What are nucleosides used for?

Nucleosides are base molecules used as starting materials for synthesizing nucleotides and phosphoramidites.

What is the difference between nucleosides and nucleotides?

Nucleosides lack phosphate groups, while nucleotides contain one or more phosphates required for enzymatic reactions.

Are nucleosides used directly in enzymatic reactions?

Nucleosides are typically chemically modified before being used in enzymatic workflows.

Can nucleosides be chemically modified?

Yes, modified nucleosides are widely used to introduce structural or functional changes in nucleic acids.

Why is nucleoside purity important?

High purity ensures correct downstream synthesis of nucleotides and phosphoramidites with predictable performance.

Nucleosides - BOC Sciences

2'-O,4'-C-Methyleneuridine

Description: 2'-O,4'-C-Methyleneuridine, a biomedical compound, plays a pivotal role in the advancement of antiviral drugs and therapeutics. Its profound efficacy against a wide array of viral infections, namely hepatitis C virus (HCV) and respiratory syncytial virus (RSV), unveils its tremendous potential in combatting viral diseases.

CAT: BRP-00070

CAS: 200435-92-3

Molecular Formula: C10H12N2O6

Molecular Weight: 256.21

Purity: ≥95%

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Storage: Store at -20 °C

Density: 1.695 g/cm3

Melting Point: 239-243°C (methanol)

InChIKey: KNLNWXXWKDEEFW-JIOCBJNQSA-N

Solubility: Soluble in Methanol

SMILES: C1C2(C(C(O1)C(O2)N3C=CC(=O)NC3=O)O)CO

IUPAC Name: 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C10H12N2O6/c13-3-10-4-17-6(7(10)15)8(18-10)12-2-1-5(14)11-9(12)16/h1-2,6-8,13,15H,3-4H2,(H,11,14,16)/t6-,7+,8-,10+/m1/s1

Synonyms: 1-(2-O,4-C-Methylene-beta-D-ribofuranosyl)uracil; LNA-U; 1-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione; (1S,3R,4R,7S)-7-Hydroxy-1-hydroxymethyl-3-(uracil-1-yl)-2,5-dioxabicyclo-[2.2.1]heptane

5-Methyl-2'-O,4'-C-methyleneuridine

Description: 5-Methyl-2'-O,4'-C-methyleneuridine is a chemically modified nucleoside where a methylene bridge connects the 2'-oxygen and 4'-carbon of the ribose sugar, and the uridine base is methylated at the 5-position. This modification enhances the stability and binding affinity of RNA molecules, making it valuable in RNA research and therapeutic applications. It is often used to study RNA structure, function, and interactions, and in the development of novel RNA-based drugs.

CAT: BRP-00071

CAS: 206055-67-6

Molecular Formula: C11H14N2O6

Molecular Weight: 270.24

Purity: ≥95%

Appearance: White to light brown powder

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Storage: Store at 2-8 °C

Density: 1.598±0.1 g/cm³ (Predicted)

Melting Point: 196-198 °C

InChIKey: TYYUAZVXLRMUMN-SZVQBCOZSA-N

SMILES: CC1=CN(C(=O)NC1=O)C2C3C(C(O2)(CO3)CO)O

IUPAC Name: 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidine-2,4-dione

InChI: InChI=1S/C11H14N2O6/c1-5-2-13(10(17)12-8(5)16)9-6-7(15)11(3-14,19-9)4-18-6/h2,6-7,9,14-15H,3-4H2,1H3,(H,12,16,17)/t6-,7+,9-,11+/m1/s1

Synonyms: LNA-5MeU; 1-[(1S,3R,4R,7S)-7-Hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidine-2,4(1H,3H)-dione; 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)thymine; 1-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-5-methyl-2,4(1H,3H)-pyrimidinedione

2'-O,4'-C-Methyleneadenosine

Description: 2'-O,4'-C-Methyleneadenosine is a highly versatile compound, skillfully inhibiting the replication of malignant cells and viruses to effectively disrupts the pathogenic cascade.

