What are nucleotides used for in molecular biology?

Nucleotides serve as substrates for enzymatic reactions such as DNA synthesis, RNA transcription, and IVT mRNA production.

What is the difference between dNTPs and NTPs?

dNTPs are used for DNA synthesis, while NTPs are used for RNA synthesis and transcription reactions.

Why is nucleotide purity important?

Impurities can inhibit enzyme activity and negatively affect reaction efficiency and fidelity.

Are nucleotides suitable for IVT mRNA synthesis?

Yes, high-purity NTPs are essential substrates for RNA polymerase-driven IVT mRNA workflows.

How does lot consistency affect nucleotide performance?

Consistent lot quality ensures reproducible enzymatic performance across repeated experiments and scale-up processes.

Nucleotides - RNA / BOC Sciences

Biotin-11-dUTP

Description: Biotin-11-dUTP, a biochemical utilized in enzymatic labeling of DNA fragments for purposes of detection and quantification, is a modified nucleotide analogue comprising of both biotin and deoxyuridine triphosphate. This multi-faceted compound plays an instrumental role within the biomedicine realm by providing researchers with a tool to study both the structure and function of DNA. It finds diverse application in the form of PCR, DNA sequencing and in situ hybridization, deftly pinpointing specific genes and mutations that may be associated with various diseases.

CAT: BRP-00138

CAS: 86303-25-5

Molecular Formula: C28H45N6O17P3S

Molecular Weight: 862.68

Purity: ≥95% by HPLC

Appearance: sterile clear aqueous solution, in 10 mM Tris-HCl

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Storage: Store at -20 °C

Density: 1.576±0.06 g/cm3

InChIKey: AZRNEVJSOSKAOC-VPHBQDTQSA-N

CanonicalSMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)C=CCNC(=O)CCCCCNC(=O)CCCCC3C4C(CS3)NC(=O)N4)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O

IUPAC Name: [[(2R,3S,5R)-5-[5-[(E)-3-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]prop-1-enyl]-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C28H45N6O17P3S/c35-19-13-24(49-20(19)15-48-53(44,45)51-54(46,47)50-52(41,42)43)34-14-17(26(38)33-28(34)40)7-6-12-30-22(36)9-2-1-5-11-29-23(37)10-4-3-8-21-25-18(16-55-21)31-27(39)32-25/h6-7,14,18-21,24-25,35H,1-5,8-13,15-16H2,(H,29,37)(H,30,36)(H,44,45)(H,46,47)(H2,31,32,39)(H,33,38,40)(H2,41,42,43)/b7-6+/t18-,19-,20+,21-,24+,25-/m0/s1

Synonyms: Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-5-[(1E)-3-[[6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]amino]-1-propen-1-yl]-; Biotin-XX-5-aminoallyl-dUTP; 2'-Deoxy-5-[(1E)-3-[[6-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxohexyl]amino]-1-propen-1-yl]uridine 5'-(tetrahydrogen triphosphate); Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-5-[3-[[6-[[5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]amino]-1-oxohexyl]amino]-1-propenyl]-, [3aS-[3aα,4β(E),6aα]]-; Bio-11-dUTP; Biotin-11-deoxyUTP; Biotinyl-11-dUTP

ATPαS

Description: ATPαS is an exceptional analogue of adenosine triphosphate (ATP), finding extensive utilization in expounding ATP-regulated enzyme kinetics and underlying mechanisms. Its principal application encompasses delving into the intricacies of ATP-dependent protein kinases thereby aiding in the comprehensive comprehension of their functionality and regulation.

CAT: BRP-00139

CAS: 29220-54-0

Molecular Formula: C10H16N5O12P3S

Molecular Weight: 523.25

Purity: ≥95% by HPLC

Appearance: clear aqueous solution

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Storage: Store at -20 °C

Density: 2.56±0.1 g/cm3

Boiling Point: 901.8±75.0 °C at 760 mmHg

InChIKey: ROYJKVPBJVNHCQ-VWJVIAGJSA-N

CanonicalSMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=S)(O)OP(=O)(O)OP(=O)(O)O)O)O)N

IUPAC Name: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate

InChI: InChI=1S/C10H16N5O12P3S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-30(23,31)27-29(21,22)26-28(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,31)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-,30?/m1/s1

