Nucleosides

4'-alpha-Azidouridine

Description: 4'-alpha-Azidouridine, a biomedical compound, assumes paramount significance in the realm of antiviral therapy. Its applications predominantly revolve around combating viral infections instigated by RNA viruses. By selectively and adeptly impeding viral replication and transcription, this compound emerges as an efficacious weapon against afflictions like influenza, hepatitis C, and HIV.

CAT: BRP-00056

CAS: 139442-01-6

Molecular Formula: C9H11N5O6

Molecular Weight: 285.21

Purity: ≥95%

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InChIKey: FHPJZSIIXUQGQE-JVZYCSMKSA-N

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)(CO)N=[N+]=[N-])O)O

IUPAC Name: 1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H11N5O6/c10-13-12-9(3-15)6(18)5(17)7(20-9)14-2-1-4(16)11-8(14)19/h1-2,5-7,15,17-18H,3H2,(H,11,16,19)/t5-,6+,7-,9-/m1/s1

Synonyms: 1-(4'-Azido-beta-D-ribofuranosyl)uracil; 4'-azidouridine; Uridine, 4-C-azido-; 1-[(2R,3R,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 4'-C-azidouridine

2'-C-methyladenosine

Description: 2'-C-Methyladenosine is an inhibitor of hepatitis C virus (HCV) replication (IC50 = 0.3 µM in Huh-7 human hepatoma cells) that is not cytotoxic at concentrations up to 100 µM.

CAT: BRP-00057

CAS: 15397-12-3

Molecular Formula: C11H15N5O4

Molecular Weight: 281.27

Purity: ≥95%

Appearance: Solid

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Storage: 4°C, protect from light
*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Density: 1.89±0.1 g/cm3

Boiling Point: 643.4±65.0 °C at 760 mmHg

InChIKey: PASOFFRBGIVJET-YRKGHMEHSA-N

Solubility: Soluble in DMF, DMSO, PBS

CanonicalSMILES: OC[C@@H]1[C@@H](O)[C@@](C)(O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1

IUPAC Name: (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol

InChI: InChI=1S/C11H15N5O4/c1-11(19)7(18)5(2-17)20-10(11)16-4-15-6-8(12)13-3-14-9(6)16/h3-5,7,10,17-19H,2H2,1H3,(H2,12,13,14)/t5-,7-,10-,11-/m1/s1

Synonyms: 2'-C-methyladenosine;15397-12-3;(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol;2'-methyl-adenosine;2-C-methyl adenosine;(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol;CHEMBL73809;2''-C-methyladenosine;2/'-C-Methyladenosine;(2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol;2-c-methyladenosine;2''-methyl-adenosine;2'-C-Methyl-adenosine;2'-C-Methyl Adenosine;Beta-2'-Methyladenosine;beta-2''-Methyladenosine;2'-C-MeA;SCHEMBL382543;2'-C-Me-A;DTXSID90333334;PASOFFRBGIVJET-YRKGHMEHSA-N;2'-C-CH3-A;BCX-4026;BDBM50144948;MFCD02682944;AKOS015914550;BS-25234;DA-49398;PD077382;F12904;(3R)-2-(6-Aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol;(2R,3R,4R,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyl-tetrahydrofuran-3,4-diol;(2R,3R,4R,5R)-5-Hydroxymethyl-3-methyl-2-(6-methylamino-purin-9-yl)-tetrahydro-furan-3,4-diol;

2-C-methyl-6-O-methyl-guanosine

Description: 2-C-methyl-6-O-methyl-guanosine - an exalted nucleoside analog flourishing in the realm of biomedical applications. As a prodigious antiviral agent, its dominion extends to combating the perils inflicted by RNA viruses like hepatitis C and respiratory syncytial virus (RSV). Proficiently curbing viral replication and subduing the viral life cycle, it has garnered reverence among scientific circles. Moreover, its boundless panorama of therapeutic possibilities in countering diverse viral afflictions continues to enthrall researchers worldwide. Beware, for this extraordinary entity is unrivaled in its prowess.