CAT: BRP-00072

CAS: 206055-70-1

Molecular Formula: C11H13N5O4

Molecular Weight: 279.25

Purity: ≥95%

Appearance: White to Off-white Powder

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Storage: Store at 2-8°C

Density: 2.14±0.1 g/cm3

Melting Point: 267-270°C

Boiling Point: 660.0±65.0°C at 760 mmHg

Shelf Life: >2 years if stored properly

InChIKey: GHKDRNDFVCEETA-KYAGDKKUSA-N

Solubility: Soluble in DMSO

SMILES: C1C2(C(C(O1)C(O2)N3C=NC4=C(N=CN=C43)N)O)CO

IUPAC Name: (1S,3R,4R,7S)-3-(6-aminopurin-9-yl)-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol

InChI: InChI=1S/C11H13N5O4/c12-8-5-9(14-3-13-8)16(4-15-5)10-6-7(18)11(1-17,20-10)2-19-6/h3-4,6-7,10,17-18H,1-2H2,(H2,12,13,14)/t6-,7+,10-,11+/m1/s1

Synonyms: (1S,3R,4R,7S)-3-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-7-ol; LNA-Adenosine; (1S,3R,4R,7S)-7-Hydroxy-1-hydroxymethyl-3-(adenin-9-yl)-2,5-dioxabicyclo-[2.2.1]heptane; 9H-Purin-6-amine, 9-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-; 9-[2,5-Anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-9H-purin-6-amine; LNA-A diol; 1-(2'-O-4-C-Methylene-b-D-ribofuranosyl)adenine; LNA-A

2'-O,4'-C-Methylenecytidine

Description: 2'-O,4'-C-Methylenecytidine is a highly imperative compound in the field of compound, finding its application in the development of antiviral medications. Underpinning its significance, this exquisite compound assuming a pivotal role in impeding viral replication dynamics.

CAT: BRP-00073

CAS: 206055-69-8

Molecular Formula: C10H13N3O5

Molecular Weight: 255.23

Purity: ≥95%

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Density: 2.0±0.1 g/cm3

Melting Point: 274-276 °C

Boiling Point: 532.9±60.0°C at 760 mmHg

InChIKey: FCMRQQIZHFHCNG-JIOCBJNQSA-N

SMILES: C1C2(C(C(O1)C(O2)N3C=CC(=NC3=O)N)O)CO

IUPAC Name: 4-amino-1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidin-2-one

InChI: InChI=1S/C10H13N3O5/c11-5-1-2-13(9(16)12-5)8-6-7(15)10(3-14,18-8)4-17-6/h1-2,6-8,14-15H,3-4H2,(H2,11,12,16)/t6-,7+,8-,10+/m1/s1

Synonyms: LNA-C; Cytidine, 2'-O,4'-C-methylene-; 4-amino-1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2 2 1]heptan-3-yl]-1,2-dihydropyrimidin-2-one; (1S,3R,4R,7S)-7-hydroxy-1-hydroxymethyl-3-(cytosin-1-yl)-2,5-dioxabicyclo[2 2 1]heptane; 4-Amino-1-[2,5-anhydro-4-(hydroxymethyl)-α-L-lyxofuranosyl]-2(1H)-pyrimidinone

5-Methyl-2'-O,4'-C-methylenecytidine

Description: 5-Methyl-2'-O,4'-C-methylenecytidine, an intriguing nucleoside analog, emerges as a captivating specimen in combating viral adversaries. Showcasing robust antiviral prowess, it has garnered remarkable interest in the realm of scientific exploration. Elucidating its potential therapeutics, 5-Methyl-2'-O,4'-C-methylenecytidine manifests as a potent weapon against notorious afflictions such as hepatitis C and COVID-19. Distinctively, through its structural idiosyncrasies, it skillfully thwarts viral replication by impeding the viral RNA synthesis process.

