Name: Nedosiran
Brand: BOC Sciences
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Nedosiran

Nedosiran (DCR-PHXC) is an RNA interference (RNAi) targeting lactate dehydrogenase (LDH). Nedosiran is a GalNAc-dsRNA conjugate. Nedosiran targets lactate dehydrogenase A (LDHA) in hepatocytes via GalNAc-mediated delivery.

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Catalog

BRP-02087

Synonyms

DCR-PHXC; DCR PHXC; RNA, (Am-sp-Um-(2'-deoxy-2'-fluoro)G-Um-(2'-deoxy-2'-fluoro)U-Gm-Um-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)C-(2'-deoxy-2'-fluoro)U-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)C-Um-Gm-Am-Gm-Cm-Am-Gm-Cm-Cm-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]G-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-[2'-O-[[2-[2-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]ethoxy]ethoxy]methyl]]A-Gm-Gm-Cm-Um-Gm-Cm), complex with RNA ([1-de-β-D-ribofuranosyl-1-[(2R,3R,4S,5R)-tetrahydro-4-hydroxy-5-[(hydroxymethoxyphosphinyl)methoxy]-3-methoxy-2-furanyl]]U-(4'→5')-sp-(2'-deoxy-2'-fluoro)C-sp-(2'-deoxy-2'-fluoro)A-sp-(2'-deoxy-2'-fluoro)G-(2'-deoxy-2'-fluoro)A-Um-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)A-(2'-deoxy-2'-fluoro)A-Am-Gm-Gm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)C-Am-Um-sp-Gm-sp-Gm) (1:1)

CAS

2266591-83-5

Molecular Weight

20,985 Da

Molecular Formula

C662H865F19N231O413P57S6

Storage

Store at -20 °C

Sequence

RNA, (auguuguccuuuuuaucugagcagccgaaaggcugc), complex with RNA (ucagauaaaaaggacaacaugg) (1:1)

Related CAS

2247026-22-6 (sodium salt)

Chemical Structure:

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BOC Sciences is a leading provider of DNA and RNA products and services that meet the needs of researchers and pharmaceutical companies worldwide. Its broad product portfolio includes various types of oligonucleotides, DNA/RNA synthesis feedstocks, RNA interference tools, and advanced drug delivery systems, among others. Designed to promote cutting-edge research and innovative therapeutic solutions, at BOC Sciences you are sure to find the right product for you.

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Nedosiran - CAS 2266591-83-5

Nedosiran

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