What are nucleotides used for in molecular biology?

Nucleotides serve as substrates for enzymatic reactions such as DNA synthesis, RNA transcription, and IVT mRNA production.

What is the difference between dNTPs and NTPs?

dNTPs are used for DNA synthesis, while NTPs are used for RNA synthesis and transcription reactions.

Why is nucleotide purity important?

Impurities can inhibit enzyme activity and negatively affect reaction efficiency and fidelity.

Are nucleotides suitable for IVT mRNA synthesis?

Yes, high-purity NTPs are essential substrates for RNA polymerase-driven IVT mRNA workflows.

How does lot consistency affect nucleotide performance?

Consistent lot quality ensures reproducible enzymatic performance across repeated experiments and scale-up processes.

Nucleotides - RNA / BOC Sciences

Guanosine 5'-triphosphate

Description: Guanosine triphosphate (GTP) is a guanine nucleotide containing three phosphate groups esterified to the sugar moiety. GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.

CAT: BRP-00310

CAS: 86-01-1

Molecular Formula: C10H16N5O14P3

Molecular Weight: 523.18

Purity: ≥98% by AX-HPLC

Appearance: Solid

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Storage: Store at -20 °C

Density: 2.8±0.1 g/cm3

Boiling Point: 1028.3 °C at 760 mmHg

InChIKey: XKMLYUALXHKNFT-UUOKFMHZSA-N

Solubility: Soluble in DMSO

CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N

IUPAC Name: [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

Synonyms: D-Guanosine 5'-triphosphate; Guanosine triphosphate; Guanosine 5'-triphosphoric acid; pppG; guanosine 5'-O-(triphosphate); [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Related CAS: 36051-31-7 (trisodium salt) ; 56001-37-7 (disodium salt)

Uridine 5’-triphosphate

Description: Uridine 5’-triphosphate, a vital RNA building block produced endogenously in human cells, plays a significant role in cell metabolism. Its indispensable value in the biomedical industry for DNA sequencing, gene expression analysis, and likely therapeutic applications cannot be overemphasized. The extensive possibilities of applying this nucleotide in the treatment of cardiovascular diseases, neurological disorders, and select types of cancer is worth being explored.

CAT: BRP-00311

CAS: 63-39-8

Molecular Formula: C9H15N2O15P3

Molecular Weight: 484.14

Purity: ≥95% by HPLC

Appearance: Colorless Liquid

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Storage: Store at 2-8°C

Density: 2.106±0.06 g/cm3 (Predicted)

Boiling Point: 868.1±75.0 °C at 760 mmHg

InChIKey: PGAVKCOVUIYSFO-XVFCMESISA-N

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O

IUPAC Name: [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C9H15N2O15P3/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

Synonyms: UTP; Uridine 5'-(tetrahydrogen triphosphate); uridine triphosphate; Uteplex

Related CAS: 74674-72-9 (x-sodium salt) ; 36051-69-1 (disodium salt) ; 19817-92-6 (trisodium salt) ; 1476-50-2 (monosodium salt) ; 14264-46-1 (tetrasodium salt)

Uridine 5'-triphosphate sodium salt

Description: The solution form of UTP. UTP is a pyrimidine nucleoside triphosphate playing an important role as a substrate for the synthesis of RNA during transcription. It also acts as a dual agonist of purinergic P2Y2 and P2Y4 receptors.

CAT: BRP-00317

CAS: 74674-72-9

Molecular Formula: C9H15N2O15P3 (free acid)

Molecular Weight: 484.14 (free acid)

Purity: ≥95% by HPLC

Appearance: Clear Aqueous Solution

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Storage: Store at -20 °C

Synonyms: UTP sodium salt; Uridine 5'-triphosphate, sodium salt; Uridine 5'-(tetrahydrogen triphosphate) sodium salt; Uridine 5'-trisphosphate sodium salt (1:x); Uridine 5'-(tetrahydrogen triphosphate), sodium salt (1:x)

Related CAS: 63-39-8 (free acid) ; 36051-69-1 (disodium salt) ; 19817-92-6 (trisodium salt) ; 1476-50-2 (monosodium salt) ; 14264-46-1 (tetrasodium salt)

Uridine 5'-triphosphate trisodium salt monohydrate

Description: UTP serves as a building block for RNA synthesis and modification, playing a vital role in cellular processes such as gene expression and protein synthesis. It is often utilized in research involving RNA labeling, transcription and RNA structural studies.

CAT: BRP-00318

CAS: 1266569-92-9

Molecular Formula: C9H14N2Na3O16P3

Molecular Weight: 568.10

Purity: ≥90% by HPLC

Appearance: lyophilized

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Storage: Store at -20 °C

InChIKey: KRFVCRUFVQMDGT-ODQFIEKDSA-K

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O)O.O.[Na+].[Na+].[Na+]

IUPAC Name: trisodium;[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;hydrate

InChI: InChI=1S/C9H15N2O15P3.3Na.H2O/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18;;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H,10,12,15)(H2,16,17,18);;;;1H2/q;3*+1;/p-3/t4-,6-,7-,8-;;;;/m1..../s1

Synonyms: Uridine 5'-(tetrahydrogen triphosphate), sodium salt, hydrate (1:3:1); Uridine 5'-triphosphate trisodium salt hydrate; UTP sodium salt hydrate; Uridine 5'-triphosphate, sodium salt hydrate

Related CAS: 19817-92-6 (anhydrous) ; 63-39-8 (anhydrous free acid) ; 116295-90-0 (dihydrate)

m7GpppGmpG

Description: m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.

CAT: BRP-00327

CAS: 1258049-00-1

Molecular Formula: C32H43N15O25P4

Molecular Weight: 1161.66

Purity: ≥98%

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Storage: Store at -20 °C, Always avoid freeze-thaw cycles

InChIKey: CDWLIVSWBYRIEX-ZQWUJQRXSA-N

CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)O)O

IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate

InChI: InChI=1S/C32H43N15O25P4/c1-44-8-47(23-14(44)26(54)43-32(35)40-23)28-18(51)16(49)10(68-28)4-65-74(57,58)71-76(61,62)72-75(59,60)66-5-11-19(20(63-2)29(69-11)46-7-37-13-22(46)39-31(34)42-25(13)53)70-73(55,56)64-3-9-15(48)17(50)27(67-9)45-6-36-12-21(45)38-30(33)41-24(12)52/h6-11,15-20,27-29,48-51H,3-5H2,1-2H3,(H12-,33,34,35,38,39,40,41,42,43,52,53,54,55,56,57,58,59,60,61,62)/t9-,10-,11-,15-,16-,17-,18-,19-,20-,27-,28-,29-/m1/s1

Synonyms: EZ Cap Reagent GG; EZ Cap Reagent GG for co-transcriptional capping of mRNA; m7G(5')ppp(5')(2'OMeG)pG; Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methylguanylyl-(3'→5')-, inner salt; m7Gppp(2'OMeG)pG; CAP GGG m7G(5')ppp(5')(2'OMeG)pG; GGG

Related CAS: 2638447-82-0 (tetraammonium salt) ; 2924872-05-7 (trisodium salt)

m7GpppGmpG ammonium salt

Description: m7GpppGmpG ammonium is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.

CAT: BRP-00328

Molecular Formula: C32H43N15O25P4 (free acid)

Molecular Weight: 1161.67 (free acid)

Purity: ≥98%

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Synonyms: EasyCap^TM GGG m7G(5')ppp(5')(2'OMeG)pG 100mM ammonium solution GMP grade; CAP GGG m7G(5')ppp(5')(2'OMeG)pG 100mM ammonium; CAP GGG m7G(5')ppp(5')(2'OMeG)pG ammonium salt; GGG ammonium salt; m7G(5')ppp(5')(2'OMeG)pG ammonium salt; m7Gppp(2'OMeG)pG ammonium salt; EZ Cap Reagent GG ammonium salt; Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methylguanylyl-(3'→5')-, inner salt, ammonium salt

Related CAS: 1258049-00-1 (free acid) ; 2638447-82-0 (tetraammonium salt) ; 2924872-05-7 (trisodium salt)

m7(3'OMeG)(5')ppp(5')(2'OMeG)pG

Description: EZ Cap Reagent GG (3'OMe) is a co-transcription capping reagent.

CAT: BRP-00329

CAS: 2089461-54-9

Molecular Formula: C33H45N15O25P4

Molecular Weight: 1175.69

Purity: ≥95% by AX-HPLC

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Storage: Store at -20°C

InChIKey: UIMYJBJWBAHYJD-UQTMIEBXSA-N

CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)OC)O

IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate

InChI: InChI=1S/C33H45N15O25P4/c1-45-9-48(24-15(45)27(54)44-33(36)41-24)29-18(51)19(63-2)11(69-29)5-66-75(57,58)72-77(61,62)73-76(59,60)67-6-12-20(21(64-3)30(70-12)47-8-38-14-23(47)40-32(35)43-26(14)53)71-74(55,56)65-4-10-16(49)17(50)28(68-10)46-7-37-13-22(46)39-31(34)42-25(13)52/h7-12,16-21,28-30,49-51H,4-6H2,1-3H3,(H12-,34,35,36,39,40,41,42,43,44,52,53,54,55,56,57,58,59,60,61,62)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1

Synonyms: EZ Cap Reagent GG (3' OMe) for co-transcriptional capping of mRNA; EZ Cap Reagent GG (3' OMe); GGG(3'OMe); m7(3'OMeG)ppp(2'OMeG)pG; Guanosine, 7-methyl-3'-O-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methylguanylyl-(3'→5')-, inner salt

Related CAS: 2924872-08-0 (trisodium salt)

m7G(5')ppp(5')(2'OMe,m6A)pG

Description: m7G(5')ppp(5')(2'OMe,m6A)pG is a trinucleotide mRNA 5' cap analogs. m7G(5')ppp(5')(2'OMe,m6A)pG can be used for RNA synthesis in vitro.

CAT: BRP-00330

CAS: 71340-22-2

Molecular Formula: C33H45N15O24P4

Molecular Weight: 1159.69

Purity: ≥98%

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InChIKey: DIMGFCCAJKOSNT-RKTALREWSA-N

CanonicalSMILES: CNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)([O-])OCC4C(C(C(O4)[N+]5=CN(C6=C5N=C(NC6=O)N)C)O)O)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)OC

IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-methoxy-5-[6-(methylamino)purin-9-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate

InChI: InChI=1S/C33H45N15O24P4/c1-36-23-14-24(38-7-37-23)46(8-39-14)31-22(63-3)21(70-73(55,56)64-4-11-17(49)19(51)29(67-11)47-9-40-15-25(47)41-32(34)43-27(15)53)13(69-31)6-66-75(59,60)72-76(61,62)71-74(57,58)65-5-12-18(50)20(52)30(68-12)48-10-45(2)16-26(48)42-33(35)44-28(16)54/h7-13,17-22,29-31,49-52H,4-6H2,1-3H3,(H10-,34,35,36,37,38,41,42,43,44,53,54,55,56,57,58,59,60,61,62)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1

Synonyms: Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-N-methyl-2'-O-methylguanylyl-(3'→5')-, inner salt; Adenosine 5'-(tetrahydrogen triphosphate), guanylyl-(5'→3')-N-methyl-2'-O-methyl-, P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium, inner salt; CAP GAG(m6A) m7G(5')ppp(5')(2'OMe,m6A)pG; GAG(m6A); m7Gppp(2'OMe,m6A)pG; m7Gpppm6AmpG

Related CAS: 2956650-99-8 (trisodium salt)

8-Azidoadenosine-5'-Triphosphate

Description: 8-Azidoadenosine-5'-Triphosphate is a crucial tool in compound for studying ATP-dependent processes. With its azido group, it enables selective photo-crosslinking to ATP-binding proteins and subsequent identification. Widely used in drug discovery and proteomics, it aids in investigating ATP-dependent diseases like cancer and neurodegenerative disorders.