CAT: BRP-00074

CAS: 847650-87-7

Molecular Formula: C11H15N3O5

Molecular Weight: 269.25

Purity: ≥95%

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Density: 1.84±0.1 g/cm3 (Predicted)

Boiling Point: 526.8±60.0°C (Predicted)

InChIKey: NELYIRACPIJATH-SZVQBCOZSA-N

SMILES: CC1=CN(C(=O)N=C1N)C2C3C(C(O2)(CO3)CO)O

IUPAC Name: 4-amino-1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylpyrimidin-2-one

InChI: InChI=1S/C11H15N3O5/c1-5-2-14(10(17)13-8(5)12)9-6-7(16)11(3-15,19-9)4-18-6/h2,6-7,9,15-16H,3-4H2,1H3,(H2,12,13,17)/t6-,7+,9-,11+/m1/s1

Synonyms: LNA-5MeC; 4-amino-1-[2,5-anhydro-4-(hydroxymethyl)-alpha-L-lyxofuranosyl]-5-methylcytosine; 4-amino-1-[2,5-anhydro-4-(hydroxymethyl)-alpha-L-lyxofuranosyl]-5-methylpyrimidin-2(1H)-one; 1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-[2,5-anhydro-4-C-(hydroxymethyl)-α-L-lyxofuranosyl]-5-methyl-

3'-O-Methylcytidine

Description: 3'-O-Methylcytidine is an indispensable compound in the biomedical field, functioning as a cytidine analogue. This compound assumes a pivotal role as a fundamental constituent in producing nucleoside analog medications and research of viral agents.

CAT: BRP-00075

CAS: 20594-00-7

Molecular Formula: C10H15N3O5

Molecular Weight: 257.24

Purity: ≥95%

Appearance: White Powder

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Storage: Store at 2-8°C

Density: 1.7±0.1 g/cm3

Melting Point: 207-210°C

Boiling Point: 506.0±60.0°C at 760 mmHg

InChIKey: RZJCFLSPBDUNDH-ZOQUXTDFSA-N

Solubility: Soluble in Methanol (10 mg/mL)

SMILES: COC1C(OC(C1O)N2C=CC(=NC2=O)N)CO

IUPAC Name: 4-amino-1-[(2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxyoxolan-2-yl]pyrimidin-2-one

InChI: InChI=1S/C10H15N3O5/c1-17-8-5(4-14)18-9(7(8)15)13-3-2-6(11)12-10(13)16/h2-3,5,7-9,14-15H,4H2,1H3,(H2,11,12,16)/t5-,7-,8-,9-/m1/s1

Synonyms: 3'-(O-Methyl) Cytidine; 3'-O-Methyl-D-cytidine; O3'-methyl-cytidine; O3'-Methylcytidine; 4-amino-1-((2R,3R,4S,5R)-3-hydroxy-5-(hydroxymethyl)-4-methoxytetrahydrofuran-2-yl)pyrimidin-2(1H)-one

2-Amino-N2-O-methyladenosine

Description: 2-Amino-N2-O-methyladenosine, a remarkable biomedicine, emerges as an efficacious treatment for a diverse array of ailments. This multifaceted compound exhibits its prowess as a viable therapeutic intervention in the realm of malignancy through its remarkable capacity to impede neoplastic proliferation and instigate apoptotic demise. Moreover, in the domain of combating viral infections, it demonstrates immense potential by specifically antagonizing the viral replication mechanisms.

CAT: BRP-00076

CAS: 80791-87-3

Molecular Formula: C11H16N6O4

Molecular Weight: 296.29

Purity: ≥97%

Appearance: White to Off-white Powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.983 g/cm3

Melting Point: 121-122°C

Boiling Point: 733.177°C at 760 mmHg

InChIKey: JLWUWXCKSOIFPS-KQYNXXCUSA-N

SMILES: COC1C(C(OC1N2C=NC3=C(N=C(N=C32)N)N)CO)O

IUPAC Name: (2R,3R,4R,5R)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)-4-methoxyoxolan-3-ol

InChI: InChI=1S/C11H16N6O4/c1-20-7-6(19)4(2-18)21-10(7)17-3-14-5-8(12)15-11(13)16-9(5)17/h3-4,6-7,10,18-19H,2H2,1H3,(H4,12,13,15,16)/t4-,6-,7-,10-/m1/s1