CAT: BRP-00058

CAS: 714249-80-6

Molecular Formula: C12H17N5O5

Molecular Weight: 311.29

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Density: 1.8±0.1 g/cm3

Boiling Point: 690.2±65.0 °C(Predicted)

InChIKey: OAIGYKVLSKBAJZ-GSWPYSDESA-N

CanonicalSMILES: CC1(C(C(OC1N2C=NC3=C2N=C(N=C3OC)N)CO)O)O

IUPAC Name: (2R,3R,4R,5R)-2-(2-amino-6-methoxypurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol

InChI: InChI=1S/C12H17N5O5/c1-12(20)7(19)5(3-18)22-10(12)17-4-14-6-8(17)15-11(13)16-9(6)21-2/h4-5,7,10,18-20H,3H2,1-2H3,(H2,13,15,16)/t5-,7-,10-,12-/m1/s1

Synonyms: (2R,3R,4R,5R)-2-(2-Amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)-3-methyltetrahydrofuran-3,4-diol; 2'-C-Methyl-6-O-methyl-guanosine; INX 08144

2'-C-Methylcytidine

Description: A nucleoside analog with anti-hepatitis C virus (HCV) activity. Upon phosphorylation into its 5-triphosphate form, this metabolite inhibits viral RNA chain elongation and viral RNA-dependent RNA polymerase activity. This blocks viral production of HCV RNA and thus viral replication.

CAT: BRP-00059

CAS: 20724-73-6

Molecular Formula: C10H15N3O5

Molecular Weight: 257.24

Purity: ≥95%

Appearance: white to off-white powder

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Storage: Store in a cool and dry place and at 2-8 °C for short term (days to weeks) or -20 °C for long term (months to years)

Density: 1.72±0.10 g/cm3

Melting Point: 243-245 °C

Boiling Point: 523.9±60.0 °C at 760 mmHg

Flash Point: 270.7±32.9 °C

Shelf Life: 2 years

InChIKey: PPUDLEUZKVJXSZ-VPCXQMTMSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: CC1(C(C(OC1N2C=CC(=NC2=O)N)CO)O)O

IUPAC Name: 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C10H15N3O5/c1-10(17)7(15)5(4-14)18-8(10)13-3-2-6(11)12-9(13)16/h2-3,5,7-8,14-15,17H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,10-/m1/s1

Synonyms: 1-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-4-aminopyrimidin-2(1H)-one; 2'-C-methyl-cytidine; valopicitabine; Cytidine, 2'-C-methyl-; (+)-2'-C-Methylcytidine; NM 107

Related CAS: 115494-60-5

2'-C-beta-Methylguanosine

Description: 2'-C-β-Methyl Guanosine is an anti-HCV agent. 2'-C-β-Methyl Guanosine is an intermediate in the synthesis of novel double prodrug INX-08189, a new clinical candidate for hepatitis C virus.

CAT: BRP-00060

CAS: 374750-30-8

Molecular Formula: C11H15N5O5

Molecular Weight: 297.27

Purity: ≥95%

Appearance: White to Beige Powder

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Storage: Store at -20°C

Density: 2.03 g/cm3

Boiling Point: 733.1±70.0°C (Predicted)

Application: A nucleoside derivative as antiviral, antitumor, and antidiabetic prodrug agents.

InChIKey: NVKAMPJSWMHVDK-GITKWUPZSA-N

Solubility: Soluble in Water

CanonicalSMILES: CC1(C(C(OC1N2C=NC3=C2N=C(NC3=O)N)CO)O)O

IUPAC Name: 2-amino-9-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C11H15N5O5/c1-11(20)6(18)4(2-17)21-9(11)16-3-13-5-7(16)14-10(12)15-8(5)19/h3-4,6,9,17-18,20H,2H2,1H3,(H3,12,14,15,19)/t4-,6-,9-,11-/m1/s1

Synonyms: 2'-C-Methylguanosine; 2'-C-β-Methyl Guanosine; 2-Amino-9-((2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)-1H-purin-6(9H)-one; 6H-Purin-6-one, 2-amino-1,9-dihydro-9-(2-C-methyl-beta-D-ribofuranosyl)-; INX 08032; INZ 08032

2'-C-Methyluridine

Description: 2'-C-Methyluridine is a 2'-C-Me branched C-nucleoside that shows HCV polymerase inhibitory activity.

CAT: BRP-00061

CAS: 31448-54-1

Molecular Formula: C10H14N2O6

Molecular Weight: 258.23

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 1.57 g/cm3

Melting Point: 110-112 °C

InChIKey: NBKORJKMMVZAOZ-VPCXQMTMSA-N

CanonicalSMILES: CC1(C(C(OC1N2C=CC(=O)NC2=O)CO)O)O

IUPAC Name: 1-[(2R,3R,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H14N2O6/c1-10(17)7(15)5(4-13)18-8(10)12-3-2-6(14)11-9(12)16/h2-3,5,7-8,13,15,17H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,10-/m1/s1

Synonyms: 2'-C-Methyl-1-β-D-ribofuranosyluracil; 1-((2R,3R,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-Methyl Uridine; 1,3-bis(N-cyclohexyl)guanidine; 1-(2-C-Methyl-β-D-ribofuranosyl)uracil; 2,4(1H,3H)-pyrimidinedione, 1-(2-C-methyl-β-D-ribofuranosyl)-

N6-Cyclopentyl-adenosine

Description: N6-Cyclopentyl-adenosine (CPA) - an adenosine analog and A1 adenosine receptor agonist - is pivotal in biomedicine as a research tool to inspect the part played by the adenosine receptor in distinct physiological processes. It also has potential therapeutic benefits that range from treating ischemia-reperfusion injuries to chronic pain.

CAT: BRP-00062

CAS: 41552-82-3

Molecular Formula: C15H21N5O4

Molecular Weight: 335.36

Purity: ≥95% by HPLC

Appearance: White to off-white solid

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Storage: Store at 2-8 °C

Density: 1.78±0.1 g/cm3 (Predicted)

Melting Point: 78.8 °C

Boiling Point: 673.4±65.0 °C at 760 mmHg

Application: Purinergic P1 Receptor Agonists

InChIKey: SQMWSBKSHWARHU-SDBHATRESA-N

Solubility: Soluble in Water

CanonicalSMILES: C1CCC(C1)NC2=C3C(=NC=N2)N(C=N3)C4C(C(C(O4)CO)O)O

IUPAC Name: (2R,3R,4S,5R)-2-[6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

InChI: InChI=1S/C15H21N5O4/c21-5-9-11(22)12(23)15(24-9)20-7-18-10-13(16-6-17-14(10)20)19-8-3-1-2-4-8/h6-9,11-12,15,21-23H,1-5H2,(H,16,17,19)/t9-,11-,12-,15-/m1/s1

Synonyms: N6-Cyclopentyladenosine; CPA; N-Cyclopentyladenosine; UK 80882; (2R,3R,4S,5R)-2-[6-(Cyclopentylamino)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

EIDD-2749

Description: 4'-Fluorouridine is an orally active RdRp inhibitor. It effectively blocks the replication of RSV and SARS-CoV-2.

CAT: BRP-00063

CAS: 1613589-24-4

Molecular Formula: C9H11FN2O6

Molecular Weight: 262.19

Purity: 98%

Appearance: Solid

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Density: 1.77±0.1 g/cm3

InChIKey: RDCYLPRXPILMRP-JVZYCSMKSA-N

CanonicalSMILES: O=C1NC(N([C@@H]2O[C@@](CO)(F)[C@@H](O)[C@H]2O)C=C1)=O

IUPAC Name: 1-[(2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C9H11FN2O6/c10-9(3-13)6(16)5(15)7(18-9)12-2-1-4(14)11-8(12)17/h1-2,5-7,13,15-16H,3H2,(H,11,14,17)/t5-,6+,7-,9-/m1/s1

Synonyms: 4'-fluorouridine;1613589-24-4;4'-C-Fluoro-uridine;1-[(2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione;1613591-91-5;SCHEMBL6839661;RDCYLPRXPILMRP-JVZYCSMKSA-N;AMY30709;EX-A6732;DA-70078;MS-23688;4'-fluorouridine (4'-FlU, EIDD-2749)?;1-((2R,3R,4S,5S)-5-fluoro-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;

3'-O-Methyluridine

Description: 3'-O-Methyluridine is a potent compound, serving as a therapeutic intervention for research of diverse viral infections and autoimmune conditions. Through its exceptional anti-replication properties, this remarkable compound effectively hampers viral proliferation.

CAT: BRP-00064

CAS: 6038-59-1

Molecular Formula: C10H14N2O6

Molecular Weight: 258.23

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at -20°C

Density: 1.53±0.1 g/cm3

Melting Point: 142-145°C

InChIKey: YKNATSNMFLEFRB-ZOQUXTDFSA-N

CanonicalSMILES: COC1C(OC(C1O)N2C=CC(=O)NC2=O)CO

IUPAC Name: 1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H14N2O6/c1-17-8-5(4-13)18-9(7(8)15)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1

Synonyms: 3'-O-Methyl-D-uridine; O3'-methyl-uridine; 1-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 3'-O-Me-Ur; 3'-O-methyl-uridine; 3'-(O-Methyl) Uridine

3'-O-Methyladenosine

Description: 3'-O-Methyladenosine, an indispensable biomolecule utilized in the realm of biomedical research, assumes a pivotal role in the meticulous exploration of RNA modifications. Ubiquitously present within a myriad of RNA molecules, this compound exerts profound influence on gene expression regulation, cellular signaling, and the genesis of diseases.

CAT: BRP-00065

CAS: 10300-22-8

Molecular Formula: C11H15N5O4

Molecular Weight: 281.27

Purity: ≥95%

Appearance: White Powder

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Storage: Store at -20°C

Density: 1.84±0.1 g/cm3(Predicted)

Melting Point: 177-178 °C

Boiling Point: 623.8±65.0 °C(Predicted)

InChIKey: RYAFZRROCNNRFK-IOSLPCCCSA-N

Solubility: Soluble in Methanol (10 mg/mL)

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO

IUPAC Name: (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-methoxyoxolan-3-ol

InChI: InChI=1S/C11H15N5O4/c1-19-8-5(2-17)20-11(7(8)18)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1

Synonyms: 3'-O-Methyl-D-adenosine; (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; NSC 103062; 3'-O-Methyl Adenosine; 3'-(O-Methyl) Adenosine

N6-Benzoyl-2'-O-methyladenosine

Description: N6-Benzoyl-2'-O-methyladenosine is an indispensable compound in the realm of biomedical research assuming a paramount role in the exploration of RNA modifications and epigenetics.

CAT: BRP-00067

CAS: 85079-00-1

Molecular Formula: C18H19N5O5

Molecular Weight: 385.37

Purity: ≥95%

Appearance: Off-white to Pale Yellow Powder

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Storage: Store at RT

Density: 1.59±0.1 g/cm3 (Predicted)

InChIKey: PHFHSPQCDRKMQJ-XWXWGSFUSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C18H19N5O5/c1-27-14-13(25)11(7-24)28-18(14)23-9-21-12-15(19-8-20-16(12)23)22-17(26)10-5-3-2-4-6-10/h2-6,8-9,11,13-14,18,24-25H,7H2,1H3,(H,19,20,22,26)/t11-,13-,14-,18-/m1/s1

Synonyms: N6-Benzoyl-2'-O-methyl-D-adenosine; Bz-2'-OMe-A; N-Benzoyl-2'-O-methyladenosine; N6-Benzoyl-2'-O-methyl-adenosine; 2'-O-methyl-N6-benzoyladenosine; N-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; N6-Bz-2'-OMe-A; N6-Bz-2'-O-Me-Ar

N2-Isobutyryl-2'-O,4'-C-methyleneguanosine

Description: N2-Isobutyryl-2'-O,4'-C-methyleneguanosine is a potent antiviral compound used in the biomedical industry. It exhibits inhibitory activity against RNA viruses like Dengue and Zika viruses. This compound blocks viral replication by interfering with viral RNA synthesis. Its unique chemical structure makes it a valuable tool in antiviral drug discovery and development.

CAT: BRP-00069

CAS: 206055-68-7

Molecular Formula: C15H19N5O6

Molecular Weight: 365.34

Purity: ≥95%

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Density: 1.87±0.1 g/cm3

Melting Point: 196-199 °C

InChIKey: FUKSKECTPBMMEQ-BQOLRUCTSA-N

Solubility: Soluble in Water

CanonicalSMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C4C(C(O3)(CO4)CO)O

IUPAC Name: N-[9-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C15H19N5O6/c1-6(2)11(23)18-14-17-10-7(12(24)19-14)16-5-20(10)13-8-9(22)15(3-21,26-13)4-25-8/h5-6,8-9,13,21-22H,3-4H2,1-2H3,(H2,17,18,19,23,24)/t8-,9+,13-,15+/m1/s1

Synonyms: guanosine, 2'-O,4'-C-methylene-N-(2-methyl-1-oxopropyl)-; (1S,3R,4R,7S)-7-Hydroxy-1-hydroxymethyl-3-(2-N-isobutyrylguanin-9-yl)-2,5-dioxabicyclo[2.2.1]heptane; N-[6,9-Dihydro-6-oxo-9-[(1S,3R,4R,7S)-1-(hydroxymethyl)-7-hydroxy-2,5-dioxabicyclo[2.2.1]heptane-3-yl]-1H-purine-2-yl]isobutyramide

2'-O,4'-C-Methyleneuridine

Description: 2'-O,4'-C-Methyleneuridine, a biomedical compound, plays a pivotal role in the advancement of antiviral drugs and therapeutics. Its profound efficacy against a wide array of viral infections, namely hepatitis C virus (HCV) and respiratory syncytial virus (RSV), unveils its tremendous potential in combatting viral diseases.

CAT: BRP-00070

CAS: 200435-92-3

Molecular Formula: C10H12N2O6

Molecular Weight: 256.21

Purity: ≥95%

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Storage: Store at -20 °C

Density: 1.695 g/cm3

Melting Point: 239-243°C (methanol)

InChIKey: KNLNWXXWKDEEFW-JIOCBJNQSA-N

Solubility: Soluble in Methanol

CanonicalSMILES: C1C2(C(C(O1)C(O2)N3C=CC(=O)NC3=O)O)CO

IUPAC Name: 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H12N2O6/c13-3-10-4-17-6(7(10)15)8(18-10)12-2-1-5(14)11-9(12)16/h1-2,6-8,13,15H,3-4H2,(H,11,14,16)/t6-,7+,8-,10+/m1/s1

Synonyms: 1-(2-O,4-C-Methylene-beta-D-ribofuranosyl)uracil; LNA-U; 1-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione; (1S,3R,4R,7S)-7-Hydroxy-1-hydroxymethyl-3-(uracil-1-yl)-2,5-dioxabicyclo-[2.2.1]heptane

5-Methyl-2'-O,4'-C-methyleneuridine

Description: 5-Methyl-2'-O,4'-C-methyleneuridine is a chemically modified nucleoside where a methylene bridge connects the 2'-oxygen and 4'-carbon of the ribose sugar, and the uridine base is methylated at the 5-position. This modification enhances the stability and binding affinity of RNA molecules, making it valuable in RNA research and therapeutic applications. It is often used to study RNA structure, function, and interactions, and in the development of novel RNA-based drugs.

CAT: BRP-00071

CAS: 206055-67-6

Molecular Formula: C11H14N2O6

Molecular Weight: 270.24

Purity: ≥95%

Appearance: White to light brown powder

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Storage: Store at 2-8 °C

Density: 1.598±0.1 g/cm³ (Predicted)

Melting Point: 196-198 °C

InChIKey: TYYUAZVXLRMUMN-SZVQBCOZSA-N

CanonicalSMILES: CC1=CN(C(=O)NC1=O)C2C3C(C(O2)(CO3)CO)O

IUPAC Name: 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C11H14N2O6/c1-5-2-13(10(17)12-8(5)16)9-6-7(15)11(3-14,19-9)4-18-6/h2,6-7,9,14-15H,3-4H2,1H3,(H,12,16,17)/t6-,7+,9-,11+/m1/s1

Synonyms: LNA-5MeU; 1-[(1S,3R,4R,7S)-7-Hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)thymine; 1-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

2'-O,4'-C-Methyleneadenosine

Description: 2'-O,4'-C-Methyleneadenosine is a highly versatile compound, skillfully inhibiting the replication of malignant cells and viruses to effectively disrupts the pathogenic cascade.

CAT: BRP-00072

CAS: 206055-70-1

Molecular Formula: C11H13N5O4

Molecular Weight: 279.25

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 2.14±0.1 g/cm3

Melting Point: 267-270°C

Boiling Point: 660.0±65.0°C at 760 mmHg

Shelf Life: >2 years if stored properly

InChIKey: GHKDRNDFVCEETA-KYAGDKKUSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: C1C2(C(C(O1)C(O2)N3C=NC4=C(N=CN=C43)N)O)CO

IUPAC Name: (1S,3R,4R,7S)-3-(6-aminopurin-9-yl)-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol

InChI: InChI=1S/C11H13N5O4/c12-8-5-9(14-3-13-8)16(4-15-5)10-6-7(18)11(1-17,20-10)2-19-6/h3-4,6-7,10,17-18H,1-2H2,(H2,12,13,14)/t6-,7+,10-,11+/m1/s1