CAT: BRP-00332

CAS: 53696-59-6

Molecular Formula: C10H15N8O13P3

Molecular Weight: 548.19

Purity: ≥90% by AX-HPLC

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Storage: Store at -20°C

Application: Affinity Labels

InChIKey: PQISXOFEOCLOCT-UUOKFMHZSA-N

CanonicalSMILES: C1=NC(=C2C(=N1)N(C(=N2)N=[N+]=[N-])C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

IUPAC Name: [[(2R,3S,4R,5R)-5-(6-amino-8-azidopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C10H15N8O13P3/c11-7-4-8(14-2-13-7)18(10(15-4)16-17-12)9-6(20)5(19)3(29-9)1-28-33(24,25)31-34(26,27)30-32(21,22)23/h2-3,5-6,9,19-20H,1H2,(H,24,25)(H,26,27)(H2,11,13,14)(H2,21,22,23)/t3-,5-,6-,9-/m1/s1

Synonyms: 8-Azido-ATP; 8-Azidoadenosine 5'-(tetrahydrogen triphosphate); 8-Azido ATP; 8-Azidoadenosine 5'-triphosphate; 8-Azidoadenosine triphosphate

Related CAS: 871119-02-7 (disodium salt) ; 1418217-88-5 (monosodium salt) ; 60731-49-9 (triethylamine salt (1:3)) ; 66895-06-5 (triethylamine salt (1:1)) ; 72504-51-9 (triethylamine salt (1:x))

Ara-CTP

Description: ara-Cytidine-5'-triphosphate (ara-CTP) is an inhibitor of DNA synthesis, DNA ligases and polymerases that is used for the treatment of acute myeloid leukemia.

CAT: BRP-00333

CAS: 13191-15-6

Molecular Formula: C9H16N3O14P3

Molecular Weight: 483.16

Purity: ≥90% by AX-HPLC

Appearance: clear aqueous solution

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Storage: Store at -20°C

Density: 2.5±0.1 g/cm3

Boiling Point: 849.2±75.0 °C at 760 mmHg

Application: Nucleic Acid Synthesis Inhibitors

InChIKey: PCDQPRRSZKQHHS-CCXZUQQUSA-N

Solubility: Soluble in Water

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O

IUPAC Name: [[(2R,3S,4S,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7+,8-/m1/s1

Synonyms: 1-β-D-arabinofuranosylcytosine TP; Aracytidine-5'-Triphosphate; ara-Cytidine-5'-triphosphate; Arabinofuranosylcytosine triphosphate; 4-Amino-1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-arabinofuranosyl]-2(1H)-pyrimidinone; 1-β-D-Arabinofuranosylcytosine 5'-triphosphate; 1-β-D-Arabinosylcytosine triphosphate; 1-β-Arabinofuranosylcytosine 5'-triphosphate; Ara-C triphosphate; Arabinosylcytosine 5'-triphosphate; AraCTP; Cytosine arabinoside 5'-triphosphate; Cytosine β-D-arabinofuranoside-5'-triphosphate

Related CAS: 102601-42-3 (disodium salt) ; 1179342-85-8 (triammonium salt) ; 1179343-17-9 (trisodium salt)

ara UTP

Description: Ara UTP, a potent nucleotide analog known for its excellent substrate activity towards RNA polymerases, has garnered significant research interest in the field of medical science. Its diverse applicability ranges from elucidating RNA editing and splicing mechanisms to synthesizing modified RNA molecules, thus serving as an invaluable tool for researchers. Furthermore, the promising antiviral activity of Ara UTP has been explored as a potential therapeutic option for hepatitis C virus infections, opening up new avenues for clinical intervention.