Synonyms: 2-Amino-2'-O-methyladenosine; 2'-O-methyl-2,6-diaminopurine-riboside; (2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-2-(hydroxymethyl)-4-methoxytetrahydrofuran-3-ol; 2-NH2-2'-O-Me-Ar

3'-O-(2-Methoxyethyl)adenosine

Description: 3'-O-(2-Methoxyethyl)adenosine, renowned in the biomedical industry, holds immense significance for a myriad of applications. With its pivotal role in the pharmaceutical realm, it contributes significantly in the combat against afflictions like cancer, viral infections, and inflammation. By orchestrating cellular pathways and regulating biological processes, this compound manifests promising therapeutic effects.

CAT: BRP-00079

CAS: 303197-30-0

Molecular Formula: C13H19N5O5

Molecular Weight: 325.32

Purity: ≥95%

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Density: 1.70±0.1 g/cm3

Boiling Point: 639.0±65.0 °C at 760 mmHg

InChIKey: RHVMAYVXDAXYHR-QYVSTXNMSA-N

Solubility: Soluble in DCM

SMILES: COCCOC1C(OC(C1O)N2C=NC3=C(N=CN=C32)N)CO

IUPAC Name: (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-ol

InChI: InChI=1S/C13H19N5O5/c1-21-2-3-22-10-7(4-19)23-13(9(10)20)18-6-17-8-11(14)15-5-16-12(8)18/h5-7,9-10,13,19-20H,2-4H2,1H3,(H2,14,15,16)/t7-,9-,10-,13-/m1/s1

Synonyms: 3'-MOE-Adenosine; 3'-MOE-rA; Adenosine, 3'-O-(2-methoxyethyl)-; (2R,3R,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-ol

2'-O-Methyl-N2-isobutyroylguanosine

Description: 2'-O-Methyl-N2-isobutyroylguanosine is a biomedicine used in the reserch of certain diseases, including cancer. It acting as an antineoplastic compound and exhibiting potent activity against specific tumor cells. Its mechanism of action involves inhibiting cell growth and inducing apoptosis.

CAT: BRP-00080

CAS: 63264-29-9

Molecular Formula: C15H21N5O6

Molecular Weight: 367.36

Purity: ≥95%

Appearance: White to Light Yellow Powder

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Storage: Store at 2-8°C

Density: 1.68±0.10 g/cm3

InChIKey: RPULCYXEYODQOG-AKAIJSEGSA-N

SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C15H21N5O6/c1-6(2)12(23)18-15-17-11-8(13(24)19-15)16-5-20(11)14-10(25-3)9(22)7(4-21)26-14/h5-7,9-10,14,21-22H,4H2,1-3H3,(H2,17,18,19,23,24)/t7-,9-,10-,14-/m1/s1

Synonyms: N2-Isobutyryl-2'-O-methylguanosine; N2-Isobutyryl-2'-O-methyl-D-guanosine; IBU-2'-OME-G; N2-isobutyryl-O2'-methyl-guanosine; N-(9-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; Guanosine, 2'-O-methyl-N-(2-methyl-1-oxopropyl)-; 2'-O-Methyl-N-(2-methyl-1-oxopropyl)guanosine

Arabinofuranosyl-guanine (ara-G)

Description: Arabinofuranosyl-guanine (ara-G) is an inhibitor of DNA synthesis used as an antimetabolic and antineoplastic agent.

CAT: BRP-00081

CAS: 38819-10-2

Molecular Formula: C10H13N5O5

Molecular Weight: 283.24

Purity: ≥98% by HPLC

Appearance: White to Off-white Solid

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Storage: Store at -20°C under inert atmosphere

Density: 2.25±0.1 g/cm3 (Predicted)

Melting Point: >245°C (dec.)

