6
IUPAC Name
3-[[(2R,3R,4R,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(2,4-dioxopyrimidin-1-yl)-4-[tri(propan-2-yl)silyloxymethoxy]oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
Molecular Weight
933.17
Molecular Formula
C49H69N4O10PSi
Canonical SMILES
CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCO[Si](C(C)C)(C(C)C)C(C)C)N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC
InChI
InChI=1S/C49H69N4O10PSi/c1-33(2)53(34(3)4)64(60-30-16-28-50)63-45-43(62-47(52-29-27-44(54)51-48(52)55)46(45)58-32-61-65(35(5)6,36(7)8)37(9)10)31-59-49(38-17-14-13-15-18-38,39-19-23-41(56-11)24-20-39)40-21-25-42(57-12)26-22-40/h13-15,17-27,29,33-37,43,45-47H,16,30-32H2,1-12H3,(H,51,54,55)/t43-,45-,46-,47-,64?/m1/s1
InChIKey
FKVFIIQPEPLSRC-BIPLCDCWSA-N
Purity
≥95%
Appearance
White to Off-white Free-flowing Powder
Storage
Store at -20 °C
Related CAS
1509908-14-8 (Deleted CAS)
Chemical Structure:
