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GTPαS (Sp isomer)

GTPαS (Sp isomer) is a non-hydrolyzable analog of GTP. It contains a sulfur atom replacing one of the non-bridging oxygen atoms in the triphosphate chain. The Sp isomer specifically refers to the stereoisomer where the sulfur atom occupies a particular spatial orientation. This compound is widely used in biochemical research to study G-protein signaling pathways, as it can activate G-proteins but is resistant to hydrolysis, thereby providing sustained signaling.

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Catalog

BRP-01755

Synonyms

Guanosine 5'-O-(1-thiotriphosphate), Sp-isomer; SP-GTP-αS; Guanosine, 5'→P''-ester with [P''(S)]-thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(O)(OH)(SH)); Guanosine, 5'→P''-ester with thiotriphosphoric acid ((HO)2P(O)OP(O)(OH)OP(S)(OH)2), (S)-

CAS

81570-51-6

Molecular Weight

539.24

Molecular Formula

C10H16N5O13P3S

SMILES

O=C1N=C(N)NC2=C1N=CN2C3OC(COP(=O)(S)OP(=O)(O)OP(=O)(O)O)C(O)C3O

InChI

InChI=1S/C10H16N5O13P3S/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(26-9)1-25-31(24,32)28-30(22,23)27-29(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,32)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-,31+/m1/s1

InChIKey

YRUWXBKVSXSSGS-URAGBVNVSA-N

Purity

≥95% by HPLC

Density

2.68±0.1 g/cm3

Appearance

Colorless to slightly yellow liquid

Storage

Store at -20 °C

Related CAS

71376-96-0 (GTPαS)