InChIKey: NYHBQMYGNKIUIF-FJFJXFQQSA-N

Solubility: Soluble in Aqueous Base (Slightly, Sonicated), DMSO (Slightly)

SMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)O)NC(=NC2=O)N

IUPAC Name: 2-amino-9-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one

InChI: InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/m1/s1

Synonyms: Arabinosylguanine; 2-Amino-9-β-D-arabinofuranosyl-1,9-dihydro-6H-purin-6-one; 2-Amino-6-hydroxy-9-(β-D-arabinofuranosyl)purine; 9-β-D-Arabinofuranosylguanine; Araguanosine; Guanine arabinoside; NSC 76352; ara-Guanosine; A 4233; Arabinoguanosine

N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine

Description: N6-Benzoyl-2'-O-(2-methoxyethyl)adenosine, an indispensable compound in the biomedical sector, showcases immense potential for therapeutic applications. Its remarkable chemical structure renders it uniquely suited for drug design, thereby paving the way for promising advancements in biomedicine. Widely employed in the pharmaceutical industry, this product plays a pivotal role in the development of medications targeting diverse ailments including cancer and viral infections.

CAT: BRP-00083

CAS: 333335-93-6

Molecular Formula: C20H23N5O6

Molecular Weight: 429.43

Purity: ≥95%

Appearance: White, off-white to faint yellow powder

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Storage: Store at 2-8 °C, Keep in a dark and dry place

Density: 1.5±0.0 g/cm3

InChIKey: RUFJMCSVNNGZFB-KHTYJDQRSA-N

SMILES: COCCOC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)CO)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)oxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C20H23N5O6/c1-29-7-8-30-16-15(27)13(9-26)31-20(16)25-11-23-14-17(21-10-22-18(14)25)24-19(28)12-5-3-2-4-6-12/h2-6,10-11,13,15-16,20,26-27H,7-9H2,1H3,(H,21,22,24,28)/t13-,15-,16-,20-/m1/s1

Synonyms: N-Benzoyl-2'-O-(2-methoxyethyl)adenosine; 2'-O-methoxyethyl-N6-benzoyl-adenosine; N-(9-((2R,3R,4R,5R)-4-Hydroxy-5-(hydroxymethyl)-3-(2-methoxyethoxy)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; N6-Bz-2'-O-MOE-A; N6-benzoyl-2'-O-methoxyethyl-adenosine

2'-O-t-Butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-N4-acetylcytidine

Description: It is used for nucleoside modification and nucleic acid synthesis.

CAT: BRP-00086

CAS: 121058-85-3

Molecular Formula: C38H47N3O8Si

Molecular Weight: 701.88

Purity: ≥95%

Appearance: White to Off-white Crystalline Powder

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Storage: Store at 2-8°C

Density: 1.19±0.1 g/cm3 (Predicted)

InChIKey: ZFRWPAYPCFTQHK-HYGOWAQNSA-N

SMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C38H47N3O8Si/c1-25(42)39-32-22-23-41(36(44)40-32)35-34(49-50(7,8)37(2,3)4)33(43)31(48-35)24-47-38(26-12-10-9-11-13-26,27-14-18-29(45-5)19-15-27)28-16-20-30(46-6)21-17-28/h9-23,31,33-35,43H,24H2,1-8H3,(H,39,40,42,44)/t31-,33-,34-,35-/m1/s1

Synonyms: 2'-O-TBDMS-5'-O-DMT-N4-Ac cytidine; N4-Acetyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-cytidine; N4-acetyl-2'-O-(t-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)cytidine; 5'-O-(4,4'-Dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl]-N4-acetylcytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]cytidine; N4-Ac-2'-O-TBDMS-5'-O-DMT-C; N4-Ac-DMT-2'-O-TBDMS-Cr; N4-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-cytidine; 5'-DMT-2'-tBDSilyl Cytidine (n-acetyl)

5'-O-DMT-2'-O-iBu-N-Bz-Guanosine

Description: 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine, an indispensable compound utilized in the biomedical sector, showcases immense promise in combatting a plethora of diseases and disorders, namely cancer and viral infections. Its extraordinary configuration empowers it to disrupt replication procedures, rendering it a highly efficacious agent against antiviral and anticancer fronts.

CAT: BRP-00087

CAS: 81279-39-2

Molecular Formula: C41H51N5O8Si

Molecular Weight: 769.96

Purity: ≥95%

Appearance: White powder

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Storage: Store at -20 °C

Density: 1.3±0.1 g/cm3

InChIKey: JMCNKJFOIJGYRG-CJEGOSRCSA-N

SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)O[Si](C)(C)C(C)(C)C

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C41H51N5O8Si/c1-25(2)36(48)44-39-43-35-32(37(49)45-39)42-24-46(35)38-34(54-55(8,9)40(3,4)5)33(47)31(53-38)23-52-41(26-13-11-10-12-14-26,27-15-19-29(50-6)20-16-27)28-17-21-30(51-7)22-18-28/h10-22,24-25,31,33-34,38,47H,23H2,1-9H3,(H2,43,44,45,48,49)/t31-,33-,34-,38-/m1/s1

Synonyms: N2-iBu-2'-O-TBDMS-5'-O-DMT-G; N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)isobutyramide; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)guanosine; N2-iBu-DMT-2'-O-TBDMS-Gr; N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(t-butyl-dimethylsilyl)-guanosine; 5'-DMT-2'-tBDSilyl Guanosine (n-ibu)

2'-O-t-Butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)-N6-benzoyladenosine

Description: It is a fluorescent adenosine-containing compound commonly used to detect DNA/RNA modifications or to add synthetic oligonucleotide blocks.

CAT: BRP-00088

CAS: 81265-93-2

Molecular Formula: C44H49N5O7Si

Molecular Weight: 787.97

Purity: ≥95%

Appearance: White to Off-white Crystalline Powder

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Storage: Store at -20°C

Density: 1.23±0.1 g/cm3 (Predicted)

InChIKey: DAZIGOPASNJPCJ-GNECSJIWSA-N

SMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C44H49N5O7Si/c1-43(2,3)57(6,7)56-38-37(50)35(55-42(38)49-28-47-36-39(45-27-46-40(36)49)48-41(51)29-14-10-8-11-15-29)26-54-44(30-16-12-9-13-17-30,31-18-22-33(52-4)23-19-31)32-20-24-34(53-5)25-21-32/h8-25,27-28,35,37-38,42,50H,26H2,1-7H3,(H,45,46,48,51)/t35-,37-,38-,42-/m1/s1

Synonyms: 5'-DMT-2'-tBDSilyl Adenosine (n-bz); 2'-O-TBDMS-5'-O-DMT-N6-Bz adenosine; N6-Benzoyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine; 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)-N-benzoyladenosine

2'-O-Tert-butyldimethylsilyl-5'-O-DMT-uridine

Description: It is used for RNA synthesis and special nucleoside modification.

CAT: BRP-00089

CAS: 81246-80-2

Molecular Formula: C36H44N2O8Si

Molecular Weight: 660.83

Purity: ≥95%

Appearance: White Solid

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Storage: Store at 2-8°C

Density: 1.3±0.1 g/cm3

InChIKey: KVHQIELPHWJPSY-WXQJYUTRSA-N

SMILES: CC(C)(C)[Si](C)(C)OC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C36H44N2O8Si/c1-35(2,3)47(6,7)46-32-31(40)29(45-33(32)38-22-21-30(39)37-34(38)41)23-44-36(24-11-9-8-10-12-24,25-13-17-27(42-4)18-14-25)26-15-19-28(43-5)20-16-26/h8-22,29,31-33,40H,23H2,1-7H3,(H,37,39,41)/t29-,31-,32-,33-/m1/s1

Synonyms: 5'-DMT-2'-tBDSilyl Uridine; 5'-O-DMT-2'-O-TBDMS uridine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-t-butyldimethylsilyl uridine; 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 2'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)uridine; 5'-O-(4,4'-Dimethoxytrityl) 2'-O-[(1,1-dimethylethyl)-dimethylsilyl]-uridine

N4-Acetyl-5'-O-DMT-2'-O-methylcytidine

Description: N4-Acetyl-5'-O-DMT-2'-O-methylcytidine, a crucial compound of immense significance in the biomedical sector, plays a pivotal role in combating viral diseases such as hepatitis C and respiratory syncytial virus (RSV) infections.

CAT: BRP-00090

CAS: 199593-08-3

Molecular Formula: C33H35N3O8

Molecular Weight: 601.65

Purity: ≥98% by HPLC

Appearance: White to Pale Yellow Powder

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Storage: Store at 2-8°C

Density: 1.28±0.1 g/cm3 (Predicted)

InChIKey: FINUHOJILDNELQ-PMFUCWTESA-N

SMILES: CC(=O)NC1=NC(=O)N(C=C1)C2C(C(C(O2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O)OC

IUPAC Name: N-[1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxopyrimidin-4-yl]acetamide

InChI: InChI=1S/C33H35N3O8/c1-21(37)34-28-18-19-36(32(39)35-28)31-30(42-4)29(38)27(44-31)20-43-33(22-8-6-5-7-9-22,23-10-14-25(40-2)15-11-23)24-12-16-26(41-3)17-13-24/h5-19,27,29-31,38H,20H2,1-4H3,(H,34,35,37,39)/t27-,29-,30-,31-/m1/s1

Synonyms: 5'-DMT-2'-O-Methyl Cytidine (n-acetyl); 5'-DMT-2'-OMe-Ac-C; N4-Acetyl-5'-O-DMT-2'-O-methyl-D-cytidine; 5'-O-(4,4'-Dimethoxytrityl)-N4-Acetyl-2'-O-Methy-Cytidine; N-Acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-cytidine; 5'-O-DMT-N4-Acetyl-2'-O-Methyl-cytidine; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methylcytidine

N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine

Description: N6-Benzoyl-5'-O-DMT-2'-O-methyladenosine is an astounding chemical compound allowing for the precise modulation of enzymes and receptors, used in studying cancer, viral infections and neurological disorders.

CAT: BRP-00091

CAS: 110764-72-2

Molecular Formula: C39H37N5O7

Molecular Weight: 687.74

Purity: ≥98% by HPLC

Appearance: White to Pale Yellow Powder

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Storage: Store at 2-8°C

Density: 1.32±0.1 g/cm3 (Predicted)

InChIKey: SARHDAQOZNKZCC-CJEGOSRCSA-N

SMILES: COC1C(C(OC1N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC)O

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]purin-6-yl]benzamide

InChI: InChI=1S/C39H37N5O7/c1-47-29-18-14-27(15-19-29)39(26-12-8-5-9-13-26,28-16-20-30(48-2)21-17-28)50-22-31-33(45)34(49-3)38(51-31)44-24-42-32-35(40-23-41-36(32)44)43-37(46)25-10-6-4-7-11-25/h4-21,23-24,31,33-34,38,45H,22H2,1-3H3,(H,40,41,43,46)/t31-,33-,34-,38-/m1/s1

Synonyms: 5'-DMT-2'-(O-Methyl) Adenosine (n-bz); 5'-DMT-2'-OMe-Bz-A; N-(9-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide; 5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyl-2'-O-methyladenosine; N-Benzoyl-5'-O-[bis(4-methoxyphenyl)-phenylmethyl]-2'-O-methyl-adenosine; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-methyladenosine

5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine

Description: 5'-O-DMT-N2-isobutyryl-2'-O-methylguanosine, a remarkable antiviral agent employed in advanced biomedical investigations, defies viral replication across diverse strains, such as the treacherous influenza and herpes simplex virus. Equally significant, this compound boasts unrivaled eminence in probing RNA biology and delineating protein synthesis intricacies. Scientific affluence beckons its application, impelling groundbreaking inquiries exploring viral replication mechanisms and pioneering antiviral therapies.