Synonyms: (1S,3R,4R,7S)-3-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol; LNA-Adenosine; (1S,3R,4R,7S)-7-Hydroxy-1-hydroxymethyl-3-(adenin-9-yl)-2,5-dioxabicyclo-[2.2.1]heptane; 9H-Purin-6-amine, 9-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-; 9-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-9H-purin-6-amine; LNA-A diol; 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)adenine; LNA-A

2'-O,4'-C-Methylenecytidine

Description: 2'-O,4'-C-Methylenecytidine is a highly imperative compound in the field of compound, finding its application in the development of antiviral medications. Underpinning its significance, this exquisite compound assuming a pivotal role in impeding viral replication dynamics.

CAT: BRP-00073

CAS: 206055-69-8

Molecular Formula: C10H13N3O5

Molecular Weight: 255.23

Purity: ≥95%

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Density: 2.0±0.1 g/cm3

Melting Point: 274-276 °C

Boiling Point: 532.9±60.0°C at 760 mmHg

InChIKey: FCMRQQIZHFHCNG-JIOCBJNQSA-N

CanonicalSMILES: C1C2(C(C(O1)C(O2)N3C=CC(=NC3=O)N)O)CO

IUPAC Name: 4-amino-1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidin-2-one

InChI: InChI=1S/C10H13N3O5/c11-5-1-2-13(9(16)12-5)8-6-7(15)10(3-14,18-8)4-17-6/h1-2,6-8,14-15H,3-4H2,(H2,11,12,16)/t6-,7+,8-,10+/m1/s1

Synonyms: LNA-C; Cytidine, 2'-O,4'-C-methylene-; 4-amino-1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2 2 1]heptan-3-yl]-1,2-dihydropyrimidin-2-one; (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(cytosin-1-yl)-2,5-dioxabicyclo[2 2 1]heptane; 4-Amino-1-[2,5-anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-2(1H)-pyrimidinone

5-Methyl-2'-O,4'-C-methylenecytidine

Description: 5-Methyl-2'-O,4'-C-methylenecytidine, an intriguing nucleoside analog, emerges as a captivating specimen in combating viral adversaries. Showcasing robust antiviral prowess, it has garnered remarkable interest in the realm of scientific exploration. Elucidating its potential therapeutics, 5-Methyl-2'-O,4'-C-methylenecytidine manifests as a potent weapon against notorious afflictions such as hepatitis C and COVID-19. Distinctively, through its structural idiosyncrasies, it skillfully thwarts viral replication by impeding the viral RNA synthesis process.

CAT: BRP-00074

CAS: 847650-87-7

Molecular Formula: C11H15N3O5

Molecular Weight: 269.25

Purity: ≥95%

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Density: 1.84±0.1 g/cm3 (Predicted)

Boiling Point: 526.8±60.0°C (Predicted)

InChIKey: NELYIRACPIJATH-SZVQBCOZSA-N

CanonicalSMILES: CC1=CN(C(=O)N=C1N)C2C3C(C(O2)(CO3)CO)O

IUPAC Name: 4-amino-1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidin-2-one

InChI: InChI=1S/C11H15N3O5/c1-5-2-14(10(17)13-8(5)12)9-6-7(16)11(3-15,19-9)4-18-6/h2,6-7,9,15-16H,3-4H2,1H3,(H2,12,13,17)/t6-,7+,9-,11+/m1/s1

Synonyms: LNA-5MeC; 4-amino-1-[2,5-anhydro-4-(hydroxymethyl)-alpha-L-lyxofuranosyl]-5-methylcytosine; 4-amino-1-[2,5-anhydro-4-(hydroxymethyl)-alpha-L-lyxofuranosyl]-5-methylpyrimidin-2(1H)-one; 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-5-methyl-

3'-O-Methylcytidine

Description: 3'-O-Methylcytidine is an indispensable compound in the biomedical field, functioning as a cytidine analogue. This compound assumes a pivotal role as a fundamental constituent in producing nucleoside analog medications and research of viral agents.