Synonyms: Adenosine, 5'→P''-ester with thiotriphosphoric acid; Adenosine-5'-RP-alpha-thio-triphosphate; Adenosine-5'-O-(1-Thiotriphosphate); Thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(S)(OH)2), P''→5'-ester with adenosine; ATP-α-S; α-Thio-dATP; ATP-αS

Related CAS: 112820-43-6 (TEA salt (1:4))

CTPαS TEA salt

Description: CTPαS, a molecule activator of soluble guanylate cyclase (sGC), is vying for a preeminent position in the study of nitric oxide signaling pathway. With its therapeutic potential locked and loaded, CTPαS is turning heads in the scientific community, demonstrating potential efficacy in addressing cardiovascular diseases such as hypertension and pulmonary arterial hypertension, as well as a wide range of central nervous system conditions, including neurodegenerative diseases and pain management alike.

CAT: BRP-00140

Molecular Formula: C9H16N3O13P3S (free acid)

Molecular Weight: 499.21 (free acid)

Purity: ≥95% by HPLC

Appearance: clear aqueous solution

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Storage: Store at -20 °C

IUPAC Name: [[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate;N,N-diethylethanamine

Synonyms: Cytidine, 5'→P''-ester with thiotriphosphoric acid TEA salt; Cytidine-5'-O-(1-thiotriphosphate) TEA salt; CTP-αS TEA salt; Cytidine-5'-(α-thio)-triphosphate, TEA salt (1:1 Mixture of Rp and Sp isomers)

Related CAS: 110972-40-2 (free base)

3'OMe-GTP

Description: 3'OMe-GTP is a nucleoside triphosphate that has undergone modification, functioning as a surrogate for guanosine triphosphate, holding immense significance in the pursuit of comprehending RNA research and development and processing. Furthermore, owing to its utilization is an avenue paved to delve into the intricate world of RNA modifications, thereby enabling a deeper exploration into afflictions such as cancer, neurodegenerative disorders is and viral infections.

CAT: BRP-00141

CAS: 61556-45-4

Molecular Formula: C11H18N5O14P3

Molecular Weight: 537.21

Purity: ≥95% by HPLC

Appearance: clear aqueous solution

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Storage: Store at -20 °C

Density: 2.50±0.1 g/cm3

InChIKey: OHOBECDATGAGJW-KQYNXXCUSA-N

CanonicalSMILES: COC1C(OC(C1O)N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O

IUPAC Name: [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C11H18N5O14P3/c1-26-7-4(2-27-32(22,23)30-33(24,25)29-31(19,20)21)28-10(6(7)17)16-3-13-5-8(16)14-11(12)15-9(5)18/h3-4,6-7,10,17H,2H2,1H3,(H,22,23)(H,24,25)(H2,19,20,21)(H3,12,14,15,18)/t4-,6-,7-,10-/m1/s1

Synonyms: (3'Ome)GTP; 3'-O-Methylguanosine-5'-triphosphate; 3'-O-Methylguanosine 5'-(tetrahydrogen triphosphate); 3'-O-methyl-GTP; 3'-O-Methylguanosine triphosphate

Related CAS: 98923-57-0 (tetrasodium salt)

Biotin-16-deoxyuridine-5'-triphosphate

Description: Biotin-16-deoxyuridine-5'-triphosphate is a fundamental element in the realm of biomedical investigations, demonstrating intricate implications. Extensively utilized in DNA annotation and sequencing examinations, it orchestrates the revelation of DNA alterations and hereditary disparities.

CAT: BRP-00143

CAS: 86303-26-6

Molecular Formula: C32H52N7O18P3S

Molecular Weight: 947.78

Purity: 95%

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Storage: Store at -20 °C

Density: 1.530±0.06 g/cm3

InChIKey: APUCJHHBLIXMRI-YGXOHKNQSA-N

CanonicalSMILES: C1C(C(OC1N2C=C(C(=O)NC2=O)C=CCNC(=O)CCCCCNC(=O)CCCNC(=O)CCCCC3C4C(CS3)NC(=O)N4)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O

IUPAC Name: [[(2R,3S,5R)-5-[5-[(E)-3-[6-[4-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]butanoylamino]hexanoylamino]prop-1-enyl]-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C32H52N7O18P3S/c40-22-16-28(55-23(22)18-54-59(50,51)57-60(52,53)56-58(47,48)49)39-17-20(30(44)38-32(39)46)8-6-14-34-25(41)10-2-1-5-13-33-27(43)12-7-15-35-26(42)11-4-3-9-24-29-21(19-61-24)36-31(45)37-29/h6,8,17,21-24,28-29,40H,1-5,7,9-16,18-19H2,(H,33,43)(H,34,41)(H,35,42)(H,50,51)(H,52,53)(H2,36,37,45)(H,38,44,46)(H2,47,48,49)/b8-6+/t21-,22-,23+,24-,28+,29-/m0/s1