CAT: BRP-00092

CAS: 114745-26-5

Molecular Formula: C36H39N5O8

Molecular Weight: 669.74

Purity: ≥98% by HPLC

Appearance: White to light yellow powder

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Storage: Store at -20 °C

Density: 1.35±0.1 g/cm3(Predicted)

InChIKey: ISQLJOGRNUQHJX-WIFIACMTSA-N

Solubility: Soluble in acetonitrile

SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)O)OC

IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C36H39N5O8/c1-21(2)32(43)39-35-38-31-28(33(44)40-35)37-20-41(31)34-30(47-5)29(42)27(49-34)19-48-36(22-9-7-6-8-10-22,23-11-15-25(45-3)16-12-23)24-13-17-26(46-4)18-14-24/h6-18,20-21,27,29-30,34,42H,19H2,1-5H3,(H2,38,39,40,43,44)/t27-,29-,30-,34-/m1/s1

Synonyms: N2-iBu-2'-OMe-5'-O-DMT-G; N2-iBu-2'-OMe-5'-O-DMT-G; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyl-N-(2-methyl-1-oxopropyl)guanosine; 5'-DMT-2'-(O-Methyl) Guanosine (n-ibu)

5'-O-DMT-2'-O-methyluridine

Description: It is used for RNA synthesis and nucleoside modification.

CAT: BRP-00093

CAS: 103285-22-9

Molecular Formula: C31H32N2O8

Molecular Weight: 560.59

Purity: ≥98% by HPLC

Appearance: White to light yellow powder

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Storage: Store at 2-8 °C

Density: 1.35±0.1 g/cm³(Predicted)

InChIKey: MFDHAVFJDSRPKC-YXINZVNLSA-N

SMILES: COC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O

IUPAC Name: 1-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxy-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione

InChI: InChI=1S/C31H32N2O8/c1-37-23-13-9-21(10-14-23)31(20-7-5-4-6-8-20,22-11-15-24(38-2)16-12-22)40-19-25-27(35)28(39-3)29(41-25)33-18-17-26(34)32-30(33)36/h4-18,25,27-29,35H,19H2,1-3H3,(H,32,34,36)/t25-,27-,28-,29-/m1/s1

Synonyms: 5'-DMT-2'-(O-Methyl) Uridine; 5'-O-(4,4'-Dimethoxytrityl)-2'-O-Methyluridine; 5'-O-DMT-2'-O-methyl-D-uridine; 1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-hydroxy-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-methyluridine

N-Isobutyrylguanosine

Description: N-Isobutyrylguanosine is used in the syntehsis of 2'-O-(o-nitrobenzyl)-3'-thioguanosine phosphoramidite which is then used to form oligonucleotides, substrates for probing the mechanism of RNA catalysis.

CAT: BRP-00103

CAS: 64350-24-9

Molecular Formula: C14H19N5O6

Molecular Weight: 353.33

Purity: ≥95%

Appearance: White to off-white solid

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Storage: Store at -20 °C under inert atmosphere

Density: 1.82±0.1 g/cm³ (Predicted)

Melting Point: >160 °C (dec.)

InChIKey: OXTYJSXVUGJSGM-HTVVRFAVSA-N

Solubility: Soluble in DMSO (Slightly), Methanol (Slightly)

SMILES: CC(C)C(=O)NC1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)CO)O)O

IUPAC Name: N-[9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-oxo-1H-purin-2-yl]-2-methylpropanamide

InChI: InChI=1S/C14H19N5O6/c1-5(2)11(23)17-14-16-10-7(12(24)18-14)15-4-19(10)13-9(22)8(21)6(3-20)25-13/h4-6,8-9,13,20-22H,3H2,1-2H3,(H2,16,17,18,23,24)/t6-,8-,9-,13-/m1/s1

Synonyms: N2-iso-Butyrylguanosine; N2-Isobutyrylguanosine; N-(2-methylpropanoyl)guanosine; N-(2-Methyl-1-oxopropyl)guanosine; N-(9-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-6-oxo-6,9-dihydro-1H-purin-2-yl)-2-methylpropanamide; ribo Guanosine (n-ibu)