Name: LNA-5-Me-C(Ac)-CE Phosphoramidite
Brand: BOC Sciences
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LNA-5-Me-C(Ac)-CE Phosphoramidite

LNA-5-Me-C(Ac)-CE Phosphoramidite is a specialized nucleotide used in oligonucleotide synthesis. It comprises a locked nucleic acid (LNA) backbone with a 5-methylcytosine base modified with an acetyl (Ac) group. Additionally, it contains a 5'-cyanoethyl (CE) phosphoramidite functionality for controlled addition during synthesis. LNAs are known for their enhanced hybridization properties and stability, and the 5-methyl modification further enhances these characteristics. This phosphoramidite is valuable in molecular biology research for applications requiring high specificity and affinity, such as antisense oligonucleotide therapy, SNP detection, and diagnostic assays.

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Catalog

BRP-00388

Synonyms

N6-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-LNA-cytidine-3'-cyanoethyl phosphoramidite; 5'-O-DMTr-2'-O-4'-C-Locked-5-Me-C(Ac) Phosphoramidite; DMT-locMeC(Ac)Amidite; DMT-locMeC(Ac) phosphoramidite; DMTr-LNA-5MeC(Ac)-3-CED-phosphoramidite; N6-Acetyl-5-methyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-cytidine-3'-cyanoethyl Phosphoramidite; LNA-5MeC(Ac)-3-CED-phosphoramidite; Ac-5-Me-C-LA-CE Phosphoramidite; DMTr-2'-O-4'-C-Locked-5-Me-rC(Ac)-3'-CE-Phosphoramidite; N4-Acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-O-4'-C-Locked-5-Methyl-Cytidine-3'-cyanoethyl Phosphoramidite; LNA MeC(Ac) amidite

IUPAC Name

N-[1-[(1R,3R,4R,7S)-1-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-7-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2,5-dioxabicyclo[2.2.1]heptan-3-yl]-5-methyl-2-oxopyrimidin-4-yl]acetamide

Molecular Weight

813.89

Molecular Formula

C43H52N5O9P

SMILES

CC1=CN(C(=O)N=C1NC(=O)C)C2C3C(C(O2)(CO3)COC(C4=CC=CC=C4)(C5=CC=C(C=C5)OC)C6=CC=C(C=C6)OC)OP(N(C(C)C)C(C)C)OCCC#N

InChI

InChI=1S/C43H52N5O9P/c1-28(2)48(29(3)4)58(55-24-12-23-44)57-38-37-40(47-25-30(5)39(45-31(6)49)46-41(47)50)56-42(38,26-53-37)27-54-43(32-13-10-9-11-14-32,33-15-19-35(51-7)20-16-33)34-17-21-36(52-8)22-18-34/h9-11,13-22,25,28-29,37-38,40H,12,24,26-27H2,1-8H3,(H,45,46,49,50)/t37-,38+,40-,42-,58?/m1/s1

InChIKey

UUPGQIYQTKJJKS-GKGIDAFMSA-N

Purity

≥95%

Appearance

Off-white to yellow powder

Storage

Store at -20 °C

Chemical Structure: