Name: LNA-C(Ac)-CE Phosphoramidite
Brand: BOC Sciences
Rating: 5 (1 reviews)

LNA-C(Ac)-CE Phosphoramidite

LNA-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It features a locked nucleic acid (LNA) backbone with a cytosine base modified with an acetyl (Ac) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the acetyl modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

* Please kindly note that our products are not to be used for therapeutic purposes and cannot be sold to patients.

Catalog

BRP-00389

Synonyms

N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; 5'-O-DMTr-2'-O-4'-C-Locked-C(Ac) Phosphoramidite; DMT-locC(Ac)Amidite; DMT-locC(Ac) phosphoramidite; DMTr-LNA-C(Ac)-3-CED-phosphoramidite; N6-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-C(Ac)-3-CED-phosphoramidite; Ac-C-LA-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-rC(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-[Bis(4-methoxyphenyl)phenylmethyl]-2'-O-4'-C-Locked-cytidine-3'-CE Phosphoramidite; N4-Ac-2'-O-4'-C-Locked-Cr-CE-Phosphoramidite

IUPAC Name

N-[1-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-2-oxopyrimidin-4-yl]acetamide

Molecular Weight

799.86

Molecular Formula

C42H50N5O9P

SMILES

CC(C)N(C(C)C)P(OCCC#N)OC1C2C(OC1(CO2)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)N6C=CC(=NC6=O)NC(=O)C

InChI

InChI=1S/C42H50N5O9P/c1-28(2)47(29(3)4)57(54-25-11-23-43)56-38-37-39(46-24-22-36(44-30(5)48)45-40(46)49)55-41(38,26-52-37)27-53-42(31-12-9-8-10-13-31,32-14-18-34(50-6)19-15-32)33-16-20-35(51-7)21-17-33/h8-10,12-22,24,28-29,37-39H,11,25-27H2,1-7H3,(H,44,45,48,49)/t37-,38+,39-,41-,57?/m1/s1

InChIKey

VLHUEAKCEPSXIL-WFNFTXKBSA-N

Purity

≥95%

Storage

Store at -20 °C

Chemical Structure:

Chemical structure of BRP-00389