rG (Ac), 2'-OAc CNA CPG is a modification reagent used in oligonucleotide synthesis. It introduces a riboguanosine (rG) residue modified with an acetyl (Ac) group onto a controlled pore glass (CPG) solid support. Additionally, it includes a 2'-O-acetyl modification to the ribose sugar and incorporates a 2'-O-methylribonucleotide (CNA) modification for enhanced stability. This reagent facilitates the synthesis of RNA oligonucleotides with specific chemical properties, such as increased resistance to nuclease degradation. These modified RNA oligonucleotides find applications in various research areas, including RNA interference (RNAi), gene expression regulation, and RNA-based therapeutics.
Chemical Structure:
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