CAT: BRP-00334

CAS: 60102-52-5

Molecular Formula: C9H15N2O15P3

Molecular Weight: 484.14

Purity: ≥95%

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Storage: Store at -20 °C, Avoid direct sunlight and keep in dry place

Density: 2.106±0.06 g/cm3

InChIKey: PGAVKCOVUIYSFO-CCXZUQQUSA-N

CanonicalSMILES: C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O

IUPAC Name: [[(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Synonyms: 1-[5-O-[Hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione; 1-β-D-Arabinofuranosyluracil-5'-triphosphate; Ara-UTP; ara-UTP; Uracil arabinoside triphosphate; arabinofuranosyluridine triphosphate

Ara-UTP sodium salt

Description: Ara-UTP can be used as an antiviral nucleotide.

CAT: BRP-00335

Molecular Formula: C9H15N2O15P3 (free acid)

Molecular Weight: 484.14 (free acid)

Purity: ≥90% by AX-HPLC

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Storage: Store at -20 °C, Always avoid freeze-thaw cycles

IUPAC Name: sodium;[[(2R,3S,4S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

Synonyms: 1-[5-O-[Hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione sodium salt; 1-β-D-Arabinofuranosyluracil-5'-triphosphate sodium salt; ara UTP sodium salt; Uracil arabinoside triphosphate sodium salt; arabinofuranosyluridine triphosphate sodium salt

Related CAS: 60102-52-5 (free acid)

7-deaza-GTP

Description: 7-Deaza-GTP, a modified nucleotide with versatile biomedical applications, has contributed significantly to the study of transcription. Its utility in various assays to examine RNA polymerases and its function as a substrate for RNA capping and labeling have been well-documented. Beyond this, the compound has been instrumental in advancing the research on RNA splicing and protein translation. Its multifaceted role in these crucial biological processes underscores its importance in the biomedical field and makes it a valuable research tool.

CAT: BRP-00336

CAS: 181356-39-8

Molecular Formula: C11H17N4O14P3

Molecular Weight: 522.19

Purity: ≥98%

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Storage: Store at -20 °C, Always avoid freeze-thaw cycles

Density: 2.59±0.1 g/cm3

Boiling Point: 944.1±75.0 °C at 760 mmHg

InChIKey: NOXMCJDDSWCSIE-DAGMQNCNSA-N

CanonicalSMILES: C1=CN(C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O

IUPAC Name: [[(2R,3S,4R,5R)-5-(2-amino-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C11H17N4O14P3/c12-11-13-8-4(9(18)14-11)1-2-15(8)10-7(17)6(16)5(27-10)3-26-31(22,23)29-32(24,25)28-30(19,20)21/h1-2,5-7,10,16-17H,3H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,12,13,14,18)/t5-,6-,7-,10-/m1/s1

Synonyms: 7-Deazaguanosine-5'-Triphosphate; 2-Amino-1,7-dihydro-7-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-4H-pyrrolo[2,3-d]pyrimidin-4-one; ((2R,3S,4R,5R)-5-(2-amino-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

Related CAS: 131933-98-7 (triammonium salt)

5'-Biotin-G-Monophosphate

Description: 5'-Biotin-G-Monophosphate, a modified nucleotide incorporating biotin, is a versatile and reliable labeling reagent for detecting nucleic acids, particularly in DNA amplification, sequencing and hybridization applications. Moreover, it serves as an ideal tool for screening and profiling enzyme activities dependent on nucleotide substrates. With its unique molecular structure, it represents a promising frontier in the field of biochemical research.