Synonyms: Biotin-16-dUTP; Biotin-16-AA-dUTP; Biotin-16-Aminoallyl-2'-dUTP; Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-5-[(1E)-3-[[6-[[4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxobutyl]amino]-1-oxohexyl]amino]-1-propen-1-yl]-; 2'-Deoxy-5-[(1E)-3-[[6-[[4-[[5-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-1-oxopentyl]amino]-1-oxobutyl]amino]-1-oxohexyl]amino]-1-propen-1-yl]uridine 5'-(tetrahydrogen triphosphate); Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-5-[3-[[6-[[4-[[5-(hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl)-1-oxopentyl]amino]-1-oxobutyl]amino]-1-oxohexyl]amino]-1-propenyl]-, [3aS-[3aα,4β(E),6aα]]-; Biotin-16-2'-deoxyuridine-5'-triphosphate

Biotin-16-dUTP TEA salt

Description: Biotin-16-dUTP is a pivotal recompound employed in diverse biomedical application. Its prevalent utilization as a substrate for DNA labeling and detection methodologies, including PCR, DNA sequencing and in situ hybridization, underscores its indispensability.

CAT: BRP-00144

Molecular Formula: C32H52N7O18P3S (free acid)

Molecular Weight: 947.78 (free acid)

Purity: ≥95% by HPLC

Appearance: sterile clear aqueous solution

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Storage: Store at -20 °C

Synonyms: Biotin-16-5-aminoallyl-dUTP; γ-[N-(Biotin-6-amino-hexanoyl-6-aminobutanoyl)]-5-(3-aminoallyl)-2'-deoxyuridine-5'-triphosphate, Triethylammonium salt

Related CAS: 86303-26-6 (free base)

Inosine 5'-monophosphate disodium salt

Description: Disodium inosinate (E631) is the disodium salt of inosinic acid with the chemical formula C10H11N4Na2O8P. It is used as a food additive and often found in instant noodles, potato chips, and a variety of other snacks. This salt is used as a flavor enhancer made from microbial fermentation growth media that are all-vegetable, usually consisting mainly of tapioca starch.

CAT: BRP-00190

CAS: 4691-65-0

Molecular Formula: C10H11N4Na2O8P

Molecular Weight: 392.17

Purity: ≥97% by HPLC

Appearance: Odourless, colourless or white crystals or powder

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Storage: Store at -20°C under inert atmosphere

Melting Point: 175 °C

Flash Point: 468.7°C

InChIKey: AANLCWYVVNBGEE-IDIVVRGQSA-L

Solubility: Soluble in Water, Ethanol (Sparingly); Practically insoluble in Ether

CanonicalSMILES: C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)([O-])[O-])O)O.[Na+].[Na+]

IUPAC Name: disodium;[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-1H-purin-9-yl)oxolan-2-yl]methyl phosphate

InChI: InChI=1S/C10H13N4O8P.2Na/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1

Synonyms: Disodium 5'-inosinate; Disodium inosinate; Sodium Inosine 5'-Phosphate (2:1); 5'-Inosinic Acid Disodium Salt; 5'-IMP Disodium Salt; Disodium 5'-IMP; Disodium 5'-Inosinate; Disodium IMP; Disodium Inosinate; Disodium Inosine 5'-Monophosphate; Disodium Inosine 5'-Phosphate; IMP Disodium Salt; Inosine 5'-Monophosphate Disodium Salt; Inosine 5'-Monophosphoric Acid Disodium Salt

Related CAS: 352195-40-5 (monohydrate) ; 20813-76-7 (octahydrate) ; 131-99-7 (free acid)

Guanosine 5'-monophosphate disodium salt

Description: Disodium guanylate, also known as sodium 5'-guanylate and disodium 5'-guanylate, is a natural sodium salt of the flavor enhancing nucleotide guanosine monophosphate (GMP). Disodium guanylate is a food additive with the E number E627. It is commonly used in conjunction with glutamic acid (monosodium glutamate, MSG).
As it is a fairly expensive additive, it is not used independently of glutamic acid; if disodium guanylate is present in a list of ingredients but MSG does not appear to be, it is likely that glutamic acid is provided as part of another ingredient such as a processed soy protein complex. It is often added to foods in conjunction with disodium inosinate; the combination is known as disodium 5'-ribonucleotides.
Disodium guanylate is produced from dried seaweed and is often added to instant noodles, potato chips and other snacks, savory rice, tinned vegetables, cured meats, and packaged soup.

CAT: BRP-00195

CAS: 5550-12-9

Molecular Formula: C10H12N5Na2O8P

Molecular Weight: 407.18

Purity: 98%

Appearance: Odourless, colourless or white crystals or white crystalline powder

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Storage: Store at 2-8 °C

Melting Point: 300 °C

Boiling Point: 890.2 °C at 760 mmHg

Flash Point: 492.2°C

InChIKey: PVBRXXAAPNGWGE-LGVAUZIVSA-L

Solubility: Soluble in Water (50 mg/mL), Ethanol (Sparingly), Ether (Practically insoluble)

CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)([O-])[O-])O)O)N=C(NC2=O)N.[Na+].[Na+]

IUPAC Name: disodium;[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

InChI: InChI=1S/C10H14N5O8P.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(23-9)1-22-24(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1

Synonyms: Disodium guanylate; Disodium GMP; Disodium 5'-gmp; GMP disodium salt; 5'-Gmp disodium salt; Disodium guanosine-5'-monophosphate; 5'-Guanylic acid disodium salt; Sodium 5'-guanylate; Guanosine 5'-phosphate disodium salt

Related CAS: 85-32-5 (free acid)

7-Methylguanosine 5'-triphosphate sodium salt

Description: 7-Methylguanosine 5'-triphosphate sodium salt, a highly indispensable reagent in the field of biomedicine, finds extensive utilization across diverse applications. Functioning as a potent guanosine triphosphate (GTP) analogue, it assumes a pivotal role in the processes of mRNA capping, RNA processing, and RNA splicing. Its auxiliary role involves facilitating the exploration of RNA-protein interactions while also serving as a substrate for RNA methyltransferases.

CAT: BRP-00206

Molecular Formula: C11H18N5O14P3·xNa

Molecular Weight: 537.21 (free acid)

Purity: ≥95%

Appearance: Clear colorless Liquid

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Storage: Store at -20 °C

Synonyms: N7-Me-GTP sodium salt; Guanosine 5'-(tetrahydrogen triphosphate), 7-methyl-, inner salt, sodium salt; 1H-Purinium, 2-amino-6,9-dihydro-9-[5-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]-β-D-ribofuranosyl]-7-methyl-6-oxo-, inner salt, sodium salt; m7GTP sodium salt

Related CAS: 26554-26-7 (free acid) ; 104809-18-9 (disodium salt)

5-Methoxyuridine 5'-triphosphate trisodium

Description: 5-Methoxyuridine-5'-Triphosphate trisodium is a modified nucleotide triphosphate (NTP). 5-Methoxyuridine-5'-Triphosphate trisodium can be added into mRNA with T7 RNA polymerase.

CAT: BRP-00207

Molecular Formula: C10H14N2Na3O16P3

Molecular Weight: 580.11

Purity: ≥97% by HPLC

Appearance: Clear colorless Liquid

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Storage: Store at -20 °C, Always avoid freeze-thaw cycles

InChIKey: RLLQJTDUZNYRLI-PASVRIBUSA-K

CanonicalSMILES: COC1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)([O-])OP(=O)([O-])OP(=O)(O)[O-])O)O.[Na+].[Na+].[Na+]

IUPAC Name: trisodium;[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-(5-methoxy-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate

InChI: InChI=1S/C10H17N2O16P3.3Na/c1-24-4-2-12(10(16)11-8(4)15)9-7(14)6(13)5(26-9)3-25-30(20,21)28-31(22,23)27-29(17,18)19;;;/h2,5-7,9,13-14H,3H2,1H3,(H,20,21)(H,22,23)(H,11,15,16)(H2,17,18,19);;;/q;3*+1/p-3/t5-,6-,7-,9-;;;/m1.../s1

Synonyms: HiPure^® 5-OMe-UTP 100mM Sodium solution GMP grade; 5-Methoxy-uridine 5'-triphosphate, trisodium salt; 5-Methoxy-UTP trisodium; 5-OMe-UTP trisodium; 5-OMe-UTP Trisodium salt; 5-Methoxyuridine 5'-triphosphate trisodium salt; 5OMeUTP trisodium salt

Related CAS: 847649-65-4 (free acid)

GP3G (Unmethylated Cap Analog)

Description: GP3G is a kind of diguanosine polyphosphate, could be found in human plasma.