CAT: BRP-00075

CAS: 20594-00-7

Molecular Formula: C10H15N3O5

Molecular Weight: 257.24

Purity: ≥95%

Appearance: White Powder

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Storage: Store at 2-8°C

Density: 1.7±0.1 g/cm3

Melting Point: 207-210°C

Boiling Point: 506.0±60.0°C at 760 mmHg

InChIKey: RZJCFLSPBDUNDH-ZOQUXTDFSA-N

Solubility: Soluble in Methanol (10 mg/mL)

CanonicalSMILES: COC1C(OC(C1O)N2C=CC(=NC2=O)N)CO

IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C10H15N3O5/c1-17-8-5(4-14)18-9(7(8)15)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1

Synonyms: 3'-(O-Methyl) Cytidine; 3'-O-Methyl-D-cytidine; O3'-methyl-cytidine; O3'-Methylcytidine; 4-amino-1-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one

2-Amino-N2-O-methyladenosine

Description: 2-Amino-N2-O-methyladenosine, a remarkable biomedicine, emerges as an efficacious treatment for a diverse array of ailments. This multifaceted compound exhibits its prowess as a viable therapeutic intervention in the realm of malignancy through its remarkable capacity to impede neoplastic proliferation and instigate apoptotic demise. Moreover, in the domain of combating viral infections, it demonstrates immense potential by specifically antagonizing the viral replication mechanisms.

CAT: BRP-00076

CAS: 80791-87-3

Molecular Formula: C11H16N6O4

Molecular Weight: 296.29

Purity: ≥97%

Appearance: White to Off-white Powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.983 g/cm3

Melting Point: 121-122°C

Boiling Point: 733.177°C at 760 mmHg

InChIKey: JLWUWXCKSOIFPS-KQYNXXCUSA-N

CanonicalSMILES: COC1C(C(OC1N2C=NC3=C(N=C(N=C32)N)N)CO)O

IUPAC Name: (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol

InChI: InChI=1S/C11H16N6O4/c1-20-7-6(19)4(2-18)21-10(7)17-3-14-5-8(12)15-11(13)16-9(5)17/h3-4,6-7,10,18-19H,2H2,1H3,(H4,12,13,15,16)/t4-,6-,7-,10-/m1/s1

Synonyms: 2-Amino-2'-O-methyladenosine; 2'-O-methyl-2,6-diaminopurine-riboside; (2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; 2-NH2-2'-O-Me-Ar

3'-O-(2-Methoxyethyl)adenosine

Description: 3'-O-(2-Methoxyethyl)adenosine, renowned in the biomedical industry, holds immense significance for a myriad of applications. With its pivotal role in the pharmaceutical realm, it contributes significantly in the combat against afflictions like cancer, viral infections, and inflammation. By orchestrating cellular pathways and regulating biological processes, this compound manifests promising therapeutic effects.

CAT: BRP-00079

CAS: 303197-30-0

Molecular Formula: C13H19N5O5

Molecular Weight: 325.32

Purity: ≥95%

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Density: 1.70±0.1 g/cm3

Boiling Point: 639.0±65.0 °C at 760 mmHg

InChIKey: RHVMAYVXDAXYHR-QYVSTXNMSA-N

Solubility: Soluble in DCM

CanonicalSMILES: COCCOC1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO

IUPAC Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-ol

InChI: InChI=1S/C13H19N5O5/c1-21-2-3-22-10-7(4-19)23-13(9(10)20)18-6-17-8-11(14)15-5-16-12(8)18/h5-7,9-10,13,19-20H,2-4H2,1H3,(H2,14,15,16)/t7-,9-,10-,13-/m1/s1

Synonyms: 3'-MOE-Adenosine; 3'-MOE-rA; Adenosine, 3'-O-(2-methoxyethyl)-; (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-ol

4'-alpha-Azidouridine

2'-C-methyladenosine

2-C-methyl-6-O-methyl-guanosine

2'-C-Methylcytidine

2'-C-beta-Methylguanosine

2'-C-Methyluridine

N6-Cyclopentyl-adenosine

EIDD-2749

3'-O-Methyluridine

3'-O-Methyladenosine

N6-Benzoyl-2'-O-methyladenosine

N2-Isobutyryl-2'-O,4'-C-methyleneguanosine

2'-O,4'-C-Methyleneuridine

5-Methyl-2'-O,4'-C-methyleneuridine

2'-O,4'-C-Methyleneadenosine

2'-O,4'-C-Methylenecytidine

5-Methyl-2'-O,4'-C-methylenecytidine

3'-O-Methylcytidine

2-Amino-N2-O-methyladenosine

3'-O-(2-Methoxyethyl)adenosine

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