CAS 2646704-10-9 Manusiran - RNA / BOC Sciences

Manusiran

Manusiran is a potent TMPRSS6 (transmembrane protease serine 6) synthesis reducer. Manusiran is a GalNAc conjugated 19-mer siRNA that reduces plasma iron and increases hepcidin levels in healthy volunteers.

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Catalog

BRP-02077

Synonyms

Divesiran; RNA, (Am-sp-(2'-deoxy-2'-fluoro)A-sp-Cm-(2'-deoxy-2'-fluoro)C-Am-(2'-deoxy-2'-fluoro)G-Am-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)A-Am-(2'-deoxy-2'-fluoro)G-Cm-(2'-deoxy-2'-fluoro)A-Gm-(2'-deoxy-2'-fluoro)G-Um-sp-(2'-deoxy-2'-fluoro)G-sp-Am), complex with RNA ((2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)A-Cm-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)G-Cm-(2'-deoxy-2'-fluoro)U-Um-(2'-deoxy-2'-fluoro)C-Um-(2'-deoxy-2'-fluoro)U-Cm-(2'-deoxy-2'-fluoro)U-Gm-(2'-deoxy-2'-fluoro)G-sp-Um-sp-(2'-deoxy-2'-fluoro)U) 5'-[O-[19-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-7,7-bis[12-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-7-mercapto-7-oxido-2,6,8-trioxa-7-phosphadodec-1-yl]-14-mercapto-14-oxido-5,9,13,15-tetraoxa-14-phosphanonadec-1-yl] hydroxy phosphate] (1:1)

CAS

2646704-10-9

Molecular Weight

14058.53

Molecular Formula

C434H570F19N145O270P40S10

Manusiran - CAS 2646704-10-9

Manusiran