LZCapAG(3'Ma-Cy5)

LZCapAG(3'Ma-Cy5), a Cap1 analog with a Cy5 label, can be used as an mRNA cotranscription capping agent. Under the action of T7 polymerase, LZCapAG(3'Ma-Cy5), NTPs and template DNA were co-transcribed to produce mRNA with 5 'Cap 1 structure, and the capped mRNA could be directly translated and expressed in cells and in vivo, with excellent expression efficiency. With LZCapAG(3'Ma-Cy5) capped mRNA, FAM fluorescence can be detected by flow cytometry and fluorescence microscopy, and the distribution of mRNA and LNP can be traced and localized.

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Catalog

BRP-00439

Synonyms

m7(3'Ma-Cy5)Gppp(2'OMe)ApG; LZCapAG(3'Ma-Cy5) ammonium salt; 2-(5-(1-(6-((((2S,3S,4R,5R)-2-((((((((((2R,3R,4R,5R)-3-(((((2R,3S,4R,5R)-5-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)oxidophosphoryl)oxy)-5-(6-amino-9H-purin-9-yl)-4-methoxytetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)methyl)-5-(2-amino-7-methyl-6-oxo-1,6-dihydro-9H-purin-7-ium-9-yl)-4-hydroxytetrahydrofuran-3-yl)methyl)amino)-6-oxohexyl)-3,3-dimethyl-5-sulfo-3H-indol-1-ium-2-yl)penta-2,4-dien-1-ylidene)-1-ethyl-3,3-dimethylindoline-5-sulfonate ammonium salt

Molecular Weight

1797.51 (free acid)

Molecular Formula

C66H84N18O30P4S2 (free acid)

Purity

≥90% by HPLC

Storage

Store at -20 °C

Chemical Structure:

Chemical structure of BRP-00439