CAT: BRP-00208

CAS: 6674-45-9

Molecular Formula: C20H27N10O18P3

Molecular Weight: 788.41

Purity: ≥95% by HPLC

Appearance: clear aqueous solution

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Storage: Store at -20 °C

Density: 2.7±0.1 g/cm3

Boiling Point: 1312.7±75.0 °C at 760 mmHg

InChIKey: AAXYAFFKOSNMEB-MHARETSRSA-N

CanonicalSMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)O)O)O)O)N=C(NC2=O)N

IUPAC Name: bis[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate

InChI: InChI=1S/C20H27N10O18P3/c21-19-25-13-7(15(35)27-19)23-3-29(13)17-11(33)9(31)5(45-17)1-43-49(37,38)47-51(41,42)48-50(39,40)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)26-20(22)28-16(8)36/h3-6,9-12,17-18,31-34H,1-2H2,(H,37,38)(H,39,40)(H,41,42)(H3,21,25,27,35)(H3,22,26,28,36)/t5-,6-,9-,10-,11-,12-,17-,18-/m1/s1

Synonyms: GpppG; G(5')ppp(5')G Cap Analog; Diguanosine triphosphate; Diguanosine-5'-triphosphate; P1-(Guanosyl) P3-(5'-(guanosyl))triphosphate; CAP; Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with guanosine; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine; Guanosine triphosphate, 5'→5'-ester with guanosine; Guanosine, 5'-ester with guanosine 5'-(tetrahydrogen triphosphate); Diguanosine 5',5'''-triphosphate; Gp3G; P1,P3-Diguanosine 5'-triphosphate; Guanosine-5'-triphosphate-5'-Guanosine

Related CAS: 102783-44-8 (triammonium salt) ; 1314754-91-0 (trisodium salt)

Guanosine 5'-triphosphate-5'-adenosine

Description: Guanosine 5'-triphosphate-5'-adenosine, the 5′ cap analog, is a fluorescent substrate analog.

CAT: BRP-00209

CAS: 10527-47-6

Molecular Formula: C20H27N10O17P3

Molecular Weight: 772.41

Purity: ≥95% by HPLC

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Storage: Store at -20 °C

Density: 2.61±0.1 g/cm3

InChIKey: PMJUJCUPNRCBNP-INFSMZHSSA-N

CanonicalSMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C5N=C(NC6=O)N)O)O)O)O)N

IUPAC Name: [[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate

InChI: InChI=1S/C20H27N10O17P3/c21-14-8-15(24-3-23-14)29(4-25-8)18-12(33)10(31)6(44-18)1-42-48(36,37)46-50(40,41)47-49(38,39)43-2-7-11(32)13(34)19(45-7)30-5-26-9-16(30)27-20(22)28-17(9)35/h3-7,10-13,18-19,31-34H,1-2H2,(H,36,37)(H,38,39)(H,40,41)(H2,21,23,24)(H3,22,27,28,35)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1

Synonyms: GpppA; Guanosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with adenosine; Adenosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with guanosine; Guanosine 5'-(tetrahydrogen triphosphate), 5'→5'-ester with adenosine; Guanosine triphosphate, 5'→5'-ester with adenosine; Gp3A; Gp3A (dinucleotide); P1-Adenosine-5' P3-guanosine-5' triphosphate

Related CAS: 1613387-42-0 (trisodium salt)

N7-Methyl-guanosine-5'-triphosphate-5'-adenosine

Description: N7-Methyl-guanosine-5’-triphosphate-5’-adenosine (m7GpppA) is a dinucleotide cap analog that can be used for in vitro RNA transcription.