CAT: BRP-00337

CAS: 2101200-52-4

Molecular Formula: C26H41N8O10PS

Molecular Weight: 688.70

Purity: >95%

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Storage: Store at -20 °C, Always avoid freeze-thaw cycles

Density: 1.81±0.1 g/cm3

InChIKey: VLZROYCITICIOM-DGWADGOTSA-N

CanonicalSMILES: O=C1N=C(N)NC2=C1N=CN2C3OC(COP(=O)(O)OCCCCCCNC(=O)CCCCC4SCC5NC(=O)NC45)C(O)C3O

IUPAC Name: ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl (6-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)hexyl) hydrogen phosphate

InChI: InChI=1S/C26H41N8O10PS/c27-25-32-22-19(23(38)33-25)29-13-34(22)24-21(37)20(36)15(44-24)11-43-45(40,41)42-10-6-2-1-5-9-28-17(35)8-4-3-7-16-18-14(12-46-16)30-26(39)31-18/h13-16,18,20-21,24,36-37H,1-12H2,(H,28,35)(H,40,41)(H2,30,31,39)(H3,27,32,33,38)/t14-,15+,16-,18-,20+,21+,24+/m0/s1

Synonyms: Biotin-7-GMP; 5'-Biotin-GMP

5-Azacytidine 5'-Triphosphate

Description: 5-Azacytidine 5'-Triphosphate is a modified nucleotide analog derived from cytidine. It contains azacytidine, a cytidine analog where the carbon at position 5 is replaced by a nitrogen atom, and it is phosphorylated at the 5' position with a triphosphate group. This modification makes it useful for various applications in molecular biology and biochemistry, particularly in RNA and DNA research. It can be incorporated into RNA or DNA during synthesis, enabling studies related to epigenetics, gene regulation, and RNA metabolism.

CAT: BRP-00338

CAS: 2226-74-6

Molecular Formula: C8H15N4O14P3

Molecular Weight: 484.14

Purity: ≥97%

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Storage: Store at -20 °C, Avoid direct sunlight and keep in dry place

Density: 2.66±0.1 g/cm3

Boiling Point: 841.2±75.0 °C at 760 mmHg

Application: A metabolite of 5-Azacytidine.

InChIKey: KFILMUPGQGKFKE-KVTDHHQDSA-N

CanonicalSMILES: C1=NC(=NC(=O)N1C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

IUPAC Name: [[(2R,3S,4R,5R)-5-(4-amino-2-oxo-1,3,5-triazin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C8H15N4O14P3/c9-7-10-2-12(8(15)11-7)6-5(14)4(13)3(24-6)1-23-28(19,20)26-29(21,22)25-27(16,17)18/h2-6,13-14H,1H2,(H,19,20)(H,21,22)(H2,9,11,15)(H2,16,17,18)/t3-,4-,5-,6-/m1/s1

Synonyms: 5-Aza CTP; 4-Amino-1-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-1,3,5-triazin-2(1H)-one; 4-Amino-1-β-D-ribofuranosyl-s-triazin-2(1H)-one 5'-Triphosphate; 5-Azacytidine Triphosphate; s-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-, 5'-(tetrahydrogen triphosphate); s-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-, 5'-triphosphate

Fluorescein-12-UTP

Description: Fluorescein-12-UTP is a vital tool used in biomedical field for the detection and imaging of RNA molecules. This fluorescent nucleotide analog incorporates into RNA during transcription is allowing for the visualization and tracking of RNA synthesand localization. With its distinct fluorescence, Fluorescein-12-UTP is valuable for research in molecular biology, gene expression analysis and the study of RNA-based diseases like cancer and viral infections.

