Name: LNA-G(dmf)-CE Phosphoramidite
Brand: BOC Sciences
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LNA-G(dmf)-CE Phosphoramidite

LNA-G(dmf)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a guanine base modified with a dimethylformamide (dmf) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the dmf modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

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Catalog

BRP-00390

Synonyms

2'-O-4'-C-Locked-rG(dmf) Phosphoramidite; 5'-Dimethoxytrityl-N-dimethylformamidine-(2'-O,4'-C-methylene)-Guanosine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite; dmf-G-LA-CE Phosphoramidite; 5'-DMT-LNA-Guanosine(N-dmf) CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rG(dmf)-3'-CE-Phosphoramidite; N'-[9-[2,5-Anhydro-4-C-[[bis(4-methoxyphenyl)phenylmethoxy]methyl]-3-O-[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]-α-L-lyxofuranosyl]-6,9-dihydro-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide; DMT-2'-O-4'-C-Locked-G(dmf)-CE; LNA-G(dmf) phosphoramidite; N2-Dimethylformamidine-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-Guanosine-3'-cyanoethyl Phosphoramidite; N2-dmf-2'-O-4'-C-Locked-Gr-CE-Phosphoramidite

CAS

709641-79-2

IUPAC Name

N'-[9-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-6-oxo-1H-purin-2-yl]-N,N-dimethylmethanimidamide

Molecular Weight

852.91

Molecular Formula

C44H53N8O8P

Canonical SMILES

CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=NC7=C6N=C(NC7=O)N=CN(C)C

InChI

InChI=1S/C44H53N8O8P/c1-29(2)52(30(3)4)61(58-24-12-23-45)60-38-37-41(51-28-46-36-39(51)48-42(49-40(36)53)47-27-50(5)6)59-43(38,25-56-37)26-57-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,37-38,41H,12,24-26H2,1-8H3,(H,48,49,53)/t37-,38+,41-,43-,61?/m1/s1

InChIKey

ACJXYPZQPQPGNE-KPKUBJDASA-N

Purity

≥95%

Appearance

Off-white to yellow powder

Storage

Store at -20 °C

Chemical Structure: