Name: GTP-αS
Brand: BOC Sciences
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GTP-αS

GTP-αS is a modified form of guanosine triphosphate (GTP). In GTP-αS, the oxygen atom in the α-phosphate group of GTP is replaced by a sulfur atom, resulting in a non-hydrolyzable analog of GTP. This modification allows GTP-αS to mimic the structure of GTP while preventing its hydrolysis. GTP-αS is commonly utilized in biochemical and molecular biology research to investigate GTP-dependent processes such as signal transduction, GTPase activity, and protein synthesis, among others.

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Catalog

BRP-00446

Synonyms

Guanosine, 5'→P''-ester with thiotriphosphoric acid; GTPαS; Guanosine-5'-Rp-Alpha-Thio-Triphosphate; Guanosine 5'-O-(1-thiotriphosphate); Guanosine 5'-O-thiotriphosphate; Alpha Thiol GTP (1-Thio-GTP)

CAS

71376-96-0

IUPAC Name

[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphinothioyl] phosphono hydrogen phosphate

Molecular Weight

539.25

Molecular Formula

C10H16N5O13P3S

SMILES

C1=NC2=C(N1C3C(C(C(O3)COP(=S)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N

InChI

InChI=1S/C10H16N5O13P3S/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-31(24,32)28-30(22,23)27-29(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,32)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-,31?/m1/s1

InChIKey

YRUWXBKVSXSSGS-AESZWTTRSA-N

Purity

≥95% by HPLC

Density

2.68±0.1 g/cm3

Appearance

Colourless to slightly yellow liquid

Storage

Store at -20 °C

Related CAS

81570-51-6 (S-isomer)