CAT: BRP-00343

CAS: 185843-23-6

Molecular Formula: C39H41N4O22P3

Molecular Weight: 1010.68

Purity: ≥95% by HPLC

Appearance: yellow-orange solution in 10 mM Tris-HCl, pH 7.5 +/- 0.5

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Storage: Store at -20 °C, Always avoid freeze-thaw cycles and avoid direct sunlight

Density: 1.80±0.1 g/cm3

InChIKey: AXRKWYJHVODLJL-QGGAYTEESA-N

CanonicalSMILES: O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC=C(C=C15)C(=O)NCCCCCC(=O)NCC=CC6=CN(C(=O)NC6=O)C7OC(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C7O

IUPAC Name: ((2R,3S,4R,5R)-5-(5-((E)-3-(6-(3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamido)hexanamido)prop-1-en-1-yl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

InChI: InChI=1S/C39H41N4O22P3/c44-22-8-11-26-28(16-22)61-29-17-23(45)9-12-27(29)39(26)25-10-7-20(15-24(25)37(51)63-39)34(49)41-13-3-1-2-6-31(46)40-14-4-5-21-18-43(38(52)42-35(21)50)36-33(48)32(47)30(62-36)19-60-67(56,57)65-68(58,59)64-66(53,54)55/h4-5,7-12,15-18,30,32-33,36,44-45,47-48H,1-3,6,13-14,19H2,(H,40,46)(H,41,49)(H,56,57)(H,58,59)(H,42,50,52)(H2,53,54,55)/t30-,32-,33-,36-/m1/s1

Synonyms: Uridine 5'-(tetrahydrogen triphosphate), 5-[3-[[6-[[(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)carbonyl]amino]-1-oxohexyl]amino]-1-propenyl]-

5-hme-UTP 100mM Sodium Solution

Description: 5-hme-UTP, the cutting-edge solution widely applied in biomedicine to scrutinize RNA, is a remarkable discovery. This chemically modified uridine triphosphate profoundly enriches RNA, rendering it selectively detectable. Expeditions using 5-hme-UTP have evinced its dendritic distribution, unveiling molecular sequences implicated in sundry ailments like cancer and neurodegenerative diseases. Hence, 5-hme-UTP has emerged as a pivotal tool to dissect RNA patterns and unravel the indelible complexities of life.

CAT: BRP-00344

CAS: 2415101-56-1

Molecular Formula: C10H17N2O16P3

Molecular Weight: 514.17

Purity: ≥95% by AX-HPLC

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Storage: Store at -20°C

Density: 2.086±0.06 g/cm3

InChIKey: PVPHLYRXKFYLQZ-JXOAFFINSA-N

CanonicalSMILES: C1=C(C(=O)NC(=O)N1C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)CO

IUPAC Name: [[(2R,3S,4R,5R)-3,4-dihydroxy-5-[5-(hydroxymethyl)-2,4-dioxopyrimidin-1-yl]oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C10H17N2O16P3/c13-2-4-1-12(10(17)11-8(4)16)9-7(15)6(14)5(26-9)3-25-30(21,22)28-31(23,24)27-29(18,19)20/h1,5-7,9,13-15H,2-3H2,(H,21,22)(H,23,24)(H,11,16,17)(H2,18,19,20)/t5-,6-,7-,9-/m1/s1

Synonyms: 5-Hydroxymethyluridine-5'-Triphosphate; 5-hm-UTP; 5-Hydroxymethyl-UTP; 5-HmUTP

Biotin-16-UTP

Description: Biotin-16-UTP is a nucleotide analog commonly used for labeling RNA transcripts in molecular biology experiments. It is incorporated into RNA transcripts during transcription via RNA polymerase, allowing for easy purification and identification of a specific RNA molecule. Biotin-16-UTP has also been used to study RNA binding proteins and RNA localization in cells.

CAT: BRP-00346

CAS: 280549-77-1

Molecular Formula: C32H52N7O19P3S

Molecular Weight: 963.78

Purity: ≥95% by HPLC

Appearance: sterile clear aequous solution in 10 mM Tris-HCl

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Storage: Store at -20 °C

Density: 1.564±0.06 g/cm3

InChIKey: LXIVUMBRYBEFKN-YAWJOENWSA-N

CanonicalSMILES: C1C2C(C(S1)CCCCC(=O)NCCCCCC(=O)NCCCC(=O)NCC=CC3=CN(C(=O)NC3=O)C4C(C(C(O4)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)NC(=O)N2

