GTPαS sodium salt

GTPαS sodium salt is a modified form of guanosine triphosphate (GTP) where one of the non-bridging oxygen atoms at the α-phosphate position is replaced by a sulfur atom. This modification makes GTPαS resistant to hydrolysis by GTPases, allowing it to act as a non-hydrolyzable analog of GTP. It is commonly used in studies of G-protein signaling, enzymatic regulation, and molecular biology research. The sodium salt form improves its solubility and stability for experimental applications.

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Catalog

BRP-00702

Synonyms

Guanosine, 5'→P''-ester with thiotriphosphoric acid sodium salt; GTP-αS sodium salt; Guanosine-5'-Rp-Alpha-Thio-Triphosphate sodium salt; Guanosine 5'-O-(1-thiotriphosphate) sodium salt; Guanosine 5'-O-thiotriphosphate sodium salt; Alpha Thiol GTP (1-Thio-GTP) sodium salt

IUPAC Name

sodium;[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate

Molecular Weight

539.25 (free acid)

Molecular Formula

C10H16N5O13P3S (free acid)

Purity

>98%

Appearance

Colorless to light yellow liquid

Storage

Store at -20 °C, Always avoid freeze-thaw cycles