CAT: BRP-00210

CAS: 62828-63-1

Molecular Formula: C21H29N10O17P3

Molecular Weight: 786.43

Purity: ≥95% by HPLC

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InChIKey: QQOHNVHGNZYSBP-XPWFQUROSA-N

CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O

IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate

InChI: InChI=1S/C21H29N10O17P3/c1-29-6-31(17-10(29)18(36)28-21(23)27-17)20-14(35)12(33)8(46-20)3-44-50(39,40)48-51(41,42)47-49(37,38)43-2-7-11(32)13(34)19(45-7)30-5-26-9-15(22)24-4-25-16(9)30/h4-8,11-14,19-20,32-35H,2-3H2,1H3,(H7-,22,23,24,25,27,28,36,37,38,39,40,41,42)/t7-,8-,11-,12-,13-,14-,19-,20-/m1/s1

Synonyms: M7-GpppA; Guanosine 5'-(tetrahydrogen triphosphate), 7-methyl-, inner salt, P''→5'-ester with adenosine; 7-Methylguanosine 5'-(tetrahydrogen triphosphate) inner salt, P''→5'-ester with adenosine; Adenosine 5'-(tetrahydrogen triphosphate), P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt; m7GpppA

Related CAS: 75252-10-7 (diammonium salt)

ARCA Sodium

Description: ARCA Sodium, a potent inhibitor of the Nav1.5 cardiac sodium channel, is adeptly utilized in mitigating arrhythmias, such as atrial fibrillation. Additionally, it exhibits promise as a therapeutic agent for the management of chronic pain conditions.

CAT: BRP-00211

Molecular Formula: C22H31N10O18P3 (free acid)

Molecular Weight: 816.46 (free acid)

Purity: ≥95% by HPLC

Appearance: Clear colorless to faint yellow Liquid

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Synonyms: ARCA, sodium salt; Anti Reverse Cap Analog sodium salt; m7(3'-O-methy)G(5')ppp(5')G sodium salt; 3'-O-Me-m7G(5')ppp(5')G sodium salt; m27, 3'-OGP3G (ARCA Cap Analog) sodium salt; 3'-O-Methyl-m7GpppG sodium salt; ARCA (anti-reverse cap analog) sodium salt; m27,3'OGpppG sodium salt; N7-Methyl-3'-O-Methyl-Guanosine-5'-Triphosphate-5'-Guanosine, sodium salt

Related CAS: 400806-46-4 (free acid) ; 400806-60-2 (trisodium salt)

M7G(3'-OMe-5')pppA(2'-OMe)

Description: M7G(3'-OMe-5')pppA(2'-OMe) is a cap analogue for mRNA synthesis in vitro.

CAT: BRP-00212

Molecular Formula: C23H33N10O17P3

Molecular Weight: 814.49

Purity: ≥95% by HPLC

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InChIKey: CDTPPKGWEOGAMN-LAMCKDNKSA-N

IUPAC Name: 2-amino-9-((2R,3R,4S,5R)-5-((((((((((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3-hydroxy-4-methoxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium

InChI: InChI=1S/C23H33N10O17P3/c1-31-8-33(19-12(31)20(36)30-23(25)29-19)21-14(35)15(43-2)10(48-21)5-46-52(39,40)50-53(41,42)49-51(37,38)45-4-9-13(34)16(44-3)22(47-9)32-7-28-11-17(24)26-6-27-18(11)32/h6-10,13-16,21-22,34-35H,4-5H2,1-3H3,(H7-,24,25,26,27,29,30,36,37,38,39,40,41,42)/t9-,10-,13-,14-,15-,16-,21-,22-/m1/s1

Synonyms: (3'-OMe-m7G)(5')ppp(5')(2'-OMe-A)

2'-Deoxyuridine 5'-triphosphate

Description: 2'-Deoxyuridine 5'-triphosphate, a nucleotide analog, is utilized in DNA synthesis and repair. The drug finds wide application in treating viral infections, most notably herpes and HIV. Administration of this drug leads to the termination of chain growth and subsequent inhibition of viral replication. It is a substrate for DNA polymerase and is incorporated during DNA chain elongation. Such incorporation plays a significant role in the fight against virally induced diseases.