IUPAC Name: [[(2R,3S,4R,5R)-5-[5-[(E)-3-[4-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]butanoylamino]prop-1-enyl]-2,4-dioxopyrimidin-1-yl]-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C32H52N7O19P3S/c40-23(10-2-1-5-13-33-24(41)11-4-3-9-22-26-20(18-62-22)36-31(46)37-26)35-15-7-12-25(42)34-14-6-8-19-16-39(32(47)38-29(19)45)30-28(44)27(43)21(56-30)17-55-60(51,52)58-61(53,54)57-59(48,49)50/h6,8,16,20-22,26-28,30,43-44H,1-5,7,9-15,17-18H2,(H,33,41)(H,34,42)(H,35,40)(H,51,52)(H,53,54)(H2,36,37,46)(H,38,45,47)(H2,48,49,50)/b8-6+/t20-,21+,22-,26-,27+,28+,30+/m0/s1

Synonyms: Biotin-16-AA-UTP; Biotin-16-Aminoallyluridine-5'-Triphosphate; 5-[3-[4-[6-[5-[(3abeta,6abeta)-2-Oxohexahydro-1H-thieno[3,4-d]imidazole-4alpha-yl]pentanoylamino]hexanoylamino]butanoylamino]-1-propenyl]uridine 5'-triphosphoric acid

Related CAS: 186033-13-6 (tetralithium salt）

5-Formyl-CTP

Description: 5-Formyl-CTP is a paramount compound, holding great significance for elucidating RNA metabolism and signaling pathways. Functioning as a modified nucleotide, it actively participates in RNA formation as a substrate during transcription. By facilitating the exploration of RNA processing, modifications and diverse cellular processes such as gene expression and regulation, this compound serves as a powerful tool for comprehensive studies.

CAT: BRP-00347

CAS: 1428903-58-5

Molecular Formula: C10H16N3O15P3

Molecular Weight: 511.17

Purity: ≥95% by AX-HPLC

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Storage: Store at -20°C

InChIKey: HBXQACAAUXRXBW-JXOAFFINSA-N

CanonicalSMILES: C1=C(C(=NC(=O)N1C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N)C=O

IUPAC Name: [[(2R,3S,4R,5R)-5-(4-amino-5-formyl-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C10H16N3O15P3/c11-8-4(2-14)1-13(10(17)12-8)9-7(16)6(15)5(26-9)3-25-30(21,22)28-31(23,24)27-29(18,19)20/h1-2,5-7,9,15-16H,3H2,(H,21,22)(H,23,24)(H2,11,12,17)(H2,18,19,20)/t5-,6-,7-,9-/m1/s1

Synonyms: 5-Formylcytidine-5'-Triphosphate; 5-fCTP; 5-FoCTP

2'-O-Methyluridine-5'-triphosphate sodium salt

Description: 2'-O-Methyluridine-5'-triphosphate sodium salt is a crucial reagent widely used in the field of biomedicine. It plays a vital role as a substrate for various enzymes involved in cellular processes. This product is commonly utilized in research related to RNA synthesis, RNA modification, and RNA labeling. Additionally, it serves as a key component in studies involving antiviral drug development and understanding certain diseases at the molecular level.

CAT: BRP-00348

Molecular Formula: C10H17N2O15P3.xNa

Molecular Weight: 498.17 (free acid)

Purity: >98%

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Storage: Store at -20 °C, Always avoid freeze-thaw cycles

Synonyms: 2'-OMe-UTP sodium salt; 2'OMe-UTP Na; 2'-methoxy-UTP sodium salt; 2'-O-Methyluridine 5'-triphosphoric acid sodium salt; 5'-(tetrahydrogen triphosphate), 2'-O-methyl-Uridine sodium salt; 2'-O-Methyluridine 5'-(tetrahydrogen triphosphate) sodium salt

Related CAS: 143028-99-3 (free acid)