LZCapAG(3'Ma-FAM)

LZCapAG(3'Ma-FAM), a Cap1 analog with an FAM fluorescent label, can be used as an mRNA cotranscription capping agent. Under the action of T7 polymerase, LZCapAG(3'Ma-FAM), NTPs and template DNA were co-transcribed to produce mRNA with 5 'Cap 1 structure, and the capped mRNA could be directly translated and expressed in cells and in vivo, with excellent expression efficiency. LZCapAG(3'Ma-FAM) capped mRNA, with FAM label, can be detected by flow cytometry and fluorescence microscopy, and the distribution of mRNA and LNP can be traced and located.

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Catalog

BRP-00437

Synonyms

m7(3'Ma-FAM)Gppp(2'OMe)ApG; LZCapAG(3'Ma-FAM) ammonium salt; ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl ((2R,3R,4R,5R)-2-((((((((((2S,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1,6-dihydro-9H-purin-7-ium-9-yl)-3-((3',6'-dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxamido)methyl)-4-hydroxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-3-yl) phosphate ammonium salt

Molecular Weight

1517.02 (free acid)

Molecular Formula

C54H56N16O29P4 (free acid)

Purity

≥90% by HPLC

Storage

Store at -20 °C

Chemical Structure:

Chemical structure of BRP-00437