CAT: BRP-00214

CAS: 1173-82-6

Molecular Formula: C9H15N2O14P3

Molecular Weight: 468.14

Purity: 95%

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Density: 2.010±0.06 g/cm3

InChIKey: AHCYMLUZIRLXAA-SHYZEUOFSA-N

Solubility: Soluble in Water

CanonicalSMILES: C1C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O

IUPAC Name: [[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C9H15N2O14P3/c12-5-3-8(11-2-1-7(13)10-9(11)14)23-6(5)4-22-27(18,19)25-28(20,21)24-26(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,18,19)(H,20,21)(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1

Synonyms: 2'-Deoxyuridine-5'-Triphosphoric Acid; Deoxyuridine triphosphate; deoxy-UTP; dUTP; Deoxyuridine-5'-Triphosphate; 2'-deoxyuridine 5'-(tetrahydrogen triphosphate); Uridine 5'-(tetrahydrogen triphosphate), 2'-deoxy-; ((2R,3S,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate

Related CAS: 93919-43-8 (disodium salt) ; 1365987-12-7 (tetrasodium salt) ; 102814-08-4 (trisodium salt) ; 6152-08-5 (monosodium salt) ; 94736-09-1 (x-sodium salt)

m7GpppAmpG

Description: m7GpppAmpG is a trinucleotide 5' cap analog with the capping efficiencies for the obtained RNAs of 90%. It is used to transcribe 5'cap mRNA in vitro to produce the Cap 1 structure, which is more suitable for mammalian systems and has higher transcriptional efficiency than the Cap 0 structure. m7GpppAmpG Cap Analog is a co-transcriptional capping agent that transcribes 5' capped mRNA in vitro to form the Cap 1 structure.

CAT: BRP-00215

CAS: 62858-30-4

Molecular Formula: C32H43N15O24P4

Molecular Weight: 1145.67

Purity: ≥95% by HPLC

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InChIKey: AGWRKMKSPDCRHI-UQTMIEBXSA-N

CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)O)O

IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate

InChI: InChI=1S/C32H43N15O24P4/c1-44-9-47(25-15(44)27(53)43-32(35)41-25)29-19(51)17(49)11(67-29)4-64-73(56,57)70-75(60,61)71-74(58,59)65-5-12-20(21(62-2)30(68-12)45-7-38-13-22(33)36-6-37-23(13)45)69-72(54,55)63-3-10-16(48)18(50)28(66-10)46-8-39-14-24(46)40-31(34)42-26(14)52/h6-12,16-21,28-30,48-51H,3-5H2,1-2H3,(H11-,33,34,35,36,37,40,41,42,43,52,53,54,55,56,57,58,59,60,61)/t10-,11-,12-,16-,17-,18-,19-,20-,21-,28-,29-,30-/m1/s1

Synonyms: m7G(5')ppp(5')(2'-OMeA)pG; GAG; Guanosine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt; Adenosine 5'-(tetrahydrogen triphosphate), guanylyl-(5'→3')-2'-O-methyl-, P''→5'-ester with 2-amino-6,9-dihydro-7-methyl-6-oxo-9-β-D-ribofuranosyl-1H-purinium inner salt; m7GpppA2'OmepG

Related CAS: 2941382-07-4 (trisodium salt) ; 2710263-09-3 (triammonium salt)

3'Ome-m7GpppAmpG

Description: 3'Ome-m7GpppAmpG is a trinucleotide Cap analogue. 3'Ome-m7GpppAmpG shows a significant translational efficiency. 3'Ome-m7GpppAmpG can be used as a potential molecular biology tool in the field of mRNA vaccines and mRNA transfection, such as protein production, gene therapy and anti-cancer immunization.

CAT: BRP-00216

CAS: 2089461-55-0

Molecular Formula: C33H45N15O24P4

Molecular Weight: 1159.69

Purity: ≥95% by HPLC

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InChIKey: QLKZOMAEOBMBOC-RKTALREWSA-N

CanonicalSMILES: CN1C=[N+](C2=C1C(=O)NC(=N2)N)C3C(C(C(O3)COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)OC)OP(=O)(O)OCC7C(C(C(O7)N8C=NC9=C8N=C(NC9=O)N)O)O)OC)O

IUPAC Name: [(2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-9-ium-9-yl)-4-hydroxy-3-methoxyoxolan-2-yl]methyl [[[(2R,3R,4R,5R)-3-[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)-4-methoxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl] phosphate

InChI: InChI=1S/C33H45N15O24P4/c1-45-10-48(26-16(45)28(53)44-33(36)42-26)30-19(51)20(62-2)12(68-30)5-65-74(56,57)71-76(60,61)72-75(58,59)66-6-13-21(22(63-3)31(69-13)46-8-39-14-23(34)37-7-38-24(14)46)70-73(54,55)64-4-11-17(49)18(50)29(67-11)47-9-40-15-25(47)41-32(35)43-27(15)52/h7-13,17-22,29-31,49-51H,4-6H2,1-3H3,(H11-,34,35,36,37,38,41,42,43,44,52,53,54,55,56,57,58,59,60,61)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,29-,30-,31-/m1/s1

Synonyms: 3'-OMe-GAG; (3'-OMe-m7G)(5')ppp(5')(2'-OMeA)pG; m7(3'OMeG)(5')ppp(5')(2'OMeA)pG; Guanosine, 7-methyl-3'-O-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt; m7(3'OMeG)(5')ppp(5')(2'OMeA)pG; CAP GAG (3'OMe)

Related CAS: 2863631-10-9 (trisodium salt)

m7G(5')ppp(5')(2'OMeA)pU

Description: A 5'cap analog used for co-transcriptional capping of mRNA. The product is specifically designed for self-replicating RNAs based on the genomes of positive sense strand RNA viruses such as Venezuelan equine encephalitis virus (VEEV), Semliki forest virus (SFV), and Sindbis virus (SIN).

CAT: BRP-00217

CAS: 2734858-38-7

Molecular Formula: C31H42N12O25P4

Molecular Weight: 1106.63

Purity: ≥95% by HPLC

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InChIKey: FTIHNRSFQMJZNB-MPTQKLLZSA-N

Solubility: Store at -20°C

CanonicalSMILES: O=C1N=C(N)NC2=C1[N+](=CN2C3OC(COP(=O)([O-])OP(=O)(O)OP(=O)(O)OCC4OC(N5C=NC=6C(=NC=NC65)N)C(OC)C4OP(=O)(O)OCC7OC(N8C=CC(=O)NC8=O)C(O)C7O)C(O)C3O)C

IUPAC Name: 2-amino-9-((2R,3R,4S,5R)-5-((((((((((2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-(((((2R,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)oxidophosphoryl)oxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-7-methyl-6-oxo-6,9-dihydro-1H-purin-7-ium

InChI: InChI=1S/C31H42N12O25P4/c1-40-10-43(25-16(40)26(49)39-30(33)38-25)28-20(48)18(46)12(64-28)6-61-70(53,54)67-72(57,58)68-71(55,56)62-7-13-21(22(59-2)29(65-13)42-9-36-15-23(32)34-8-35-24(15)42)66-69(51,52)60-5-11-17(45)19(47)27(63-11)41-4-3-14(44)37-31(41)50/h3-4,8-13,17-22,27-29,45-48H,5-7H2,1-2H3,(H9-,32,33,34,35,37,38,39,44,49,50,51,52,53,54,55,56,57,58)/t11-,12-,13-,17-,18-,19-,20-,21-,22-,27-,28-,29-/m1/s1

Synonyms: Uridine, 7-methylguanylyloxyphosphinicooxyphosphinico-(5'→5')-2'-O-methyladenylyl-(3'→5')-, inner salt; (m7)Gppp(5')(m2'O)ApU; m7G(5')ppp(5')(2'-OMeA)pU; m7Gppp(5')A2'OMepU; m7GpppAmpU trinucleotide cap; GAU

Related CAS: 2941382-10-9 (trisodium salt) ; 3056773-38-4 (triammonium salt)

Cytidine 5'-triphosphate

Description: Cytidine 5'-triphosphate is a vital molecule in biomedicine that serves as a building block for DNA and RNA synthesis. It plays a crucial role in cellular processes, such as cell growth, proliferation, and signal transduction. Cytidine 5'-triphosphate is used in the treatment of certain viral infections and cancer where it acts as an antiviral and antineoplastic agent.

CAT: BRP-00309

CAS: 65-47-4

Molecular Formula: C9H16N3O14P3

Molecular Weight: 483.16

Purity: ≥98% by AX-HPLC

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Storage: Store at -20 °C

Density: 2.5±0.1 g/cm3

Melting Point: 215-218 °C

Boiling Point: 849.2±75.0 °C at 760 mmHg

InChIKey: PCDQPRRSZKQHHS-XVFCMESISA-N

CanonicalSMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O

IUPAC Name: [[(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate

InChI: InChI=1S/C9H16N3O14P3/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(24-8)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,21,22)(H2,10,11,15)(H2,16,17,18)/t4-,6-,7-,8-/m1/s1

Synonyms: CTP; Cytidine triphosphate; Cytidine 5'-(tetrahydrogen triphosphate)