G-TOM-CE Phosphoramidite - CAS 253586-14-0

Catalog number: BRA-054

The synthesis of RNA using monomers containing the 2'-O-Triisopropylsilyloxymethyl (TOM) group (TOM-Protecting-Group) has very high coupling efficiency along with fast, simple deprotection.

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Synonyms

5'-Dimethoxytrityl-N-acetyl-Guanosine, 2'-O-triisopropylsilyloxymethyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; (2R,3R,4R,5R)-5-(2-acetamido-6-oxo-1,6-dihydro-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(((triisopropylsilyl)oxy)methoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite; N-Acetyl-2'-O-[(triisopropylsilyloxy)methyl]-3'-O-[diisopropylamino(2-cyanoethoxy)phosphino]-5'-O-(4,4'-dimethoxytrityl)guanosine; Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]; Guanosine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[[[tris(1-methylethyl)silyl]oxy]methyl]-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite]

CAS

253586-14-0

IUPAC Name

N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-[tri(propan-2-yl)silyloxymethoxy]oxolan-2-yl]-6-oxo-1H-purin-2-yl]acetamide

Molecular Weight

1014.24

Molecular Formula

C52H72N7O10PSi

Canonical SMILES

CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCO[Si](C(C)C)(C(C)C)C(C)C)N2C=NC3=C2N=C(NC3=O)NC(=O)C)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC

InChI

InChI=1S/C52H72N7O10PSi/c1-33(2)59(34(3)4)70(66-29-17-28-53)69-46-44(30-65-52(39-18-15-14-16-19-39,40-20-24-42(62-12)25-21-40)41-22-26-43(63-13)27-23-41)68-50(47(46)64-32-67-71(35(5)6,36(7)8)37(9)10)58-31-54-45-48(58)56-51(55-38(11)60)57-49(45)61/h14-16,18-27,31,33-37,44,46-47,50H,17,29-30,32H2,1-13H3,(H2,55,56,57,60,61)/t44-,46-,47-,50-,70?/m1/s1

InChIKey

IVLLKXVYBCLHEZ-VPVWFKJASA-N

Appearance

White to Golden Free-flowing Powder

Storage

Store at -20°C

Chemical Structure: